DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tep3 and zgc:165453

DIOPT Version :9

Sequence 1:	NP_523507.2	Gene:	Tep3 / 34045	FlyBaseID:	FBgn0041181	Length:	1469	Species:	Drosophila melanogaster
Sequence 2:	XP_009297326.1	Gene:	zgc:165453 / 566238	ZFINID:	ZDB-GENE-070720-13	Length:	1455	Species:	Danio rerio

Alignment Length:	1524	Identity:	371/1524 - (24%)
Similarity:	641/1524 - (42%)	Gaps:	263/1524 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 LYSIIAPNTLRPNSQFHVAVSLHNAPESATFKVGILGSSYTDFKTVEL---RPFSTQLLHFEIPA 91
            |:.:..|:.:..:::..:..||.....|.|..:.::....|:.:.|:.   |.|. :..||:.|.
Zfish    45 LFLVTFPSLIESDTEAKLCASLLKPKGSVTMTISLVDEKSTEIQLVQQTSGRKFH-RCFHFQAPQ 108

  Fly    92 LRTDRYRLTAEGLGGVQF--TNETQLHFESKQHTVLVQTDKSIYKPGDLVHYRVLILDANLKPA- 153
            :..|..:.....:.|..|  |.|:::.|.|......:||||.:|.||..|::|||.:.....|.
Zfish   109 VSGDSVQTVRVVIQGQSFKMTEESKVMFRSYLPLTFIQTDKPLYNPGQRVNFRVLTMSDTFVPQD 173

  Fly   154 RGYGRVHVDIKDSGDNIIRSYKDIRLTNSIYSNELRLSDSPRFGTWSIVVDVSDQEHTQTFEILD 218
            :.|..|.|:  |:....||.:.||..||.|......|....:.||:::...:.|:..:|:|::..
Zfish   174 QMYSLVVVE--DNNKIRIRQWTDISSTNWILELSHVLDKEAQVGTYTLKAYIGDRTISQSFDVKK 236

  Fly   219 HILPKFVVDIDTPKHAIYKDGKIAATVRAHYAFGQPIVGEATLSIYPTFFGSLQ-PFVNDLITRK 282
            ::||||.:.::||:.....|..:.....|.|.:|||:.|:.::::....|..:| |.|...:...
Zfish   237 YVLPKFDMTLNTPQTYNVADVGLKVEACAKYTYGQPVPGQVSVNLCRQHFTFIQDPKVTICLNET 301

  Fly   283 VVPID---------GNAYFEFDIENELHLKQDYERQYLLDALVEEKSTGSVQNYSTVLTLHLNHY 338
            .:..|         .:.:|...:|:.|      :..::::..:.|:.|..|.:.|..:::.....
Zfish   302 ALMDDTGCTSLTFSTSTFFGTSLESSL------QNSFVVNVNLTEQGTDVVMSKSATVSITYEVG 360

  Fly   339 RVEAVKVPSYYIPGVPFEATARIARNDGGQLRDFNPQITAYLTNVYGSSEMYNRTAYSLDASGEI 403
            :|..|.:|.:|..|....|...::        |||            .:.:.|:..|.|| .|:.
Zfish   361 KVTFVDLPKFYDYGSTINAKISVS--------DFN------------GNAISNKVVYLLD-HGQW 404

  Fly   404 KMKFTVPIGDRDEFHSIIVDYQGVIS---EVGKIPSKHLHSKNYITAKVL-----NDRP---TVN 457
            :.|.         ..::..|..|:..   .....|..:|    |:.|.|:     ||..   |.:
Zfish   405 RPKV---------LFNVTTDESGLAEFSLNTTNFPKANL----YLVASVIPQLWFNDNSPHFTTD 456

  Fly   458 QEISVVVRSFAP--------------------------IKY------------FMYQVVGRGDII 484
            .::..:.::.||                          :||            .:|.|:.||.|:
Zfish   457 SQVVQLSQTAAPDNPTYSDLSIVSLQQPLKCGTTYPVTVKYTFVGETGDYSADIIYMVMSRGVIV 521

