Protein Alignment Tep3 and Mug1

DIOPT Version :10

• Sequence 1: NP_523507.2
• Gene: Tep3 / 34045
• FlyBaseID: FBgn0041181
• Length: 1469
• Species: Drosophila melanogaster
• Sequence 2: XP_006237344.1
• Gene: Mug1 / 497794
• RGDID: 621366
• Length: 1494
• Species: Rattus norvegicus
• Alignment Length: 1535
• Identity: 394/1535 - (25%)
• Similarity: 655/1535 - (42%)
• Gaps: 240/1535 - (15%)

  Fly    31 YSIIAPNTLRPNSQFHVAVSLHNAPESATFKVGILGSSYT----DFKTVELRPFSTQLLHFEIPA 91
            |.::.|:.|...:...:.:.|::..|:.|....::....|    |...|:...|  ..|.|.||.
  Rat    31 YMVLVPSQLYTETPEKICLHLYHLNETVTVTASLISQRGTRKLFDELVVDKDLF--HCLSFTIPR 93

  Fly    92 L----RTDRYRLTAEGLGGVQFTNETQLHFESKQHTVLVQTDKSIYKPGDLVHYRVLILDANLKP 152
            |    ..:...:..|| ...:|:....:..::|:..|.|||||.:||||..|.:||:.:|.||.|
  Rat    94 LPSSEEEESLDINIEG-AKHKFSERRVVLVKNKESVVFVQTDKPMYKPGQSVKFRVVSMDKNLHP 157

  Fly   153 AR-----GYGRVHVDIKDSGDNIIRSYKDIRLTNSIYSNELRLSDSPRFGTWSIVV-DVSDQEHT 211
            ..     .|      |:|...|.|..::|::..|.:......||..|..|.:.||: ..|..:..
  Rat   158 LNELFPLAY------IEDPKMNRIIQWQDVKTENGLKQLSFSLSAEPIQGPYKIVILKQSGVKEE 216

  Fly   212 QTFEILDHILPKFVVDIDTPKHAIYKDGKIAATVRAHYAFGQPIVGEATLSI---YPTFFGSLQP 273
            .:|.:::.:||:|.||:..|......|..|..|..|.|.:|:|:.|...:|:   .|:|....:.
  Rat   217 HSFTVMEFVLPRFGVDVKVPNAISVYDEIINVTACAIYTYGKPVPGHVKISLCHGNPSFSSETKS 281

  Fly   274 FVNDLITRKVVPIDGNAYFEFDIE-NELHLKQDY---ERQYLLDALVEEKSTGSVQNYSTVLTLH 334
            ...:    :...:|.|.....::. .|..||::|   .:.:.::|.|.|:.|||..:.|..:.:.
  Rat   282 ACKE----EDSELDNNGCSTQEVNITEFQLKENYLKMHQAFHVNATVTEEGTGSEFSGSGRIEVE 342

  Fly   335 LNHYRVEAVKVPSYYIPGVPFEATARIARNDGGQLRDFNPQI-----TAYLTNVYGSSEMYNRTA 394
            ....:...:|..|::..|:||....|:....|..:.  |.|:     .|..||. .:::.:....
  Rat   343 RTRNKFLFLKADSHFRHGIPFFVKIRLVDIKGDPIP--NEQVFIKAQEAGYTNA-TTTDQHGLAK 404

  Fly   395 YSLDASGEIKMKFTVPIGDRDE----------------------FHSIIVDYQGVISEVGKIPSK 437
            :|:|.|........:.:..::|                      .:|:...|..:.:|.|.:|..
  Rat   405 FSIDTSSISGYSLNIKVYHKEESSCIHSSCTAERHAEEHHTAYAVYSLSKSYIYLDTEAGVLPCN 469

