DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ntl and Slc6a9

DIOPT Version :9

Sequence 1:	NP_609135.1	Gene:	Ntl / 34046	FlyBaseID:	FBgn0267326	Length:	590	Species:	Drosophila melanogaster
Sequence 2:	NP_001342104.1	Gene:	Slc6a9 / 14664	MGIID:	95760	Length:	652	Species:	Mus musculus

Alignment Length:	598	Identity:	256/598 - (42%)
Similarity:	376/598 - (62%)	Gaps:	47/598 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MANNQPPT------------TNATRKDKRIERDENRGQWKSKSEFILSLLGYAIGIGNVWRFPYL 53
            ||:.|.|.            :.||:||:.:    .||.|.::.||:|:.:|||:|:|||||||||
Mouse    15 MASAQGPVATPSPEQNGAVPSEATKKDQNL----TRGNWGNQIEFVLTSVGYAVGLGNVWRFPYL 75

  Fly    54 CYRSGGAAFLIPYLLMVILAGIPLFYMEILIGQFSSTGCTGMFRMTPLLKGTGIAQVVVNAYCVC 118
            |||:||.||:.||.:|:|..|||||:||:..|||:|.||.|::|::|:.||.|...:||:.|...
Mouse    76 CYRNGGGAFMFPYFIMLIFCGIPLFFMELSFGQFASQGCLGVWRISPMFKGVGYGMMVVSTYIGI 140

  Fly   119 YYSVIISYPIRMIFYCFFKK----VPWEDCSNSWNTDDCVTASDMG-----------KQNSSDVF 168
            ||:|:|.    :.||.||..    :||..|:|.|||.||....|..           ..|.|.:|
Mouse   141 YYNVVIC----IAFYYFFSSMTHVLPWAYCNNPWNTPDCAGVLDASNLTNGSRPAALSGNLSHLF 201

  Fly   169 -----KTS-ADEFFHLEVLRISTDISDLGGMVWEQLTALIITWIIIYFCLMRGIKSVGKVVYFTV 227
                 :|| ::|::.|.||::|.||.:.|.:....|..|.::|::::.||:||:||.|||||||.
Mouse   202 NYTLQRTSPSEEYWRLYVLKLSDDIGNFGEVRLPLLGCLGVSWVVVFLCLIRGVKSSGKVVYFTA 266

  Fly   228 PFPYLLLFILLIRGATLPGAWKGIKFYLYPEWHRLLDLKVWADAAVQMFFGIGPGWGGIVNMASF 292
            .|||::|.||.:||.||.||:.||.:||.|:|.::|:.|||.|||.|:|:.:|..|||::.|||:
Mouse   267 TFPYVVLTILFVRGVTLEGAFTGIMYYLTPQWDKILEAKVWGDAASQIFYSLGCAWGGLITMASY 331

  Fly   293 SSFRNNAKCDSVLIVSINVFTSLLAGFVVFSVLGFLSEKSGIPVESVATGGAGLAFVTYPEAIAL 357
            :.|.||...|||:|...|..||:.||||:||:|||::...|:.|..||..|.|||||.||||:.|
Mouse   332 NKFHNNCYRDSVIISITNCATSVYAGFVIFSILGFMANHLGVDVSRVADHGPGLAFVAYPEALTL 396

  Fly   358 LPVPQLWALMFFFMLFLLGIDSVFVQLEAIMSSILDEW--YWVRSHKCKLTL-ISCLIFLGLSSI 419
            ||:..||:|:|||||.|||:.:.|..||.::::|:||.  .|:...|..:|| ::...|| |...
Mouse   397 LPISPLWSLLFFFMLILLGLGTQFCLLETLVTAIVDEVGNEWILQKKTYVTLGVAVAGFL-LGIP 460

  Fly   420 MCTNGGMFILQLFDWYSSAIAVIVICLVEIIMVAWIYGIKNFMLDVEFMLGKRPTLYWRIVWQVV 484
            :.:..|::.|.|.|.|:::.:::||..:..:.:.:|||.:|:..|::.|||..|.|:::|.|:.|
Mouse   461 LTSQAGIYWLLLMDNYAASFSLVVISCIMCVSIMYIYGHRNYFQDIQMMLGFPPPLFFQICWRFV 525

  Fly   485 TPVIIIFILITSIVFIRTITYNNIPYPQWAIIIGWASCFTSVMWIPLYIFYIMIRKRA-TLCDSL 548
            :|.||.||||.:::..|.||||:..||.||:.||:....:||:.||||..:.:.|... ||...|
Mouse   526 SPAIIFFILIFTVIQYRPITYNHYQYPGWAVAIGFLMALSSVICIPLYALFQLCRTDGDTLLQRL 590

  Fly   549 KKRLKP-LDWTPA 560
            |...|| .||.||
Mouse   591 KNATKPSRDWGPA 603

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ntl	NP_609135.1	SLC5-6-like_sbd	24..554	CDD:294310	242/554 (44%)
Slc6a9	NP_001342104.1	SLC6sbd_GlyT1	30..613	CDD:212067	252/583 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5050
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	1	1.000	-	-		FOG0009703
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6310
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.820