DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Tep3 and PZP

DIOPT Version :9

Sequence 1:NP_523507.2 Gene:Tep3 / 34045 FlyBaseID:FBgn0041181 Length:1469 Species:Drosophila melanogaster
Sequence 2:XP_011519106.1 Gene:PZP / 5858 HGNCID:9750 Length:1500 Species:Homo sapiens


Alignment Length:1538 Identity:394/1538 - (25%)
Similarity:651/1538 - (42%) Gaps:244/1538 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly    13 VLILVTACLLCQTSAQGLYSIIAPNTLRPNSQFHVAVSLHNAPESATFKVGILG-----SSYTDF 72
            ||:|:........|.:..|.::.|:.|...:.....|.|.:..|:.|....:..     |.:||.
Human    12 VLLLILLSASDSNSTEPQYMVLVPSLLHTEAPKKGCVLLSHLNETVTVSASLESGRENRSLFTDL 76

  Fly    73 KTVELRPFSTQLLH---FEIPALRTDRYRLTAE---GLGGVQFTNETQLHFESKQHTVL------ 125
            ..      ...|.|   |.:|       |::|.   ....:|....|| .|. |::|||      
Human    77 VA------EKDLFHCVSFTLP-------RISASSEVAFLSIQIKGPTQ-DFR-KRNTVLVLNTQS 126

  Fly   126 ---VQTDKSIYKPGDLVHYRVLILDANLKPARGYGRVHVDIKDSGDNIIRSYKDIRLTNSIYSNE 187
               |||||.:||||..|.:||:.:|.|.:| |......:.:::...|.|..::.::|...|....
Human   127 LVFVQTDKPMYKPGQTVRFRVVSVDENFRP-RNELIPLIYLENPRRNRIAQWQSLKLEAGINQLS 190

  Fly   188 LRLSDSPRFGTWSIVVDVSDQEHTQ-TFEILDHILPKFVVDIDTPKHAIYKDGKIAATVRAHYAF 251
            ..||..|..|::.:||........| .|.:.:.:||||.|.:..||.....|.|:..||...|.:
Human   191 FPLSSEPIQGSYRVVVQTESGGRIQHPFTVEEFVLPKFEVKVQVPKIISIMDEKVNITVCGEYTY 255

  Fly   252 GQPIVGEATLSIYPTFFGSLQPFVNDLITRKVVPIDGNAYFEFDIENELHLKQ------DYERQY 310
            |:|:.|.||:|:.......|.....::.......::.|..    |..::|.|.      .:|.:.
Human   256 GKPVPGLATVSLCRKLSRVLNCDKQEVCEEFSQQLNSNGC----ITQQVHTKMLQITNTGFEMKL 316

  Fly   311 LLDALVEEKST------GSVQNYSTVLTLHLNHYRVEAVKVPSYYIPGVPFEATARIARNDGG-- 367
            .::|.:.|:.|      ..:...:.:::      :::.|||.|::..|:||.|...:....|.  
Human   317 RVEARIREEGTDLEVTANRISEITNIVS------KLKFVKVDSHFRQGIPFFAQVLLVDGKGVPI 375

  Fly   368 -------QLRDFNPQITAYLTNVYGSSEMYNRTAYSLDASGEIKMKFTVPIGDRDEFHSIIVDYQ 425
                   .:.|.|....| .||..|.::....|. |:..:......|||.......:..:..|:|
Human   376 PNKLFFISVNDANYYSNA-TTNEQGLAQFSINTT-SISVNKLFVRVFTVHPNLCFHYSWVAEDHQ 438

  Fly   426 G-------VIS----------EVGKIPSKHLHSKNYITAKVLNDRPTVNQ--EISVVVRSFAPIK 471
            |       |.|          ..|.:|..|..:   |||....:|..:.:  |:|          
Human   439 GAQHTANRVFSLSGSYIHLEPVAGTLPCGHTET---ITAHYTLNRQAMGELSELS---------- 490

