Protein Alignment Tep3 and C4B

DIOPT Version :10

• Sequence 1: NP_523507.2
• Gene: Tep3 / 34045
• FlyBaseID: FBgn0041181
• Length: 1469
• Species: Drosophila melanogaster
• Sequence 2: NP_001002029.3
• Gene: C4B / 721
• HGNCID: 1324
• Length: 1744
• Species: Homo sapiens
• Alignment Length: 1700
• Identity: 398/1700 - (23%)
• Similarity: 650/1700 - (38%)
• Gaps: 438/1700 - (25%)

  Fly    33 IIAPNTLRPNSQFHVAVSLHNAPESATFKVGIL----------GSSYTDFKTVELRPFSTQLLHF 87
            :.:|:.:.......|.|.|.:.|.....|..:.          .|...||.....|.|:  ||..
Human    25 LFSPSVVHLGVPLSVGVQLQDVPRGQVVKGSVFLRNPSRNNVPCSPKVDFTLSSERDFA--LLSL 87

  Fly    88 EIP-----------ALRTDRYRLTA------EGLGGVQFTNETQLHFESKQHTVLVQTDKSIYKP 135
            ::|           .||....:|.|      :.|..........|.|.|::..:.:|||:.||.|
Human    88 QVPLKDAKSCGLHQLLRGPEVQLVAHSPWLKDSLSRTTNIQGINLLFSSRRGHLFLQTDQPIYNP 152

  Fly   136 GDLVHYRVLILDANLKPARGYGRVHVDIKDSGDNIIRSYKDIRLTNSIYSNELRLSDSPRFGTWS 200
            |..|.|||..||..::|:.  ..:.|.:::|....:|. |::.:.:||:.::..:.|....|||.
Human   153 GQRVRYRVFALDQKMRPST--DTITVMVENSHGLRVRK-KEVYMPSSIFQDDFVIPDISEPGTWK 214

  Fly   201 IVVDVSD--QEHTQT-FEILDHILPKFVVDI--------DTPKHAIYKDGKIAATVRAHYAFGQP 254
            |....||  :.::.| ||:..::||.|.|.|        ..|.|.    .::...::|.|.:|:|
Human   215 ISARFSDGLESNSSTQFEVKKYVLPNFEVKITPGKPYILTVPGHL----DEMQLDIQARYIYGKP 275

  Fly   255 IVGEATLSIYPTFFGSLQPFVNDLITRKVVPIDGNAYFEFDIENELHL----------KQDYE-- 307
            :.|.|.:.     ||.|..             ||...|...:|::..|          |.:::
Human   276 VQGVAYVR-----FGLLDE-------------DGKKTFFRGLESQTKLVNGQSHISLSKAEFQDA 322

  Fly   308 --------------RQYLLDALVEEKSTGSVQNYSTVLTLHL--NHYRVEAVKVPSYYIPGVPFE 356
                          |.|:..|::|  |.|.....:.:.:.:.  :.:.::..|...:.:||.||.
Human   323 LEKLNMGITDLQGLRLYVAAAIIE--SPGGEMEEAELTSWYFVSSPFSLDLSKTKRHLVPGAPFL 385

  Fly   357 ATARIARNDGGQLRDFNPQITAYLTNVYGSSEMYNRTAYSLDASGEIKMKFTVPIGDRDEFHSII 421
            ..|.:....|........:::|.:::. ||.........:.|.||::.:...:|        ..|
Human   386 LQALVREMSGSPASGIPVKVSATVSSP-GSVPEVQDIQQNTDGSGQVSIPIIIP--------QTI 441

  Fly   422 VDYQGVIS-----------EVGKIPSKHLHSKNYITAKVLNDRP-----TVNQEISVVVRSFAPI 470
            .:.|..:|           .|...||   ....:::.:..:.||     |:|..:. .|.|.|..
Human   442 SELQLSVSAGSPHPAIARLTVAAPPS---GGPGFLSIERPDSRPPRVGDTLNLNLR-AVGSGATF 502

