Protein Alignment Tep3 and c5

DIOPT Version :10

• Sequence 1: NP_523507.2
• Gene: Tep3 / 34045
• FlyBaseID: FBgn0041181
• Length: 1469
• Species: Drosophila melanogaster
• Sequence 2: XP_001919226.4
• Gene: c5 / 565774
• ZFINID: ZDB-GENE-120510-2
• Length: 1704
• Species: Danio rerio
• Alignment Length: 1668
• Identity: 358/1668 - (21%)
• Similarity: 631/1668 - (37%)
• Gaps: 376/1668 - (22%)

  Fly    13 VLILVTACLLCQTSAQGLYSIIAPNTLRPNSQFHVAVSLHNAPESATFKVGI-----LGSSYTDF 72
            :|..:....:|.|..:.:|.|.||..||.::...|.|.|....:..|..:.:     :|:...|:
Zfish     5 LLFCIFNLFVCFTVQENVYLITAPKVLRLDASETVVVQLFGFDQETTVHLHLKNTLAVGNKEYDY 69

  Fly    73 KTVELRPFST-------QLLHFEIPALRTDRYRLTAEGLGGVQFTNETQLHFESKQHTVLVQTDK 130
            ::::|...:.       ::|..:.|...|..|..|...    .||:..::...:....:.:||||
Zfish    70 QSLKLNAANNYQASATLRILAKDFPKEDTSVYLQTISS----AFTDNVKIPVTTVNGFLFIQTDK 130

  Fly   131 SIYKPGDLVHYRVLILDANLKPA-----------RGYGRVHVDIKDSGDNIIRSYKDIRLTNSIY 184
            .:|.|...|..||..|:..|:.:           ||   |.|:|.|..|  |...|.:
Zfish   131 PLYTPEQEVQVRVYSLNEELRKSARTVTLTFQDPRG---VKVEIIDMTD--INGAKPL------- 183

  Fly   185 SNELRLSDSPRFGTWSIVVDVSDQ-EHTQT--FEILDHILPKFVVDIDTPKHAIYKDG--KIAAT 244
            ....::...|.:|.|.||...:|. |.|.|  ||:.:::||...|.|:...:.|.::.  .....
Zfish   184 LPPFKIPLKPIYGIWKIVATYADNFETTATAEFEVKEYVLPSISVQIEPETNYISEENFDTFKLK 248

  Fly   245 VRAHYAFGQPIVGEATLSIYPTFFGSLQPFVNDLIT---RKVVPIDGNAYFEFDIENELHLKQD- 305
            :.|.|..|.|:.....|    ..||...|....:|.   |..:..:|....:.||.:.|..|.|
Zfish   249 ISAKYVQGMPVKSANIL----LKFGYSTPEETVIIPSTYRSYMLYNGKMEVDLDIRSALSSKPDA 309

  Fly   306 -------YERQYLLDALVEEKSTGSVQNYSTVLTLHLNH-------YRVEAVKVPSYYIPGVPFE 356
                   .|..:|...::.::|||.:...:.     |:|       :.:..:..|.:..||:|:.
Zfish   310 PQFLNAMKENTFLYVEVLLQESTGGLSQEAV-----LSHVKFVETPFTLSIIATPPFIKPGLPYA 369

  Fly   357 ATARIARNDGGQLRDFNPQITAYLTNVYGSSEMYNRTAYSLDASGEIKMKFTVPIGDRDEFHSII 421
            ....:....|..::|.:..:.|..|.|...|:               .:||   :|.:|   |:.
Zfish   370 MRVLVKDPLGEPVKDVSVTMRATATTVDNLSD---------------NLKF---LGHQD---SVT 413

  Fly   422 V--DYQGVISEVGKIPSK--------------------HLHSKNYITAK---VLNDRP------T 455
            |  ...||......||:.                    .|.:::|::..   :..|.|      .
Zfish   414 VPSSKDGVAYFTCNIPANVKNAEFTFETEDASWSQGPLTLKAESYVSVNHRYLYIDLPPESSVFE 478

