DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tep3 and C3

DIOPT Version :9

Sequence 1:NP_523507.2 Gene:Tep3 / 34045 FlyBaseID:FBgn0041181 Length:1469 Species:Drosophila melanogaster
Sequence 2:NP_000055.2 Gene:C3 / 718 HGNCID:1318 Length:1663 Species:Homo sapiens


Alignment Length:1618 Identity:394/1618 - (24%)
Similarity:672/1618 - (41%) Gaps:298/1618 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 GADMGAIPVLILVTACLLCQTSAQGLYSIIAPNTLRPNSQFHVAVSLHNA----PESATF----- 60
            |...|...:|:|:|...|...|.  :||||.||.||..|:..:.:..|:|    |.:.|.     
Human     2 GPTSGPSLLLLLLTHLPLALGSP--MYSIITPNILRLESEETMVLEAHDAQGDVPVTVTVHDFPG 64

  Fly    61 KVGILGSSYTDFKTVELRPFSTQL--LHFEIPA---LRTDRYR---LTAEGLGGVQFTNETQLHF 117
            |..:|.|.    ||| |.|.:..:  :.|.|||   .::::.|   :|.:...|.|...:..| .
Human    65 KKLVLSSE----KTV-LTPATNHMGNVTFTIPANREFKSEKGRNKFVTVQATFGTQVVEKVVL-V 123

  Fly   118 ESKQHTVLVQTDKSIYKPGDLVHYRVLILDANLKPARGYGR-VHVDIKDSGDNIIRSYKDIRLTN 181
            ..:...:.:||||:||.||..|.||:..::..|.|.   || |.|:| ::.:.|  ..|...|::
Human   124 SLQSGYLFIQTDKTIYTPGSTVLYRIFTVNHKLLPV---GRTVMVNI-ENPEGI--PVKQDSLSS 182

  Fly   182 SIYSNELRLS-DSP---RFGTWSI--VVDVSDQEHTQT-FEILDHILPKFVVDID-TPK-HAIYK 237
            ......|.|| |.|   ..|.|.|  ..:.|.|:...| ||:.:::||.|.|.:: |.| :.||.
Human   183 QNQLGVLPLSWDIPELVNMGQWKIRAYYENSPQQVFSTEFEVKEYVLPSFEVIVEPTEKFYYIYN 247

  Fly   238 DGKIAATVRAHYAFGQPIVGEATLSIYPTFFGSLQPFVNDLITR-------KVVPIDGNAYFEFD 295
            :..:..|:.|.:.:|:.:.|.|.:     .||     :.|...|       |.:||:       |
Human   248 EKGLEVTITARFLYGKKVEGTAFV-----IFG-----IQDGEQRISLPESLKRIPIE-------D 295

  Fly   296 IENELHLKQDYERQYLLDALVE---EKSTGSVQNYSTVLTLH----------------LNHYRVE 341
            ...|:.|    .|:.|||.:..   |...|.....|..:.||                .:.|::.
Human   296 GSGEVVL----SRKVLLDGVQNPRAEDLVGKSLYVSATVILHSGSDMVQAERSGIPIVTSPYQIH 356

  Fly   342 AVKVPSYYIPGVPFEATARIARNDGGQLRDFNPQITAYLTNVYGSSEMYNRTAYSLDASGEIKMK 406
            ..|.|.|:.||:||:....:...||.         .||...|....|   .|..|| ..|:...|
Human   357 FTKTPKYFKPGMPFDLMVFVTNPDGS---------PAYRVPVAVQGE---DTVQSL-TQGDGVAK 408

  Fly   407 FTVPIGDRDEFHSIIV--------DYQGVISEVGKIPSKHL-HSKNYITAKVLND--RPTVNQEI 460
            .::......:..||.|        :.:.....:..:|...: :|.||:...||..  ||.....:
Human   409 LSINTHPSQKPLSITVRTKKQELSEAEQATRTMQALPYSTVGNSNNYLHLSVLRTELRPGETLNV 473

  Fly   461 SVVVR----SFAPIKYFMYQVVGRGDIILS--------RNVDVAPGTFHTIKFLASFAMMPRANL 513
            :.::|    ..|.|:|:.|.::.:|.::.:        :::.|.|.:. |..|:.||.:     :
Human   474 NFLLRMDRAHEAKIRYYTYLIMNKGRLLKAGRQVREPGQDLVVLPLSI-TTDFIPSFRL-----V 532

