DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tep3 and c3a.3

DIOPT Version :9

Sequence 1:NP_523507.2 Gene:Tep3 / 34045 FlyBaseID:FBgn0041181 Length:1469 Species:Drosophila melanogaster
Sequence 2:NP_001032313.2 Gene:c3a.3 / 565074 ZFINID:ZDB-GENE-990415-37 Length:1651 Species:Danio rerio


Alignment Length:1655 Identity:377/1655 - (22%)
Similarity:659/1655 - (39%) Gaps:382/1655 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly    15 ILVTACLLCQTSAQGLYSIIAPNTLRPNSQ--------------FHVAVSLHNAP----ESATFK 61
            :|:::.||  |....||.:.|||.||..|.              .:|.:|:.|.|    |.....
Zfish    11 VLLSSALL--TLCDPLYVLSAPNLLRVGSSENVFVEAQDYSGGPLNVRISVKNFPAKNVEMMQKT 73

  Fly    62 VGILGSSYTDFKTVELRPFSTQLLHFEIPALRTDRYRLTAEGLGGVQFTNE-------TQLHFES 119
            |.:.|:.|            ..|...:||..|.             .|:::       .|.||.|
Zfish    74 VTLTGAKY------------QSLTDIQIPGDRN-------------YFSDDEKKQYVYLQAHFPS 113

  Fly   120 -----------KQHTVLVQTDKSIYKPGDLVHYRVLILDANLKPARGYGRVHVDIKD------SG 167
                       :...:.|||||.||.||..||||:..:..||||....| :.|||.:      :.
Zfish   114 VTLEKVVMVSFQSGYLFVQTDKPIYTPGSNVHYRIFSMTPNLKPFSKPG-ITVDITNPQGITVAS 177

  Fly   168 DNIIRSYKDIRLTNSIYSNELRLSDSPRFGTWSIV---VDVSDQEHTQTFEILDHILPKFVVDID 229
            |.|   :.:..:.:|||:    :.:....|.|.:|   .:...:..|..||:.:::||.|.|.:.
Zfish   178 DTI---FAEKGVKSSIYN----IPEVTSLGMWKVVTRYANTPQKTFTAEFEVKEYVLPTFEVKLK 235

  Fly   230 TPKHAIY---------KDGKIAATVRAHYAFGQPIVGEATLSIYPTFFGSLQ-PFVNDLITRKVV 284
            |.|...|         :|..:...:.|.|.||:.:.|.|.: ::....|::: ..||.|  :||.
Zfish   236 TSKSFYYVGDSKPKNNEDDSLTVDMEAKYLFGKKMDGNAFV-VFGVMDGAMKTSIVNSL--QKVQ 297

  Fly   285 PIDGNAYFEFDIE---------NELHLKQDYERQYLL----DALVEEKSTGSVQNYSTVLTLHLN 336
            ..:|....|...|         .:|..|..|....||    ..:||.:..| :|..::..|:   
Zfish   298 VFNGVGTAELTREMITKTFKNIKDLVGKSIYVSVNLLTESGSEMVEAEKRG-IQIVTSPYTI--- 358

  Fly   337 HYRVEAVKVPSYYIPGVPFEATARIARNDGGQLRDFNPQITAYLTNVYGSSEMYNRTAYSLDASG 401
            ||:    :...::.||:|...:..:...|.....|...::.     |.|...:.::|    .|:|
Zfish   359 HYK----RTSQFFKPGMPLGVSVYVTNPDETPAEDVEVEVL-----VDGVGGVNSKT----KANG 410

  Fly   402 EIKMKFTVPIG---------DRDEFHSIIVDYQGVISEVGKIPSKHLHSKNYITAKV------LN 451
            ..|:......|         .||.  .:..:.|...:.:.:....:|.||||:...:      :.
Zfish   411 IAKVTVNTKAGVSTLKITATTRDP--ELANEQQADKTMIAQAYKTNLGSKNYLHINIESAEFEIG 473

  Fly   452 DRPTV--NQEISVVVRSFAPIKYFMYQVVGRGDIILSRNVDVAPGTFHTIKFLASFAMMPRANLL 514
            |:.||  |...|..|:.    :.|.|.::.:|.|:|:........|..::....:..|:|....:
Zfish   474 DQMTVYLNTGESPGVKD----QDFTYMILSKGQIVLAERFKRQGQTLVSLSLPVTKDMVPSFRFV 534