  Fly   472 YFMYQVVGRGDIILSRNVDVAPGTFHTI---------KFLASFA----MMPRANLLVYTVI-DGE 522
             |.|.::.:|.|:.|       || ||:         .|..||.    :.|.|.:.::.:: |||
Human   491 -FHYLIMAKGVIVRS-------GT-HTLPVESGDMKGSFALSFPVESDVAPIARMFIFAILPDGE 546

  Fly   523 FVYDEQVIQLEENLLNAVQVD-APIRAPPGQDIDIGISTKPYSYVGLMLVDQNANDLRSGHDLTH 586
            .|.|.:..::|..|.|.|.:. :|.::||.....:.::..|.|...|..|||:...::...:|:.
Human   547 VVGDSEKFEIENCLANKVDLSFSPAQSPPASHAHLQVAAAPQSLCALRAVDQSVLLMKPEAELSV 611

  Fly   587 KRLMDALRSYELSDVNTPMGSPGKESGVITMSNTDYFIEKEA-----ESNPA--------LDREV 638
            ..:.:.|...:|::....:....:|.|   .....:||...|     .||.|        :..:|
Human   612 SSVYNLLTVKDLTNFPDNVDQQEEEQG---HCPRPFFIHNGAIYVPLSSNEADIYSFLKGMGLKV 673

  Fly   639 STGPEEDKLTTVRKTDIGPAHKIEVNTLPPGKGRYAFS-------YTPKPFWHN----------- 685
            .|   ..|:...:...:.|:    |:....|:|.|...       |.|:...:|           
Human   674 FT---NSKIRKPKSCSVIPS----VSAGAVGQGYYGAGLGVVERPYVPQLGTYNVIPLNNEQSSG 731

  Fly   686 PRVHVMRD--PADTWLFLNISASSDGRNSIHRRIPSEMTSWVVSAFALDPVNGLGLSPPNGKLEA 748
            |....:|.  | :||::..::.:|.|...:...:|..:|.|...||.|....|||:| ....|.|
Human   732 PVPETVRSYFP-ETWIWELVAVNSSGVAEVGVTVPDTITEWKAGAFCLSEDAGLGIS-STASLRA 794

  Fly   749 YKEFYISTELPYSIKRDELIAIPFVVHNNRDSDLNVEVTFYNSALDFDFPQLDPKATNQPKVELY 813
            ::.|::...:|||:.|.|:..:...|.|.....:.|.|....|....        |:...|.|  
Human   795 FQPFFVELTMPYSVIRGEVFTLKATVLNYLPKCIRVSVQLKASPAFL--------ASQNTKGE-- 849

  Fly   814 RRRSLQVPGRSARSVSFIVTPKRVGPLLVKAMAASSQA----------------GDTVEQNLLVE 862
              .|..:.|...:::|:.||||.:|.:.....|.:.|:                .|||.:.||||
Human   850 --ESYCICGNERQTLSWTVTPKTLGNVNFSVSAEAMQSLELCGNEVVEVPEIKRKDTVIKTLLVE 912

  Fly   863 HPGAMERINRGFLFELNSNAQNRRNVTIAVPRNAIPESTRIEVSAVGDLIGSLVGNLDSLILLPT 927
            ..| :|:..........|.|.....:::.:|.|.:.||.|...|.:||::||.:.|:.:|:.:|.
Human   913 AEG-IEQEKTFSSMTCASGANVSEQLSLKLPSNVVKESARASFSVLGDILGSAMQNIQNLLQMPY 976

  Fly   928 GCGEQTMVNFVPNLIVLRYLGRLRQLTPEVELRATNNLAIGYQRILYYRHENGAFSAFGLDIKRS 992
            |||||.||.|.||:.||.||...:|||.|::.:|...|..||||.|.|:|::|::|.||....|:
Human   977 GCGEQNMVLFAPNIYVLNYLNETQQLTQEIKAKAVGYLITGYQRQLNYKHQDGSYSTFGERYGRN 1041

