DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tep3 and A2ml1

DIOPT Version :9

Sequence 1:	NP_523507.2	Gene:	Tep3 / 34045	FlyBaseID:	FBgn0041181	Length:	1469	Species:	Drosophila melanogaster
Sequence 2:	XP_038964772.1	Gene:	A2ml1 / 362442	RGDID:	1565709	Length:	1458	Species:	Rattus norvegicus

Alignment Length:	1414	Identity:	328/1414 - (23%)
Similarity:	576/1414 - (40%)	Gaps:	219/1414 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   119 SKQHTVLVQTDKSIYKPGDLVHYRVLILDANLKPARGYGRVHVD-------IKDSGDNIIRSYKD 176
            ::::...||||..::||||.||:||:.|:..|||        ||       :::...|:|..:.:
  Rat   116 AEENATFVQTDTPVHKPGDTVHFRVVTLNTWLKP--------VDELYPLITVQNPQGNVIFQWIN 172

  Fly   177 IRLTNSIYSNELRLSDSPRFGTWSIVVDVSDQEHTQTFEILDH------ILPKFVVDIDTPKHAI 235
            :....:|.....:|:..|..|.:.||:     :......::||      :||:|.|::..|:...
  Rat   173 VTTFRNITQLSFQLTPEPVLGDYMIVI-----KKQSGMTVVDHFTVNQDVLPRFEVELTAPETIT 232

  Fly   236 YKDGKIAATVRAHYAFGQPIVGEATLSIYPTFF--GSLQPFVNDLITRKVVPI-DGNAYFEFDIE 297
            ..|.:....:.|.|.:|||:.|:|.:.:....|  |..:...|::..:..:.: ||.|.:..:.:
  Rat   233 IADNQFPVVMCAKYIYGQPVRGKAQIKVCRELFSPGYCESNENEICEQFTLQLKDGCASYIVNTK 297

  Fly   298 NELHLKQDYERQYLLDALVEEKSTGSVQ---NYSTVLTLHLNHYRVEAVKVPSYYIPGVPFEATA 359
            .....:........::.::.|..|| ||   .:|..:|..|.....|  .:.|:|..|:|:..|.
  Rat   298 VFQLYRSGLFMTLNINGVITESGTG-VQISKTHSVFITSVLGTVSFE--NMDSFYRRGIPYFGTL 359

  Fly   360 RIAR-------NDGGQLRDFNPQITAYLTNVYGSSEMYNRTAYSLDASGEIKMKFTVPIG----- 412
            :.:.       |...||......:..|.|:..|.::....|:...:|...:|..:..|..
  Rat   360 KFSGPNNTPMVNKLLQLELDGKPLGNYTTDEKGEAQFSINTSEIFEAQMSLKATYVRPRSCHRSS 424

  Fly   413 -----------DRDEFHSIIVDYQGVISEVGKIPSKH------LHSKNYITAKVLNDRPTVNQEI 460
                       ....|:|....:..:|.|...:|...      |:|.|          |.|.:|.
  Rat   425 WLDPEYLDAYFSASRFYSQTSSFMKIILEPKPLPCDQEKMVSVLYSLN----------PEVYKEA 479

  Fly   461 SVVVRSFAPIKYFMYQVVGRGDIILSRNVDV----APGTFHTIKFLASFAMMPRANLLVYTV-ID 520
            |.|.        |.|.|:.||.|:||...:|    ..|.| :...:.:..:.|.|:|.|||: ..
  Rat   480 SKVT--------FFYLVMVRGSILLSGQTEVKVQAQNGNF-SFPIIVTADLAPAADLFVYTLHPS 535

  Fly   521 GEFVYDEQVIQLEENLLNAVQVD-APIRAPPGQDIDIGISTKPYSYVGLMLVDQNANDLRSGHDL 584
            ||.|.|...:|.|:...|.|.:. :..:..||.:..:.:...|.|:..|..||::|..|..|.::
  Rat   536 GEIVADSVKLQTEKCFKNKVSIKFSKEQDLPGSNTSLHLQAAPGSFCALRAVDKSALLLNHGQEM 600

  Fly   585 THKRLMDAL----------RSYELSDVNTPMGSPGKESGVITMSNTDYFIEKEAES--------- 630
            |.:.:.:.|          ....|.|.......|.|:    ...|..|:  |...:
  Rat   601 TPESVYNMLPYVHQYGYFYNGLNLDDERADPCIPQKD----LFHNGLYY--KPTSNVWDGDLSNL 659

  Fly   631 --NPAL---------DREVSTGPEEDKLTTVRKTDIGPAHKIEVNTLPPGKG---RYAFSYTPKP 681
              |.||         ..||.:..|...|.   :|...|..:|.:.....|.|   ..||...|..
  Rat   660 VRNMALKIFTNIRYRKPEVCSSQENQPLL---RTFNDPNERIMMYGGGGGGGAPAASAFHDAPDS 721

  Fly   682 FWHNP---RVHVMRDPADTWLFLNISASSDGRNSIHRRIPSEMTSWVVSAFALDPVNGLGLSPPN 743
            ..|..   :..|..:...|||:..||..|.|..::...:|..:|.|..|.|.::...|.|:| |.
  Rat   722 ISHAKVAIKETVRTNFPKTWLWNLISVDSSGSTNVSFLVPDTITQWQASTFCVNGNAGFGIS-PK 785

  Fly   744 GKLEAYKEFYISTELPYSIKRDELIAIPFVVHNNRDSDLNVEVTFYNSALDFDFPQLDPKATNQP 808
            ..|:..:.|::....|:|:.|.|...:...|.|.|.:.:.:.|            ||:.....:.
  Rat   786 VSLQISQPFFMEVTSPFSVVRSEQSDLIVTVFNYRTTCVEISV------------QLEASENYEA 838

