DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ntl and si:ch211-132b12.1

DIOPT Version :9

Sequence 1:	NP_609135.1	Gene:	Ntl / 34046	FlyBaseID:	FBgn0267326	Length:	590	Species:	Drosophila melanogaster
Sequence 2:	NP_001076533.1	Gene:	si:ch211-132b12.1 / 100034467	ZFINID:	ZDB-GENE-050420-315	Length:	586	Species:	Danio rerio

Alignment Length:	579	Identity:	232/579 - (40%)
Similarity:	351/579 - (60%)	Gaps:	26/579 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 ENRGQWKSKSEFILSLLGYAIGIGNVWRFPYLCYRSGGAAFLIPYLLMVILAGIPLFYMEILIGQ 86
            |.||.|.||.||:|::.|..:|:|||||||||||:.||.|||||||:.|:..|:|||.:|:.:||
Zfish     9 EERGYWGSKMEFLLAVAGNVVGLGNVWRFPYLCYKYGGGAFLIPYLVFVVTCGVPLFLLEMAMGQ 73

  Fly    87 FSST-GCTGMFRMTPLLKGTGIAQVVVNAYCVCYYSVIISYPIRMIFYCFFKKVPWEDCSNSWNT 150
            ::.. |.|...|:.||.:|.|....::..|...||.||:::.:..:.:.|..::||..|.|:|||
Zfish    74 YTQQGGVTCWHRLCPLAEGIGYGGQLILLYSCMYYIVILAWALFYLIFSFKSQLPWATCDNTWNT 138

  Fly   151 DDCV--TASDMGKQNSSDVFKT-SADEFFHLEVLRISTDISDLGGMVWEQLTALIITWIIIYFCL 212
            |||:  ...::....:|.:..| :|.||:...||.:|..|.|:|.:.||.|..||..|||.|||:
Zfish   139 DDCINLVTKNLTINRTSLINSTPAATEFWERRVLSLSGGIEDIGKINWEILLCLIAMWIICYFCV 203

  Fly   213 MRGIKSVGKVVYFTVPFPYLLLFILLIRGATLPGAWKGIKFYLYPEWHRLLDLKVWADAAVQMFF 277
            .:|:||.|||||||..|||::|.:|||||.|||||.:|:.||||||..||.|.:||.:|..|:.|
Zfish   204 WKGVKSTGKVVYFTATFPYVMLLVLLIRGLTLPGALQGVVFYLYPEPARLADPQVWLEAGTQILF 268

  Fly   278 GIGPGWGGIVNMASFSSFRNNAKCDSVLIVSINVFTSLLAGFVVFSVLGFLSEKSGIPVESVATG 342
            ......|.|..:||::.:.||...|.:.:..:|..||.:|||.||:||||::::.|:|:|.||..
Zfish   269 SYSVSVGSITVLASYNKYHNNCYRDCLGLCLLNSVTSFVAGFAVFTVLGFMAQEQGVPIEEVAES 333

  Fly   343 GAGLAFVTYPEAIALLPVPQLWALMFFFMLFLLGIDSVFVQLEAIMSSILDEWYWVRSHKCK--- 404
            |.||||:.||:|:|::|.|||||:.||.|:.|||:|:.||.:||:::|::|.:..|...:.:
Zfish   334 GPGLAFIAYPQAVAMMPFPQLWAVCFFIMIILLGLDTQFVSMEAVVTSVMDMFPVVLRREGRREI 398

  Fly   405 LTLISCL-IFLGLSSIMCTNGGMFILQLFDWYS-SAIAVIVICLVEIIMVAWIYGIKNFMLDVEF 467
            |.|..|| .|.| ..||.|.|||::.||||:|: :...::.:.:.|.:.:.||:|.......:|.
Zfish   399 LLLFFCLTCFFG-QFIMVTEGGMYVFQLFDYYACNGTCLLFLSVFESLTMGWIFGADRLFDIIED 462

  Fly   468 MLGKRPTLYWRIVWQVVTPVIIIFILITSIVFIRTITYNN-IPYPQWAIIIGWASCFTSVMWIPL 531
            |...||...:.:.|:.:||::.:...:.|:|..:.:|:|. ..:|.||.::||....:|::.:|.
Zfish   463 MTKSRPNYIFMLCWKYLTPLVSLVCFVCSMVEYQPLTFNRWYVFPDWAYVLGWLLALSSIVLVPG 527

  Fly   532 YIFYIMIRKRATLCD---SLKKRLKPLDWTPADPQDRAEYEAFRRQRRMPGFMSDTDME 587
            :..       ..||.   |||:|.:.|  ..|| :|.......|.|.:...||  |:||
Zfish   528 WAL-------GRLCSEKGSLKQRWRRL--CSAD-KDLPLTCKQRAQLKETAFM--TEME 574

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ntl	NP_609135.1	SLC5-6-like_sbd	24..554	CDD:294310	220/542 (41%)
si:ch211-132b12.1	NP_001076533.1	SLC6sbd-TauT-like	11..549	CDD:271387	221/547 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820