DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ntl and Slc6a18

DIOPT Version :9

Sequence 1:	NP_609135.1	Gene:	Ntl / 34046	FlyBaseID:	FBgn0267326	Length:	590	Species:	Drosophila melanogaster
Sequence 2:	NP_058859.2	Gene:	Slc6a18 / 29323	RGDID:	69352	Length:	615	Species:	Rattus norvegicus

Alignment Length:	623	Identity:	195/623 - (31%)
Similarity:	324/623 - (52%)	Gaps:	96/623 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 ATRKDKRIERDENRGQWKSKSEFILSLLGYAIGIGNVWRFPYLCYRSGGAAFLIPYLLMVILAGI 75
            |:..|..::.::.|.:|.:|.:::||.:|:|:|:||:|||||||:..||.||||||.:.::..||
  Rat     4 ASGMDPLVDIEDERPKWDNKLQYLLSCIGFAVGLGNIWRFPYLCHTHGGGAFLIPYFIALVFEGI 68

  Fly    76 PLFYMEILIGQFSSTGCTGMFR-MTPLLKGTGIAQVVVNAYCVCYYSVIISYPIRMIFYCFFKKV 139
            ||||:|:.|||....|..|::: ::|.|.|.|:....|:.....||:.|:.:.:......|...:
  Rat    69 PLFYIELAIGQRLRRGSIGVWKTISPYLGGVGLGCFSVSFLVSLYYNTILLWVLWFFLNSFQHPL 133

  Fly   140 PWEDCSNSWN----TDDCVTASDMGKQNSSDVFKTSADEFFHLEVLRISTDISDLGGMVWEQLTA 200
            ||..|....|    ..:|        |:|..|     ..|::.:.|.|::|||:.|.:.|:....
  Rat   134 PWSTCPLDLNRTGFVQEC--------QSSGTV-----SYFWYRQTLNITSDISNTGTIQWKLFLC 185

  Fly   201 LIITWIIIYFCLMRGIKSVGKVVYFTVPFPYLLLFILLIRGATLPGAWKGIKFYLYPEWHRLLDL 265
            |:..|..:|.|::|||:|.|||:|||..||||:|.|.||||.|||||.:|:.:...|....|.:.
  Rat   186 LVACWTTVYLCVIRGIESTGKVIYFTALFPYLVLTIFLIRGLTLPGATEGLTYLFTPNMKILQNP 250

  Fly   266 KVWADAAVQMFFGIGPGWGGIVNMASFSSFRNNAKCDSVLIVSINVFTSLLAGFVVFSVLGFLSE 330
            :||.|||.|:||.:...:||.:..||::..|||.:.|:|.|..:|..|||.|...:||::||.:.
  Rat   251 RVWLDAATQIFFSLSLAFGGHIAFASYNQPRNNCEKDAVTIALVNSMTSLYASITIFSIMGFKAS 315

  Fly   331 K--------------------------------------------SGIPVESV--------ATGG 343
            .                                            :.:|:::.        :..|
  Rat   316 NDYGRCLDRNILSLINEFDFPELSISRDEYPSVLMYLNATQPERVARLPLKTCHLEDFLDKSASG 380

  Fly   344 AGLAFVTYPEAIALLPVPQLWALMFFFMLFLLGIDSVFVQLEAIMSSILDEWYWVRS-HKCKLTL 407
            .||||:.:.||:..:|...:|:::||.|||.||:.|:|..:|.:::.:.|.....:. .|..:|.
  Rat   381 PGLAFIVFTEAVLHMPGASVWSVLFFGMLFTLGLSSMFGNMEGVITPLFDMGILPKGVPKETMTG 445

  Fly   408 ISCLIFLGLSSIMCT-NGGMFILQLFDWYSSAIAVIVICLVEIIMVAWIYGIKNFMLDVEFMLGK 471
            :.|.|.. ||:|..| ..|.:.|::||.:::::.:|:...:|::.|..:||||.|..|:|:|.|:
  Rat   446 VVCFICF-LSAICFTLQSGSYWLEIFDSFAASLNLIIFAFMEVVGVIHVYGIKRFCDDIEWMTGR 509

  Fly   472 RPTLYWRIVWQVVTPVIIIFILITSIVFIRTIT---------YNNIP------YPQWAIIIGWAS 521
            ||:|||::.|:||:|:::..|.::.||.:...:         |.:.|      ||.|..:.....
  Rat   510 RPSLYWQVTWRVVSPMLLFGIFLSYIVLLAQSSPSYKAWNPQYEHFPSREEKLYPGWVQVTCVLL 574

  Fly   522 CFTSVMWIP-----LYIFYIMIRKRATLCDSLKKRLKP 554
            .|...:|:|     ..:|....|.:.|   .|:..|||
  Rat   575 SFLPSLWVPGIALAQLLFQYRQRWKNT---HLESALKP 609

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ntl	NP_609135.1	SLC5-6-like_sbd	24..554	CDD:294310	191/608 (31%)
Slc6a18	NP_058859.2	SLC6sbd_B0AT3	16..591	CDD:212086	186/588 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810