DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ntl and Slc6a4

DIOPT Version :9

Sequence 1:	NP_609135.1	Gene:	Ntl / 34046	FlyBaseID:	FBgn0267326	Length:	590	Species:	Drosophila melanogaster
Sequence 2:	NP_034614.2	Gene:	Slc6a4 / 15567	MGIID:	96285	Length:	630	Species:	Mus musculus

Alignment Length:	550	Identity:	220/550 - (40%)
Similarity:	347/550 - (63%)	Gaps:	21/550 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 RGQWKSKSEFILSLLGYAIGIGNVWRFPYLCYRSGGAAFLIPYLLMVILAGIPLFYMEILIGQFS 88
            |..|..|.:|:||::|||:.:||:|||||:||::||.|||:||.:|.|..||||||||:.:||:.
Mouse    79 RETWGKKMDFLLSVIGYAVDLGNIWRFPYICYQNGGGAFLLPYTIMAIFGGIPLFYMELALGQYH 143

  Fly    89 STGCTGMF-RMTPLLKGTGIAQVVVNAYCVCYYSVIISYPIRMIFYCFFKKVPWEDCSNSWNTDD 152
            ..||..:: ::.|:.||.|.|..::..|...||:.||::.:..:...|..::||..|.|||||.:
Mouse   144 RNGCISIWKKICPIFKGIGYAICIIAFYIASYYNTIIAWALYYLISSFTDQLPWTSCKNSWNTGN 208

  Fly   153 CVT--ASDMGKQNSSDVFKTS-ADEFFHLEVLRI--STDISDLGGMVWEQLTALIITWIIIYFCL 212
            |..  |.|   ..:..:..|| |:||:...||:|  |..:.|||.:.|:....:::.:.||||.:
Mouse   209 CTNYFAQD---NITWTLHSTSPAEEFYLRHVLQIHQSKGLQDLGTISWQLALCIMLIFTIIYFSI 270

  Fly   213 MRGIKSVGKVVYFTVPFPYLLLFILLIRGATLPGAWKGIKFYLYPEWHRLLDLKVWADAAVQMFF 277
            .:|:|:.||||:.|..|||::|.:||:|||||||||:|:.|||.|.|.:||:..||.|||.|:||
Mouse   271 WKGVKTSGKVVWVTATFPYIVLSVLLVRGATLPGAWRGVVFYLKPNWQKLLETGVWVDAAAQIFF 335

  Fly   278 GIGPGWGGIVNMASFSSFRNNAKCDSVLIVSINVFTSLLAGFVVFSVLGFLSEKSGIPVESVA-T 341
            .:|||:|.::..||::.|.||...|:::...:|..||.::|||:|:|||:::|.....|..|| .
Mouse   336 SLGPGFGVLLAFASYNKFNNNCYQDALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKD 400

  Fly   342 GGAGLAFVTYPEAIALLPVPQLWALMFFFMLFLLGIDSVFVQLEAIMSSILDEW--YWVRSHKCK 404
            .|..|.|:||.||||.:|....:|::||.||..||:||.|..||.:::::|||:  .|.:..:..
Mouse   401 AGPSLLFITYAEAIANMPASTFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHIWAKRREWF 465

  Fly   405 LTLISCLIFLGLSSIMCTNGGMFILQLFDWYSSAIAVIVICLVEIIMVAWIYGIKNFMLDVEFML 469
            :.::.....|| |.:..|:||.:::.|.:.|::..||:.:.|:|.::|:|.|||..|..||:.||
Mouse   466 VLIVVITCILG-SLLTLTSGGAYVVTLLEEYATGPAVLTVALIEAVVVSWFYGITQFCSDVKEML 529

  Fly   470 GKRPTLYWRIVWQVVTPVIIIFILITSIVF---IRTITYNNIPYPQWAIIIGWASCFTSVMWIPL 531
            |..|..:|||.|..::|:.::||:.:.::.   :|...||   ||.|:||:|:....:||:.||:
Mouse   530 GFSPGWFWRICWVAISPLFLLFIICSFLMSPPQLRLFQYN---YPHWSIILGYCIGTSSVICIPI 591

  Fly   532 YIFYIMIRKRATLCDSLKKRLKPLDWTPAD 561
            ||.|.:|....||.:.:.|.:.|  .||.:
Mouse   592 YIIYRLISTPGTLKERIIKSITP--ETPTE 619

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ntl	NP_609135.1	SLC5-6-like_sbd	24..554	CDD:294310	217/541 (40%)
Slc6a4	NP_034614.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..63
		5HT_transport_N	24..64	CDD:281488
		SLC6sbd_SERT	79..615	CDD:271399	218/544 (40%)
		Interaction with RAB4A. /evidence=ECO:0000250	616..624		2/3 (67%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820