Protein Alignment Tep3 and a2m

DIOPT Version :10

• Sequence 1: NP_523507.2
• Gene: Tep3 / 34045
• FlyBaseID: FBgn0041181
• Length: 1469
• Species: Drosophila melanogaster
• Sequence 2: XP_031761241.1
• Gene: a2m / 619586
• XenbaseID: XB-GENE-481725
• Length: 1457
• Species: Xenopus tropicalis
• Alignment Length: 1571
• Identity: 379/1571 - (24%)
• Similarity: 639/1571 - (40%)
• Gaps: 307/1571 - (19%)

  Fly    17 VTACLLCQTSAQG-------LYSIIAPNTLRPNSQFHVAVSLHNAPES--ATFKVGILGSSYTDF 72
            :|.|||......|       .|.::.|..|...|:....:.|.:..||  .|..:|:...:.|..
 Frog     6 LTLCLLLTAFPGGDPAPPDPKYMLLVPTVLHGGSEEKFCLLLSHLNESVVVTLTMGLERQNETLL 70

  Fly    73 KTVELRPFSTQLLHFEIPALRTDR---YRLTAEGLGGVQFTNETQLHFESKQHTVLVQTDKSIYK 134
            :...:.......:.|..|.|....   ..|..:| ..:.||:...:..:..|:.|.|||||.|||
 Frog    71 EKQVMEKEDDSCVTFMTPKLDAPEVAYLTLLVDG-DSLHFTSRRSVLIKPVQNLVFVQTDKPIYK 134

  Fly   135 PGDLVHYRVLILDANLKP-ARGYGRVHVDIKDSGDNIIRSYKDIRLTNSIYSNELRLSDSPRFGT 198
            ||..|.:|::.||.|..| :..:..|:  |.|...|.|..:.::.|...:.....:||..|..||
 Frog   135 PGQKVQFRIVSLDENFYPVSEKFPAVY--ITDPQGNRISQWLNVELKKGLTQEFFQLSPEPTLGT 197

  Fly   199 WSIVVDVSDQEH----TQTFEILDHILPKFVVDIDTPKHAIYKDGKIAATVRAHYAFGQPIVGEA 259
            :|::|   ::|.    |.:|.:.:::|||:.|.:..|........::..||...|.:|:|::|..
 Frog   198 YSLIV---EREKGAPVTHSFSVEEYVLPKYEVQVKLPATLTILGQEVPVTVCGRYTYGKPVLGRI 259

  Fly   260 TLSIYPTFF--------------------GSLQPFVNDLITRKVVPIDGNAYFEFDIENELHLKQ 304
            .:.:...|.                    ..|...::|::..||          |.:.     :.
 Frog   260 NVRVCRKFSDRYNLCQGEEDGVCEEISQRADLNGCISDVVNTKV----------FQMR-----RA 309

  Fly   305 DYERQYLLDALVEEKST-------GSVQNYSTVLTLHLNHYRVEAVKVPSYYIPGVPF------- 355
            .||.:.:..|.:.|..|       ||.:..||:.|:...|       :.|:|..|:|.
 Frog   310 GYEMKIIASAKITEDGTGVELTGEGSSEIKSTLATVSFRH-------LDSHYKKGIPLYGQVFLE 367

  Fly   356 ---------EATARIARNDGGQLRDFNPQITAYLTNVYGSSEMYNRTAYSLDAS----GEIKMKF 407
                     |.......|||...        .|.|...|::|      :|:|.|    ..:::|.
 Frog   368 DAAGNPMSNETVVVYVGNDGTNF--------TYTTGQDGTAE------FSIDTSSFQLSSVRIKA 418

  Fly   408 TVPIGDRDEFHS-IIVDYQGVISEVGKIPSKHLHSKNYITAKVLNDRPTVNQEISVVVRSFAPIK 471
            :...||....|. :...|:.....|     .|.:|::....|:.....|:..:|...|.    :.
 Frog   419 SYKTGDYCSGHRWLTASYEEDTRHV-----NHFYSRSKSFLKIQPIHRTLECQIVEKVN----VH 474

