Protein Alignment Tep3 and A2ml1

DIOPT Version :10

• Sequence 1: NP_523507.2
• Gene: Tep3 / 34045
• FlyBaseID: FBgn0041181
• Length: 1469
• Species: Drosophila melanogaster
• Sequence 2: NP_001418713.1
• Gene: A2ml1 / 362442
• RGDID: 1565709
• Length: 1458
• Species: Rattus norvegicus
• Alignment Length: 1414
• Identity: 328/1414 - (23%)
• Similarity: 576/1414 - (40%)
• Gaps: 219/1414 - (15%)

  Fly   119 SKQHTVLVQTDKSIYKPGDLVHYRVLILDANLKPARGYGRVHVD-------IKDSGDNIIRSYKD 176
            ::::...||||..::||||.||:||:.|:..|||        ||       :::...|:|..:.:
  Rat   116 AEENATFVQTDTPVHKPGDTVHFRVVTLNTWLKP--------VDELYPLITVQNPQGNVIFQWIN 172

  Fly   177 IRLTNSIYSNELRLSDSPRFGTWSIVVDVSDQEHTQTFEILDH------ILPKFVVDIDTPKHAI 235
            :....:|.....:|:..|..|.:.||:     :......::||      :||:|.|::..|:...
  Rat   173 VTTFRNITQLSFQLTPEPVLGDYMIVI-----KKQSGMTVVDHFTVNQDVLPRFEVELTAPETIT 232

  Fly   236 YKDGKIAATVRAHYAFGQPIVGEATLSIYPTFF--GSLQPFVNDLITRKVVPI-DGNAYFEFDIE 297
            ..|.:....:.|.|.:|||:.|:|.:.:....|  |..:...|::..:..:.: ||.|.:..:.:
  Rat   233 IADNQFPVVMCAKYIYGQPVRGKAQIKVCRELFSPGYCESNENEICEQFTLQLKDGCASYIVNTK 297

  Fly   298 NELHLKQDYERQYLLDALVEEKSTGSVQ---NYSTVLTLHLNHYRVEAVKVPSYYIPGVPFEATA 359
            .....:........::.::.|..|| ||   .:|..:|..|.....|  .:.|:|..|:|:..|.
  Rat   298 VFQLYRSGLFMTLNINGVITESGTG-VQISKTHSVFITSVLGTVSFE--NMDSFYRRGIPYFGTL 359

  Fly   360 RIAR-------NDGGQLRDFNPQITAYLTNVYGSSEMYNRTAYSLDASGEIKMKFTVPIG----- 412
            :.:.       |...||......:..|.|:..|.::....|:...:|...:|..:..|..
  Rat   360 KFSGPNNTPMVNKLLQLELDGKPLGNYTTDEKGEAQFSINTSEIFEAQMSLKATYVRPRSCHRSS 424

  Fly   413 -----------DRDEFHSIIVDYQGVISEVGKIPSKH------LHSKNYITAKVLNDRPTVNQEI 460
                       ....|:|....:..:|.|...:|...      |:|.|          |.|.:|.
  Rat   425 WLDPEYLDAYFSASRFYSQTSSFMKIILEPKPLPCDQEKMVSVLYSLN----------PEVYKEA 479

  Fly   461 SVVVRSFAPIKYFMYQVVGRGDIILSRNVDV----APGTFHTIKFLASFAMMPRANLLVYTV-ID 520
            |.|.        |.|.|:.||.|:||...:|    ..|.| :...:.:..:.|.|:|.|||: ..
  Rat   480 SKVT--------FFYLVMVRGSILLSGQTEVKVQAQNGNF-SFPIIVTADLAPAADLFVYTLHPS 535

  Fly   521 GEFVYDEQVIQLEENLLNAVQVD-APIRAPPGQDIDIGISTKPYSYVGLMLVDQNANDLRSGHDL 584
            ||.|.|...:|.|:...|.|.:. :..:..||.:..:.:...|.|:..|..||::|..|..|.::
  Rat   536 GEIVADSVKLQTEKCFKNKVSIKFSKEQDLPGSNTSLHLQAAPGSFCALRAVDKSALLLNHGQEM 600

  Fly   585 THKRLMDAL----------RSYELSDVNTPMGSPGKESGVITMSNTDYFIEKEAES--------- 630
            |.:.:.:.|          ....|.|.......|.|:    ...|..|:  |...:
  Rat   601 TPESVYNMLPYVHQYGYFYNGLNLDDERADPCIPQKD----LFHNGLYY--KPTSNVWDGDLSNL 659

  Fly   631 --NPAL---------DREVSTGPEEDKLTTVRKTDIGPAHKIEVNTLPPGKG---RYAFSYTPKP 681
              |.||         ..||.:..|...|.   :|...|..:|.:.....|.|   ..||...|..
  Rat   660 VRNMALKIFTNIRYRKPEVCSSQENQPLL---RTFNDPNERIMMYGGGGGGGAPAASAFHDAPDS 721

  Fly   682 FWHNP---RVHVMRDPADTWLFLNISASSDGRNSIHRRIPSEMTSWVVSAFALDPVNGLGLSPPN 743
            ..|..   :..|..:...|||:..||..|.|..::...:|..:|.|..|.|.::...|.|:| |.
  Rat   722 ISHAKVAIKETVRTNFPKTWLWNLISVDSSGSTNVSFLVPDTITQWQASTFCVNGNAGFGIS-PK 785

