DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tep3 and c3b.1

DIOPT Version :9

Sequence 1:	NP_523507.2	Gene:	Tep3 / 34045	FlyBaseID:	FBgn0041181	Length:	1469	Species:	Drosophila melanogaster
Sequence 2:	XP_009294664.1	Gene:	c3b.1 / 563665	ZFINID:	ZDB-GENE-030131-2211	Length:	1768	Species:	Danio rerio

Alignment Length:	1727	Identity:	383/1727 - (22%)
Similarity:	644/1727 - (37%)	Gaps:	443/1727 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 ILVTACLLCQ-------------------------TSAQGLYSIIAPNTLRPNSQFHVAVSLHNA 54
            :|:.|.||||                         ......:|::||..:||.::.::.|..||.
Zfish     5 LLLWATLLCQICDGKAFPQRHKRTVWRHMRQIEPVKDPSPSFSLLAPAKIRPGTKQNILVEGHNL 69

  Fly    55 PESATFKVGIL-----------GS-------SYTDFKTVELRPFSTQLLHFEIPALRTDRYRLTA 101
            .:.....|.:.           ||       :|:..:|:|:.|   .||   :|..:....:|.|
Zfish    70 AQVVEVTVVVYDYPNSQTALSRGSVFLNSDNNYSVLQTLEINP---NLL---LPDGKKKYVKLVA 128

  Fly   102 EGLGGVQFTN----ETQLHFESKQHTVLVQTDKSIYKPGDLVHYRVLILDANLKPARGYGRVHVD 162
                  ||:|    |..:....:...:.:||||.||.|||.|.:|..:.|...:.:.  ..:.::
Zfish   129 ------QFSNIYRAEKVMAVSFRSGHIFIQTDKPIYNPGDKVRFRAFVSDLEFRSSE--RTISLE 185

  Fly   163 IKDSGDNIIRSYKDIRLTNSIYSNELRLSDSPRFGTWSIVVDV---SDQEHTQTFEILDHILPKF 224
            |::.....:.....::..:.::|:...||...:.|.|.:|...   .:...::.||:..::||.|
Zfish   186 IQNPDGIAVHGIGRVKAIDGVFSDIFSLSTVVKEGRWKVVAKFDQGKENVFSREFEVKKYVLPAF 250

  Fly   225 VVDIDTPK--HAIYKDGKIAATVRAHYAFGQPIVGEATLSIYPTFFG-----------SLQPFVN 276
            .|.: |||  |......|:...:.|.|.:|..:.|.|.:     .||           |::. ::
Zfish   251 NVTL-TPKTSHLSLDAEKLEVEITARYLYGAQVKGVAYV-----LFGIEINGEKKRLTSMKQ-ID 308

  Fly   277 DL------ITRKVVPIDGNAYFEFD--IENELHLKQDYERQYLLDALVEEKSTGSVQNYSTVLTL 333
            ||      :|.:.:.   .||.:.:  :.:.|::|.........|.:..|||...:.....:||:
Zfish   309 DLNGGSVSLTMEEIK---RAYPDINSLLGSTLYVKASVLTSSGSDLVEAEKSGIKIVKSPYMLTI 370

  Fly   334 HLNHYRVEAVKVPSYYIPGVPFEATARIARNDGGQLRDFNPQITAYLTNVYGSSEMYNRTAYSLD 398
            .         ..|.||.||:|...|..::.:||..    .|.|...:|.:.....::
Zfish   371 K---------DTPKYYKPGLPLAMTVIVSNHDGSP----TPNIPVKVTFLESPISVH-------- 414

  Fly   399 ASGEIKMKFTVP-----IGDRDEFHSIIVD-----YQGVISEVGKIP----SKHLHSKNYITAKV 449
             ||.|.:...:|     .|:........||     .|..|.||...|    |.|   .|::...|
Zfish   415 -SGTINIHINMPKTHILYGNSQILKVETVDPSLKPEQQAIQEVYVKPYSTFSGH---DNFLHVSV 475

  Fly   450 LNDRPTVNQEISV--VVRSFAP-----IKYFMYQVVGRGDIILSRNVDVAPGTFHTIKFLASFAM 507
            ...|..|...:||  .::|..|     :::..|.|:.:|.||.:..|:|......::..|.:..|
Zfish   476 GASRVVVGGSVSVQMYIKSSLPNHRALVEHLTYIVLNKGKIIQAGRVNVKGQDVTSVHLLITTEM 540