  Fly   514 LVYTVIDG----EFVYDEQVIQLEENLLNAVQV---DAPIRAP-PGQDIDIGISTKPYSYVGLML 570
            ..||:|..    |.|.|...:.::::.:.::.|   .:..|.| |||.:.:.|.....:.|.|:.
Human   533 AYYTLIGASGQREVVADSVWVDVKDSCVGSLVVKSGQSEDRQPVPGQQMTLKIEGDHGARVVLVA 597

  Fly   571 VDQNANDLRSGHDLTHKRLMDALRSYELSDVNTPMGSPGK-------ESGVITMSNTDYFIEKEA 628
            ||:....|...:.||..::.|.:   |.:|:....|| ||       ::|:...|::.....:.|
Human   598 VDKGVFVLNKKNKLTQSKIWDVV---EKADIGCTPGS-GKDYAGVFSDAGLTFTSSSGQQTAQRA 658

  Fly   629 E---SNPALDREVSTGPEEDKLTTV-------------------------RKT---DIGPAHK-- 660
            |   ..||..|..|....|.::..|                         |:|   .:|.|.|  
Human   659 ELQCPQPAARRRRSVQLTEKRMDKVGKYPKELRKCCEDGMRENPMRFSCQRRTRFISLGEACKKV 723

  Fly   661 -----IEVNTLPPGKGR-----YAFSYTPKPFWHNPRVHVMRDPADTWLFLNISASSDGRNSIHR 715
                 ..:..|.....|     .|.|...:.......:....:..::||:.........:|.|..
Human   724 FLDCCNYITELRRQHARASHLGLARSNLDEDIIAEENIVSRSEFPESWLWNVEDLKEPPKNGIST 788

  Fly   716 R-----IPSEMTSWVVSAFALDPVNGLGLSPPNGKLEAYKEFYISTELPYSIKRDELIAIPFVVH 775
            :     :...:|:|.:.|.::....|:.::.| .::...::|:|...||||:.|:|.:.|..|::
Human   789 KLMNIFLKDSITTWEILAVSMSDKKGICVADP-FEVTVMQDFFIDLRLPYSVVRNEQVEIRAVLY 852

  Fly   776 NNR-DSDLNVEVTFYNSALDFDFPQLDPKATNQPKVELYRRRSLQVPGRSARSVSFIVTPKRVG- 838
            |.| :.:|.|.|...::      |.....||.:.:    .::::.:|.:|:.||.:::.|.:.| 
Human   853 NYRQNQELKVRVELLHN------PAFCSLATTKRR----HQQTVTIPPKSSLSVPYVIVPLKTGL 907

  Fly   839 -PLLVKAMAASSQAGDTVEQNLLVEHPGAMERINRGFLF------ELNSNAQNRRNVTIAVPRNA 896
             .:.|||........|.|.::|.|...|.  |:|:....      .|......:.::..|...:.
Human   908 QEVEVKAAVYHHFISDGVRKSLKVVPEGI--RMNKTVAVRTLDPERLGREGVQKEDIPPADLSDQ 970

  Fly   897 IPES---TRI--EVSAVGDLIGSLVG--NLDSLILLPTGCGEQTMVNFVPNLIVLRYLGRLRQLT 954
            :|::   |||  :.:.|..:....|.  .|..||:.|:|||||.|:...|.:|.:.||....|..
Human   971 VPDTESETRILLQGTPVAQMTEDAVDAERLKHLIVTPSGCGEQNMIGMTPTVIAVHYLDETEQWE 1035

  Fly   955 P---EVELRATNNLAIGYQRILYYRHENGAFSAFGLDIKRS-STWLTAYVARSLRQAAPFTQVDS 1015
            .   |....|...:..||.:.|.:|..:.||:||   :||: ||||||||.:....|.....:||
Human  1036 KFGLEKRQGALELIKKGYTQQLAFRQPSSAFAAF---VKRAPSTWLTAYVVKVFSLAVNLIAIDS 1097