  Fly   485 LSRNVDVAPGTFHTIKFLAS---------------FAMMPRANLLVYTVIDGEFVYDEQV-IQLE 533
            |.        .|.|::..||               ..|.|...:||::|:..|.|..... ...|
Zfish   522 LH--------GFKTVQAWASDTLTTGTVTFDLPVHAKMAPMVQILVFSVLPSETVVTGSASFDTE 578

  Fly   534 ENLLNAVQVD-APIRAPPGQDIDIGISTKPYSYVGLMLVDQNANDLRSGHDLTHKRLMDALRSYE 597
            :...|.|.:. :|..|.||:...:.:|.:..|..||..:||:...::||..|:.:.:.:.|....
Zfish   579 KCFSNQVSLQFSPATAVPGEGSILTVSAQAGSLCGLSAIDQSVLIMQSGGRLSAEAMFNLLPVRS 643

  Fly   598 LSDVNTPMGSPGKESGVITMSNTDYFIEKEAESNPALDREVSTGPEEDKLTTVRKTDIGPAHKIE 662
            |||.     .||.|.                :.|....|.:...|.:....|.:...|..|..:.
Zfish   644 LSDY-----PPGVED----------------QQNCLNVRPLRDVPTDQAYNTFKGVGIKTATNLP 687

  Fly   663 VNTLPPGKGRYAFSYTPKPFWHN-PRV---------HVMRDPA---------------------- 695
            |.. ||     ..:|....::.| |.|         .|:..|.
Zfish   688 VRE-PP-----CLTYRGLSYYRNFPGVLYSPVESSDLVLNAPVPVELGELVRGDSGSSAVTIRTY 746

  Fly   696 --DTWLFLNISASSDGRNSIHRRIPSEMTSWVVSAFALDPVNGLGLSPPNGKLEAYKEFYISTEL 758
              :||::..::....|..|:...:|..:|:|...||.| ..:|.||:|| ..|.:::.|::...|
Zfish   747 FPETWIWQLVTVGDSGSTSVPLTVPDTITAWDTEAFCL-ASSGFGLAPP-VLLTSFQPFFLEITL 809

  Fly   759 PYSIKRDELIAIPFVVHNNRDSDLNVEVTFYNSALDFDFPQLDPKATNQPKVELYRRRSLQVPGR 823
            ||||.|.|::.:...|.|.....:.|:||              |..::...::.:...|..:...
Zfish   810 PYSIIRGEILNLKATVFNYLPQCIKVQVT--------------PTPSSNFTLKSFGHYSSHLSAN 860

  Fly   824 SARSVSFIVTPKRVGPLLVKAMAASSQA----------------GDTVEQNLLVEHPGAMERINR 872
            ..::..:.:|...:|.:.|...|.:|.:                .|.|.::|||...|......|
Zfish   861 GRKTFKWDLTASVIGTINVTISAQASPSEQLCDNQLVTVPSRGHTDIVTRSLLVLAEGVERTFIR 925

  Fly   873 GFLFELNSNAQNRRNVTIAVPRNAIPESTRIEVSAVGDLIGSLVGNLDSLILLPTGCGEQTMVNF 937
            .:|.....:..: .:|.|..|...|..|.|..|||:||::|..:.||.:|:.:|.|||||.|:..
Zfish   926 NWLLCPKGSILS-ESVKITFPTKVIQGSARCSVSAIGDIMGRALKNLANLLQMPYGCGEQNMIIL 989

  Fly   938 VPNLIVLRYLGRLRQLTPEVELRATNNLAIGYQRILYYRHENGAFSAFGLDIKRSSTWLTAYVAR 1002
            .||:..|:||....||||.::..|.:.|..||||.|.|||.:|:||.|  ....|:||||.:|.|
Zfish   990 APNIYTLQYLKVTAQLTPAIQDTAASYLLSGYQRELNYRHSDGSFSTF--PYSPSNTWLTTFVMR 1052

