DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ntl and mod-5

DIOPT Version :9

Sequence 1:	NP_609135.1	Gene:	Ntl / 34046	FlyBaseID:	FBgn0267326	Length:	590	Species:	Drosophila melanogaster
Sequence 2:	NP_491095.3	Gene:	mod-5 / 171879	WormBaseID:	WBGene00003387	Length:	671	Species:	Caenorhabditis elegans

Alignment Length:	580	Identity:	204/580 - (35%)
Similarity:	326/580 - (56%)	Gaps:	41/580 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 NQP--------PTTN----ATRKDKRIERDENRGQWKSKSEFILSLLGYAIGIGNVWRFPYLCYR 56
            |:|        ||..    |.|:...:.||    :|.:|.||:|:::|||:.:||:||||.:||:
Worm    72 NEPIAALGGLTPTKEGRVAALRRRSSMVRD----KWATKMEFLLAVVGYAVDLGNIWRFPSVCYK 132

  Fly    57 SGGAAFLIPYLLMVILAGIPLFYMEILIGQFSSTGCTGMFR-MTPLLKGTGIAQVVVNAYCVCYY 120
            .||.||||||.:|:::.|:|:||||:::|||..:||..::| :.||.:|.|.....:..:...:|
Worm   133 HGGGAFLIPYFIMLMIGGLPMFYMELVLGQFHRSGCVSIWRKVCPLFRGIGYGICCICTFIAIFY 197

  Fly   121 SVIISYPIRMIFYCFFK----KVPWEDCSNSWNTDDCVTASDMGKQNSSDVFKTSADEFFHLEVL 181
            :.||:..:........|    :|||..|.|.|||..|....::....:.....|.::|::..:||
Worm   198 NAIIAQAVYFAIVSLSKIWDSEVPWASCGNPWNTPRCSDDLNVTISRNGTPLTTPSEEYYLYKVL 262

  Fly   182 RI--STDISDLGGMVWEQLTALIITWIIIYFCLMRGIKSVGKVVYFTVPFPYLLLFILLIRGATL 244
            .:  ||...||||:.......|:..:|::||.|.:|.:|.||:|:.|...||::|.||||||..|
Worm   263 EVQKSTGFDDLGGVKTSMAVCLLAVFIMVYFALWKGPQSSGKIVWVTATAPYIILSILLIRGLLL 327

  Fly   245 PGAWKGIKFYLYPEWHRLLDLKVWADAAVQMFFGIGPGWGGIVNMASFSSFRNNAKCDSVLIVSI 309
            |||..|:.:|:.|::.:|.|..||:.||.|:||.:|||:|.::.::|::.|.||...|:|....|
Worm   328 PGAKNGLYYYVTPDFEKLKDPAVWSAAATQIFFSLGPGFGVLLALSSYNDFNNNCYRDAVTTSII 392

  Fly   310 NVFTSLLAGFVVFSVLGFLSEKSGIPV-ESVATGGAGLAFVTYPEAIALLPVPQLWALMFFFMLF 373
            |..||..:|.||||.||::|..:..|: |.|....|.|.|:.||:|:|.:.....|:.:||.||.
Worm   393 NCATSFFSGCVVFSTLGYMSLLTNKPINEVVGEHDASLIFIVYPQALATMDYSCFWSFIFFVMLI 457

  Fly   374 LLGIDSVFVQLEAIMSSILDEWYWVRSHKCKLTLISCLIFLGLSSIMCTNGGMFILQLFDWYSSA 438
            .|||||.|..:||.::...||..::..::....|:.|:|:..||....:.||.|::...|.|..:
Worm   458 TLGIDSTFAGIEAFITGFCDESRFLSKNRKWFVLVICIIYYFLSFPAISYGGQFVIPFLDEYGVS 522

  Fly   439 IAVIVICLVEIIMVAWIYGIKNFMLDVEFMLGKRPTLYWRIVWQVVTPVIIIFILITSIVFIRTI 503
            ::|:.|...|:|.|.|.||:..|..|:..|||..|.:|||:.| ..:||.|      |::||.|:
Worm   523 LSVLFIVTCEMIAVCWFYGVDQFSKDIRAMLGFYPGIYWRVCW-TCSPVFI------SVIFIMTV 580

  Fly   504 TYN---------NIPYPQWAIIIGWASCFTSVMWIPLYIFYIMIRKRATLCDSLKKRLKP 554
             ||         :..:|.|::|:||.....||:.||::....::....||.:..:..:.|
Worm   581 -YNSSFKPIQMASYTFPWWSVILGWFLRLLSVLAIPVFAIIYLLSGTGTLYERFRWAITP 639

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ntl	NP_609135.1	SLC5-6-like_sbd	24..554	CDD:294310	195/546 (36%)
mod-5	NP_491095.3	SLC6sbd_SERT-like	100..639	CDD:271388	197/550 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820