  Fly   472 Y--------------FMYQVVGRGDII--------LSRNVDVAPGTFHTIKFLASFAMMPRANLL 514
            |              |.|.|:.:|.|:        |..|.: |.|.| .........:.|.|.:|
 Frog   475 YILTPEGVGEARNAVFHYLVMAKGGIVENGKHTLALIPNQE-AQGNF-LFDLPVGTNVSPSAKIL 537

  Fly   515 VYTVID-GEFVYDEQVIQLEENLLNAVQVD-APIRAPPGQDIDIGISTKPYSYVGLMLVDQNAND 577
            ||.|:: ||.:.|...:::.:...|.|::. :|....||....:.:.|.|.|...:..||::...
 Frog   538 VYLVLESGEVIADSITLKVVQCFENKVKLSFSPTEGLPGSQAHLRLVTNPTSLCAVRAVDESVLL 602

  Fly   578 LRSGHDLTHKRLMDALRSYELSDVN-----------------TPMGSPG---------------- 609
            |:...:|:.:.:.|.|...:||..:                 .||...|
 Frog   603 LKPEAELSARTIYDLLPLKDLSGYDHDGKFLEELRDDPCLPLEPMYINGIYYTPSNPDWDTDTYT 667

  Fly   610 --KESGVITMSNTDYFIEKEAESNPALDREVSTGPEE------------DKLTTVRKTDIGPAHK 660
              |..|:...:||:.......|....::.|::...||            :.:.||||
 Frog   668 ILKSLGLKVFTNTNIRTPVVCERRWKMENELAYDSEEELAMAPMAMRYMEVIETVRK-------- 724

  Fly   661 IEVNTLPPGKGRYAFSYTPKPFWHNPRVHVMRDPADTWLFLNISASSDGRNSIHRRIPSEMTSWV 725
                            |.|                :|||:..:...:||:..:...:|..:|:|.
 Frog   725 ----------------YFP----------------ETWLWDLVETDADGKADLAVTVPDTITTWK 757

  Fly   726 VSAFALDPVNGLGLSPPNGKLEAYKEFYISTELPYSIKRDELIAIPFVVHNNRDSDLNVEVTFYN 790
            ...|......|.||| ....|.|::.|::...||||..|.|...:...|.|.....:.|.::..:
 Frog   758 AGMFCTSQGAGFGLS-ETISLVAFQPFFLELTLPYSAIRGEKFILKATVFNYLSQTIRVAISLED 821

  Fly   791 SALDFDFPQLDPKATNQPKVELYRRRSLQ-----VPGRSARSVSFIVTPKRVGPLLVKAMAASSQ 850
            |      .|...|.:|           ||     |.|....::|:.||.|.:|.:.. .|:|.:.
 Frog   822 S------DQFLAKPSN-----------LQEDGYCVKGNGRVTLSWDVTLKSLGEVNF-TMSAETL 868

  Fly   851 AG----------------DTVEQNLLVEHPGAMERINRGFLFELNSNAQNRRNVTIAVPRNAIPE 899
            .|                ||:.:::||| |..:|:............::...::.:.:|...:..
 Frog   869 TGEGLCENEIVDPIQGRKDTITKHILVE-PEGVEKEETQNAMICGKGSEITEDIHLKLPERVVEG 932

  Fly   900 STRIEVSAVGDLIGSLVGNLDSLILLPTGCGEQTMVNFVPNLIVLRYLGRLRQLTPEVELRATNN 964
            |.|...|||||::|:.:.||.:|:.:|.|||||.||.|.|.:.:..||.:..|||||::.:..:.
 Frog   933 SARAYFSAVGDILGTAIQNLGNLVQMPYGCGEQNMVLFTPIIYISEYLNKTNQLTPEMKSKTLSY 997

