DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ntl and Slc6a13

DIOPT Version :9

Sequence 1:	NP_609135.1	Gene:	Ntl / 34046	FlyBaseID:	FBgn0267326	Length:	590	Species:	Drosophila melanogaster
Sequence 2:	NP_001366036.1	Gene:	Slc6a13 / 14412	MGIID:	95629	Length:	602	Species:	Mus musculus

Alignment Length:	599	Identity:	231/599 - (38%)
Similarity:	357/599 - (59%)	Gaps:	32/599 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 PTTNATRKDKRIERDENRGQWKSKSEFILSLLGYAIGIGNVWRFPYLCYRSGGAAFLIPYLLMVI 71
            |......:|..:||:    .|.:|.||:||:.|..||:|||||||||||::||.||.||||:.:.
Mouse    19 PAMEKVEEDGTLERE----HWNNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYLIFLF 79

  Fly    72 LAGIPLFYMEILIGQFSST-GCTGMFRMTPLLKGTGIAQVVVNAYCVCYYSVIISYPIRMIFYCF 135
            ..|||:|::|..:||:::. |.|...|:.|:.:|.|.|..::.:....||.|::::.:..:|..|
Mouse    80 TCGIPVFFLETALGQYTNQGGITAWRRICPIFEGIGYASQMIVSLLNVYYIVVLAWALFYLFSSF 144

  Fly   136 FKKVPWEDCSNSWNTDDCVTASDMGKQNSS-DVFKTSAD----EFFHLEVLRISTDISDLGGMVW 195
            ...:||..||:.|||::||   :..|.|.| :|...:|.    ||:...||::|..|..||.:.|
Mouse   145 TTDLPWGSCSHEWNTENCV---EFQKANDSMNVTSENATSPVIEFWERRVLKLSDGIQHLGSLRW 206

  Fly   196 EQLTALIITWIIIYFCLMRGIKSVGKVVYFTVPFPYLLLFILLIRGATLPGAWKGIKFYLYPEWH 260
            |.:..|::.|||.|||:.:|:||.|||||||..||||:|.:|||||.|||||.:||:|||||...
Mouse   207 ELVLCLLLAWIICYFCIWKGVKSTGKVVYFTATFPYLMLVVLLIRGVTLPGAAQGIQFYLYPNIT 271

  Fly   261 RLLDLKVWADAAVQMFFGIGPGWGGIVNMASFSSFRNNAKCDSVLIVSINVFTSLLAGFVVFSVL 325
            ||.|.:||.||..|:||......|.:..:.|::.:.||...|.:.:..:|..||.:|||.:||:|
Mouse   272 RLWDPQVWMDAGTQIFFSFAICLGCLTALGSYNKYHNNCYRDCIALCILNSSTSFMAGFAIFSIL 336

  Fly   326 GFLSEKSGIPVESVATGGAGLAFVTYPEAIALLPVPQLWALMFFFMLFLLGIDSVFVQLEAIMSS 390
            ||:|::.|:|:..||..|.||||:.||.|:.:||...|||..||||:.|||:||.||.:|:::::
Mouse   337 GFMSQEQGVPISEVAESGPGLAFIAYPRAVVMLPFSPLWACCFFFMVVLLGLDSQFVCVESLVTA 401

  Fly   391 ILDEW---YWVRSHKCKLTLISCLI--FLGLSSIMCTNGGMFILQLFDWY-SSAIAVIVICLVEI 449
            ::|.:   :..::.:..|.||..:|  |:||  ||.|.|||::.||||:| :|.:.::.:.:.|.
Mouse   402 LVDMYPRVFRKKNRREVLILIVSVISFFIGL--IMLTEGGMYVFQLFDYYAASGMCLLFVAIFES 464

  Fly   450 IMVAWIYGIKNFMLDVEFMLGKRPTLYWRIV---WQVVTPVIIIFILITSIVFIRTITYN-NIPY 510
            :.|||:||...|..::|.|:|.:|   |.::   |...||.:.:...:.|::....:||| ...|
Mouse   465 LCVAWVYGAGRFYDNIEDMIGYKP---WPLIKYCWLFFTPAVCLATFLFSLIKYTPLTYNKKYTY 526

  Fly   511 PQWAIIIGWASCFTSVMWIPLYIFYIMIRKRATLCDSLKKRLKPLDWTPADPQDRAEYEAFRRQR 575
            |.|...:||....:|::.||.:..|    |..||...|::||:.|.....|...:.:.|......
Mouse   527 PWWGDALGWLLALSSMICIPAWSIY----KLRTLKGPLRERLRQLVCPAEDLPQKNQPEPTAPAT 587

  Fly   576 RMPGFMSDTDMESS 589
            .|...:..|::||:
Mouse   588 PMTSLLRLTELESN 601

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ntl	NP_609135.1	SLC5-6-like_sbd	24..554	CDD:294310	220/545 (40%)
Slc6a13	NP_001366036.1	SLC5-6-like_sbd	32..575	CDD:382020	223/558 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820