DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Tep3 and c4

DIOPT Version :9

Sequence 1:NP_523507.2 Gene:Tep3 / 34045 FlyBaseID:FBgn0041181 Length:1469 Species:Drosophila melanogaster
Sequence 2:XP_005157429.1 Gene:c4 / 566261 ZFINID:ZDB-GENE-030131-5697 Length:1700 Species:Danio rerio


Alignment Length:1674 Identity:392/1674 - (23%)
Similarity:689/1674 - (41%) Gaps:359/1674 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    33 IIAPNTLRPNSQFHVAVSLHNAPESATFKVG----------------ILGSSYTDFKTVELRPFS 81
            |:|||.:....:..|.|.||.|.:....|:.                ||..:......|:|:..:
Zfish    24 IVAPNVIHLGVEETVGVQLHGATKEIRMKLYFEKQKESEILSEIRSIILNENNNYQAVVKLKVDA 88

  Fly    82 TQL------LHFEIPALRTDRYRLTAEGLGGVQFTNETQLHFESKQHTVLVQTDKSIYKPGDLVH 140
            |..      .:.::.|:..|.:.        .|...:..::..:|:..:.|||||.||.||:.|.
Zfish    89 TMYGDVEKNSYVQLAAISNDIFE--------KQDARKANIYLSTKRGYIFVQTDKPIYNPGENVK 145

  Fly   141 YRVLILDANLKPARGYGRVHVDIKDSGDNIIRSYKDIRLTNSIYSNELRLSDSPRFGTWSIVVDV 205
            ||:.|||..:.|.:  ..:||.|.:|...|:  |..:.:.|.|....:.:.:..:.|.|.|:...
Zfish   146 YRIFILDNYMLPIQ--DELHVQITNSKGLIV--YNRVLIINQILDKTITIPEVEQTGKWKIITSF 206

  Fly   206 SD-QEHTQT--FEILDHILPKFVVDIDT--PKHAIYKDGKIAATVRAHYAFGQPIVGEATLSIYP 265
            .. .|.|.|  ||:.:::||.|.|.|:.  |.|.:..: .....:.|.|.:|:.:.|.|.:.   
Zfish   207 HKFPESTTTVEFEVKEYVLPTFEVKIEASQPYHILMSE-SFPFNISARYTYGKGVNGIAYVR--- 267

  Fly   266 TFFGSLQPFVNDLI---TRKVVPID----GNAYFEFDIEN-ELHLKQDY-ERQYLLDAL-VEEKS 320
              ||.:....|.:.   |.|.:.::    |.|....|::. ..::.|.| |..|:..|: |.:|:
Zfish   268 --FGLVDEKHNKIYLPGTEKQITVEDGTAGTAVLTKDLKTASQNITQGYIEGYYIYIAVSVLDKA 330

  Fly   321 TGSVQN-YSTVLTLHLNHYRVEAVKVPSYYIPGVPFEATARIARNDGGQLRDFNPQITAYLTNVY 384
            :|.::. .|:.:.:..:.|.|:..|..:|:.||..|...|.....||.  |..|.:.||.:| :.
Zfish   331 SGMLEEAESSSVKIVTSPYVVDLSKTKTYFTPGGVFSVLATATYPDGN--RAPNLKFTATIT-ID 392

  Fly   385 GSSEMYNRTAYSLDASGEIKMKFTVPIGDRDEFHSIIVD--YQGVISEVGKIPSKHL--HSKNYI 445
            ||||...:.....:..|::.|.|.:|...::...::..:  .|.||....|:.:..:  ..::|:
Zfish   393 GSSEQILQNESWGNEMGDVAMSFQIPPQAKNLAITVFAEGGDQVVIRSDNKMTASAITAEEQSYL 457

  Fly   446 TAKVLNDRPTVNQEISVVVRSFAP-----IKYFMYQVVGRGDIILSRNVDVAPGT-FHTIKFLAS 504
            :.:|........:::...:|...|     ..:|.:.|..:|.|:....|   |.| |.|:....:
Zfish   458 SLEVEKQFLQAGEDLKARLRDITPEGAAKPTFFYFMVWSKGQIVQMGRV---PRTAFTTVNVKVN 519

