Protein Alignment Ntl and Slc6a1

DIOPT Version :9

• Sequence 1: NP_609135.1
• Gene: Ntl / 34046
• FlyBaseID: FBgn0267326
• Length: 590
• Species: Drosophila melanogaster
• Sequence 2: NP_848818.1
• Gene: Slc6a1 / 232333
• MGIID: 95627
• Length: 599
• Species: Mus musculus
• Alignment Length: 582
• Identity: 221/582 - (37%)
• Similarity: 362/582 - (62%)
• Gaps: 27/582 - (4%)

  Fly     7 PTTNATRKDKRIERDENRGQWKSKSEFILSLLGYAIGIGNVWRFPYLCYRSGGAAFLIPYLLMVI 71
            |.|...:..|:.....:|..||.:.:|::|.:|||||:||||||||||.::||.||||||.|.:|
Mouse    27 PKTLVVKVQKKAGDLPDRDTWKGRFDFLMSCVGYAIGLGNVWRFPYLCGKNGGGAFLIPYFLTLI 91

  Fly    72 LAGIPLFYMEILIGQFSSTGCTGMFRMTPLLKGTGIAQVVVNAYCVCYYSVIISYPIRMIFYCFF 136
            .||:|||.:|..:||::|.|..|::::.|:.||.|:|..|::.:...||.||||:.|..::..|.
Mouse    92 FAGVPLFLLECSLGQYTSIGGLGVWKLAPMFKGVGLAAAVLSFWLNIYYIVIISWAIYYLYNSFT 156

  Fly   137 KKVPWEDCSNSWNTDDCVTASDMGKQNSSDVFKTSA-DEFFHLEVLRISTDISDLGGMVWEQLTA 200
            ..:||:.|.|.||||.|.  |:....|::::  ||| .||:...:.:::..:...|.:.|.....
Mouse   157 TTLPWKQCDNPWNTDRCF--SNYSLVNTTNM--TSAVVEFWERNMHQMTDGLDKPGQIRWPLAIT 217

  Fly   201 LIITWIIIYFCLMRGIKSVGKVVYFTVPFPYLLLFILLIRGATLPGAWKGIKFYLYPEWHRLLDL 265
            |.|.|:::|||:.:|:...||||||:..:||::|.||..||.|||||.:||.||:.|.:.:|.|.
Mouse   218 LAIAWVLVYFCIWKGVGWTGKVVYFSATYPYIMLIILFFRGVTLPGAKEGILFYITPNFRKLSDS 282

  Fly   266 KVWADAAVQMFFGIGPGWGGIVNMASFSSFRNNAKCDSVLIVSINVFTSLLAGFVVFSVLGFLSE 330
            :||.|||.|:||..|.|.|.::.:.|::||.||...||:::..||..||:.||||:||::||::.
Mouse   283 EVWLDAATQIFFSYGLGLGSLIALGSYNSFHNNVYRDSIIVCCINSCTSMFAGFVIFSIVGFMAH 347

  Fly   331 KSGIPVESVATGGAGLAFVTYPEAIALLPVPQLWALMFFFMLFLLGIDSVFVQLEAIMSSILDEW 395
            .:...:..||..|.||||:.||||:..||:..|||::||.||.:|||||.|..:|..:::::||:
Mouse   348 VTKRSIADVAASGPGLAFLAYPEAVTQLPISPLWAILFFSMLLMLGIDSQFCTVEGFITALVDEY 412

  Fly   396 YWVRSHKCKLTLIS-CLI--FLGLSSIMCTNGGMFILQLFDWYS-SAIAVIVICLVEIIMVAWIY 456
            ..:..::.:|.:.: |::  .:|||:|  |.||:::.:|||:|| |.::::.:...|.:.::|.|
Mouse   413 PRLLRNRRELFIAAVCIVSYLIGLSNI--TQGGIYVFKLFDYYSASGMSLLFLVFFECVSISWFY 475

  Fly   457 GIKNFMLDVEFMLGKRPTLYWRIVWQVVTPVIIIFILITSIVFIRTITYNNIPYPQWAIIIGWAS 521
            |:..|..:::.|:|.||.::|::.|...||:|:..:.:.|.|.:..:|..:..:|:|...:||..
Mouse   476 GVNRFYDNIQEMVGSRPCIWWKLCWSFFTPIIVAGVFLFSAVQMTPLTMGSYVFPKWGQGVGWLM 540

  Fly   522 CFTSVMWIPLYIFYIMIRKRATLCDSLKKRLKPL----------DWTPADPQ--DRAEYEAF 571
            ..:|::.||.|:.|:.:    ||..|||:||:.:          :..|..||  ..|..||:
Mouse   541 ALSSMVLIPGYMAYMFL----TLKGSLKQRLQVMIQPSEDIVRPENGPEQPQAGSSASKEAY 598

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ntl	NP_609135.1	SLC5-6-like_sbd	24..554	CDD:294310	212/534 (40%)
Slc6a1	NP_848818.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..23
		SLC6sbd_GAT1	2..599	CDD:212075	221/582 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	577..599		6/22 (27%)
		PDZ-binding	597..599		1/2 (50%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S2610
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.770