Protein Alignment Tep3 and Mug2

DIOPT Version :10

• Sequence 1: NP_523507.2
• Gene: Tep3 / 34045
• FlyBaseID: FBgn0041181
• Length: 1469
• Species: Drosophila melanogaster
• Sequence 2: XP_038963907.1
• Gene: Mug2 / 408236
• RGDID: 1302962
• Length: 1497
• Species: Rattus norvegicus
• Alignment Length: 1586
• Identity: 403/1586 - (25%)
• Similarity: 661/1586 - (41%)
• Gaps: 300/1586 - (18%)

  Fly    10 AIPVLILVTACLLCQTSAQGLYSIIAPNTLRPNSQFHVAVSLHNAPESATFKVGILGSSYTDFKT 74
            ::.:..|.:|.||...|.   |.::.|:.|...:...:.:.|::..|:.|....::....|. |.
  Rat    13 SVLLAFLPSASLLFGNSK---YMVLVPSQLYTETPEKICLHLYHLNETVTVTASLISQRGTR-KL 73

  Fly    75 VELRPFSTQLLH---FEIPALRTDRYRLTAEGLGGVQFTNETQLHFESKQHTVL---------VQ 127
            .:.......|.|   |.||.|.      ::|....:....|...|..||:|.||         ||
  Rat    74 FDEPVVDKDLFHCVSFTIPRLP------SSEEEESLDINIEGAKHKFSKRHVVLVKNKESVVFVQ 132

  Fly   128 TDKSIYKPGDLVHYRVLILDANLKPAR-----GYGRVHVDIKDSGDNIIRSYKDIRLTNSIYSNE 187
            |||.:||||..|.:||:.:|.||.|.:     .|      |:|...|.|..::|::..|.:....
  Rat   133 TDKPMYKPGQSVKFRVVSMDKNLYPLKELFPLAY------IEDPKMNRIMQWQDVKTENGLKQLS 191

  Fly   188 LRLSDSPRFGTWSIVV-DVSDQEHTQTFEILDHILPKFVVDIDTPKHAIYKDGKIAATVRAHYAF 251
            ..||..|..|.:.||| ..|..:...:|.:::.:||:|.||:..|......|..|:.|..|.|.:
  Rat   192 FSLSAEPIQGPYKIVVLKQSGVKEEHSFTVMEFVLPRFGVDVKVPNAISVYDEIISVTACATYTY 256

  Fly   252 GQPIVGEATLSI---YPTFFGSLQPFVNDLITRKVVPIDGNAYFEFDIE-NELHLKQDY---ERQ 309
            |:|::|...:.:   .|:|....:....:..::    :|.|.....::. .|..||::|   .:.
  Rat   257 GKPVLGRVKVRLCHGNPSFSSETKSACKEENSK----LDNNGCSTQEVNITEFQLKENYLKVRQA 317

  Fly   310 YLLDALVEEKSTGSVQNYSTVLTLHLNHY-RVEA---------VKVPSYYIPGVPFEATARIARN 364
            :.::|.|.|:.|||          ....| |:|.         :|..|::..|:||....|:...
  Rat   318 FHVNATVTEEGTGS----------EFGGYGRIEVERTRNKFLFLKADSHFRHGIPFFVKVRLVDI 372

  Fly   365 DGGQLRDFNPQI-----TAYLTNVYGSSEMYNRTAYSLDASGEIKMKFTVPIGDRDE-------- 416
            .|..:.  |.|:     .|..||. .:::.:....:|:|.|........:.:..::|
  Rat   373 KGDPIP--NEQVFIKAQEAGYTNA-TTTDQHGLAKFSIDTSSISGYSLNIKVYHKEENLCIHSSC 434

  Fly   417 --------------FHSIIVDYQGVISEVGKIPSKHLHSKN---YITAKVLNDRPTVNQEISVVV 464
                          .:|:...|..:.:|.|.:|...:|:..   .:..:||...|.:
  Rat   435 TAERHAEAHHTAYAVYSLSKSYIYLDTEAGVLPCNQIHTVQAHFILKGQVLGVLPQI-------- 491

