DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ntl and Slc6a18

DIOPT Version :9

Sequence 1:	NP_609135.1	Gene:	Ntl / 34046	FlyBaseID:	FBgn0267326	Length:	590	Species:	Drosophila melanogaster
Sequence 2:	NP_001035782.1	Gene:	Slc6a18 / 22598	MGIID:	1336892	Length:	615	Species:	Mus musculus

Alignment Length:	594	Identity:	192/594 - (32%)
Similarity:	313/594 - (52%)	Gaps:	88/594 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 ATRKDKRIERDENRGQWKSKSEFILSLLGYAIGIGNVWRFPYLCYRSGGAAFLIPYLLMVILAGI 75
            |:..|..::.::.|.:|.:|.:::||.:|:|:|:||:|||||||...||.||||||.:.::..||
Mouse     4 ASGMDPLVDIEDERPKWDNKLQYLLSCIGFAVGLGNIWRFPYLCQTHGGGAFLIPYFIALVFEGI 68

  Fly    76 PLFYMEILIGQFSSTGCTGMFR-MTPLLKGTGIAQVVVNAYCVCYYSVIISYPIRMIFYCFFKKV 139
            ||||:|:.|||....|..|::: ::|.|.|.|:....|:.....||:.::.:.:......|...:
Mouse    69 PLFYIELAIGQRLRRGSIGVWKTISPYLGGVGLGCFSVSFLVSLYYNTVLLWVLWFFLNSFQHPL 133

  Fly   140 PWEDCSNSWN----TDDCVTASDMGKQNSSDVFKTSADEFFHLEVLRISTDISDLGGMVWEQLTA 200
            ||..|....|    ..:|        |:|..|     ..|::.:.|.|::|||:.|.:.|:....
Mouse   134 PWSTCPLDLNRTGFVQEC--------QSSGTV-----SYFWYRQTLNITSDISNTGTIQWKLFLC 185

  Fly   201 LIITWIIIYFCLMRGIKSVGKVVYFTVPFPYLLLFILLIRGATLPGAWKGIKFYLYPEWHRLLDL 265
            |:..|..:|.|::|||:|.|||:|||..||||:|.|.||||.|||||.:|:.:...|....|.:.
Mouse   186 LVACWSTVYLCVIRGIESTGKVIYFTALFPYLVLTIFLIRGLTLPGATEGLIYLFTPNMKTLQNP 250

  Fly   266 KVWADAAVQMFFGIGPGWGGIVNMASFSSFRNNAKCDSVLIVSINVFTSLLAGFVVFSVLGF--- 327
            :||.|||.|:||.:...:||.:..||::..|||.:.|:|:|..:|..|||.|...:|||:||
Mouse   251 RVWLDAATQIFFSLSLAFGGHIAFASYNPPRNNCEKDAVIIALVNSMTSLYASIAIFSVMGFKAS 315

  Fly   328 -------------LSEKSGIPVESV------------------------------------ATGG 343
                         |..:..:|..|:                                    :..|
Mouse   316 NDYGRCLDRNILSLINEFDLPELSISRDEYPSVLMYLNATQTARVAQLPLKTCHLEDFLDKSASG 380

  Fly   344 AGLAFVTYPEAIALLPVPQLWALMFFFMLFLLGIDSVFVQLEAIMSSILDEWYWVRS-HKCKLTL 407
            .||||:.:.||:..:|...:|:::||.|||.||:.|:|..:|.:::.:||.....:. .|..:|.
Mouse   381 PGLAFIVFTEAVLHMPGASVWSVLFFGMLFTLGLSSMFGNMEGVITPLLDMGILPKGIPKEVMTG 445

  Fly   408 ISCLIFLGLSSIMCT-NGGMFILQLFDWYSSAIAVIVICLVEIIMVAWIYGIKNFMLDVEFMLGK 471
            :.|.... ||:|..| ..|.:.|::||.:::::.:|:...:|::.|..|||:|.|..|:|:|.|:
Mouse   446 VICFACF-LSAICFTLQSGGYWLEIFDSFAASLNLIIFAFMEVVGVIHIYGMKRFCDDIEWMTGR 509

  Fly   472 RPTLYWRIVWQVVTPVIIIFILITSIV-FIRT--------ITYNNIP------YPQWAIIIGWAS 521
            ||.|||::.|:||:|:::..|.::.|| .|:|        ..|.:.|      ||.|..:.....
Mouse   510 RPGLYWQVTWRVVSPMLLFGIFLSYIVLLIQTPPSYKAWNPQYEHFPSREEKFYPGWVQVTCVLL 574

  Fly   522 CFTSVMWIP 530
            .|...:|:|
Mouse   575 SFLPSLWVP 583

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ntl	NP_609135.1	SLC5-6-like_sbd	24..554	CDD:294310	190/581 (33%)
Slc6a18	NP_001035782.1	SLC6sbd_B0AT3	16..591	CDD:212086	190/582 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810