DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ntl and Slc6a20a

DIOPT Version :9

Sequence 1:	NP_609135.1	Gene:	Ntl / 34046	FlyBaseID:	FBgn0267326	Length:	590	Species:	Drosophila melanogaster
Sequence 2:	NP_631881.1	Gene:	Slc6a20a / 102680	MGIID:	2143217	Length:	592	Species:	Mus musculus

Alignment Length:	595	Identity:	192/595 - (32%)
Similarity:	308/595 - (51%)	Gaps:	88/595 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 DENRGQWKSKSEFILSLLGYAIGIGNVWRFPYLCYRSGGAAFLIPYLLMVILAGIPLFYMEILIG 85
            ::.|.||....:|:.:.:.||:|:||||||||||...||.:||:||::|:|:.|:||.|:|:.:|
Mouse     2 EKARPQWGHPLQFVFACISYAVGLGNVWRFPYLCQMYGGGSFLVPYIIMLIVEGMPLLYLELAVG 66

  Fly    86 QFSSTGCTGMFR-MTPLLKGTGIAQVVVNAYCVCYYSVIISYPIRMIFYCFFKKVPWEDCS-NSW 148
            |....|..|.:| ::|.|.|.|:|.|||:.:...||:||.::....:|:.|...:||..|. ||.
Mouse    67 QRMRQGSIGAWRTISPYLSGVGVASVVVSFFLSMYYNVINAWGFWYLFHSFQDPLPWSVCPLNSN 131

  Fly   149 NT---DDCVTASDMGKQNSSDVFKTSADEFFHLEVLRISTDISDLGGMVWEQLTALIITWIIIYF 210
            :|   ::|..||             |...|::.:.|.||..|.:.||:.||....|.:.|:::|.
Mouse   132 HTGYDEECEKAS-------------STQYFWYRKTLNISPSIQENGGVQWEPALCLTLAWLMVYL 183

  Fly   211 CLMRGIKSVGKVVYFTVPFPYLLLFILLIRGATLPGAWKGIKFYLYPEWHRLLDLKVWADAAVQM 275
            |::||.:|.|||||||...||.:|.|.|:||.||.||..|:.:...|:..:|.:.|.|.:||.|:
Mouse   184 CILRGTESTGKVVYFTASMPYCVLIIYLVRGLTLHGATNGLMYMFTPKMEQLANPKAWINAATQI 248

  Fly   276 FFGIGPGWGGIVNMASFSSFRNNAKCDSVLIVSINVFTSLLAGFVVFSVLGF------------- 327
            ||.:|.|:|.::..||::...||.:..::::..||..||:.|..|.||:.||
Mouse   249 FFSLGLGFGSLIAFASYNEPSNNCQKHAIIVSIINSSTSIFASIVTFSIYGFKATFNYENCLNKV 313

  Fly   328 -------------------LSE-----KSGIP--------------VES---VATGGAGLAFVTY 351
                               |.|     .|..|              :||   .|..|.||||:.|
Mouse   314 ILLLTNSFDLEDGFLTVSNLEEVKNYLASTYPNKYSEVFPHIRNCSLESELDTAVQGTGLAFIVY 378

  Fly   352 PEAIALLPVPQLWALMFFFMLFLLGIDSVFVQLEAIMSSILDEWYWVRSH--KCKLTLISCLIFL 414
            .|||..:.|.|||::::||||.:|||.|:.....||::.:.|... :.|:  |..::.:.|||..
Mouse   379 TEAIKNMEVSQLWSVLYFFMLLMLGIGSMLGNTAAILTPLTDSKV-ISSYLPKEAISGLVCLINC 442

  Fly   415 GLSSIMCTNGGMFILQLFDWYSSAIAVIVICLVEIIMVAWIYGIKNFMLDVEFMLGKRPTLYWRI 479
            .:..:.....|.:...:|:.|::.:::::|.|||.|.|.::||:|.|..|:..|.|:..:.||::
Mouse   443 AVGMVFTMEAGNYWFDIFNDYAATLSLLLIVLVETIAVCYVYGLKRFESDLRAMTGRTLSWYWKV 507

  Fly   480 VWQVVTPVIIIFILI---TSIVFIRTITYN----------NIPYPQWAIIIGWASCFTSVMWIPL 531
            :|..|:|::|:.:.|   :..:...|:.|.          ...||..|:.:......:|.|.|||
Mouse   508 MWAFVSPLLIVGLFIFYLSDYILTGTLQYQAWDATQGQLVTKDYPPHALAVIGLLVASSTMCIPL 572

  Fly   532 YIFYIMIRKR 541
            ......||.|
Mouse   573 VALGTFIRNR 582

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ntl	NP_609135.1	SLC5-6-like_sbd	24..554	CDD:294310	192/592 (32%)
Slc6a20a	NP_631881.1	SLC5-6-like_sbd	2..577	CDD:294310	189/588 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810