  Fly   508 MPRANLLVYTVID----GEFVYDEQVIQLEENL---LNAVQVDAPIRA--PPGQDIDIGISTKPY 563
            :|....:.|.|:.    .|.|.|...:.:|:..   ||...||..|.:  .||......:.....
Zfish   541 LPAFRFVAYYVLPWQHRAEVVADSVFVDVEDRCVGSLNVGPVDGEIVSSYSPGSSFKFQVKGDVG 605

  Fly   564 SYVGLMLVDQNANDLRSGHDLTHKRLMDALRSYELSDVNTPMGSPGKESGVI----------TMS 618
            :.|.|:.|| ||..|.|.:.||.|::.:.:   :.:|:....|......||.          |..
Zfish   606 AKVSLVAVD-NAIFLLSKNRLTQKKVWEVV---DQADMGCTAGGGKDNMGVFSDAGLMFHSSTGG 666

  Fly   619 NTDYFIEKE------------------------AESNPALDREVSTGPEEDKL------------ 647
            :||   .||                        |.|:..|.|....|.:|..:
Zfish   667 STD---SKEDCSSKTKRRRRSAAKLQLRDQLEKAYSDELLQRCCVDGMKEIPMPYSCYRRSLYIT 728

  Fly   648 -------------TTVRKTDIGPAHKIEVNTLPPGKG---------------RYAFSYTPKPFWH 684
                         ...|..::|...:....|.||...               .|.|...|..|..
Zfish   729 EDWSCVLAFLRCCAEYRGEELGVITRPPPTTAPPTIAPPTTSPPTLFLVPHLEYHFPEQPVFFVR 793

  Fly   685 N------PRVH-------VMRDP---------------------------------ADTWLFLNI 703
            :      |::|       |.:|.                                 .::||:.:|
Zfish   794 DRVLQSMPKLHAEANVVGVRQDSYREVVVEEEEEAASVFEEDDLSDLEDIYVRSKFFESWLWTDI 858

  Fly   704 ----SASSDGRN--SIHRRIPSEMTSWVVSAFALDPVNGLGLSPPNGKLEAYKEFYISTELPYSI 762
                :|.|||..  .:...:|..:|.|...|.:..|..|:.::.|. .:..:|.|:|...||:|:
Zfish   859 RLPSTAKSDGLAVFPVDTVLPDSITQWGFLAVSASPEKGVCVAEPY-NVRVWKPFFIDLRLPHSV 922

  Fly   763 KRDELIAIPFVVHNNRDSDLNVEVTFYNSALDFDFPQLDPKATNQPKVELYRRRSLQVPGRSARS 827
            .|:|.:.|..|:||.::|.|.|.|     .|:..........|.|      .|:.:.|...|::.
Zfish   923 SRNEQVEIKAVIHNYKNSTLEVMV-----ILEKTEDMCSVAYTGQ------HRQQVTVAAGSSKL 976

  Fly   828 VSFIVTPKRVG--PLLVKAMAASSQAGDTVEQNLLVEHPGAMERINRGFLFELNSNAQ------- 883
            :::.:.|.:.|  ||.|.|:|||....|.|::||.|...|......|.|:  ||.:.:
Zfish   977 ITYTIIPLKTGELPLQVTAVAASFMGQDAVKKNLRVVVEGIQTLKVRSFV--LNPSEKGGSAGQQ 1039

  Fly   884 ----NRRNVTIAVPRNAIPESTRIEVSAVGDLIGSLVGN------LDSLILLPTGCGEQTMVNFV 938
                .:..:...||: ::||:.   |:..|||:...:.|      |.:||.:|.||.||.:....
Zfish  1040 LIQVKKMQLDAVVPK-SVPETF---VNVRGDLLADSIDNSIKEDSLAALIRMPGGCVEQNLARIT 1100

  Fly   939 PNLIVLRYLGRLRQLTPEVEL-------RATNNLAIGYQRILYYRHENGAFSAFGLDIKRSSTWL 996
            ..||...||.|    :.:.|:       .|...:..||:..|.|:..:.::..:..:  .:|||:
Zfish  1101 LPLIAAHYLDR----SADWEIVGISRREEAIKYIQRGYENQLNYKKSDDSYPPYANE--GTSTWI 1159