  Fly   465 RSFAPIKYFMYQVVGRGDIILSRN------VDVAPGTFHTIKFLASFAMMPRANLLVYTVI-DGE 522
                   .|.|.|:.:|.|:.:.|      ..|..|.| .::....|:|:|.|.:|:||:: |||
  Rat   492 -------VFHYLVMAQGSILQTGNHTHQVESGVLQGNF-ALEIPVEFSMVPMAKMLIYTILPDGE 548

  Fly   523 FVYDEQVIQLEENLLNAVQVD-APIRAPPGQDIDIGISTKPYSYVGLMLVDQNANDLRSGHDLTH 586
            .:.|....|:|:.|.|.|.:. :|.::.|.....:.::..|.|..||..|||:...||...:|:.
  Rat   549 VIADSVKFQVEKCLRNKVHLSFSPSQSLPASQTHMRVTASPQSLCGLRAVDQSVLLLRPEAELSP 613

  Fly   587 KRLMDALRSYELSDVNTPMGSPG-KESGVITMSNTDYFIEKEAESNPALDRE-----VSTGPEED 645
            ..:.|.               || ::|..|..|:..:..|.:.......|.|     |..|.|:|
  Rat   614 SLIYDL---------------PGMQDSNFIPRSHHPFEDEDDCLMYQPRDTEELTYSVPYGREKD 663

  Fly   646 KLTTVRKTDIG-----------PAH------------KIEVNTLPPGKGRYAFSYTPKPFWHN-- 685
            ....||  |:|           |.:            .:|:||              .|.|..
  Rat   664 VYRYVR--DMGLTAFTNLKIKHPTYCYDDEIFEIFEPTVELNT--------------SPMWEKIE 712

  Fly   686 -----------PRVHVMRDP-------------------ADTWLFLNISASSDGRNSIHRRIPSE 720
                       |:....:||                   .:||::..::.:|.|...:...:|..
  Rat   713 IMALIANENPLPKEPPRKDPPRKDPEPKDTVVETIRNYFPETWVWDLVTVNSSGVTEVEMTVPDT 777

  Fly   721 MTSWVVSAFALDPVNGLGLSPPNGKLEAYKEFYISTELPYSIKRDELIAIPFVVHNNRDSDLNVE 785
            :|.|...|..|....|||||.. ..|:|::.|::...:|||:.|.|...:...|.|...:.|.:.
  Rat   778 ITEWKAGALCLSNDTGLGLSSV-ATLQAFQPFFVELTMPYSVIRGEAFTLKATVMNYLPTSLPMT 841

  Fly   786 VTFYNSALDFDFPQLDPKATNQPKVELYRRRSLQVPGRSARSVSFIVTPKRVG----PLLVKAMA 846
            |....|.   ||..: |...:|...      .|...||  .:.|::||||.:|    .:.|:|..
  Rat   842 VQLEASP---DFTAV-PVGNDQDSY------CLGANGR--HTSSWLVTPKSLGNVNFSVSVEAQQ 894

  Fly   847 ASSQAG------------DTVEQNLLVEHPGAMERINRGFLFE---LNSNAQNRRNVTIAVPRNA 896
            :....|            |||.:.|:||..|    |.:...|.   ..|:|:....:::.:|...
  Rat   895 SPEPCGSEVATVPETGRKDTVIKVLIVEPEG----IKKEHTFSSLLCASDAELSETLSLLLPPRV 955

  Fly   897 IPESTRIEVSAVGDLIGSLVGNLDSLILLPTGCGEQTMVNFVPNLIVLRYLGRLRQLTPEVELRA 961
            :.:|.|...|.:||::.|.:.|..:||.:|.|||||.||.|.||:.||:||...:|||..::.:|
  Rat   956 VKDSARAHFSVMGDILSSAIKNTQNLIQMPYGCGEQNMVLFAPNIYVLKYLNETQQLTENIKSKA 1020