  Fly   505 FAMMPRANLLVY----TVIDGEFVYDEQVIQLEENLLNAVQVDAPIRAPPGQDIDIGISTKPYSY 565
            ..|:|...|:.|    :......|.|...:.:::.....::::......|....::.:.|.|.:.
Zfish   520 VDMVPSFRLVAYYFTGSASKESVVADSVWVDVKDVCKGKIEINPLAEIKPATQFEVTVETNPKTK 584

  Fly   566 VGLMLVDQNANDLRSGHDLTHKRLMDALRSYELSDVNTPMGSPGKESGVITMSNTDYFIEKEAES 630
            |.|:.|| :|..:.:.:.|:.:::.|.:.||:|:   ..:|.....|.|:..:...:......::
Zfish   585 VALVAVD-SAVYILNKNKLSLQKMFDYMNSYDLA---CSVGGGEDSSAVLQRAGLTFICNCALKT 645

  Fly   631 NPALDRE--------VSTGPE---------------------------------EDKLTTV---- 650
            ..||:.:        |...|:                                 .|:|..|    
Zfish   646 PTALEHKCNKKTTNRVRRAPDYVAKYNAVVNSFKNQDRKCCLDGVRPSKMQTSCVDRLKRVKESE 710

  Fly   651 ------------------------RKTDIGPA-----HKIEVNTLPPGKGRYAFSYTPKPFWHNP 686
                                    |||.:|..     .:|.:|.    ...|..:|.|:      
Zfish   711 SCRKAFKECCEAADERRKREKFEKRKTSLGRVVGDSFDEIVINE----DLIYIRNYFPQ------ 765

  Fly   687 RVHVMRDPADTWLFLNISASSDGRNSIHRRI--PSEMTSWVVSAFALDPVNGLGLSPPNGKLEAY 749
                      :|::..|  .||.:..|...:  |..:|:|.|.|..:.|..|..::.|. .|..:
Zfish   766 ----------SWMWTVI--ESDNKGLIRHEVVAPDSITTWEVQAVGISPTKGFCIAEPK-PLTVF 817

  Fly   750 KEFYISTELPYSIKRDELIAIPFVVHNNRDSDLNVEVTFYNSALDFDFPQLDPKATNQPKVELYR 814
            |:|::|..||||:||:|.:.:..||:|.:...|.|.|....      ...|.....|..|.|   
Zfish   818 KDFFLSVNLPYSVKRNEQLQVKAVVYNYKQESLKVIVKLNK------VEGLCTAGGNDVKEE--- 873

  Fly   815 RRSLQVPGRSARSVSFIVTPKRVGPLLVKAMA-ASSQAGDTVEQNLLVEHPGAMERINRGFLFEL 878
               :.|.|.||.:|.|.|.|..:|.|.:..:| ||....|.||:.|.||..|.:..|:|.|..:.
Zfish   874 ---VTVSGNSAVTVYFTVVPLIIGNLHIDVLAYASEIIHDRVEKKLRVEGEGELTSIDREFNIDP 935

  Fly   879 NSNAQNRRNVTIAVPRNAIPESTRIEVSA--VGDLIGSLVGN------LDSLILLPTGCGEQTMV 935
            |   ..:....|:.|.:.:|..:..|.|.  .|.::|..:.|      :|.||.|||||.|||||
Zfish   936 N---LKKIEFNISSPVDEVPAGSDSETSLGFKGGVMGESIDNCLNLEGIDKLIQLPTGCAEQTMV 997

  Fly   936 NFVPNLIVLRYLGRLRQ-LTPEVELR--ATNNLAIGYQRILYYRHENGAFSAFGLDIKR-SSTWL 996
            ...|.:..:|||....| |:.:.|.|  |.:.:..||..:|.::.::|::.||   ::. ||.||
Zfish   998 KMSPAIHAMRYLDATNQWLSLKAERRDEARSMIQTGYNTVLTHKKDDGSYGAF---LRTPSSIWL 1059

  Fly   997 TAYVARSLRQAAPFTQVDSNVLQKALTYLGSVQSANGGFEERGDVFER-------FGDDGISLTA 1054
            ||::|:.|..:.....|:...:|:|::||.|.|.:||.:::...:|::       ...|.:.|||
Zfish  1060 TAFIAKELTGSQDIVNVNKLYIQEAMSYLISKQKSNGAWDDPNRLFDQGMKGGVEQATDDVPLTA 1124

