Protein Alignment Tep3 and C5

DIOPT Version :9

• Sequence 1: NP_523507.2
• Gene: Tep3 / 34045
• FlyBaseID: FBgn0041181
• Length: 1469
• Species: Drosophila melanogaster
• Sequence 2: NP_001304092.1
• Gene: C5 / 727
• HGNCID: 1331
• Length: 1682
• Species: Homo sapiens
• Alignment Length: 1656
• Identity: 366/1656 - (22%)
• Similarity: 638/1656 - (38%)
• Gaps: 367/1656 - (22%)

  Fly    23 CQTSAQGL---YSIIAPNTLRPNSQFHVAVSLHNAPESATFKVGILGSSYTDFKTVELRPFSTQL 84
            |...|.||   |.|.||...|..:..::.:.::...|:  |...|...||.|.|.    .:|:..
Human    18 CGAFAFGLRCRYVISAPKIFRVGASENIVIQVYGYTEA--FDATISIKSYPDKKF----SYSSGH 76

  Fly    85 LH------FEIPALRTDRYRLTAEGLGGVQFT--NETQLHF-ESKQHTV-------LVQTDKSIY 133
            :|      |:..|:.|.:.:....|...|.:.  .....|| :||:..:       .:.|||.:|
Human    77 VHLSSENKFQNSAILTIQPKQLPGGQNPVSYVYLEVVSKHFSKSKRMPITYDNGFLFIHTDKPVY 141

  Fly   134 KPGDLVHYRVLILDANLKPARGYGRV--------HVDIKDSGDNI-IRSYKDIRLTNSIYSNELR 189
            .|...|..||..|:.:||||:....:        .||:.:..|:| |.|:.|.::.:
Human   142 TPDQSVKVRVYSLNDDLKPAKRETVLTFIDPEGSEVDMVEEIDHIGIISFPDFKIPS-------- 198

  Fly   190 LSDSPRFGTWSIVVDVSDQ---EHTQTFEILDHILPKFVVDIDTPKHAI-YKDGK-IAATVRAHY 249
               :||:|.|:|.....:.   ..|..||:.:::||.|.|.|:...:.| ||:.| ...|::|.|
Human   199 ---NPRYGMWTIKAKYKEDFSTTGTAYFEVKEYVLPHFSVSIEPEYNFIGYKNFKNFEITIKARY 260

  Fly   250 AFGQPIVGEATLSIYPTFFGSLQPFVND------LITRKVVPIDGNAYFEFDIENEL-----HLK 303
             |...:|.||  .:|.| ||..:...:|      ...:..:.|:|.|...||.|..:     :..
Human   261 -FYNKVVTEA--DVYIT-FGIREDLKDDQKEMMQTAMQNTMLINGIAQVTFDSETAVKELSYYSL 321

  Fly   304 QDYERQYLLDALVEEKSTGSVQNYSTV--LTLHLNHYRVEAVKVPSYYIPGVPFEATARIARNDG 366
            :|...:||..|:...:|||.....:.:  :...|:.|::..|..|.:..||:|:....
Human   322 EDLNNKYLYIAVTVIESTGGFSEEAEIPGIKYVLSPYKLNLVATPLFLKPGIPYPIKV------- 379

  Fly   367 GQLRDFNPQITAYLTNVYGSSEMYNRTAYSLDASGEIKMKFTVPIGDRDEFHSIIVDYQGVISEV 431
             |::|...|:      |.|.....|  |.::|.:.|        ..|.|...|:.....||.|.|
Human   380 -QVKDSLDQL------VGGVPVTLN--AQTIDVNQE--------TSDLDPSKSVTRVDDGVASFV 427

  Fly   432 GKIPSKHLHSKNYITAKVLNDRP------------------------------------TVNQEI 460
            ..:||    ....:...|..|.|                                    .|.:.:
Human   428 LNLPS----GVTVLEFNVKTDAPDLPEENQAREGYRAIAYSSLSQSYLYIDWTDNHKALLVGEHL 488

  Fly   461 SVVVRSFAP----IKYFMYQVVGRGDII-LSRNVDVAPGTFHTIKFLASFAMMPRANLLVYTVID 520
            :::|...:|    |.::.|.::.:|.|| .......:..::.:|....:..|:|.:.||||.::.
Human   489 NIIVTPKSPYIDKITHYNYLILSKGKIIHFGTREKFSDASYQSINIPVTQNMVPSSRLLVYYIVT 553

