DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ntl and Slc6a6

DIOPT Version :9

Sequence 1:	NP_609135.1	Gene:	Ntl / 34046	FlyBaseID:	FBgn0267326	Length:	590	Species:	Drosophila melanogaster
Sequence 2:	XP_008761345.1	Gene:	Slc6a6 / 29464	RGDID:	61912	Length:	631	Species:	Rattus norvegicus

Alignment Length:	571	Identity:	219/571 - (38%)
Similarity:	352/571 - (61%)	Gaps:	21/571 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 PPTTNATR-KDKRIERDENRGQWKSKSEFILSLLGYAIGIGNVWRFPYLCYRSGGAAFLIPYLLM 69
            |..:..|| :|:...:...|.:|.||.:|:||:.|..:|:|||||||||||::||.||||||.:.
  Rat    32 PGKSPGTRPEDEADGKPPQREKWSSKIDFVLSVAGGFVGLGNVWRFPYLCYKNGGGAFLIPYFIF 96

  Fly    70 VILAGIPLFYMEILIGQFSST-GCTGMFRMTPLLKGTGIAQVVVNAYCVCYYSVIISYPIRMIFY 133
            :..:|:|:|::|::|||::|. |.|...::.||..|.|.|.:|:.:....||.||:::....:|.
  Rat    97 LFGSGLPVFFLEVIIGQYTSEGGITCWEKICPLFSGIGYASIVIVSLLNVYYIVILAWATYYLFQ 161

  Fly   134 CFFKKVPWEDCSNSWNTDDCVTASDMGKQNSSDVFKTSAD-------EFFHLEVLRISTDISDLG 191
            .|.|.:||..|::||||..|:  .|..::|.|.....||.       ||:...||.:|:.|...|
  Rat   162 SFQKDLPWAHCNHSWNTPQCM--EDTLRRNESHWVSLSAANFTSPVIEFWERNVLSLSSGIDHPG 224

  Fly   192 GMVWEQLTALIITWIIIYFCLMRGIKSVGKVVYFTVPFPYLLLFILLIRGATLPGAWKGIKFYLY 256
            .:.|:....|::.|::.:||:.:|::|.|||||||..||:.:|.:||:||.|||||.:|||||||
  Rat   225 SLKWDLALCLLLVWLVCFFCIWKGVRSTGKVVYFTATFPFAMLLVLLVRGLTLPGAGEGIKFYLY 289

  Fly   257 PEWHRLLDLKVWADAAVQMFFGIGPGWGGIVNMASFSSFRNNAKCDSVLIVSINVFTSLLAGFVV 321
            |...||.|.:||.||..|:||......|.:.::.|::.::.|:..|.:|:..:|..||.::||.:
  Rat   290 PNISRLEDPQVWIDAGTQIFFSYAICLGAMTSLGSYNKYKYNSYRDCMLLGCLNSGTSFVSGFAI 354

  Fly   322 FSVLGFLSEKSGIPVESVATGGAGLAFVTYPEAIALLPVPQLWALMFFFMLFLLGIDSVFVQLEA 386
            ||:|||::::.|:.:..||..|.||||:.||:|:.::|:|..|:::||.||.|||:||.||::|.
  Rat   355 FSILGFMAQEQGVDIADVAESGPGLAFIAYPKAVTMMPLPTFWSILFFIMLLLLGLDSQFVEVEG 419

  Fly   387 IMSSILDEW--YWVRSHKCKLTL-ISCLIFLGLSSIMCTNGGMFILQLFDWY-SSAIAVIVICLV 447
            .::|::|.:  :..:.::.::.: |.|.|...|...|.|.|||::.||||:| :|.:.::.:...
  Rat   420 QITSLVDLYPSFLRKGYRREIFIAIVCSISYLLGLTMVTEGGMYVFQLFDYYAASGVCLLWVAFF 484

  Fly   448 EIIMVAWIYGIKNFMLDVEFMLGKRPTLYWRIVWQVVTPVIIIFILITSIVFIRTITYNNI-PYP 511
            |..::|||||..|....:|.|:|.||..:.:..|.|:||.:.:...|.|:|....:|||.: .||
  Rat   485 ECFVIAWIYGGDNLYDGIEDMIGYRPGPWMKYSWAVITPALCVGCFIFSLVKYVPLTYNKVYRYP 549

  Fly   512 QWAIIIGWASCFTSVMWIPLYIFYIMIRKRATLCDSLKKRLKPLDWTPADP 562
            .|||.:||....:|::.|||.|..::.|...    .|:.|:|.| .||.:|
  Rat   550 DWAIGLGWGLALSSMVCIPLVIVILLCRTEG----PLRVRIKYL-ITPREP 595

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ntl	NP_609135.1	SLC5-6-like_sbd	24..554	CDD:294310	210/542 (39%)
Slc6a6	XP_008761345.1	SLC5-6-like_sbd	51..592	CDD:382020	212/547 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820