DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ntl and Slc6a12

DIOPT Version :9

Sequence 1:	NP_609135.1	Gene:	Ntl / 34046	FlyBaseID:	FBgn0267326	Length:	590	Species:	Drosophila melanogaster
Sequence 2:	NP_001368835.1	Gene:	Slc6a12 / 14411	MGIID:	95628	Length:	628	Species:	Mus musculus

Alignment Length:	566	Identity:	240/566 - (42%)
Similarity:	355/566 - (62%)	Gaps:	17/566 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 PTTNATRKDKRIERDENRGQWKSKSEFILSLLGYAIGIGNVWRFPYLCYRSGGAAFLIPYLLMVI 71
            |........|..::.::||||.:|.||:||:.|..||:|||||||||||::||.||.|||.:...
Mouse    33 PEEGEMMDQKGKDQVKDRGQWTNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYFIFFF 97

  Fly    72 LAGIPLFYMEILIGQFSSTG-CTGMFRMTPLLKGTGIAQVVVNAYCVCYYSVIISYPIRMIFYCF 135
            ..|||:|::|:.:||:||.| .|...::.|||:|.|:|.||:.:|...||.:|:::.:..:|..|
Mouse    98 SCGIPVFFLEVALGQYSSQGSVTAWRKICPLLQGIGMASVVIESYLNIYYIIILAWALFYLFSSF 162

  Fly   136 FKKVPWEDCSNSWNTDDCV---TASDMGKQNSSDVFKTSADEFFHLEVLRISTDISDLGGMVWEQ 197
            ..::||..|:|||||:.||   ..|.....:||:.|.:...||:...||.|::.|.|||.:.||.
Mouse   163 TWELPWTTCTNSWNTEHCVDFLNHSSARGVSSSENFTSPVMEFWERRVLGITSGIHDLGSLRWEL 227

  Fly   198 LTALIITWIIIYFCLMRGIKSVGKVVYFTVPFPYLLLFILLIRGATLPGAWKGIKFYLYPEWHRL 262
            ...|::.|||.|||:.:|:||.|||||||..||||:|.||||||.|||||::||.|||.|:..||
Mouse   228 ALCLLLAWIICYFCIWKGVKSTGKVVYFTATFPYLMLIILLIRGVTLPGAYQGIVFYLKPDLLRL 292

  Fly   263 LDLKVWADAAVQMFFGIGPGWGGIVNMASFSSFRNNAKCDSVLIVSINVFTSLLAGFVVFSVLGF 327
            .|.:||.||..|:||......|.:..:.|::.:.||...||:.:..:|..||.:|||||||:|||
Mouse   293 KDPQVWMDAGTQIFFSFAICQGCLTALGSYNKYHNNCYRDSIALCFLNSATSFVAGFVVFSILGF 357

  Fly   328 LSEKSGIPVESVATGGAGLAFVTYPEAIALLPVPQLWALMFFFMLFLLGIDSVFVQLEAIMSSIL 392
            :|::.|||:..||..|.||||:.:|:|:.::|:.|||:.:||.||..||:||.||.:|.::::.:
Mouse   358 MSQEQGIPISEVAESGPGLAFIAFPKAVTMMPLSQLWSCLFFIMLLFLGLDSQFVCMECLVTASM 422

  Fly   393 DEW--YWVRSHKCKLTL--ISCLIFLGLSSIMCTNGGMFILQLFDWY-SSAIAVIVICLVEIIMV 452
            |.:  ...:|.:.:|.:  ||.|.:| :..::.|.|||:|.||||:| ||.|.::.:.|.|:|.:
Mouse   423 DMFPQQLRKSGRRELLILAISVLCYL-MGLLLVTEGGMYIFQLFDYYASSGICLLFLSLFEVICI 486

  Fly   453 AWIYGIKNFMLDVEFMLGKRPTLYWRIVWQVVTPVIIIFILITSIVFIRTITYNNI-PYPQWAII 516
            .|:||...|..:||.|:|.||....:|.|..:||.:.:.....|:.....:.|||: .||.|...
Mouse   487 GWVYGADRFYDNVEDMIGYRPWPLVKISWLFLTPGLCLATFFFSLSKYTPLKYNNVYMYPSWGYS 551

  Fly   517 IGWASCFTSVMWIPLYIFYIMIRKRATLCDSLKKRLKPLDWTPADP 562
            |||...|:|:..:||:|....::.:.    |.||||:.| .|| ||
Mouse   552 IGWLLAFSSMACVPLFIIITFLKTQG----SFKKRLRRL-ITP-DP 591

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ntl	NP_609135.1	SLC5-6-like_sbd	24..554	CDD:294310	233/539 (43%)
Slc6a12	NP_001368835.1	SLC5-6-like_sbd	49..589	CDD:382020	234/545 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820