  Fly  1016 NVLQKALTYL-GSVQSANGGFEERGDVF--ERFG------DDGISLTAFVTLALMENVDLYPEYR 1071
            .||..|:.:| ...|..:|.|:|...|.  |..|      :..::|||||.::|.|..|:..|..
Human  1098 QVLCGAVKWLILEKQKPDGVFQEDAPVIHQEMIGGLRNNNEKDMALTAFVLISLQEAKDICEEQV 1162

  Fly  1072 N----NINKALDFITRGLDGSSNLHAMAIGTYVLSRANHNAKAAFLQRLDSMATNKDGLKWWNKT 1132
            |    :|.||.||:..........:.:||..|.|::.. ..|...|.:.  :.|.||..:|    
Human  1163 NSLPGSITKAGDFLEANYMNLQRSYTVAIAGYALAQMG-RLKGPLLNKF--LTTAKDKNRW---- 1220

  Fly  1133 APAGEQQSPWYNATRSVNIEISAYAALALLENNLVGDALPVLNWLMDQRNPKGGFVASQDTVVGL 1197
                  :.|   ..:..|:|.::||.||||:........||:.||.:||...||:.::|.|.:..
Human  1221 ------EDP---GKQLYNVEATSYALLALLQLKDFDFVPPVVRWLNEQRYYGGGYGSTQATFMVF 1276

  Fly  1198 QALLMF-AERFSSQGNNLQIGFHYGEGAETIIN-VNAENSLALQTVELPNNLKNLSVSATGRGMA 1260
            |||..: .:....|..||.:.......:..|.: ::.|::..|::.|...| :..:|:|.|:|..
Human  1277 QALAQYQKDAPDHQELNLDVSLQLPSRSSKITHRIHWESASLLRSEETKEN-EGFTVTAEGKGQG 1340

  Fly  1261 LAQVSYTYNTNVTS--AWPRFVLDPTV-------NRNSHA-DYLHLSACASFVSVVGENEQRSNM 1315
            ...|...|:.....  ...:|.|..|:       .|...| :.:.|..|..:     ..:|.:.|
Human  1341 TLSVVTMYHAKAKDQLTCNKFDLKVTIKPAPETEKRPQDAKNTMILEICTRY-----RGDQDATM 1400

  Fly  1316 AVMEVHLPSGFVVDRDTLPTLES--SERIKKVET----QNRNTKVVIYFDYLDRRE---VCPTLH 1371
            :::::.:.:||..|.|.|..|.:  ...|.|.|.    .:||| ::||.|.:...|   :...:|
Human  1401 SILDISMMTGFAPDTDDLKQLANGVDRYISKYELDKAFSDRNT-LIIYLDKVSHSEDDCLAFKVH 1464

  Fly  1372 AYKTVKVTKHRPVAVVMYDYYDSARRARQFYRAPKSN--ICDICEHANCGDLCEKAEK 1427
            .|..|::.  :|.||.:|.||:......:||...|.:  :..:|.    .:||..||:
Human  1465 QYFNVELI--QPGAVKVYAYYNLEESCTRFYHPEKEDGKLNKLCR----DELCRCAEE 1516

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Tep3NP_523507.2 A2M_N 124..215 CDD:280081 32/98 (33%)
A2M_N_2 448..573 CDD:285005 32/146 (22%)
A2M 697..787 CDD:278630 23/95 (24%)
A2M_2 918..1203 CDD:239227 96/301 (32%)
A2M_comp 967..1200 CDD:284982 77/246 (31%)
A2M_recep 1313..1402 CDD:284981 26/97 (27%)
C3NP_000055.2 A2M_N 129..224 CDD:280081 33/100 (33%)
A2M_N_2 458..604 CDD:285005 33/151 (22%)
ANATO 678..747 CDD:237984 8/68 (12%)
A2M 770..866 CDD:278630 24/96 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 954..973 1/18 (6%)
complement_C3_C4_C5 996..1282 CDD:239226 96/304 (32%)
A2M_comp 1051..1282 CDD:284982 79/249 (32%)
A2M_recep 1398..1493 CDD:284981 26/97 (27%)
NTR_complement_C3 1513..1661 CDD:239638 2/4 (50%)
Interaction with CFP/properdin. /evidence=ECO:0000269|PubMed:28264884, ECO:0000269|PubMed:31507604 1634..1659
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165149987
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2373
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11412
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
54.800

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