DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tep3 and Cd109

DIOPT Version :9

Sequence 1:	NP_523507.2	Gene:	Tep3 / 34045	FlyBaseID:	FBgn0041181	Length:	1469	Species:	Drosophila melanogaster
Sequence 2:	NP_001102241.2	Gene:	Cd109 / 363104	RGDID:	1311287	Length:	1442	Species:	Rattus norvegicus

Alignment Length:	1570	Identity:	432/1570 - (27%)
Similarity:	713/1570 - (45%)	Gaps:	265/1570 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 LVTACLLCQTSAQGLYSIIAPNTLRPNSQFHVAVS-LHNAPESATFKVGILGSSYTDFKTVELRP 79
            |::.|::...:....:.:..|..:||.:...:.|. |.|:|.....|..:|       |....|
  Rat    12 LLSVCVVAVAAHGSRFLVTVPGIIRPGANMTIGVELLQNSPPQVLVKARVL-------KIASNR- 68

  Fly    80 FSTQLL---------HFEI---PALRTDR----YRLTAEGLGGVQ--FTNETQLHFESKQHTVLV 126
             ||.:|         ||.|   |||...:    |.|...|....:  |:|.|:|.|:||:.:|.:
  Rat    69 -STTVLEAEGVFNRGHFGILVLPALPLHKANKIYELHISGKSETEIVFSNRTRLTFDSKRISVFI 132

  Fly   127 QTDKSIYKPGDLVHYRVLILDANLKPARGYGRVHVDIKDSGDNIIRSYKDIRLTNSIYSNELRLS 191
            ||||.||||...|.:|||.|.::|||.:  ..|.:.|||...|:|:.:........:.|...:||
  Rat   133 QTDKVIYKPKQEVKFRVLTLFSDLKPYK--TPVDIYIKDPKSNLIQQWLSQEGELGVVSKTFQLS 195

  Fly   192 DSPRFGTWSIVVDVSDQEHTQTFEILDHILPKFVVDIDTPKHAIYKDGKIAATVRAHYAFGQPIV 256
            ..|..|.|||.|.|.||.:.|:|::||::||||.|.:.||.:...|...:...|.|.|.:|:|:.
  Rat   196 SHPILGDWSIQVQVIDQLYYQSFQVLDYVLPKFEVTLQTPLYCSLKAKYLRGNVTAKYTYGKPVK 260

  Fly   257 GEATLSIYP-TFFGSLQPFVNDLITRKVVPIDGNAYFEFD---IENELHLKQ-------DYERQY 310
            |..:|:..| :|:|..:...      |...|:|...|.||   ::..::||:       :|::
  Rat   261 GSLSLTFIPLSFWGKKKNIT------KNFEINGFTNFAFDADEMKKVMNLKKATEISDGNYDQ-- 317

  Fly   311 LLD----------ALVEEKSTGSVQNYSTVLTLHLNHYRVEAVKVPSYYIPGVPFEATARIARND 365
             :|          |.|.|..||:.:..||.:....:.|.:|.....:...|.:.|.||.:|:|:|
  Rat   318 -VDPVFPGPVEIVATVTESLTGTSRKASTNVFFKQHDYVIEIFDYTTVLKPTLNFTATVKISRSD 381

  Fly   366 GGQL----------------RDFNP-----QITAYLTNVYGSSEMYNRTAYSLDASGEIKMKFTV 409
            |.||                ::.||     |.|.|:          ..|.||:..:|.:|::|.:
  Rat   382 GKQLTPEEMENDLVTVVTQKKNDNPTREKAQGTDYI----------QMTEYSVPHNGVVKVEFPI 436

  Fly   410 PIGDRDEFHSIIVDYQGVISEVGKIPSKHLH------SKNYITAKVLNDRPTVNQEISVVVRSFA 468
             :.|..|.       |...|.:....|..:|      |..||..|..::..||....::.|....
  Rat   437 -MSDSSEL-------QLKASFLDSASSVAVHSVFTSPSNTYIQLKTRDEHITVGSPFNLTVSGNQ 493

