DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ntl and NAAT1

DIOPT Version :9

Sequence 1:	NP_609135.1	Gene:	Ntl / 34046	FlyBaseID:	FBgn0267326	Length:	590	Species:	Drosophila melanogaster
Sequence 2:	NP_572219.1	Gene:	NAAT1 / 31457	FlyBaseID:	FBgn0029762	Length:	641	Species:	Drosophila melanogaster

Alignment Length:	599	Identity:	216/599 - (36%)
Similarity:	341/599 - (56%)	Gaps:	38/599 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 TNA--TRKDKRIERDENRGQWKSKSEFILSLLGYAIGIGNVWRFPYLCYRSGGAAFLIPYLLMVI 71
            |||  |.|....:....|..|.:..||::|.:..::|:|||||||:..|.:||.||||||::::.
  Fly    21 TNAASTEKTDAEKPTAERTNWGNGLEFLMSCISVSVGLGNVWRFPFTAYENGGGAFLIPYIIVLF 85

  Fly    72 LAGIPLFYMEILIGQFSSTGCTGMFRMTPLLKGTGIAQVVVNAYCVCYYSVIISYPIRMIFYCFF 136
            |.|.|::|:|:::|||:|.|...::.:.|...|.|..|.......:.|||.:::..:..:|..|.
  Fly    86 LIGKPMYYLEMIMGQFTSQGTVKIWSVVPGFVGVGYGQAFGTICIISYYSSLLALTLYYLFVSFQ 150

  Fly   137 KKVPWEDCSNSWN----------TDDCVTASDMGKQNS-----------SDVFKTSADEFFHLEV 180
            .::||..|.:.|.          .|:.:|...:..:::           ::..::|::.:|...|
  Fly   151 SELPWSYCRDEWTNCVNSRPQEYVDNLLTGVSLANESARNLSGIVANDETEKLQSSSELYFLNVV 215

  Fly   181 LRISTDISD-LGGMVWEQLTALIITWIIIYFCLMRGIKSVGKVVYFTVPFPYLLLFILLIRGATL 244
            ::...|||| :|...|:...||.:.|::|:..:|||:||.||..||...|||::||:||||..||
  Fly   216 IKEKLDISDGVGDPDWKLTLALFVAWVVIFLVIMRGVKSSGKAAYFLALFPYVVLFVLLIRAVTL 280

  Fly   245 PGAWKGIKFYLYPEWHRLLDLKVWADAAVQMFFGIGPGWGGIVNMASFSSFRNNAKCDSVLIVSI 309
            .||..||.|:|.|:|..||:..||.:|.||.||.:..|.|.|:..||::.|.:....|::::.::
  Fly   281 EGARDGILFFLEPQWGELLNPTVWKEAVVQCFFSLAVGSGPIIMFASYNRFDHGIYRDAMIVTTL 345

  Fly   310 NVFTSLLAGFVVFSVLGFLSEKSGIP-VESVATGGAGLAFVTYPEAIA-LLPVPQLWALMFFFML 372
            :..||||.|..:|::||.|:....|. :..|...|.||||::||:||: ...||||::::|||||
  Fly   346 DTLTSLLGGITIFAILGNLAHNLQIENIRDVVRSGTGLAFISYPDAISKFQAVPQLFSVLFFFML 410

  Fly   373 FLLGIDSVFVQLEAIMSSILDE---W-YWVRSHKCKLTLISCLIFLGLSSIMCTNGGMFILQLFD 433
            |:|||.|:......|::.|.|:   | ||    |..||...|...:||  :..|.||.:||.|.|
  Fly   411 FVLGIGSIVALQSTIVTIICDQFKGWKYW----KVALTTSVCGFLMGL--VYVTPGGQWILTLVD 469

  Fly   434 WYSSAIAVIVICLVEIIMVAWIYGIKNFMLDVEFMLGKRPTLYWRIVWQVVTPVIIIFILITSIV 498
            :|.....|.::.:.|:..:.|:||::||..|:|||..:|.:||||:.|...|||::|.|.|.|:|
  Fly   470 FYGGTYVVFILAIFELAGIVWVYGLQNFCDDIEFMCNRRVSLYWRVCWSFFTPVMMIIIFIYSMV 534

  Fly   499 FIRTITYNNIPYPQWAIIIGWASCFTSVMWIPLY-IFYIMIRKRATLCDSLKKRLKPLD-WTPAD 561
            .|..|.|:.:.:|:.|.|.||..........||: ::||....:.|...|||..|||.| |.||:
  Fly   535 TIEPIKYSELYFPEAANIAGWLLFAIGAAQFPLWGLWYISRHPQGTYWKSLKASLKPSDRWGPAN 599

  Fly   562 PQDRAEYEAFRRQR 575
            |:.|.|:..|:.|:
  Fly   600 PEIRREWVIFKNQK 613

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ntl	NP_609135.1	SLC5-6-like_sbd	24..554	CDD:294310	200/558 (36%)
NAAT1	NP_572219.1	SLC6sbd	40..533	CDD:271359	180/498 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45440754
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11616
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.850