Protein Alignment Ntl and Slc6a5

DIOPT Version :10

• Sequence 1: NP_609135.1
• Gene: Ntl / 34046
• FlyBaseID: FBgn0267326
• Length: 590
• Species: Drosophila melanogaster
• Sequence 2: XP_006540608.1
• Gene: Slc6a5 / 104245
• MGIID: 105090
• Length: 831
• Species: Mus musculus
• Alignment Length: 594
• Identity: 232/594 - (39%)
• Similarity: 363/594 - (61%)
• Gaps: 36/594 - (6%)

  Fly     9 TNATRKDKRIERDENRGQWKSKSEFILSLLGYAIGIGNVWRFPYLCYRSGGAAFLIPYLLMVILA 73
            |....:|::.:.::.||.|.||.:||||::|||:|:|||||||||.:::||.|||||||:|:.||
Mouse   210 TTTIPEDEQGDENKARGNWSSKLDFILSMVGYAVGLGNVWRFPYLAFQNGGGAFLIPYLMMLALA 274

  Fly    74 GIPLFYMEILIGQFSSTGCTGMFRMTPLLKGTGIAQVVVNAYCVCYYSVIISYPIRMIFYCFFKK 138
            |:|:|::|:.:|||:|.|...:::..|.|:|.|||.::::.....||:|||.|.:..:|..|...
Mouse   275 GLPIFFLEVSLGQFASQGPVSVWKAIPALQGCGIAMLIISVLIAIYYNVIICYTLFYLFASFVSV 339

  Fly   139 VPWEDCSNSWNTDDC---------------------------------VTASDMGKQNSSDVFKT 170
            :||..|:|.|||.:|                                 :|..:...| ::..|.:
Mouse   340 LPWGSCNNPWNTPECKDKTKLLLDSCVIGDHPKIQIKNSTFCMTAYPNLTMVNFTSQ-TNKTFVS 403

  Fly   171 SADEFFHLEVLRISTDISDLGGMVWEQLTALIITWIIIYFCLMRGIKSVGKVVYFTVPFPYLLLF 235
            .::|:|...||:||..|...|.:.|.....|.:.|:|:|..|.:||||.|||||||..|||::|.
Mouse   404 GSEEYFKYFVLKISAGIEYPGEIRWPLAFCLFLAWVIVYASLAKGIKSSGKVVYFTATFPYVVLV 468

  Fly   236 ILLIRGATLPGAWKGIKFYLYPEWHRLLDLKVWADAAVQMFFGIGPGWGGIVNMASFSSFRNNAK 300
            ||||||.|||||..||.:::.|:|.:|.|..||.|||.|:||.:...|||::.::|::.|.||..
Mouse   469 ILLIRGVTLPGAGAGIWYFITPKWEKLTDATVWKDAATQIFFSLSAAWGGLITLSSYNKFHNNCY 533

  Fly   301 CDSVLIVSINVFTSLLAGFVVFSVLGFLSEKSGIPVESVATGGAGLAFVTYPEAIALLPVPQLWA 365
            .|::::...|..||:.||||:|||:||::.:..:.:|:||..|.|:|||.||||:..||:...||
Mouse   534 RDTLIVTCTNSATSIFAGFVIFSVIGFMANERKVNIENVADQGPGIAFVVYPEALTRLPLSPFWA 598

  Fly   366 LMFFFMLFLLGIDSVFVQLEAIMSSILDEW-YWVRSHKCKLTLISCLIFLGLSSIMCTNGGMFIL 429
            ::||.||..||:|::|..:|.|::||.||: .::|:||...||..|:.|..:...|.|.||:::.
Mouse   599 IIFFLMLLTLGLDTMFATIETIVTSISDEFPKYLRTHKPVFTLGCCICFFIMGFPMITQGGIYMF 663

  Fly   430 QLFDWYSSAIAVIVICLVEIIMVAWIYGIKNFMLDVEFMLGKRPTLYWRIVWQVVTPVIIIFILI 494
            ||.|.|:::.|:::|.:.|::.::::||::.|..|:|.|:|.:|.::|::.|..|||.|:.|||.
Mouse   664 QLVDTYAASYALVIIAIFELVGISYVYGLQRFCEDIEMMIGFKPNIFWKVCWAFVTPTILTFILC 728

  Fly   495 TSIVFIRTITYNNIPYPQWAIIIGWASCFTSVMWIPLYIFYIMIRKRATLCDSLKKRLKPL-DWT 558
            .|......:||.:..||.|::::||.....||:|||:.....|........:.||....|. ||.
Mouse   729 FSFYQWEPMTYGSYRYPNWSMVLGWLMLACSVIWIPIMFVIKMYLAPGRFIERLKLVCSPQPDWG 793

  Fly   559 PADPQDRAE 567
            |...|.|.|
Mouse   794 PFLAQHRGE 802

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ntl	NP_609135.1	SLC5-6-like_sbd	24..554	CDD:444915	223/563 (40%)
Slc6a5	XP_006540608.1	SLC6sbd_GlyT2	225..821	CDD:271389	230/579 (40%)