  Fly   469 PIKYFMYQVVGRGDIIL-----SRNVDVAPGTFHTIKFLASFAMMPRANLLVYTV-IDGEFVYDE 527
            ..|...|.|:.:|.::.     ||...:.|.        ||:|  |:|.::||.: .|||.:.|.
  Rat   494 KFKEISYMVISKGQLVAVGKQSSRTFSLTPE--------ASWA--PKACIIVYYIEQDGEVISDI 548

  Fly   528 QVIQLEENLLNAVQVD-APIRAPPGQDIDIGIS-TKPYSYVGLMLVDQNANDLRSGHDLTHKRLM 590
            ..|.::.:..|.:::. :..|..|...:.:.|| |:.||.||::.||::...:.:.:|:|.:.::
  Rat   549 LKIPVQLDFKNKIKLSWSKPRVKPSDKVSLRISVTQSYSLVGIVAVDKSVKLIGNSNDITMENVV 613

  Fly   591 DALRSYE----------------------LSDVNTPMGSPGKESGVITMSNTDYFIEKEAESNPA 633
            ..|..|.                      |:|.|.      ....:..:.:|..:.|:.||.|.|
  Rat   614 HELELYNTEYYLGMFLNSFAVFQECGLWVLTDANL------VRDNIDEVYDTQEYSERFAEENEA 672

  Fly   634 --LDREVSTGPEEDKLTTVRKTDIGPAHKIEVNTLPPGKGRYAFSYTPKPFWHNPRVHVMRDPAD 696
              :|.|.::.....                                           ||.:...:
  Rat   673 NLVDFEDTSSASNS-------------------------------------------HVRKHFPE 694

  Fly   697 TWLFLNISASSDGRNSIHRRIPSEMTSWVVSAFALDPVNGLGLSPPNGKLEAYKEFYISTELPYS 761
            :|::|:....|.........:|..:||||.|||.:....|.||:....:|.|::.|:||..||||
  Rat   695 SWIWLDFYMGSKNHEEYEVTVPDSITSWVASAFVISEDLGFGLTATPAELHAFQPFFISLNLPYS 759

  Fly   762 IKRDELIAIPFVVHNNRDSDLNVEVTFYNSALDFDFPQLDPKATNQPKVELYRRRSLQVPGRSAR 826
            :.|.|..|:...:.|.......|.|....|. .||.........|    .:||:.:| ||..::.
  Rat   760 VIRGEEFALEVSIVNYLKDTTKVVVLIEESD-SFDILMFSNDINN----TIYRKTAL-VPRENSV 818

  Fly   827 SVSFIVTPKRVGPLLVKAMAASSQAGDTVEQNLLVEHPGAMERINRGFLFELNSNAQNR--RNVT 889
            ::.|.:.|..:|.:.:...|||..:.|.|.:.::|:..|..:..::..|.||....|..  ::::
  Rat   819 TLVFPIKPTHLGNVPITVTAASPTSSDVVTRTIVVKPEGVAKSYSQSVLLELIDKKQQTEPKSLS 883

  Fly   890 IAVPRNAIPESTRIEVSAVGDLIGSLVGNLDSLILLPTGCGEQTMVNFVPNLIVLRYLGRLRQLT 954
            .:.|.:.|..|.||:::|:||::||.:..|.|||.||.|||||.||...||:.:|.||.:.:|||
  Rat   884 FSFPPDTISGSERIQITAIGDILGSSINGLSSLIRLPYGCGEQNMVYLAPNVYILDYLTKQKQLT 948

  Fly   955 PEVELRATNNLAIGYQRILYYRHENGAFSAFGLDIKRSSTWLTAYVARSLRQAAPFTQVDSNVLQ 1019
            ..::.:|.:.:..||||.|.|:.|:|:|||||......||||:|:|.|...:||.:..:|.:||.
  Rat   949 VNLKEKALSFMRQGYQRELLYQREDGSFSAFGNSDSSGSTWLSAFVLRCFMEAAQYIDIDQDVLH 1013

  Fly  1020 KALTYLGSVQSANGGFEERGDVFERFGDDG----ISLTAFVTLALMENVDLYPEYRNN--INKAL 1078
            :..::|.:.:..||.|.|.|.|.......|    |:|||:|..:|:.    |.:|:.|  |..::
  Rat  1014 RTYSWLEAHKKTNGEFWEPGRVIHIELQGGNKSPITLTAYVVTSLLG----YKKYQPNIEIQDSI 1074