  Fly   438 HLHSKN---YITAKVLNDRPTVNQEISVVVRSFAPIKYFMYQVVGRGDIILSRN--------VDV 491
            .:|:..   .:..:||...|.:               .|.|.|:.:|.|:.:.|        |..
  Rat   470 QIHTVQAHFILKGQVLGVLPQI---------------VFHYLVMAQGSILQTGNHTHQVEPGVSQ 519

  Fly   492 APGTFHTIKFLASFAMMPRANLLVYTVI-DGEFVYDEQVIQLEENLLNAVQVD-APIRAPPGQDI 554
            ..|.| .::....|:|:|.|.:|:||:: |||.:.|....|:|:.|.|.|.:. :|.::.|....
  Rat   520 VQGNF-ALEIPVEFSMVPVAKMLIYTILPDGEVIADSVTFQVEKCLRNKVHLSFSPSQSLPASQT 583

  Fly   555 DIGISTKPYSYVGLMLVDQNANDLRSGHDLTHKRLMDALRSYELSDVNTPMGSPGKESGVITMSN 619
            .:.::..|.|..||..|||:...|:...:|:...:.|.               ||.:......|:
  Rat   584 HMRVTASPQSLCGLRAVDQSVLLLKPEAELSPSLIYDL---------------PGMQDSNFIPSS 633

  Fly   620 TDYFIEK------EAESNPALDREVSTGPEEDKLTTVRKTDIG-----------PAHKIEVN--- 664
            ...|.::      :......|...|..|.|:|....||  |:|           |.:..|:|
  Rat   634 YHPFEDEYDCLMYQPRDTEELTYSVPYGREKDVYRYVR--DMGLTAFTNLKIKHPTYCYEMNMVV 696

  Fly   665 --------TLPPGKGRYAF-------SYTPK------PFWHNPRVHVMRD--PADTWLFLNISAS 706
                    .|.|..|.:..       |..||      |...:|.:..:|:  | :||::..::.:
  Rat   697 LSAPAVESELSPRGGEFEMMPLGVNKSPLPKEPPRKDPPPKDPVIETIRNYFP-ETWIWDLVTVN 760

  Fly   707 SDGRNSIHRRIPSEMTSWVVSAFALDPVNGLGLSPPNGKLEAYKEFYISTELPYSIKRDELIAIP 771
            |.|...:...:|..:|.|...|..|....|||||.. ..|:|::.|::...:|||:.|.|...:.
  Rat   761 SSGVTEVEMTVPDTITEWKAGALCLSNDTGLGLSSV-ATLQAFQPFFVELTMPYSVIRGEAFMLK 824

  Fly   772 FVVHNNRDSDLNVEVTFYNSALDFDFPQLDPKATNQPKVELYRRRSLQVPGRSARSVSFIVTPKR 836
            ..|.|...:.|.:.|....|.   ||..: |...:|...      .|...||  .:.|::||||.
  Rat   825 ATVMNYLPTSLPMAVQLEASP---DFTAV-PVGNDQDSY------CLGANGR--HTSSWLVTPKS 877

  Fly   837 VG----PLLVKAMAASSQAG------------DTVEQNLLVEHPGAMERINRGFLFE---LNSNA 882
            :|    .:.|:|..:....|            |||.:.|:||..|    |.:...|.   ..|:|
  Rat   878 LGNVNFSVSVEAQQSPELCGSQVATVPETGRKDTVVKVLIVEPEG----IKKEHTFSSLLCASDA 938

  Fly   883 QNRRNVTIAVPRNAIPESTRIEVSAVGDLIGSLVGNLDSLILLPTGCGEQTMVNFVPNLIVLRYL 947
            :....:::.:|...:.:|.|...|.:||::.|.:.|..:||.:|.|||||.||.|.||:.||:||
  Rat   939 ELSETLSLLLPPTVVKDSARAHFSVMGDILSSAIKNTQNLIQMPYGCGEQNMVLFAPNIYVLKYL 1003

