DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ntl and Slc6a20b

DIOPT Version :9

Sequence 1:	NP_609135.1	Gene:	Ntl / 34046	FlyBaseID:	FBgn0267326	Length:	590	Species:	Drosophila melanogaster
Sequence 2:	NP_035861.2	Gene:	Slc6a20b / 22599	MGIID:	1336891	Length:	635	Species:	Mus musculus

Alignment Length:	582	Identity:	185/582 - (31%)
Similarity:	304/582 - (52%)	Gaps:	88/582 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 RGQWKSKSEFILSLLGYAIGIGNVWRFPYLCYRSGGAAFLIPYLLMVILAGIPLFYMEILIGQFS 88
            |.:|.:..:|:|..:.||:|:||||||||||...||.:||:||::|:|:.|:||.|:|:.:||..
Mouse    48 RPKWDNPLQFLLVCISYAVGLGNVWRFPYLCQMYGGGSFLVPYIIMLIVEGMPLLYLELAVGQRM 112

  Fly    89 STGCTGMFR-MTPLLKGTGIAQVVVNAYCVCYYSVIISYPIRMIFYCFFKKVPWEDCS-NSWNT- 150
            ..|..|.:| ::|.|.|.|||.:||:.....|::||.::.:..:|:.|...:||..|. ||.:|
Mouse   113 RQGSIGAWRTISPYLSGVGIASLVVSFLASVYFNVINTWALWYLFHSFQDPLPWSVCPLNSNHTG 177

  Fly   151 --DDCVTASDMGKQNSSDVFKTSADEFFHLEVLRISTDISDLGGMVWEQLTALIITWIIIYFCLM 213
              ::|..||             |...|::.:.|.||..|.:.||:.||....|.:.|:::|.|::
Mouse   178 YDEECEKAS-------------STQYFWYRKTLNISPSIQENGGVQWEPALCLTLAWLMVYLCIL 229

  Fly   214 RGIKSVGKVVYFTVPFPYLLLFILLIRGATLPGAWKGIKFYLYPEWHRLLDLKVWADAAVQMFFG 278
            ||.:|.|||||||...||.:|.|.|:||.||.||..|:.:...|:..:|.:.|.|.:||.|:||.
Mouse   230 RGTESTGKVVYFTTSLPYFVLIIYLVRGLTLHGATNGLAYMFTPKIEQLANPKAWINAATQIFFS 294

  Fly   279 IGPGWGGIVNMASFSSFRNNAKCDSVLIVSINVFTSLLAGFVVFSVLGF---------------- 327
            :|.|.||::..||::...|:.:..::::..||..|::.:..|.||:.||
Mouse   295 LGLGCGGLIAFASYNEPSNDCQKHALIVSVINSTTAIFSSIVTFSIYGFKATFNYENCLNKVILL 359

  Fly   328 ----------------LSE-----KSGIP--------------VES---VATGGAGLAFVTYPEA 354
                            |.|     .|..|              :||   .|..|.||||:.|.||
Mouse   360 LTNSFDLEDGFLTVSNLEEVKNYLASTYPNKYSEVFPHIRNCSLESELDTAVQGTGLAFIVYTEA 424

  Fly   355 IALLPVPQLWALMFFFMLFLLGIDSVFVQLEAIMSSILDEWYWVRSH--KCKLTLISCLIFLGLS 417
            |..:.|.|||::::||||..||:.|:.....||::.:.|... :.|:  |..::.:.||:...:.
Mouse   425 IKNMEVSQLWSVLYFFMLLTLGMGSMVGTGTAILTPLTDSKI-ISSYLPKEAISGLVCLLNCAIG 488

  Fly   418 SIMCTNGGMFILQLFDWYSSAIAVIVICLVEIIMVAWIYGIKNFMLDVEFMLGKRPTLYWRIVWQ 482
            .:.....|.:...||:.|::.:::::|.|||.|.|.::||:|.|..|:..|.|:..:.||:::|.
Mouse   489 MVFTMEAGNYWFDLFNDYTATLSLLLIVLVETIAVCYVYGLKRFESDLRAMTGRTLSWYWKVMWA 553

  Fly   483 VVTPVIIIFILI---TSIVFIRTITYN----------NIPYPQWAIIIGWASCFTSVMWIPL 531
            .|:|::|:.:.|   :..:...|:.|.          ...||.:|:.:......:|.|.|||
Mouse   554 FVSPLLIVGLFIFYLSDYILTGTLQYQAWDATQGHVVTKDYPTYALAVIGLLVASSTMCIPL 615

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ntl	NP_609135.1	SLC5-6-like_sbd	24..554	CDD:294310	185/582 (32%)
Slc6a20b	NP_035861.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..38
Slc6a20b	NP_035861.2	SLC5-6-like_sbd	45..620	CDD:294310	185/582 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810