  Fly  1079 DFITRGLD-GSSNLHAMAIGTYVLSRANHNAKAAFLQRLDSMATNKDGLKWWNKTAPAGEQQSPW 1142
            .|:....: |.|:.:.:|:.||.||..........|..|...|..:...::|  .:...|....|
  Rat  1075 KFLENEFNRGISDNYTLALVTYALSAVGSPKAEEALTMLTQQAEKEGDTQFW--LSSTSESSESW 1137

  Fly  1143 YNATRSVNIEISAYAALALLENNLVGDALPVLNWLMDQRNPKGGFVASQDTVVGLQALLMFAERF 1207
            .:.  |..|||:|||.||..::: |.:.:|::.||:.|||..||||::||||:.|:||..|:...
  Rat  1138 QSL--SAQIEIAAYALLAHTQHH-VPEGIPIMKWLIKQRNSLGGFVSTQDTVMALKALSEFSALV 1199

  Fly  1208 SSQGNNLQIGFHYGEGAETIIN--VNAENSLALQTVEL-PNNLKNLSVSATGRGMALAQVSYTYN 1269
            ..:..::|:... |......|.  ::::|...|...|| |.:...::|||.|.|.|:.|::..||
  Rat  1200 YKENRDMQVTIK-GPNVPKPIRFWIDSQNLFKLHKEELAPLDPIAVNVSAHGSGFAICQLNVDYN 1263

  Fly  1270 TNVTSAWPR---------FVLDPTVNRNSHADYLHLSACASFVSVVGENEQRSNMAVMEVHLPSG 1325
            ...:|::.|         |.||..||......|:.|:.|.|.:     ...|:.||::||:|.||
  Rat  1264 VKASSSFKRRRSMENPIGFDLDVDVNDEHDLRYMKLNVCTSHL-----GPGRTGMALLEVNLLSG 1323

  Fly  1326 FVVDRDTLPTLESSERIKKVETQNRNTKVVIYFDYLDRREVCPTLHAYKTVKVTKHRPVAVVMYD 1390
            |....|::|.   ||.:||||.:  ..|:.:|.|:::..:.|..:...:..||:..|...|.:.|
  Rat  1324 FTATSDSIPL---SEILKKVEYE--PGKLNLYLDHVNETQFCVKIPTVRDFKVSNIRDGLVSIVD 1383

  Fly  1391 YYDSARRA-RQFYRAPKSNICDICEHANCGDLCEKAEKRESKRPDDYTAIAGHSSGSRHTAIPLA 1454
            ||:.:|:| |.:....|.:.|.:....||....::|  .:|.|         |||
  Rat  1384 YYEPSRQAVRSYNTQMKLSSCYLSADPNCRSYMDRA--TDSLR---------HSS---------- 1427

  Fly  1455 SVVMVLSMLL 1464
            |::::.|.||
  Rat  1428 SLLVLCSTLL 1437

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tep3	NP_523507.2	A2M_N	124..215	CDD:280081	36/90 (40%)
		A2M_N_2	448..573	CDD:285005	34/132 (26%)
		A2M	697..787	CDD:278630	28/89 (31%)
		A2M_2	918..1203	CDD:239227	106/291 (36%)
		A2M_comp	967..1200	CDD:284982	82/239 (34%)
		A2M_recep	1313..1402	CDD:284981	30/89 (34%)
Cd109	NP_001102241.2	YfaS	<122..>1019	CDD:225248	270/990 (27%)
		A2M_N_2	470..601	CDD:400170	36/140 (26%)
		A2M	695..784	CDD:395153	28/88 (32%)
		A2M_2	909..1195	CDD:239227	106/294 (36%)
		A2M_recep	1311..1395	CDD:400149	30/88 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166343855
Domainoid	1	1.000	229	1.000	Domainoid score	I2388
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H25183
Inparanoid	1	1.050	570	1.000	Inparanoid score	I1022
OMA	1	1.010	-	-		QHG45959
OrthoDB	1	1.010	-	-		D177369at33208
OrthoFinder	1	1.000	-	-		FOG0002157
OrthoInspector	1	1.000	-	-		otm44434
orthoMCL	1	0.900	-	-		OOG6_100452
Panther	1	1.100	-	-	O	PTHR11412
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2582
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.910