  Fly   993 --STWLTAYVARSLRQAAPFTQVDSNVLQKALTYLGSVQSANGGFEERGDVFERFGDDGI----S 1051
              :|||||:|.::..||..:..:|...:.::||:|..:|..||.|...|.:.......|:    :
Human  1042 QGNTWLTAFVLKTFAQARSYIFIDEAHITQSLTWLSQMQKDNGCFRSSGSLLNNAIKGGVEDEAT 1106

  Fly  1052 LTAFVTLALMENVDL---YPEYRNN---INKALDFITRGLDGSSNLHAMAIGTY---VLSRANHN 1107
            |:|:||:||:| :.|   .|..||.   :..|.:....|..| |:::..|:..|   :|.:.|.|
Human  1107 LSAYVTIALLE-IPLPVTNPIVRNALFCLESAWNVAKEGTHG-SHVYTKALLAYAFSLLGKQNQN 1169

  Fly  1108 AKAAFLQRLDSMATNKDGLKWWNK----TAPAG---EQQSPWYNATRSVNIEISAYAALALLENN 1165
            .:  .|..||..|..:|.|..|.:    .||.|   :.|:|      |..:|:::|..||.|...
Human  1170 RE--ILNSLDKEAVKEDNLVHWERPQRPKAPVGHLYQTQAP------SAEVEMTSYVLLAYLTAQ 1226

  Fly  1166 ---LVGD---ALPVLNWLMDQRNPKGGFVASQDTVVGLQALLMF-AERFSSQGNNLQIGFHYGEG 1223
               ..||   |..::.|:|.|:|.:|||.::|||||.|.||..: |..|:......|:.....:.
Human  1227 PAPTSGDLTSATNIVKWIMKQQNAQGGFSSTQDTVVALHALSRYGAATFTRTEKTAQVTVQDSQT 1291

  Fly  1224 AETIINVNAENSLALQTVELPNNLKNLSVSATGRGMALAQVSYTYNTNVTSAWPRFVLD-PTVNR 1287
            ..|...|:..|.|.||.:.||.......::.||......|.|..||.........|.|. .||.:
Human  1292 FSTNFQVDNNNLLLLQQISLPELPGEYVITVTGERCVYLQTSMKYNILPEKEDSPFALKVQTVPQ 1356

  Fly  1288 NSHADYLHLSACASF-VSVVGENEQRSNMAVMEVHLPSGFVVDRDTLPTLESSERIKKVETQNRN 1351
            .......|.|...|. :|..| |...|||.:::|.:.|||:..:.|:..||.|..:.:.|..|.:
Human  1357 TCDGHKAHTSFQISLTISYTG-NRPASNMVIVDVKMVSGFIPLKPTVKMLERSSSVSRTEVSNNH 1420

  Fly  1352 TKVVIYFDYLDRREVCPTLHAYKTVKVTKHRPVAVVMYDYYDS 1394
              |:||.:.:..:.:..:....:.:.|...:|..|.:||||::
Human  1421 --VLIYVEQVTNQTLSFSFMVLQDIPVGDLKPAIVKVYDYYET 1461

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Tep3NP_523507.2 A2M_N 124..215 CDD:280081 29/100 (29%)
A2M_N_2 448..573 CDD:285005 33/141 (23%)
A2M 697..787 CDD:278630 25/89 (28%)
A2M_2 918..1203 CDD:239227 109/312 (35%)
A2M_comp 967..1200 CDD:284982 84/260 (32%)
A2M_recep 1313..1402 CDD:284981 23/82 (28%)
PZPXP_011519106.1 A2M_N 128..220 CDD:280081 28/92 (30%)
A2M_N_2 457..602 CDD:285005 41/166 (25%)
A2M 744..834 CDD:278630 26/90 (29%)
SVA <796..891 CDD:283081 24/106 (23%)
A2M_2 964..1270 CDD:239227 109/315 (35%)
A2M_comp 1016..1272 CDD:284982 86/265 (32%)
A2M_recep 1382..1464 CDD:284981 23/82 (28%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165149983
Domainoid 1 1.000 57 1.000 Domainoid score I10853
eggNOG 1 0.900 - - E1_COG2373
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 1 0.950 - 0 Normalized mean entropy S7033
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D177369at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100452
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
76.600

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