Protein Alignment Ntl and SLC6A14

DIOPT Version :10

• Sequence 1: NP_609135.1
• Gene: Ntl / 34046
• FlyBaseID: FBgn0267326
• Length: 590
• Species: Drosophila melanogaster
• Sequence 2: NP_009162.1
• Gene: SLC6A14 / 11254
• HGNCID: 11047
• Length: 642
• Species: Homo sapiens
• Alignment Length: 604
• Identity: 220/604 - (36%)
• Similarity: 354/604 - (58%)
• Gaps: 54/604 - (8%)

  Fly    19 ERDEN--RGQWKSKSEFILSLLGYAIGIGNVWRFPYLCYRSGGAAFLIPYLLMVILAGIPLFYME 81
            |.|||  ||.|..||:::||::|||:|:|||||||||.|.:||.||||||.:|:.|||:|||::|
Human    29 ENDENQDRGNWSKKSDYLLSMIGYAVGLGNVWRFPYLTYSNGGGAFLIPYAIMLALAGLPLFFLE 93

  Fly    82 ILIGQFSSTGCTGMFRMTPLLKGTGIAQVVVNAYCVCYYSVIISYPIRMIFYCFFKKVPWEDCSN 146
            ..:|||:|.|...::|:.||.:|.||..|:::.:...||:|||:|.:..:|..|..::||::||
Human    94 CSLGQFASLGPVSVWRILPLFQGVGITMVLISIFVTIYYNVIIAYSLYYMFASFQSELPWKNCS- 157

  Fly   147 SWNTDDC----------VTASDMGKQ------------------NSSDVFKTS---ADEFFHLEV 180
            ||:..:|          |:..:.|.|                  |.|::::..   ::::::...
Human   158 SWSDKNCSRSPIVTHCNVSTVNKGIQEIIQMNKSWVDINNFTCINGSEIYQPGQLPSEQYWNKVA 222

  Fly   181 LRISTDISDLGGMVWEQLTALIITWIIIYFCLMRGIKSVGKVVYFTVPFPYLLLFILLIRGATLP 245
            |:.|:.:::.|.:||.....|::.|:|:...|.:||||.|||||||..|||::|.|||:|||||.
Human   223 LQRSSGMNETGVIVWYLALCLLLAWLIVGAALFKGIKSSGKVVYFTALFPYVVLLILLVRGATLE 287

  Fly   246 GAWKGIKFYL--YPEWHRLLDLKVWADAAVQMFFGIGPGWGGIVNMASFSSFRNNAKCDSVLIVS 308
            ||.|||.:|:  ...:.:|.:.:||.|||.|:|:.:...|||:|.::|::.|:||...|::::..
Human   288 GASKGISYYIGAQSNFTKLKEAEVWKDAATQIFYSLSVAWGGLVALSSYNKFKNNCFSDAIVVCL 352

  Fly   309 INVFTSLLAGFVVFSVLGFLSEKSGIPVESVATGGAGLAFVTYPEAIALLPVPQLWALMFFFMLF 373
            .|..||:.|||.:||:||.::..||..|..|...|..|||:.||||:|.||....|:::|||||.
Human   353 TNCLTSVFAGFAIFSILGHMAHISGKEVSQVVKSGFDLAFIAYPEALAQLPGGPFWSILFFFMLL 417

  Fly   374 LLGIDSVFVQLEAIMSSILDEWYWV-RSHKCKLTLISCLIFLGLSSIMCTNGGMFILQLFDWYSS 437
            .||:||.|..:|.|.::|.|.:..| :..:..:||..||:...|..:..|..|::.:.|.|.:.:
Human   418 TLGLDSQFASIETITTTIQDLFPKVMKKMRVPITLGCCLVLFLLGLVCVTQAGIYWVHLIDHFCA 482

  Fly   438 AIAVIVICLVEIIMVAWIYGIKNFMLDVEFMLGKRP---TLYWRIVWQVVTPVIIIFILITSIVF 499
            ...:::..::|::.:.||||...|:.|.|.|:|.:.   .|:||..|.|:||:::|.|.|.|:|.
Human   483 GWGILIAAILELVGIIWIYGGNRFIEDTEMMIGAKRWIFWLWWRACWFVITPILLIAIFIWSLVQ 547

  Fly   500 IRTITYNNIPYPQWAIIIGWASCFTSVMWIPLYIFYIMIRKRATLCDSLKKRLKPL-DWTP---- 559
            .....|..||||.|.:.:||......::|||:.....:|:.:..:...|....:|. :|.|
Human   548 FHRPNYGAIPYPDWGVALGWCMIVFCIIWIPIMAIIKIIQAKGNIFQRLISCCRPASNWGPYLEQ 612

  Fly   560 ---------ADPQDRAEYE 569
                     .||:..|::|
Human   613 HRGERYKDMVDPKKEADHE 631

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ntl	NP_609135.1	SLC5-6-like_sbd	24..554	CDD:444915	209/566 (37%)
SLC6A14	NP_009162.1	SLC6sbd_ATB0	36..641	CDD:271391	216/597 (36%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	622..642		4/10 (40%)