  Fly   744 GKLEAYKEFYISTELPYSIKRDELIAIPFVVHNNRDSDLNVEVTFYNSALDFDFPQLDPKATNQP 808
            ..|:..:.|::....|:|:.|.|...:...|.|.|.:.:.:.|            ||:.....:.
  Rat   786 VSLQISQPFFMEVTSPFSVVRSEQSDLIVTVFNYRTTCVEISV------------QLEASENYEA 838

  Fly   809 KVELYRRRSLQV-PGRSARSVSFIVTPKRVGPLLVKAMAASSQAG---------------DTVEQ 857
            .:........:| |....::..:.||||.:|.:.:..:|.|.|:.               |||.:
  Rat   839 SINTQSNTDSEVLPAGEQKTYVWTVTPKTLGKVNITVVATSKQSSACPNDAHEEQDVNWKDTVVK 903

  Fly   858 NLLVEHPGAMERINRGFLFELNSNAQNRRNVTIAVPRNAIPESTRIEVSAVGDLIGSLVGNLDSL 922
            .||||..|..:...:.||. .....:..:.:|:.:|.:.:..|.|..|:.|||::|..:.||:||
  Rat   904 TLLVEPEGIEKESTQSFLI-CPKGTKASKQITLELPNDVVEGSARSFVTFVGDILGVAMQNLESL 967

  Fly   923 ILLPTGCGEQTMVNFVPNLIVLRYLGRLRQLTPEVELRATNNLAIGYQRILYYRHENGAFSAFGL 987
            :..|.|||||.:.....::.:|.||...:|||.||..:|...|:.|||:.|.:::.:|::..|..
  Rat   968 LQTPYGCGEQNIAQLAADIYILDYLNATKQLTEEVRSKALLLLSKGYQKHLSFKNYDGSYDVFCH 1032

  Fly   988 DIKRSSTWLTAYVARSLRQAAPFTQVDSNVLQKALTYLGSVQSANGGFEERGDVF----ERFGDD 1048
            :.:..|.||:|...::..:...:..::..|.::.|.:|...|.:||.|.:..::.    |...:|
  Rat  1033 NNQEGSVWLSALSFKTFEKMKEYIFIEETVPKQTLIWLVKKQKSNGCFRKNENLVNNAQEDSDED 1097

  Fly  1049 GISLTAFVTLALMENVDLYPEYRNNINKALDFITRGL--------DGSSNLHAMAIGTYVLSRAN 1105
            .|:|||:|..|.:|         ..:|.:...:..||        ...::.|..||..||.:.|.
  Rat  1098 DIALTAYVVGAFLE---------GGLNSSFPALRNGLYCLEEAFSSSVTDDHTQAIMAYVFTLAG 1153

  Fly  1106 HNAKA-AFLQRLDSMATNKDGLKWWNK-TAPAGEQQSPWYNATRSVNIEISAYAALALLENNL-- 1166
            ...:. :.|..||..||..:.:.:|.| ..|..:....:..:..|...|.:.|..||:|..:.
  Rat  1154 KQQQVKSLLPILDRSATKTNNMIYWEKDEKPKADSSPSFIPSALSGETEKTCYVLLAVLSQDTPD 1218

  Fly  1167 VGDALPVLNWLMDQRNPKGGFVASQDTVVGLQALLMFAE-RFSSQGNNLQIGFHYGEGAETIINV 1230
            :..|..::.||..:.|..|||.|.|||.|.|.||..:.: ..|:..|.:.:.   .|.:|.:.::
  Rat  1219 LDYASKIVQWLAQRMNSHGGFSAVQDTTVCLLALTRYMKLTGSNPQNTITLS---TEESEEVFHI 1280

  Fly  1231 NAENSLALQTVELPNNLKNLSVSATGRGMALAQVSYTYNTNVTSAWPRFVLDPTVNRNSHADYLH 1295
            |.:|.|.:|..::....:..:|...|.|.:..|.:..||..:......|.|.....:::.:|.|.
  Rat  1281 NRDNRLLVQHSKVSEGHRRYTVDVEGDGCSFTQATLRYNVPLPKEASGFSLSVKTRKSNSSDELQ 1345

  Fly  1296 LSACASF-----VSVVGENEQRSNMAVMEVHLPSGFVVDRDTLPTLESSERIK----KVETQNRN 1351
                ..|     ::..|.:|. |...:::|.:.|||.      |...|.|.:|    .::|..:|
  Rat  1346 ----TKFDLMVTLTYTGAHES-SGTVLVDVRMLSGFT------PVFSSIEELKFNGQAMKTDIKN 1399

  Fly  1352 TKVVIYFDYLDRREVCPTLHAYKTVKVTKHRPVAVVMYDY------YDS 1394
            ..|:.|...:.:.....|....:|..|...:|..|.::.|      :||
  Rat  1400 GHVLFYLKNVPKAATSFTFSIEQTNLVVNIQPAPVTVHSYEKDEYAFDS 1448

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tep3	NP_523507.2	YfaS	<128..1399	CDD:441940	326/1405 (23%)
		A2M_2	918..1203	CDD:239227	84/300 (28%)
A2ml1	NP_001418713.1	A2M_2	960..1255	CDD:239227	84/303 (28%)
		A2M_recep	1361..1450	CDD:462226	22/95 (23%)
		YfaS	<122..1379	CDD:441940	312/1337 (23%)