DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ntl and Slc6a5

DIOPT Version :9

Sequence 1:	NP_609135.1	Gene:	Ntl / 34046	FlyBaseID:	FBgn0267326	Length:	590	Species:	Drosophila melanogaster
Sequence 2:	NP_976079.1	Gene:	Slc6a5 / 171148	RGDID:	621824	Length:	799	Species:	Rattus norvegicus

Alignment Length:	626	Identity:	235/626 - (37%)
Similarity:	367/626 - (58%)	Gaps:	62/626 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 NNQPP--------------------------TTNATRKDKRIERDENRGQWKSKSEFILSLLGYA 41
            ||.||                          .|....:|::.:.::.||.|.||.:||||::|||
  Rat   146 NNTPPVGWVNMSQSTVVLGTDGIASVLPGSVATTTIPEDEQGDENKARGNWSSKLDFILSMVGYA 210

  Fly    42 IGIGNVWRFPYLCYRSGGAAFLIPYLLMVILAGIPLFYMEILIGQFSSTGCTGMFRMTPLLKGTG 106
            :|:|||||||||.:::||.|||||||:|:.|||:|:|::|:.:|||:|.|...:::..|.|:|.|
  Rat   211 VGLGNVWRFPYLAFQNGGGAFLIPYLMMLALAGLPIFFLEVSLGQFASQGPVSVWKAIPALQGCG 275

  Fly   107 IAQVVVNAYCVCYYSVIISYPIRMIFYCFFKKVPWEDCSNSWNTDDC------------------ 153
            ||.::::.....||:|||.|.:..:|..|...:||..|:|.|||.:|
  Rat   276 IAMLIISVLIAIYYNVIICYTLFYLFASFVSVLPWGSCNNPWNTPECKDKTKLLLDSCVIGDHPK 340

  Fly   154 ---------------VTASDMGKQNSSDVFKTSADEFFHLEVLRISTDISDLGGMVWEQLTALII 203
                           :|..:...| ::..|.:.::|:|...||:||..|...|.:.|.....|.:
  Rat   341 IQIKNSTFCMTAYPNLTMVNFTSQ-ANKTFVSGSEEYFKYFVLKISAGIEYPGEIRWPLPFCLFL 404

  Fly   204 TWIIIYFCLMRGIKSVGKVVYFTVPFPYLLLFILLIRGATLPGAWKGIKFYLYPEWHRLLDLKVW 268
            .|:|:|..|.:|||:.|||||||..|||::|.||||||.|||||..||.:::.|:|.:|.|..||
  Rat   405 AWVIVYASLAKGIKTSGKVVYFTATFPYVVLVILLIRGVTLPGAGAGIWYFITPKWEKLTDATVW 469

  Fly   269 ADAAVQMFFGIGPGWGGIVNMASFSSFRNNAKCDSVLIVSINVFTSLLAGFVVFSVLGFLSEKSG 333
            .|||.|:||.:...|||::.::|::.|.||...|::::...|..||:.||||:|||:||::.:..
  Rat   470 KDAATQIFFSLSAAWGGLITLSSYNKFHNNCYRDTLIVTCTNSATSIFAGFVIFSVIGFMANERK 534

  Fly   334 IPVESVATGGAGLAFVTYPEAIALLPVPQLWALMFFFMLFLLGIDSVFVQLEAIMSSILDEW-YW 397
            :.:|:||..|.|:|||.||||:..||:...||::||.||..||:|::|..:|.|::||.||: .:
  Rat   535 VNIENVADQGPGIAFVVYPEALTRLPLSPFWAIIFFLMLLTLGLDTMFATIETIVTSISDEFPKY 599

  Fly   398 VRSHKCKLTLISCLIFLGLSSIMCTNGGMFILQLFDWYSSAIAVIVICLVEIIMVAWIYGIKNFM 462
            :|:||...||..|:.|..:...|.|.||:::.||.|.|:::.|:::|.:.|::.::::||::.|.
  Rat   600 LRTHKPVFTLGCCICFFIMGFPMITQGGIYMFQLVDTYAASYALVIIAIFELVGISYVYGLQRFC 664

  Fly   463 LDVEFMLGKRPTLYWRIVWQVVTPVIIIFILITSIVFIRTITYNNIPYPQWAIIIGWASCFTSVM 527
            .|:|.|:|.:|.::|::.|..|||.|:.|||..|......:||.:..||.|::::||.....||:
  Rat   665 EDIEMMIGFQPNIFWKVCWAFVTPTILTFILCFSFYQWEPMTYGSYRYPNWSMVLGWLMLACSVI 729

  Fly   528 WIPLYIFYIMIRKRATLCDSLKKRLKPL-DWTPADPQDRAE 567
            |||:.....|........:.||....|. ||.|...|.|.|
  Rat   730 WIPIMFVIKMYLAPGRFIERLKLVCSPQPDWGPFLAQHRGE 770

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ntl	NP_609135.1	SLC5-6-like_sbd	24..554	CDD:294310	222/563 (39%)
Slc6a5	NP_976079.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..64
Slc6a5	NP_976079.1	SLC6sbd_GlyT2	193..789	CDD:271389	229/579 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100873
Panther	1	1.100	-	-	O	PTHR11616
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.820