  Fly   521 G----EFVYDEQVIQLEENLLNAVQV----DAPIRAPPGQDIDIGISTKPYSYVGLMLVDQNAND 577
            |    |.|.|...:.:||...|.:||    ||...: |||.:.:.::|...|:|.|..||.....
Human   554 GEQTAELVSDSVWLNIEEKCGNQLQVHLSPDADAYS-PGQTVSLNMATGMDSWVALAAVDSAVYG 617

  Fly   578 LRSGHDLTHKRLMDALRSYELSDVNTPMGSPGKESGV--------ITMSNTDYFIEKEAESNP-- 632
            ::.|   ..|.|....:..|.||:....|.....:.|        :|.:|.|   :.:....|
Human   618 VQRG---AKKPLERVFQFLEKSDLGCGAGGGLNNANVFHLAGLTFLTNANAD---DSQENDEPCK 676

  Fly   633 -------ALDREVSTGPEEDKLTTVRK--------------------TDIGP------------- 657
                   .|.:::.....:.|.:.|:|                    ..:||
Human   677 EILRPRRTLQKKIEEIAAKYKHSVVKKCCYDGACVNNDETCEQRAARISLGPRCIKAFTECCVVA 741

  Fly   658 -------AHK------IEVNTLPPGKGRYAFSYTPKPF-WHNPRVHVMRDPADTWLFLNISASSD 708
                   :||      :.:.||.|.......||.|:.: |   .||::                .
Human   742 SQLRANISHKDMQLGRLHMKTLLPVSKPEIRSYFPESWLW---EVHLV----------------P 787

  Fly   709 GRNSIHRRIPSEMTSWVVSAFALDPVNGLGLS------PPNGKLEAYKEFYISTELPYSIKRDEL 767
            .|..:...:|..:|:|        .:.|:|:|      ....|.:.:|:.::...:|||:.|.|.
Human   788 RRKQLQFALPDSLTTW--------EIQGVGISNTGICVADTVKAKVFKDVFLEMNIPYSVVRGEQ 844

  Fly   768 IAIPFVVHNNRDSDLN--VEVTFYNSALDFDFPQLDPKATNQPKVELYRRRSLQVPGRSARSVSF 830
            |.:...|:|.|.|.:.  |:::........:.|.:|.:.|...|  ..|::   |.|.|:..|:|
Human   845 IQLKGTVYNYRTSGMQFCVKMSAVEGICTSESPVIDHQGTKSSK--CVRQK---VEGSSSHLVTF 904

  Fly   831 IVTPKRVG--------------PLLVKAMAA-------SSQAGDTVEQNLLVEHPGAMERINRGF 874
            .|.|..:|              .:|||.:..       .|.:|.|::..      |....|:|
Human   905 TVLPLEIGLHNINFSLETWFGKEILVKTLRVVPEGVKRESYSGVTLDPR------GIYGTISR-- 961

  Fly   875 LFELNSNAQNRRNVTIAVPRNAIPESTRIEVSAVGDLIGSLVGNLDSLIL----------LPTGC 929
                      |:.....:|.:.:|::   |:..:..:.|.|||.:.|.:|          ||.|.
Human   962 ----------RKEFPYRIPLDLVPKT---EIKRILSVKGLLVGEILSAVLSQEGINILTHLPKGS 1013

  Fly   930 GEQTMVNFVPNLIVLRYL-----GRLRQLTPEVE-LRATNNLAIGYQRILYYRHENGAFSAF--G 986
            .|..:::.||...|..||     ..:....|.:| .:....|..|...|:.||:.:.::|.:  |
Human  1014 AEAELMSVVPVFYVFHYLETGNHWNIFHSDPLIEKQKLKKKLKEGMLSIMSYRNADYSYSVWKGG 1078

  Fly   987 LDIKRSSTWLTAYVARSLRQAAPFTQVDSNVLQKALTYL-GSVQSANGGFEE---------RGDV 1041
                .:||||||:..|.|.|...:.:.:.|.:..:|.:| .:.|..||.|:|         :|.:
Human  1079 ----SASTWLTAFALRVLGQVNKYVEQNQNSICNSLLWLVENYQLDNGSFKENSQYQPIKLQGTL 1139