  Fly  1003 SLRQAAPFTQVDSNVLQKALTYLGSVQSANGGFEERGDVFER----FGDDGISLTAFVTLALMEN 1063
            :...|..||.:|.||||.|..:|...|.::|.|.::|.::.:    ..||.:::|.::..:::|
Zfish  1053 TFGLARNFTYIDPNVLQSAKDWLIGTQGSDGCFVQQGTLYHKDMKGGVDDNVTMTGYIVASMLE- 1116

  Fly  1064 VDLYPEYRNNINKALDFITRGLDGSSNLHAMAIGTYVLSRANH-NAKAAFLQRLDSMATNKDGLK 1127
            :.: |.....|.|||.|:...:....|.:..|:..|..|.|.. :.:|..|..|.:.|.::....
Zfish  1117 IGV-PVTDPVITKALSFLRPLVGNLGNTYVTALLAYTFSLAGETSTRAQLLNSLRNTAISEGTTL 1180

  Fly  1128 WWNKTAPAGEQQSPWYNATRSVNIEISAYAALALLENNLV-----GDALPVLNWLMDQRNPKGGF 1187
            .|::|. :|:          ::.:|||||..||:|....|     |.|..::|||:.|:||.|||
Zfish  1181 HWSQTT-SGD----------TLAVEISAYVLLAVLTVQPVTTANLGYANRIVNWLVAQQNPYGGF 1234

  Fly  1188 VASQDTVVGLQALLMFAERFSSQGNNLQIGFHYGEGAETIIN--VNAENSLALQTVELPNNLKNL 1250
            .::|||||.||||.|:|.:..|.|.:..:.......|..:.|  |...|.|..|...|.|.....
Zfish  1235 SSTQDTVVALQALSMYAAQVFSPGGSSTVTVQSSVPAGDVFNFDVTPNNRLLYQESPLNNFPGTY 1299

  Fly  1251 SVSATGRGMALAQVSYTYN--TNVTSAWPRFVLDPTVNRNSHADYLHLSACASFVSVVGENEQRS 1313
            ||.|.|...|..||...||  |.|..:....|: ..|:.|..|..::|  ..:|.:.....:..:
Zfish  1300 SVVAAGAACASVQVLCFYNIPTPVRVSKTLSVV-AKVSGNCQATPVNL--MLTFTAKYTGPKPTT 1361

  Fly  1314 NMAVMEVHLPSGFVVDRDTLPTLES-SERIKKVETQNRNTKVVIYFDYLDRR-EVCPTLHAYKTV 1376
            ||.::::.|.|||..|...|.:..: :..:::|:::..:  |:||...:.:. .|..::...:||
Zfish  1362 NMVLVDIKLLSGFTADTSLLGSPPNFAPLVQRVDSEGDH--VLIYLQEVPKGVPVTFSIQLTQTV 1424

  Fly  1377 KVTKHRPVAVVMYDYYDSARRARQFYRAP 1405
            .|...:|..:.:||||..:......|::|
Zfish  1425 AVQNLKPAVINIYDYYQRSDSFETAYKSP 1453

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tep3	NP_523507.2	A2M_N	124..215	CDD:280081	28/91 (31%)
		A2M_N_2	448..573	CDD:285005	36/187 (19%)
		A2M	697..787	CDD:278630	27/89 (30%)
		A2M_2	918..1203	CDD:239227	105/294 (36%)
		A2M_comp	967..1200	CDD:284982	82/242 (34%)
		A2M_recep	1313..1402	CDD:284981	21/90 (23%)
zgc:165453	XP_009297326.1	A2M_N	143..234	CDD:280081	29/92 (32%)
		A2M_N_2	478..622	CDD:285005	32/151 (21%)
		A2M	750..838	CDD:278630	27/89 (30%)
		A2M_2	967..1250	CDD:239227	105/297 (35%)
		A2M_comp	1019..1252	CDD:284982	85/247 (34%)
		A2M_recep	1361..1450	CDD:284981	21/90 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170584133
Domainoid	1	1.000	217	1.000	Domainoid score	I2610
eggNOG	1	0.900	-	-		E1_COG2373
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	517	1.000	Inparanoid score	I1243
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D177369at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm6406
orthoMCL	1	0.900	-	-		OOG6_100452
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.700