  Fly   997 TAYVARSLRQAAPFTQVDSNVLQKALTY-LGSVQSANGGFEERGDVFE-------RFGDDGISLT 1053
            ||||.:....|..|..|:...|...|.| |.:.|..:|.|:|...|::       |..:...|||
Zfish  1160 TAYVVKVFSMAHSFINVNEKHLCGPLLYLLKNKQGYDGTFQEDNPVYDTSMTGAMRGSEYKASLT 1224

  Fly  1054 AFVTLALMENVDLYP------EYRNNINKALDFITRGLDGSSNLHAMAIGTYVLSRANHNAKAAF 1112
            |||.:||.|..|...      ..|:...:|..::|......:..:..||..|.|:.:|:....:.
Zfish  1225 AFVLIALAEAQDKVTCQDQEVNIRDKSRQAAGYLTEHFSRLTRPYTAAIACYALAVSNNACVKSM 1289

  Fly  1113 LQRLDSMATNKDGLKWWNKTAPAGEQQSPWYNATR-SVNIEISAYAALALLENNLVGDALPVLNW 1176
            |            ||:      |....|.|.::.. ...:|.:.||.|||:::..:.:|.....|
Zfish  1290 L------------LKF------ASPDHSHWPDSNNYFFTLEATGYALLALIKSGHMEEAEAPFRW 1336

  Fly  1177 LMDQRNPKGGFVASQDTVVGLQALLMF-AERFSSQGNNLQIGFHYGEGAETIINVNAENSLALQT 1240
            |.:.|...||:.::|.|:|.||||..: .:|......||.:.......::.....|...:...::
Zfish  1337 LNEHRGIGGGYGSTQSTMVVLQALSEYLVKRPPPSDLNLLVQLSVPGRSDVRWTFNPNLAYVARS 1401

  Fly  1241 VELPNNLKNLSVSATGRGMALAQVSYTYNTNVTSAWPRFVLDPTVNRNSHADYLHLSACASF--- 1302
            ..:|.: :..||:|:|.|..:.:|...|:..           |.|..|        |.|..|
Zfish  1402 SRVPLD-QEFSVAASGNGKGVLEVVTVYHQL-----------PDVYEN--------STCNGFQLD 1446

  Fly  1303 VSVVGENEQRSN---------------------MAVMEVHLPSGFVVDRDTLPTLESSERIKKVE 1346
            ||:...||:.|:                     |.::::.||:||..:...|..|.:|     |:
Zfish  1447 VSIAETNEKTSSDVEKSFRLNVNVRALEERQVRMVILDIGLPTGFEPENSDLELLTNS-----VD 1506

  Fly  1347 TQNRNTKVVIYFDYL-DRREVCPTLHAYKT---------------VKVTKHRPVAVVMYDYYDSA 1395
            ....|.:||   |.| ||..:  .:|.:|.               .||...:|..|.:|.||:..
Zfish  1507 RYINNFQVV---DNLSDRGSL--IIHLFKVSNKEAEMISFRLNQKFKVGLLQPSTVKVYQYYNKD 1566

  Fly  1396 RRARQFYRAP--KSNICDICEHANC----GDLCEKAE 1426
            :...:||..|  |..:..|||...|    ||.|...|
Zfish  1567 KSCSRFYSPPEDKQQLDQICEGDVCRCSQGDCCVMKE 1603

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tep3	NP_523507.2	A2M_N	124..215	CDD:280081	19/93 (20%)
		A2M_N_2	448..573	CDD:285005	33/140 (24%)
		A2M	697..787	CDD:278630	29/95 (31%)
		A2M_2	918..1203	CDD:239227	83/312 (27%)
		A2M_comp	967..1200	CDD:284982	65/247 (26%)
		A2M_recep	1313..1402	CDD:284981	26/125 (21%)
c3b.1	XP_009294664.1	A2M_N	149..242	CDD:280081	20/94 (21%)
		A2M_N_2	500..619	CDD:285005	29/119 (24%)
		ANATO	691..747	CDD:237984	7/55 (13%)
		A2M	852..948	CDD:278630	30/101 (30%)
		TRAPPC10	<939..>991	CDD:289361	12/62 (19%)
		complement_C3_C4_C5	1079..1363	CDD:239226	82/307 (27%)
		A2M_comp	1133..1363	CDD:284982	67/249 (27%)
		A2M_recep	1480..1573	CDD:284981	25/102 (25%)
		NTR_like	1593..1766	CDD:295338	4/11 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170584209
Domainoid	1	1.000	48	1.000	Domainoid score	I11904
eggNOG	1	0.900	-	-		E1_COG2373
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11412
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	7	6.800