  Fly   515 V-YTVIDGEFVYDEQVIQLEENLLNAVQVDAPIRA---PPGQDIDIGISTKPYSYVGLMLVDQNA 575
            . |.|...|.|.|...:.:::..:..::|:...:.   ..|.::::.||....:.|||::||:..
Zfish   535 AYYHVGKDEVVSDSVWVDVKDTCMGKLKVEVTEKQKFYETGNEVNLQISGDFGARVGLVVVDKAV 599

  Fly   576 NDLRSGHDLTHKRLMDALRSYELSDVNTPMGSPGKES-GVITMSNTDYFIEKEAESNPALDREVS 639
            ..|.... ||..::.|.:..::....    |..||:| ||.:.:...:      ||:||......
Zfish   600 QVLNKNR-LTQSKIWDVIEKHDTGCT----GGGGKDSMGVFSDAGLMF------ESDPAGGTNTR 653

  Fly   640 TGPE----------EDKLTTVRKTDIGP-AHKIEVNTLP---PGKGRYAFSYT------------ 678
            |.|:          .:.|.|:..|..|. ..||.    |   .|.......||            
Zfish   654 TEPKCPAPPKRKRRSESLQTITTTLAGQYTEKIR----PCCYDGMRNNRIGYTCERRASYVIDGE 714

  Fly   679 --PKPFWH-------------NPRVHVMRDPADT--------------------WLF----LNIS 704
              .|.|.|             ...:...:|..:|                    ||:    |...
Zfish   715 ECVKAFLHCCKEVKNHKETEEEELILARKDDEETYEEDYEDYDDITSRKQFPESWLWEEFDLCDK 779

  Fly   705 ASSDGRNSIHRRIPSEMTSWVVSAFALDPVNGLGLSPPNGKLEAYKEFYISTELPYSIKRDELIA 769
            .|...:|.: ..:...:|:|.:.|.:|.|.:|:.::.|. ::..:|.|:|..::|||..|.|.:.
Zfish   780 CSKPSKNKV-TYLKDSITTWQILAISLSPTHGICVAEPE-EIVVFKSFFIDLKVPYSAVRGEQVE 842

  Fly   770 IPFVVHNNRDSDL-NVEVTFYNSALDFDFPQLDPKATNQPKVELYRRRSLQVPGRSARSVSFIVT 833
            |..::||.....| .|.|.|..:|      .:...|:.:.|.    |.::.|...|:.:|||::.
Zfish   843 IKAIIHNYTPKHLKKVRVEFLETA------GVCSAASKKGKY----RATVNVDKDSSIAVSFVIV 897

  Fly   834 PKRVGPLLVKAMAASSQAGDTVEQNLLVEHPGAMERINRGFLFELNSNAQNRRNVTI--AVPRNA 896
            |..:....::..|:.....|.|.:.|.|...|.:.:.....| |||...:..:.:.:  .:|.:.
Zfish   898 PMTLESQHIEVKASILDYTDGVRKTLKVVSEGVLTKFQSQKL-ELNPAKKGEQPLLLRAGIPGDQ 961

  Fly   897 IPESTRIE--VSAVGDLI---------GSLVGNLDSLILLPTGCGEQTMVNFVPNLIVLRYLGRL 950
            :| .|.:.  ::..|:.|         ||.:|   .||..|.|||||.|......::...||...
Zfish   962 VP-GTPVHSYITVTGEEISQSIEHAINGSFMG---ELIKRPGGCGEQNMAKMTLPVVATHYLDNT 1022

  Fly   951 RQL-TPEVELR--ATNNLAIGYQRILYYRHENGAFSAFGLDIKRSSTWLTAYVARSLRQAAPFTQ 1012
            .|. :..::.|  |.|::..||...|.||..:|:: |..::.. ||||||||||:....|..|..
Zfish  1023 NQWESVGIDRRKVAINHIKTGYDGQLKYRKPDGSY-AIWINTP-SSTWLTAYVAKVFAMANDFFA 1085

  Fly  1013 VDSNVLQKALTYL-GSVQSANGGFEERGDVFERF---GDDG----ISLTAFVTLALMENVDL--- 1066
            ::.||:..||.:| ...|..:|.|:|...|:::.   |.:|    :||||||.:|:.|..::   
Zfish  1086 IEENVICSALKWLVMHKQLPDGSFKEDAPVYDKSIMGGIEGQNTDVSLTAFVLIAMQEGKEICGG 1150