  Fly   471 KYFMYQVVGRGDII------------LSRNVD--VAPGTFHTIKFLASFAMMPRANLLVYTVIDG 521
            .::.|.::.||.|:            :|..||  :|| :|:.:.|. .....|.||.|
Human   503 SHYYYMILSRGQIVFMNREPKRTLTSVSVFVDHHLAP-SFYFVAFY-YHGDHPVANSL------- 558

  Fly   522 EFVYDEQVIQLEENLLNAVQVDAPIRAPPGQDIDIGISTKPYSYVGLMLVDQNANDLRSGHDLTH 586
              ..|.|....|..|  .:.||...:...|:.:.:.:.|...:.|.|..:|   ..|.:....:|
Human   559 --RVDVQAGACEGKL--ELSVDGAKQYRNGESVKLHLETDSLALVALGALD---TALYAAGSKSH 616

  Fly   587 K-----RLMDALRSYELSDVNTPMGSPGKESGV-------ITMSNTDYFIEKEAESNPALDREVS 639
            |     ::.:|:.||:|.     .|..|.:|.:       :..|:.|.:         .|.|:..
Human   617 KPLNMGKVFEAMNSYDLG-----CGPGGGDSALQVFQAAGLAFSDGDQW---------TLSRKRL 667

  Fly   640 TGPEEDKLTTVRKTDIGPAHKIEVNTLPPGKGRYAFSYTPKPFWHN--PRVHVMR---------- 692
            :.|:|.  ||.:|.::.....|....     |:|| |.|.|....:  .|:.:||
Human   668 SCPKEK--TTRKKRNVNFQKAINEKL-----GQYA-SPTAKRCCQDGVTRLPMMRSCEQRAARVQ 724

  Fly   693 --DPADTWL-------FLNISASSDGRNSIHRR-------------------------------- 716
              |..:.:|       .|...:...|:..:.|.
Human   725 QPDCREPFLSCCQFAESLRKKSRDKGQAGLQRALEILQEEDLIDEDDIPVRSFFPENWLWRVETV 789

  Fly   717 ---------IPSEMTSWVVSAFALDPVNGLGLSPPNGKLEAYKEFYISTELPYSIKRDELIAIPF 772
                     :|..:|:|.:...:|....||.::.| .:|..::||::...||.|::|.|.:.:..
Human   790 DRFQILTLWLPDSLTTWEIHGLSLSKTKGLCVATP-VQLRVFREFHLHLRLPMSVRRFEQLELRP 853

  Fly   773 VVHNNRDSDLNVEVTFYNSALDFDFPQLDPKATNQPKVELY-------RRRSLQVPGRSARSVSF 830
            |::|..|.:|.|.|            .:.|       ||..       ..:.:.||..|||.|:|
Human   854 VLYNYLDKNLTVSV------------HVSP-------VEGLCLAGGGGLAQQVLVPAGSARPVAF 899

  Fly   831 IVTPKRVGPLLVKAMAASS---QAGDTVEQNLLVEHPGAMERINRGFLFELNSNAQNRRNVTIAV 892
            .|.|.....:.:|.:|..|   ..||.|.:.|.:|..||:.|  ...::||  |..:.|..|:.:
Human   900 SVVPTAATAVSLKVVARGSFEFPVGDAVSKVLQIEKEGAIHR--EELVYEL--NPLDHRGRTLEI 960

  Fly   893 PRNA----IPES-----TRIEVSAVGDLIGS----LVGNLDSLILLPTGCGEQTMVNFVPNLIVL 944
            |.|:    ||:.     .|:..|...|.:||    ..|.:.||:.||.|||||||:...|.|...
Human   961 PGNSDPNMIPDGDFNSYVRVTASDPLDTLGSEGALSPGGVASLLRLPRGCGEQTMIYLAPTLAAS 1025

  Fly   945 RYLGRLRQ---LTPEVELRATNNLAIGYQRILYYRHENGAFSAFGLDIKR-SSTWLTAYVARSLR 1005
            |||.:..|   |.||.:..|.:.:..||.||..:|..:|:::|:   :.| |||||||:|.:.|.
Human  1026 RYLDKTEQWSTLPPETKDHAVDLIQKGYMRIQQFRKADGSYAAW---LSRGSSTWLTAFVLKVLS 1087

