DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Tep3 and C4b

DIOPT Version :9

Sequence 1:NP_523507.2 Gene:Tep3 / 34045 FlyBaseID:FBgn0041181 Length:1469 Species:Drosophila melanogaster
Sequence 2:NP_001002805.1 Gene:C4b / 406161 RGDID:1591983 Length:1737 Species:Rattus norvegicus


Alignment Length:1675 Identity:404/1675 - (24%)
Similarity:647/1675 - (38%) Gaps:395/1675 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly    33 IIAPNTLRPNSQFHVAVSLHNAPESATFKVGILGSSY------------TDFKTVELRPFSTQLL 85
            :.:|:.:...:...|.|.|.:||.....|    ||.|            .|||......|  .||
  Rat    25 LFSPSVVNLGTPLSVGVQLLDAPAGQEVK----GSVYLRNPTSGPCSPKKDFKLSSGNDF--VLL 83

  Fly    86 HFEIP-----------ALRTDRYRLTAEG---LGGVQFTNETQ---LHFESKQHTVLVQTDKSIY 133
            ..|:|           ..|....:|.|..   ........|||   |.|.|::..:.||||:.||
  Rat    84 RLEVPLEDVRNCGLFDLRRAPHIQLVAYSPWLKNTAPKATETQGVNLLFSSRRGHIFVQTDQPIY 148

  Fly   134 KPGDLVHYRVLILDANLKPARGYGRVHVDIKDSGDNIIRSYKDIRLTNSIYSNELRLSDSPRFGT 198
            .||..|.|||..||..::|:.  ..:.|.:::|....:|. |.:....||::::..:.|....||
  Rat   149 NPGQRVRYRVFALDQKMRPST--DTLTVTVENSHGLRVRK-KVVFAPTSIFTDDFVIPDISEPGT 210

  Fly   199 WSIVVDVSD---QEHTQTFEILDHILPKFVVDIDTPKHAI-----YKDGKIAATVRAHYAFGQPI 255
            |.|....||   ...:..||:..::||.|.|.:...|..|     |:: :|...::|.|.:|:|:
  Rat   211 WKISARFSDGLESNRSTHFEVKKYVLPNFEVKLTPWKPYILTVPSYRE-EIQLDIQARYVYGKPV 274

  Fly   256 VGEATLSIYPTFF----GSLQPFVNDLITRKVVPIDGNAYFEFD----------IENELHLKQDY 306
            .|.|    |..|.    ...:.|:..|.|:..: ::|..:....          :..|:   .|.
  Rat   275 QGVA----YTRFALMDEQGKKTFLRGLETQTKL-VEGQTHISISRDQFQAALGKVNTEI---GDL 331

  Fly   307 E--RQYLLDALV-------EEKSTGSVQNYSTVLTLHLNHYRVEAVKVPSYYIPGVPFEATARIA 362
            |  |.|...|::       ||....|....|:..:|.|:|.:       .:.:||.||...|.:.
  Rat   332 EGLRLYAAVAVIESPGGEMEEAELTSWPFVSSAFSLDLSHTK-------QHLVPGAPFLLQALVR 389

  Fly   363 RNDGGQLRDFNPQITAYLTNVYGSSEMYNRTAYSLDASGEIKMKFTVP--IGDRDEFHSIIVDYQ 425
            ...|.:..|...:::|.|.:  ||.........:.:..|::.....||  |.:.    .::|...
  Rat   390 EMSGSEASDVPVKVSATLLS--GSDSKVLDFQQNTNGIGQVSFSIHVPPTITEL----RLLVSAG 448

  Fly   426 GVISEVGKI-----PSKHLHSKNYITAKVLNDR-PTVNQEISVVVRSFA-PI---KYFMYQVVGR 480
            .:...|.|:     ||:   ...:::.:.|:.| |.|.....:.:|:.. |:   .::.|.::.|
  Rat   449 SLYPAVAKLTVQAPPSR---GPGFLSIEPLDLRSPRVGDTFILNLRTVGIPVPTFSHYYYMIISR 510

  Fly   481 GDII-LSRN-----------VD--VAPGTFHTIKFLASF--AMMPRANLLVYTVIDGEFVYDEQV 529
            |.|: :||.           ||  :||..:    |:|.|  ..:|.||.|:..|..|:.   |..
  Rat   511 GQIMAMSREPRTTLTSISVLVDHHLAPSFY----FVAYFYHQGLPVANSLLINVQPGDC---EGK 568