  Fly  1067 -YPEYRNNINKALDFITRGLDGSSNLHAMAIGTYVLSRANHNAKAAFLQRLDSMATNKDGLKWWN 1130
             ......::.||:.|:...|...:|.:|:|:.:|.|:.|:...||..:..    :|..:..::||
Zfish  1151 TVGSLHESMRKAVAFLKDQLPKLTNPYAVALTSYALANADSLNKAILMMH----STKVNDERFWN 1211

  Fly  1131 KTAPAGEQQSPWYNATRSVNIEISAYAALALLENNLVGDALPVLNWLMDQRNPKGGFVASQDTVV 1195
                ..|:|  :|      :||.:|||.|||::......|...::||..|::..||:..:|.|::
Zfish  1212 ----VPERQ--YY------SIEATAYAVLALVKAKDYDTAGEAVHWLAKQKSSHGGYDTTQVTIM 1264

  Fly  1196 GLQALLMF-----------------------AERFSSQGNNLQIGFHYGEGAETIINVNAENSLA 1237
            ..||:..:                       .:|::.|.:|:    |........:|        
Zfish  1265 VFQAVAEYHAQTQDLNNFDLNVELVVPGRRKTDRWTIQRSNV----HLARSGNVDLN-------- 1317

  Fly  1238 LQTVELPNNLKNLSVSATGRGMALAQVSYTY-------NTNVTSAWPRFVLD--PTVNRNSHADY 1293
                      |:.:|.|.|.|.|:..|...|       .|:.|.......||  |.....::..|
Zfish  1318 ----------KDFTVIAKGTGSAILSVLTLYYARPFEKKTDCTFFDLSVKLDKIPETKPGTNGTY 1372

  Fly  1294 LHLSACASFV-SVVGENEQR-SNMAVMEVHLPSGFVVDRDTLPTLESS-----ERIKKVETQNRN 1351
                   :|: ....:|::. :.|.::::.||:||.:|...|..|.:.     ::.:|.:..:..
Zfish  1373 -------NFILDFFYKNKKNDATMTILDIGLPTGFDIDEADLKQLSTGKERYIQKYEKNKVLSER 1430

  Fly  1352 TKVVIYFDYLDRREVCPTL--HAYKTVKVTKHRPVAVVMYDYYDSARRARQFYRAPK--SNICDI 1412
            ..::||.:.:. .||...|  ..:||..|...:|.:|.:|:||....|.:::|...:  |.:..:
Zfish  1431 GSLIIYLNKVS-HEVSEKLVFRMHKTFNVALLQPASVTIYEYYSPDARCKKYYHPEREDSALYRL 1494

  Fly  1413 CEHANCGDLCEKAEKR----------ESKR 1432
            |:    ||||..||:.          ||||
Zfish  1495 CK----GDLCVCAEENCSYQKKNHVDESKR 1520

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Tep3NP_523507.2 A2M_N 124..215 CDD:280081 30/99 (30%)
A2M_N_2 448..573 CDD:285005 27/136 (20%)
A2M 697..787 CDD:278630 26/114 (23%)
A2M_2 918..1203 CDD:239227 90/299 (30%)
A2M_comp 967..1200 CDD:284982 74/244 (30%)
A2M_recep 1313..1402 CDD:284981 23/95 (24%)
c3a.3NP_001032313.2 A2M_N 128..222 CDD:280081 31/101 (31%)
A2M_N_2 463..599 CDD:285005 28/139 (20%)
ANATO 674..737 CDD:237984 11/66 (17%)
A2M 768..861 CDD:278630 25/94 (27%)
complement_C3_C4_C5 987..1272 CDD:239226 93/305 (30%)
A2M_comp 1042..1272 CDD:284982 75/247 (30%)
A2M_recep 1387..1482 CDD:284981 23/95 (24%)
NTR_complement_C3 1502..1649 CDD:239638 6/19 (32%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C170584189
Domainoid 1 1.000 56 1.000 Domainoid score I10957
eggNOG 1 0.900 - - E1_COG2373
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11412
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
ZFIN 00.000 Not matched by this tool.
65.800

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