  Fly  1055 FVTLALMENVDLY-----PEYRNNINKALDFITRGLDGSSNLHAMAIGTYVLSRANHNAKAA--F 1112
            ||.:::...:.:|     .|.|..::||..::...||...:.:::|:..|..|..:|.:..|  .
Zfish  1125 FVLISMHHALKVYDLGSDTELRVAMDKAKSYLEAQLDAVRSPYSLAVTAYSFSLHDHRSAEARKA 1189

  Fly  1113 LQRLDSMATNKDGLKWWNKTAPAGEQQSPWYNATRSVNIEISAYAALALLENNLVGD---ALPVL 1174
            .|:|..:|...|.:.:|......||.:    :...:.::|.:|||.|..|   :|||   :..:.
Zfish  1190 QQKLQDIANCDDKMCFWKAKGGRGEPK----DKADARSVETTAYALLTTL---IVGDKSKSKLIA 1247

  Fly  1175 NWLMDQRNPKGGFVASQDTVVGLQALLMFAERFSSQGN-----NLQIGFHYGEGAETIINVNAEN 1234
            |||.:||...|||.::||||:.|:||    .::|.|.|     ||::......|.:..:::...|
Zfish  1248 NWLTEQRRHGGGFRSTQDTVLALEAL----TKYSIQNNDVDDLNLRVEMCLENGQKKDLHLTKNN 1308

  Fly  1235 SLALQTVELPNNLK-NLSVSATGRG-MALAQVSYTYNTNVTSAWPRFVLDPTVNRNSHADYLHLS 1297
            :|.|..|::.:..| .|::..|||| :|:.|   ||.|             .....|..|..||:
Zfish  1309 ALTLSAVKVRDVGKVTLNIQGTGRGTLAVVQ---TYRT-------------MKKDESFCDLFHLT 1357

  Fly  1298 ACASFVSVVGENEQRSN------------------------------------------------ 1314
                 |:|.||.|.:::                                                
Zfish  1358 -----VTVKGELEYKTDNSQDLLEDYYESYDTSEAQNDEPMSNMQWFDLRSRRKRQISEEPIKES 1417

  Fly  1315 -----------------MAVMEVHLPSGFVVD-RDTLPTLESSER-IKKVETQNRNTKVVIYFDY 1360
                             |.::::.|.||.:.: :|....::.:|: |...|.  .:.||.:||..
Zfish  1418 SLIYTVCVGLKKKNSEGMIIVDISLLSGLIPNSKDLEHNVKGTEKYIDHYEI--HHNKVYLYFAK 1480

  Fly  1361 LDRREVCPTLHAYKTVKVTKHRPVAVVMYDYYDSARRARQFYRAPK-----SNIC--DICEHANC 1418
            :...|.|....|.:.|.:...:|.:.|:||||...:|...||.||:     |.:|  |:|..|..
Zfish  1481 ITETEECLQFGADQAVPMGLVQPASAVIYDYYSPEKRCGIFYTAPQKSPMISKLCQGDVCTCAEG 1545

  Fly  1419 GDLCEKAEKRESKRPDDYTAIAGHSSGSRHT------AIPLASVVMVLS 1461
            |  |.|.:...||..:         |.||.:      ::....|:.:||
Zfish  1546 G--CAKLKVTFSKNME---------SNSRSSFACYDPSVDYVYVIKILS 1583

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Tep3NP_523507.2 A2M_N 124..215 CDD:280081 30/93 (32%)
A2M_N_2 448..573 CDD:285005 24/134 (18%)
A2M 697..787 CDD:278630 29/91 (32%)
A2M_2 918..1203 CDD:239227 96/311 (31%)
A2M_comp 967..1200 CDD:284982 71/250 (28%)
A2M_recep 1313..1402 CDD:284981 23/155 (15%)
c4XP_005157429.1 A2M_N 128..220 CDD:280081 31/95 (33%)
A2M_N_2 459..595 CDD:285005 26/139 (19%)
ANATO 675..731 CDD:237984 3/55 (5%)
A2M 766..856 CDD:278630 30/92 (33%)
complement_C3_C4_C5 977..1276 CDD:239226 95/312 (30%)
A2M_comp 1032..1278 CDD:284982 73/259 (28%)
A2M_recep 1434..1522 CDD:284981 23/89 (26%)
NTR_complement_C4 1540..1698 CDD:239639 13/55 (24%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C170584117
Domainoid 1 1.000 56 1.000 Domainoid score I10957
eggNOG 1 0.900 - - E1_COG2373
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D177369at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11412
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
ZFIN 00.000 Not matched by this tool.
76.810

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