  Fly   965 LAIGYQRILYYRHENGAFSAFGLDIKRSSTWLTAYVARSLRQAAPFTQVDSNVLQKALTYLGSVQ 1029
            ::.|||:.|.|:|.:|::||||......:|||||:..:|..:|.....::..::..|||:|.:.|
 Frog   998 MSTGYQKQLSYKHYDGSYSAFGQQYGEGNTWLTAFTMKSFARARAHIYIEEKLISDALTWLSNHQ 1062

  Fly  1030 SANGGFEERGDVFE---RFG-DDGISLTAFVTLALMENVDLY--PEYRNNINKALDFITRGLDGS 1088
            ..||.|...|.:|.   :.| ||.::|.|::|:||:|    |  |.....:..||..:...|.|.
 Frog  1063 KENGCFHSVGKLFNNAMKGGVDDEVTLAAYITIALLE----YPLPVTHPTVRNALFCLESALGGK 1123

  Fly  1089 SNLHAMAIGTYVLSRANH-NAKAAFLQRLDSMATNKDGLKWWNK---TAPAGEQQSPWYNATRSV 1149
            ::::..|:..|..:.|.. :.:...||.||..|..|||...|.:   :..:|..::| |:...|.
 Frog  1124 NSIYTKALMAYAFTLAGRMDIRRQLLQSLDEQAIKKDGTVHWQRPETSDDSGHYRNP-YSQAPSA 1187

  Fly  1150 NIEISAYAALALLENNLVGD-----ALPVLNWLMDQRNPKGGFVASQDTVVGLQALLMFAERFSS 1209
            .:|:::|..|.||....|.|     |..|::|::.|:||.|||.::|||||.||||.::.....|
 Frog  1188 EVEMTSYGLLTLLSKPDVSDEDLTLATQVVSWIIKQQNPSGGFSSTQDTVVALQALALYGSLTLS 1252

  Fly  1210 QGNNLQIGFHYGEGAETIINVNAENSLALQTVELPNNLKNLSVSATGRGMALAQVSYTYNTNVTS 1274
            ..:...:.....:......||...|.|.||.:.|.....:.:.:.:|.|....:.:..||.....
 Frog  1253 HDSTRTVLLSLEKTPVAKFNVEDSNRLLLQQIALKEVPGDYTATVSGSGCLYLKTALRYNVPHPK 1317

  Fly  1275 AWPRFVL----DPTV-NRNSHADYLHLSACASFVSVVGENEQRSNMAVMEVHLPSGFVVDRDT-- 1332
            ....|.:    :||. :|.|    |...|..:.||.:|: ...||||:||:.:|||.|..:.:
 Frog  1318 EDAAFTILVTTEPTACDRKS----LKSFAIVANVSYIGK-RANSNMALMEIKMPSGHVPVKSSVK 1377

  Fly  1333 -LPTLESSERIKKVETQNRNTKVVIYFDYLDRREVCPTLHAYKTVKVTKHRPVAVVMYDYYDSAR 1396
             ||.|.:.  ||:.|.|  ..||.:||:.|.:.....:....:.:.::..:|...::||||:...
 Frog  1378 KLPRLNNF--IKRTEIQ--TNKVNVYFELLSKDIQSFSFLVEQDIPISNLQPATAIIYDYYEKDD 1438

  Fly  1397 RARQFYRAPKS 1407
            .|...|.||.|
 Frog  1439 FAVTKYSAPCS 1449

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tep3	NP_523507.2	YfaS	<128..1399	CDD:441940	348/1438 (24%)
		A2M_2	918..1203	CDD:239227	104/299 (35%)
a2m	XP_031761241.1	YfaS	<94..1414	CDD:441940	351/1446 (24%)
		A2M_2	948..1246	CDD:239227	104/302 (34%)