  Fly   809 KVELYRRRSLQV-PGRSARSVSFIVTPKRVGPLLVKAMAASSQAG---------------DTVEQ 857
            .:........:| |....::..:.||||.:|.:.:..:|.|.|:.               |||.:
  Rat   839 SINTQSNTDSEVLPAGEQKTYVWTVTPKTLGKVNITVVATSKQSSACPNDAHEEQDVNWKDTVVK 903

  Fly   858 NLLVEHPGAMERINRGFLFELNSNAQNRRNVTIAVPRNAIPESTRIEVSAVGDLIGSLVGNLDSL 922
            .||||..|..:...:.||. .....:..:.:|:.:|.:.:..|.|..|:.|||::|..:.||:||
  Rat   904 TLLVEPEGIEKESTQSFLI-CPKGTKASKQITLELPNDVVEGSARSFVTFVGDILGVAMQNLESL 967

  Fly   923 ILLPTGCGEQTMVNFVPNLIVLRYLGRLRQLTPEVELRATNNLAIGYQRILYYRHENGAFSAFGL 987
            :..|.|||||.:.....::.:|.||...:|||.||..:|...|:.|||:.|.:::.:|::..|..
  Rat   968 LQTPYGCGEQNIAQLAADIYILDYLNATKQLTEEVRSKALLLLSKGYQKHLSFKNYDGSYDVFCH 1032

  Fly   988 DIKRSSTWLTAYVARSLRQAAPFTQVDSNVLQKALTYLGSVQSANGGFEERGDVF----ERFGDD 1048
            :.:..|.||:|...::..:...:..::..|.::.|.:|...|.:||.|.:..::.    |...:|
  Rat  1033 NNQEGSVWLSALSFKTFEKMKEYIFIEETVPKQTLIWLVKKQKSNGCFRKNENLVNNAQEDSDED 1097

  Fly  1049 GISLTAFVTLALMENVDLYPEYRNNINKALDFITRGL--------DGSSNLHAMAIGTYVLSRAN 1105
            .|:|||:|..|.:|         ..:|.:...:..||        ...::.|..||..||.:.|.
  Rat  1098 DIALTAYVVGAFLE---------GGLNSSFPALRNGLYCLEEAFSSSVTDDHTQAIMAYVFTLAG 1153

  Fly  1106 HNAKA-AFLQRLDSMATNKDGLKWWNK-TAPAGEQQSPWYNATRSVNIEISAYAALALLENNL-- 1166
            ...:. :.|..||..||..:.:.:|.| ..|..:....:..:..|...|.:.|..||:|..:.
  Rat  1154 KQQQVKSLLPILDRSATKTNNMIYWEKDEKPKADSSPSFIPSALSGETEKTCYVLLAVLSQDTPD 1218

  Fly  1167 VGDALPVLNWLMDQRNPKGGFVASQDTVVGLQALLMFAE-RFSSQGNNLQIGFHYGEGAETIINV 1230
            :..|..::.||..:.|..|||.|.|||.|.|.||..:.: ..|:..|.:.:.   .|.:|.:.::
  Rat  1219 LDYASKIVQWLAQRMNSHGGFSAVQDTTVCLLALTRYMKLTGSNPQNTITLS---TEESEEVFHI 1280

  Fly  1231 NAENSLALQTVELPNNLKNLSVSATGRGMALAQVSYTYNTNVTSAWPRFVLDPTVNRNSHADYLH 1295
            |.:|.|.:|..::....:..:|...|.|.:..|.:..||..:......|.|.....:::.:|.|.
  Rat  1281 NRDNRLLVQHSKVSEGHRRYTVDVEGDGCSFTQATLRYNVPLPKEASGFSLSVKTRKSNSSDELQ 1345

  Fly  1296 LSACASF-----VSVVGENEQRSNMAVMEVHLPSGFVVDRDTLPTLESSERIK----KVETQNRN 1351
                ..|     ::..|.:|. |...:::|.:.|||.      |...|.|.:|    .::|..:|
  Rat  1346 ----TKFDLMVTLTYTGAHES-SGTVLVDVRMLSGFT------PVFSSIEELKFNGQAMKTDIKN 1399

  Fly  1352 TKVVIYFDYLDRREVCPTLHAYKTVKVTKHRPVAVVMYDY------YDS 1394
            ..|:.|...:.:.....|....:|..|...:|..|.::.|      :||
  Rat  1400 GHVLFYLKNVPKAATSFTFSIEQTNLVVNIQPAPVTVHSYEKDEYAFDS 1448

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tep3	NP_523507.2	A2M_N	124..215	CDD:280081	26/97 (27%)
		A2M_N_2	448..573	CDD:285005	36/130 (28%)
		A2M	697..787	CDD:278630	25/89 (28%)
		A2M_2	918..1203	CDD:239227	84/300 (28%)
		A2M_comp	967..1200	CDD:284982	62/248 (25%)
		A2M_recep	1313..1402	CDD:284981	21/92 (23%)
A2ml1	XP_038964772.1	A2M_N	122..204	CDD:396416	26/94 (28%)
		MG3	217..303	CDD:407663	19/85 (22%)
		MG4	340..434	CDD:407661	16/95 (17%)
		A2M_N_2	448..594	CDD:400170	44/164 (27%)
		A2M	740..830	CDD:395153	26/102 (25%)
		A2M_2	960..1255	CDD:239227	84/303 (28%)
		A2M_recep	1363..1449	CDD:400149	21/92 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166343863
Domainoid	1	1.000	64	1.000	Domainoid score	I9862
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D177369at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100452
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.750