  Fly   456 VNQ--EISVV--VRSFAPIKYFMYQVVGRGDII------------LSRNVDVAPGTFHTIKFLAS 504
            |.|  :||||  .|.:..:..|.||::.:|.::            .|.|:.:.|.
Zfish   479 VGQYVDISVVFSYRDYLSLDTFSYQIISKGKVVKYDTVKRVSEKSQSLNIKITPD---------- 533

  Fly   505 FAMMPRANLLVYTVIDG----EFVYDEQVIQLE----ENL---LNAVQVDAPIRAPPGQDIDIGI 558
              |:|.|.||||.|:.|    |.|.|...|.::    :||   |:.:::....:.....:|.:..
Zfish   534 --MVPSARLLVYYVLYGEEKAELVADSTWIDVKAKCVKNLNLELSTLKLQDDYKPKDKLEIKVSS 596

  Fly   559 STKPYSYVGLMLVDQNANDLRSGHDLTHKR--LMDALRSYELSDVNTPMGSPGKESGVITMSNTD 621
            .:|..|.|....||....:||     |:|:  |...|:..|.||:....|.....:.|...:...
Zfish   597 RSKGESLVAFSAVDTALFNLR-----TNKKDPLKKILQHVEKSDLGCGKGGGKNNADVFDRAGLM 656

  Fly   622 YFIEKEAESNPALDREVSTGPEEDKLTTVRKTDIGPAHKIEVNTLPPGKGR-YAFSYTPKPFWHN 685
            :.....|:::.|      .|...|.|...|..|:  ..|.|......|..| |..|.|..    :
Zfish   657 FITNANAKASSA------GGTCSDTLRPKRSVDL--KKKFEDKAQKYGAFREYCLSGTRS----S 709

  Fly   686 PRVHVMRDPA------------------------------------------------------- 695
            |.:...:|.|
Zfish   710 PTLETCKDRANRVTLPNKKTRRDYEKEKYCRLAFEQCCVFAKDLRKENAENIILSRAAIDFLMDA 774

  Fly   696 ----------DTWLFLNISASSDGRNSIHRRIPSEMTSWVVSAFALDPVNGLGLSPPNGKLEAYK 750
                      ::||: ....|..|..||.:.:|..:|:|.:.|..   |...|:...:.::...:
Zfish   775 PLSQVRSYFPESWLW-EEHLSKSGSVSISKTLPDSITTWELKAVG---VFNEGICVSDKRIPVSQ 835

  Fly   751 EFYISTELPYSIKRDELIAIPFVVHNNRDSDLNVEVTFYNSALDFDF---PQLDPKATNQPKVEL 812
            :.::...||||:.|.|.|.:...|:|.|.|.:...||...|:....|   .|..|..||:
Zfish   836 DIWVDVPLPYSMVRGEQILLKGSVYNQRSSGIKFTVTLTASSAVCVFHGAQQGKPDKTNE----- 895

  Fly   813 YRRRSLQVPGRSARSVSFIVTPKRVGPLLVKAMAASSQAGDTVEQNLLVEHPG-AME-----RIN 871
               .|.||.|.|...|||.:.....|...:.....:....::|.:.|.|...| .||     ||:
Zfish   896 ---NSGQVAGGSVAMVSFYIMALEAGTHTLTFTLTTDWITESVVKKLRVVPEGIRMEEYIGKRID 957

  Fly   872 RGFLFELNSNAQNRRNVTIAVPRNAIPEST--RIEVSAVGDLIGSLVGNLDS------LILLPTG 928
            ...:|.........:||   :|...:|:|:  || ::..|:::|.::..|::      |..||.|
Zfish   958 PNGVFGTPMRKLEFKNV---IPPKIVPKSSVDRI-ITVNGEVLGDILSILNNPEGIKMLTNLPRG 1018

  Fly   929 CGEQTMVNFVPNLIVLRYLGRLRQ--------LTPEVELRATNNLAIGYQRILYYRHENG-AFSA 984
            ..|..:::.:|...|..||.:..:        ...|.||:  ..:..|...|:.::.:|| |||.
Zfish  1019 SAELELMSLLPVYYVYHYLDKTEKWNILGKEAAASEKELK--RKMQAGITSIMSFQLKNGEAFSM 1081