  Fly   948 GRLRQLTPEVELRATNNLAIGYQRILYYRHENGAFSAFGLDIK---RSSTWLTAYVARSLRQAAP 1009
            ...:|||.:::.:|...|..||||.|.|:|::|::|||| |..   :.:|||||:|.:|..||..
  Rat  1004 NETQQLTEKIKSKALGYLRAGYQRELNYKHKDGSYSAFG-DHNGQGQGNTWLTAFVLKSFAQARA 1067

  Fly  1010 FTQVDSNVLQKALTYLGSVQSANGGFEERGDVFE---RFG-DDGISLTAFVTLALMENVDLYPEY 1070
            |..:|.:.:..|.|:|...|..:|.|...|.:|.   :.| ||.|:|:|::|:||:|:  ..|:.
  Rat  1068 FIFIDESHITDAFTWLSKQQKDSGCFRSSGSLFNNAMKGGVDDEITLSAYITMALLES--SLPDT 1130

  Fly  1071 RNNINKAL-------DFITRGLDGSSNLHAMAIGTYVLSRA-NHNAKAAFLQRLDSMATNKDGLK 1127
            ...::|||       :.|.:|.:||. ::...:..|..:.| |...:...|:.||..|..:|...
  Rat  1131 DPVVSKALGCLEASWETIEQGRNGSF-VYTKTLMAYAFALAGNQEKRNEILKSLDKEAIREDNSI 1194

  Fly  1128 WWNKTAPAGEQQSPWYNAT---RSVNIEISAYAALALLENNLVGDALP----------VLNWLMD 1179
            .|.:  |....:|..|..|   .|..:|:|||..||    .|.....|          .:.||..
  Rat  1195 HWER--PQKPTKSEGYLYTPQASSAEVEMSAYVVLA----RLTAQPAPSPEDLALSMGTIKWLTK 1253

  Fly  1180 QRNPKGGFVASQDTVVGLQALLMF-AERFSSQGNNLQIGFHYGEGAETIINVNAENSLALQTVEL 1243
            |:|..|||.::|||||.|.||..: |..||.......:.............|:..|.|.||.|.|
  Rat  1254 QQNSHGGFSSTQDTVVALDALSKYGAATFSKSQKTPLVTIQSSGSFSQKFQVDNSNRLLLQQVSL 1318

  Fly  1244 PNNLKNLSVSATGRGMALAQVSYTYNTNVTSAWPRFVLDP-----TVNRNSHADYLHLSACASFV 1303
            |:...|.:||.:|.|...||.:..||..:....|.|.|..     |.|.....:...:|...|:.
  Rat  1319 PDIPGNYTVSVSGEGCVYAQTTLRYNMPLEKQQPAFALKVQTVPLTCNNPKGQNSFQISLEISYT 1383

  Fly  1304 SVVGENEQRSNMAVMEVHLPSGFVVDRDTLPTLESSERIKKVETQNRNTKVVIYFDYLDRREVCP 1368
            .    :...|||.:.:|.:.|||:..:.|:..||..|.:.:.|....|  |::|.|.:..:.:..
  Rat  1384 G----SRPASNMVIADVKMLSGFIPLKPTVKKLERLEHVSRTEVTTNN--VLLYLDQVTNQTLSF 1442

  Fly  1369 TLHAYKTVKVTKHRPVAVVMYDYYDSARRARQFYRAPKSN 1408
            :....:.:.|...:|..|.:||||::...|...|.:|.|:
  Rat  1443 SFIIQQDIPVKNLQPAIVKVYDYYETDEVAFAEYSSPCSS 1482

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tep3	NP_523507.2	YfaS	<128..1399	CDD:441940	368/1419 (26%)
		A2M_2	918..1203	CDD:239227	110/312 (35%)
Mug1	XP_006237344.1	YfaS	<129..1359	CDD:441940	344/1303 (26%)
		A2M	751..841	CDD:459711	26/90 (29%)
		A2M_2	971..1277	CDD:239227	110/315 (35%)
		A2M_recep	1387..1477	CDD:462226	24/91 (26%)