  Fly  1006 QAAPFTQVDSNVLQKALTYLGSVQSANGGFEERGDVFERF-------GDDGISLTAFVTLALMEN 1063
            .|..........||:...:|.|.|.|:|.|::...|..|.       .|:.::||||||:||...
Human  1088 LAQEQVGGSPEKLQETSNWLLSQQQADGSFQDLSPVIHRSMQGGLVGNDETVALTAFVTIALHHG 1152

  Fly  1064 VDLYPE---------YRNNINKALDFI----TRGLDGSSNLHAMAIGTY--VLSRANHNAKAAFL 1113
            :.::.:         ...:|:||..|:    :.||.|:   ||.||..|  .|::|..:.:....
Human  1153 LAVFQDEGAEPLKQRVEASISKASSFLGEKASAGLLGA---HAAAITAYALTLTKAPADLRGVAH 1214

  Fly  1114 QRLDSMATNK-DGLKWWNKTAPAGEQQSP-----------------WYNATRSVNIEISAYAAL- 1159
            ..|.:||... |.|.|.:.|.......||                 |        ||.:|||.|
Human  1215 NNLMAMAQETGDNLYWGSVTGSQSNAVSPTPAPRNPSDPMPQAPALW--------IETTAYALLH 1271

  Fly  1160 ALLENNLVGDALPVLNWLMDQRNPKGGFVASQDTVVGLQALLMF-------AER-----FSSQG- 1211
            .||.......|.....||..|.:.:|||.::||||:.|.||..:       .||     .||.|
Human  1272 LLLHEGKAEMADQAAAWLTRQGSFQGGFRSTQDTVIALDALSAYWIASHTTEERGLNVTLSSTGR 1336

  Fly  1212 ----------NNLQI-----GFHYGEGAETIINVNAENSLALQTVELPN--NLKN-----LSVSA 1254
                      ||.||     ...:..|::..:.|...:...|:.:...|  ::||     |.:..
Human  1337 NGFKSHALQLNNRQIRGLEEELQFSLGSKINVKVGGNSKGTLKVLRTYNVLDMKNTTCQDLQIEV 1401

  Fly  1255 TGRGMALAQVSYTYNTN--------------------VTSAWPRFVLDPTVNR---------NSH 1290
            |.:|    .|.||...|                    :....|..:.:...||         ...
Human  1402 TVKG----HVEYTMEANEDYEDYEYDELPAKDDPDAPLQPVTPLQLFEGRRNRRRREAPKVVEEQ 1462

  Fly  1291 ADYLHLSACASFVSVVGENEQRSNMAVMEVHLPSGFVVDRDTLPTLES-SER-IKKVETQNRNTK 1353
            ...:|.:.|......||    .|.||:.:|.|.|||...|..|..|.| |:| :...||:..:
Human  1463 ESRVHYTVCIWRNGKVG----LSGMAIADVTLLSGFHALRADLEKLTSLSDRYVSHFETEGPH-- 1521

  Fly  1354 VVIYFDYLDRREVCPTLHAYKTVKVTKHRPVAVVMYDYYDSARRARQFYRAPKSN--ICDICEHA 1416
            |::|||.:.....|....|.:.|.|...:|.:..:||||:..||...||.||..:  :..:|.
Human  1522 VLLYFDSVPTSRECVGFEAVQEVPVGLVQPASATLYDYYNPERRCSVFYGAPSKSRLLATLCS-- 1584

  Fly  1417 NCGDLCEKAE 1426
              .::|:.||
Human  1585 --AEVCQCAE 1592

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tep3	NP_523507.2	YfaS	<128..1399	CDD:441940	367/1547 (24%)
		A2M_2	918..1203	CDD:239227	104/329 (32%)
C4B	NP_001002029.3	YfaS	<138..1336	CDD:441940	312/1313 (24%)
		ANATO	686..750	CDD:237984	13/69 (19%)
		A2M	781..869	CDD:459711	21/100 (21%)
		TED_complement	982..1315	CDD:462227	109/346 (32%)
		A2M_recep	1481..1570	CDD:462226	31/90 (34%)
		NTR_complement_C4	1588..1742	CDD:239639	2/4 (50%)