  Fly   962 TNNLAIGYQRILYYRHENGAFSAFGLDIK---RSSTWLTAYVARSLRQAAPFTQVDSNVLQKALT 1023
            ...|..||||.|.|:|::|::|||| |..   :.:|||||:|.:|..||..|..:|.:.:..|.|
  Rat  1021 LGYLRAGYQRELNYKHKDGSYSAFG-DHNGQGQGNTWLTAFVLKSFAQARAFIFIDESHITDAFT 1084

  Fly  1024 YLGSVQSANGGFEERGDVFE---RFG-DDGISLTAFVTLALMENVDLYPEYRNNINKAL------ 1078
            :|...|..:|.|...|.:|.   :.| ||.|:|:|::|:||:|:  ..|:....::|||
  Rat  1085 WLSKQQKDSGCFRSSGSLFNNAMKGGVDDEITLSAYITMALLES--SLPDADPVVSKALGCLEAS 1147

  Fly  1079 -DFITRGLDGSSNLHAMAIGTYVLSRA-NHNAKAAFLQRLDSMATNKDGLKWWNKTAPAGEQQSP 1141
             :.|.:|.:||. ::..|:..|..:.| |...:...|:.||..|..:|....|.:  |....:|.
  Rat  1148 WETIEQGRNGSF-VYTKALMAYAFTLAGNQEKRNEILKSLDKEAIKEDNSIHWER--PQKPMKSE 1209

  Fly  1142 WYNAT---RSVNIEISAYAALALLENNLVGDALP----------VLNWLMDQRNPKGGFVASQDT 1193
            .|..|   .||.:|:|||..||    .|.....|          .:.||..|:|..|||.::|||
  Rat  1210 HYLYTPQASSVEVEMSAYVVLA----RLTAHPAPSPEDLALSTGTIKWLTKQQNSHGGFSSTQDT 1270

  Fly  1194 VVGLQALLMF-AERFSSQGNNLQIGFHYGEGAETIINVNAENSLALQTVELPNNLKNLSVSATGR 1257
            ||.|.||..: |..||.......:.............|:..|.|.||.|.||:...|.::..:|.
  Rat  1271 VVALDALSKYGAATFSKSQKTPSVTVQSSGSFSQKFQVDKSNRLLLQQVSLPDIPGNYTIRVSGE 1335

  Fly  1258 GMALAQVSYTYNTNVTSAWPRFVLDP-----TVNRNSHADYLHLSACASFVSVVGENEQRSNMAV 1317
            |...||.:..||..:....|.|.|..     |.|.....:...:|...|:..    :...|||.:
  Rat  1336 GCVYAQTTLRYNLPLEKQQPAFALKVKTVPLTCNNPKGQNSFQISLEISYTG----SRPASNMVI 1396

  Fly  1318 MEVHLPSGFVVDRDTLPTLESSERIKKVETQNRNTKVVIYFDYLDRREVCPTLHAYKTVKVTKHR 1382
            .:|.:.|||:..:.|:..||..|.:.:.|....|  |::|.|.:..:.:..:....:.:.|...:
  Rat  1397 ADVKMLSGFIPLKPTVKKLERLEHVSRTEVTTNN--VLLYLDQVTNQTLSFSFIIQQDIPVKNLQ 1459

  Fly  1383 PVAVVMYDYYDSARRARQFYRAPKSN 1408
            |..|.:||||::...|...|.:|.|:
  Rat  1460 PAIVKVYDYYETDEVAFAEYSSPCSS 1485

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tep3	NP_523507.2	YfaS	<128..1399	CDD:441940	370/1445 (26%)
		A2M_2	918..1203	CDD:239227	112/312 (36%)
Mug2	XP_038963907.1	YfaS	<129..1356	CDD:441940	342/1323 (26%)
		A2M	754..844	CDD:459711	26/90 (29%)
		A2M_2	974..1280	CDD:239227	112/315 (36%)
		A2M_recep	1390..1480	CDD:462226	24/91 (26%)