  Fly   530 IQLEENLLNAVQVDAPIRAPPGQDIDIGISTKPYSYVGLMLVDQ--NANDLRSGHDLTHKRLMDA 592
            ::|        :||.......|:.:.:.:.|...:.|.|..||.  .|...||...|...::.:.
  Rat   569 LEL--------KVDGAKEYRNGESMKLQLQTDSEALVALGAVDTALYAVGGRSHKPLDMSKVFEV 625

  Fly   593 LRSYELS----------DVNTPMGSPGKESGVITMSNTDYFIEKEAES----NPALDREVSTGPE 643
            :.||.|.          .|....|....:...:|.:..|....||..|    |....:.:|    
  Rat   626 MNSYNLGCGPGGGDDALQVFQTAGLAFSDGDRLTQTKEDLSCPKEKISRQKRNVNFQKAIS---- 686

  Fly   644 EDKLTTVRKTDIGPAHKIEVNTLPPGKG-RYAFSYTPKPFWHNP-----------RVHVMRDPAD 696
             :||......|.....:..:..||..:. ....:..|:|....|           |.:..|..|.
  Rat   687 -EKLGQYSSPDTKRCCQDGMTKLPMARTCEQRAARVPQPACREPFLSCCKFAEDLRRNQTRSQAG 750

  Fly   697 TWLFLNISASSD--GRNSIHRR-----------------------IPSEMTSWVVSAFALDPVNG 736
            .....|:....|  ..:.|..|                       :|..:|:|.:...:|....|
  Rat   751 LARAQNVMQEEDLIDEDDILVRSFFPENWLWKVEPVDRSKLLTVWLPDSLTTWEIHGVSLSKSKG 815

  Fly   737 LGLSPPNGKLEAYKEFYISTELPYSIKRDELIAIPFVVHNNRDSDLNVEVTFYNSALDFDFPQLD 801
            |.::.|. ::..::||::...||.|::|.|.:.:..|::|....|:.|.|            .:.
  Rat   816 LCVAKPT-RVRVFREFHLHLRLPISVRRFEQLELRPVLYNYLSEDVTVSV------------HVS 867

  Fly   802 PKATNQPKVE--------LYRRRSLQVPGRSARSVSFIVTPKRVGPLLVKAMAASS-QAGDTVEQ 857
            |       ||        |..:: :.||..|||.|:|.|.|.....:.:|.:|..| ..||.|.:
  Rat   868 P-------VEGLCLAGGGLLAQQ-VSVPAGSARPVAFSVVPTAAASMPLKVVARGSFDIGDAVSK 924

  Fly   858 NLLVEHPGAMERINRGFLFELNSNAQNRRNVTIAVP----RNAIPES-----TRIEVSAVGDLIG 913
            .|.:|..||:.|..    ...|.:..|....::.:|    .|.||:.     .|:..|...:.:|
  Rat   925 ILQIEKEGAIHREE----IVYNLDPLNNLGRSLEIPGSSDPNVIPDGDFSSFVRVTASEPLETLG 985

  Fly   914 S----LVGNLDSLILLPTGCGEQTMVNFVPNLIVLRYLGRLRQ---LTPEVELRATNNLAIGYQR 971
            |    ..|.:.||:.|||||.|||||...|.|...|||.|..|   |.||.:..|.:.:..|:.|
  Rat   986 SEGALSPGGVASLLKLPTGCAEQTMVLLAPTLTASRYLDRTEQWSKLPPETKDHAVDLIQKGHMR 1050

  Fly   972 ILYYRHENGAFSAFGLDIKRSSTWLTAYVARSLRQAAPFTQVDSNVLQKALTYLGSVQSANGGFE 1036
            |..:|.::|:|.|: || :.|||||||:|.:.|..|..........||:...:|...|..:|.|.
  Rat  1051 IQQFRKKDGSFGAW-LD-RDSSTWLTAFVLKILSLAQEQIGDSPEKLQETAGWLLGQQLDDGSFH 1113