  Fly  1042 FERFGDDGISLTAFVTLALMENVDLYP--EYRNNINKALDFITRGLDGSSNLHAMAIGTYVLS-- 1102
            .....::.:.||||..:.:.:..|:.|  :....:.||.:|:......:.:...:||..|.||
Human  1140 PVEARENSLYLTAFTVIGIRKAFDICPLVKIDTALIKADNFLLENTLPAQSTFTLAISAYALSLG 1204

  Fly  1103 ---RANHNAKAAFLQRLDSMATNKDGLKWWNKTAPAGEQQSPWYNATRSVNIEISAYAALALLEN 1164
               .....:..:.|:|...:..|....::|.......:...|  |...:..:|.:|||.|..|..
Human  1205 DKTHPQFRSIVSALKREALVKGNPPIYRFWKDNLQHKDSSVP--NTGTARMVETTAYALLTSLNL 1267

  Fly  1165 NLVGDALPVLNWLMDQRNPKGGFVASQDTVVGLQALLMFAERFSSQGNNLQIGFHY-GEGAETII 1228
            ..:....||:.||.:::...|||.::|||:..::.|..::........::.|...| .:||....
Human  1268 KDINYVNPVIKWLSEEQRYGGGFYSTQDTINAIEGLTEYSLLVKQLRLSMDIDVSYKHKGALHNY 1332

  Fly  1229 NVNAENSLALQTVELPNNLKNLSVSATGRGMALAQVSYT---YNTNVTSAWPRFVL--DPTVNRN 1288
            .:..:|.|......|.|:  :|.|| ||.|..||.|..|   :.|:.:.....|.|  |......
Human  1333 KMTDKNFLGRPVEVLLND--DLIVS-TGFGSGLATVHVTTVVHKTSTSEEVCSFYLKIDTQDIEA 1394

  Fly  1289 SH------ADYLHLSACASFVSVVGENEQRSNMAVMEVHLPSGFVVDRDTLPTLESSERIKKVET 1347
            ||      :||..:.||||:.....|:...|:.|||::.||:|...:.:.|..|.........:.
Human  1395 SHYRGYGNSDYKRIVACASYKPSREESSSGSSHAVMDISLPTGISANEEDLKALVEGVDQLFTDY 1459

  Fly  1348 QNRNTKVVIYFDYLDRRE-VCPTLHAYKTVKVTKHRPVAVVMYDYYDSARRARQFYRAPKSNICD 1411
            |.::..|::..:.:...: :|.....::..:|....|....:|:|:...::...||......|..
Human  1460 QIKDGHVILQLNSIPSSDFLCVRFRIFELFEVGFLSPATFTVYEYHRPDKQCTMFYSTSNIKIQK 1524

  Fly  1412 ICE-------HANCG------DLCEKAEKRE 1429
            :||       .|:||      ||...||.|:
Human  1525 VCEGAACKCVEADCGQMQEELDLTISAETRK 1555

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tep3	NP_523507.2	A2M_N	124..215	CDD:280081	26/109 (24%)
		A2M_N_2	448..573	CDD:285005	37/173 (21%)
		A2M	697..787	CDD:278630	20/97 (21%)
		A2M_2	918..1203	CDD:239227	75/319 (24%)
		A2M_comp	967..1200	CDD:284982	60/251 (24%)
		A2M_recep	1313..1402	CDD:284981	16/89 (18%)
C5	NP_001304092.1	A2M_N	132..225	CDD:280081	27/103 (26%)
		A2M_N_2	478..616	CDD:285005	35/138 (25%)
		ANATO	688..756	CDD:237984	7/67 (10%)
		A2M	778..865	CDD:278630	23/113 (20%)
		complement_C3_C4_C5	999..1306	CDD:239226	73/312 (23%)
		A2M_comp	1057..1307	CDD:284982	61/255 (24%)
		A2M_recep	1427..1515	CDD:284981	15/87 (17%)
		NTR_complement_C5	1533..1682	CDD:239637	8/23 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149959
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2373
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D177369at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11412
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	6	5.810