  Fly   985 FGLDIKRSSTWLTAYVARSLRQAAPFTQVDSNVLQKALTYL-GSVQSANGGFEE--RGDVFERFG 1046
            :....|..|||:||.:.::|.....:..||::||..|:.:| .:.|:.:|.|.|  :.:..:..|
Zfish  1082 WAQKDKTPSTWVTALIIKTLSDIHEYVYVDTDVLANAIHWLIKNCQNEDGSFSELAKTNPHKLMG 1146

  Fly  1047 ------DDGISLTAFVTLAL-----MENVDLYPEYRNNINKALDFITRGLDGSS----NLHAMAI 1096
                  :..:.||::|.:.:     :.|:.| ..:::.:::.:.::......||    :|:..||
Zfish  1147 AGVGVTEKSVYLTSYVMIGIKNALKIPNLKL-QVFKDALDRGMQYLISRFRKSSHKIESLYVRAI 1210

  Fly  1097 GTYVLSRAN----------HNAK-----------AAFLQRLDSMATNKDGLKWWNKTAPAGEQQS 1140
            .:|.::.|:          .|.|           ..|.|..|   ||.|.||..:.||.
Zfish  1211 ASYAMTVADIDDGTAVNVYENIKKKAKIDGNPPRVCFWQESD---TNIDPLKPSSVTAK------ 1266

  Fly  1141 PWYNATRSVNIEISAYAALALLENNLVGDALPVLNWLMDQRNPKGGFVASQDTVVGLQALLMFAE 1205
                     ::|.:.|..|..|.......|.|:||||...:...||..::|||::.|:||.|::.
Zfish  1267 ---------SVETTVYVLLNTLTRGETEYAKPILNWLTQDQRYGGGVYSTQDTILTLEALTMYSI 1322

  Fly  1206 RFSSQGNNLQIGFHYGEGAETI--INVNAENSLALQTVELPNNLKNLSVSATGRGMALAQVSYTY 1268
            :......|:.:...|....|.|  |.:..:..:| :.:|:..|...:..:|...|::..::...|
Zfish  1323 KAREANLNMVVDIEYKTRGERISRIQLTQQKPVA-KPIEVTQNDDVIVKTAMSTGVSFVKLKTVY 1386

  Fly  1269 NTNVTSAWPRFVLDPTV-----NRNSHADYL---HLSACASFVSVVGENEQRSNMAVMEVHLPSG 1325
            .. :|.:....:.|.|:     ::||....|   .:.|||.|.......|..|.:.|||::||:|
Zfish  1387 YV-MTESNKSCLFDTTIDIHDSDQNSDDPMLLSQRIVACAKFKPPENSLETESALTVMEINLPTG 1450

  Fly  1326 FVVDRDTLPTLESSERIKK-VETQNRN-----TKVVIYFDYLDRRE-VCPTLHAYKTVKVTKHRP 1383
                  ..|.||..:..:. :|::..|     .|||:..|.:.... .|......:..:....:.
Zfish  1451 ------VTPVLEDLDEYQNGLESRISNYEVIGDKVVLQIDSIPSDNFYCVGFRILEEFETGMTKA 1509

  Fly  1384 VAVVMYDYYDSARRARQFYRAPKSNICDICEHANCGDLCEKAE 1426
            ....:|:|...|.:..:.|:.....:..:||..:|  .|..||
Zfish  1510 SEFTVYEYQAPAFKCTKLYQKQTRKLLRLCEEDHC--QCMAAE 1550

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tep3	NP_523507.2	YfaS	<128..1399	CDD:441940	327/1512 (22%)
		A2M_2	918..1203	CDD:239227	80/338 (24%)
c5	XP_001919226.4	MG1	20..118	CDD:465508	20/101 (20%)
		YfaS	<120..1387	CDD:441940	296/1375 (22%)
		A2M_BRD	468..616	CDD:462235	38/159 (24%)
		ANATO	687..756	CDD:237984	10/72 (14%)
		ISOPREN_C2_like	1005..1320	CDD:415487	79/335 (24%)
		A2M_recep	1436..1529	CDD:462226	20/98 (20%)
		NTR_like	1546..1698	CDD:470599	3/5 (60%)