  Fly  1037 ERGDVFER------FG-DDGISLTAFVTLALMENVDLYPEYRN---------NINKALDFI---- 1081
            :...|.:|      .| |:.::|||||.:||...:.::.:..:         :|.||..|:    
  Rat  1114 DPCPVIQRGMQGGLVGTDETVALTAFVVIALHHGLAVFQDENSQQLKKRVEASIMKANSFLGQKA 1178

  Fly  1082 TRGLDGSSNLHAMAIGTY--VLSRANHNAKAAFLQRLDSMATNKDGLKWW--------------- 1129
            :.||.|:   ||.||..|  .|::|:.:.:......|.:||.......:|               
  Rat  1179 SAGLLGA---HASAITAYALTLTKASEDLRNVAHNSLMAMAEETGENLYWGLAIGSQDNVVSSTA 1240

  Fly  1130 ---NKTAPAGEQQSPWYNATRSVNIEISAYAALALLENNLVGD-ALPVLNWLMDQRNPKGGFVAS 1190
               |.:.|..:..:.|        ||.:||..|.||.....|: |.....||..|.:.:|||.::
  Rat  1241 APRNPSEPVPQAPALW--------IETTAYGLLHLLLREGKGEMADKAATWLTHQGSFQGGFRST 1297

  Fly  1191 QDTVVGLQALLMF-------AER-----FSSQGNN------LQIGFHYGEGAE--------TIIN 1229
            |||||.|.||..:       .|:     .||.|.|      ||:..|..:|.|        :.||
  Rat  1298 QDTVVALDALSAYWIASHTTEEKALNVTLSSMGRNGYKSHLLQLNNHQVKGLEEELKFSLGSTIN 1362

  Fly  1230 V----NAENSLALQTVELPNNLKN-------LSVSATG--RGMALAQVSYTYNTNVTSAWPRFVL 1281
            |    |::.:|.:.......::||       :.|:.||  .....|...|.|:.::.:|     .
  Rat  1363 VKVGGNSKGTLKILRTYNVLDMKNTTCQDLRIEVTITGYVEYTREANEDYEYDYDMPAA-----D 1422

  Fly  1282 DPTVN----------------RNSHADYLHLSACASFVSVVGENEQR---------------SNM 1315
            ||:|:                |...|.           ....|.|.|               |.|
  Rat  1423 DPSVHSQPVTPLQLFEGRRSRRRREAP-----------KAADEQESRVQYTVCIWRNGNLGLSGM 1476

  Fly  1316 AVMEVHLPSGFVVDRDTLPTLES-SER-IKKVETQNRNTKVVIYFDYLDRREVCPTLHAYKTVKV 1378
            |:.::.|.|||...|..|..|.| |:| :...||...:  |::|||.:.....|....|.:.|.|
  Rat  1477 AIADITLLSGFQALRADLEKLTSLSDRYVSHFETDGPH--VLLYFDSVPTTRECVGFGALQEVAV 1539

  Fly  1379 TKHRPVAVVMYDYYDSARRARQFYRAP-KSNICD-ICEHANCGDLCEKAE 1426
            ...:|.:.|:||||....:...||..| ||.:.. :|.    .|:|:.||
  Rat  1540 GLVQPASAVLYDYYSPDHKCSVFYAGPTKSKLLSTLCS----ADVCQCAE 1585

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Tep3NP_523507.2 A2M_N 124..215 CDD:280081 28/93 (30%)
A2M_N_2 448..573 CDD:285005 34/145 (23%)
A2M 697..787 CDD:278630 22/114 (19%)
A2M_2 918..1203 CDD:239227 103/328 (31%)
A2M_comp 967..1200 CDD:284982 78/273 (29%)
A2M_recep 1313..1402 CDD:284981 29/90 (32%)
C4bNP_001002805.1 A2M_N 139..231 CDD:280081 29/94 (31%)
A2M_N_2 475..608 CDD:285005 35/147 (24%)
ANATO 684..752 CDD:237984 12/72 (17%)
A2M 779..866 CDD:278630 19/99 (19%)
complement_C3_C4_C5 991..1310 CDD:239226 104/331 (31%)
A2M_comp 1046..1312 CDD:284982 80/278 (29%)
A2M_recep 1474..1563 CDD:284981 29/90 (32%)
NTR_complement_C4 1581..1735 CDD:239639 3/5 (60%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166343875
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2373
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D177369at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11412
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
65.810

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