DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ntl and Slc6a13

DIOPT Version :9

Sequence 1:	NP_609135.1	Gene:	Ntl / 34046	FlyBaseID:	FBgn0267326	Length:	590	Species:	Drosophila melanogaster
Sequence 2:	XP_006237280.2	Gene:	Slc6a13 / 171163	RGDID:	620788	Length:	608	Species:	Rattus norvegicus

Alignment Length:	605	Identity:	231/605 - (38%)
Similarity:	358/605 - (59%)	Gaps:	38/605 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 PTTNATRKDKRIERDENRGQWKSKSEFILSLLGYAIGIGNVWRFPYLCYRSGGAAFLIPYLLMVI 71
            |......:|..:||:    ||.:|.||:||:.|..||:|||||||||||::||.||.||||:.:.
  Rat    19 PVMEKVEEDGTLERE----QWTNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYLIFLF 79

  Fly    72 LAGIPLFYMEILIGQFSST-GCTGMFRMTPLLK------GTGIAQVVVNAYCVCYYSVIISYPIR 129
            ..|||:|::|..:||:::. |.|...::.|:.:      |.|.|..::.:....||.|::::.:.
  Rat    80 TCGIPVFFLETALGQYTNQGGITAWRKICPIFEASVPSPGIGYASQMIVSLLNVYYIVVLAWALF 144

  Fly   130 MIFYCFFKKVPWEDCSNSWNTDDCVTASDMGKQNSS-DVFKTSAD----EFFHLEVLRISTDISD 189
            .:|..|...:||..||:.|||::||   :..|.|:| :|...:|.    ||:...||:||..|..
  Rat   145 YLFSSFTTDLPWGSCSHEWNTENCV---EFQKTNNSLNVTSENATSPVIEFWERRVLKISDGIQH 206

  Fly   190 LGGMVWEQLTALIITWIIIYFCLMRGIKSVGKVVYFTVPFPYLLLFILLIRGATLPGAWKGIKFY 254
            ||.:.||.:..|::.|||.|||:.:|:||.|||||||..||||:|.:|||||.|||||.:||:||
  Rat   207 LGSLRWELVLCLLLAWIICYFCIWKGVKSTGKVVYFTATFPYLMLVVLLIRGVTLPGAAQGIQFY 271

  Fly   255 LYPEWHRLLDLKVWADAAVQMFFGIGPGWGGIVNMASFSSFRNNAKCDSVLIVSINVFTSLLAGF 319
            |||...||.|.:||.||..|:||......|.:..:.|::.:.||...|.|.:..:|..||.:|||
  Rat   272 LYPNITRLWDPQVWMDAGTQIFFSFAICLGCLTALGSYNKYHNNCYRDCVALCILNSSTSFVAGF 336

  Fly   320 VVFSVLGFLSEKSGIPVESVATGGAGLAFVTYPEAIALLPVPQLWALMFFFMLFLLGIDSVFVQL 384
            .:||:|||:|::.|:|:..||..|.||||:.||.|:.:||...|||..||||:.|||:||.||.:
  Rat   337 AIFSILGFMSQEQGVPISEVAESGPGLAFIAYPRAVVMLPFSPLWACCFFFMVVLLGLDSQFVCV 401

  Fly   385 EAIMSSILDEWYWVRSHKCKLTLISCLI-----FLGLSSIMCTNGGMFILQLFDWY-SSAIAVIV 443
            |:::::::|.:..|...|.:..::..::     |:||  ||.|.|||::.||||:| :|.:.::.
  Rat   402 ESLVTALVDMYPRVFRKKNRREILILIVSVVSFFIGL--IMLTEGGMYVFQLFDYYAASGMCLLF 464

  Fly   444 ICLVEIIMVAWIYGIKNFMLDVEFMLGKRPTLYWRIV---WQVVTPVIIIFILITSIVFIRTITY 505
            :.:.|.:.|||:||...|..::|.|:|.:|   |.::   |...||.:.:...:.|::....:||
  Rat   465 VAIFESLCVAWVYGASRFYDNIEDMIGYKP---WPLIKYCWLFFTPAVCLATFLFSLIKYTPLTY 526

  Fly   506 N-NIPYPQWAIIIGWASCFTSVMWIPLYIFYIMIRKRATLCDSLKKRLKPLDWTPADPQDRAEYE 569
            | ...||.|...:||....:|::.||.:..|    |..||...|::||:.|.....|...:::.|
  Rat   527 NKKYTYPWWGDALGWLLALSSMVCIPAWSIY----KLRTLKGPLRERLRQLVCPAEDLPQKSQPE 587

  Fly   570 AFRRQRRMPGFMSDTDMESS 589
            .......|...:..|::||:
  Rat   588 LTSPATPMTSLLRLTELESN 607

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ntl	NP_609135.1	SLC5-6-like_sbd	24..554	CDD:294310	220/551 (40%)
Slc6a13	XP_006237280.2	SLC5-6-like_sbd	32..581	CDD:382020	223/564 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820