Protein Alignment Tep3 and Tep4

DIOPT Version :10

• Sequence 1: NP_523507.2
• Gene: Tep3 / 34045
• FlyBaseID: FBgn0041181
• Length: 1469
• Species: Drosophila melanogaster
• Sequence 2: NP_001260590.1
• Gene: Tep4 / 35248
• FlyBaseID: FBgn0041180
• Length: 1498
• Species: Drosophila melanogaster
• Alignment Length: 1545
• Identity: 489/1545 - (31%)
• Similarity: 773/1545 - (50%)
• Gaps: 172/1545 - (11%)

  Fly     3 LQGADMGAIPVLILVTACLLCQT----SAQGLYSIIAPNTLRPNSQFHVAVSLHNAPESATFKVG 63
            ::.||..|:.:.:::.   |.||    .|:|.|:|:.|.|:..:..::|||::|...|..|.|||
  Fly     1 MRRADAFAVSLCVILA---LLQTMEPVKAEGKYTIVGPGTIHSHRDYNVAVAVHQTKEPVTLKVG 62

  Fly    64 ILGSSYTDFKTVELRPFST-QLLHFEIPALRTDRYRLTAEGLGGVQFTNETQLHFESKQHTVLVQ 127
            |.|.||...:||||..... :.:.|::|.|....|.|||||:.|::|.|.|:|::|:.:..:.:|
  Fly    63 ITGPSYNKTETVELATAGEFKQITFKLPPLEAGEYNLTAEGVKGLEFKNSTKLNWENFKPYIKIQ 127

  Fly   128 TDKSIYKPGDLVHYRVLILDANLKPARGYGRVHVDIKDSGDNIIRSYKDIRLTNSIYSNELRLSD 192
            |||..|||||.::|||:.||.||:|......|.|..:||..|.|:..|.|:.|..:|:.:..||:
  Fly   128 TDKGKYKPGDTINYRVIFLDENLRPDTAKDEVVVWFEDSKRNRIKQEKHIKTTGGVYTGKFELSE 192

  Fly   193 SPRFGTWSIVVDVSDQEH------------------------TQTFEILDHILPKFVVDIDTPKH 233
            ....|:||:.|...||.|                        ...||:..::|||:.|.:|..:.
  Fly   193 FATLGSWSLHVQNGDQHHDGGIYFGGRKQFGGFGHRWHRSDELVNFEVEKYVLPKYSVKMDATQQ 257

  Fly   234 AIYKDGKIAATVRAHYAFGQPIVGEATLSIYPTFFGSLQPFVNDLITRKVVPID----------- 287
            ...:||:....::|:|.:|:|:.|:..::::   ..|...:.|  :..|.|..|
  Fly   258 VSVRDGEFNVVLKANYTYGKPVNGKVLVNVH---LDSTSSWEN--VDGKTVQTDYPGHSVVGTAD 317

  Fly   288 ---GNAYFEFDIEN-ELHLKQDYERQYL-LDALVEEKSTGSVQNYSTVLTLHLNHYRVEAVKVPS 347
               |.|....|::: ..:|.......|. :.|.|||..||...|.:..:.|:...|.:......|
  Fly   318 MVGGKAKLTMDLKDFASYLPHKTSSSYAQITATVEEDFTGVKLNETGGVQLYPYRYEMSCTDYSS 382

  Fly   348 YYI--PGVPFEATARIARNDGGQLRDFNPQITAYLTNVYGSSEMYNRTAYS-------------- 396
            .:.  |....|...:|...||..:.|....:.|..|.  |....|...|:.
  Fly   383 CFSFKPDKEHELNFKITYVDGSLITDTKSVVKAKFTE--GIRRNYAFYAFGTDHQEPELPTIEKK 445

  Fly   397 -------LDASGEIKMKFTVP----IGDRDEFHSIIVDYQGVISEVGKI--------------PS 436
                   |:|||....|..:|    |.:...::||.:::   :.|...:              ||
  Fly   446 TFVFESHLNASGVAPFKVVLPDLPDIANFTRYYSIELEF---VDEKRDLYTTYPYREPKQIENPS 507

  Fly   437 KHLHSKNYITAKVLNDRP------TVNQEISVVVRSFAPIKYFMYQVVGRGDIILSRNVDVA-PG 494
            .. ..|.:..|:|  .||      .:.||..|::.|..|:|||:|.:||||:|:.::.||:| |.
  Fly   508 SE-EEKEWFRAEV--QRPKDVWNLKIGQEYQVILNSSRPLKYFVYNIVGRGNILETKRVDLAEPQ 569

  Fly   495 TFHTIKFLASFAMMPRANLLVYTVID-GEFVYDEQVIQLEENLLNAVQVDAPIRAPPGQDIDIGI 558
            |...:....:|...|...:..|.|.: |||.|.|:...:|..|.|.:::.||....||.|:.:.|
  Fly   570 TTVNVTIKPTFLTTPYGRVYFYYVDETGEFRYTEETFSVEVELQNQIEIKAPAEVKPGADVALEI 634

  Fly   559 STKPYSYVGLMLVDQNANDLRSGHDLTHKRLMDALRSYELSDVNTPMGS-----PGKESGVITMS 618
            .|.|.|:|||:.|||:...|.|.:||..:.....|..|   |.:||...     ||:.:||:||:
  Fly   635 KTSPKSFVGLLAVDQSVLLLGSNNDLNKESFNWRLNGY---DTSTPWQGGYSYYPGERTGVVTMT 696

  Fly   619 NTDYFIEKEAESNPALDREVSTGPEEDKLT--------TVRKTDIGPAHKIEVNTLPPGKGRYAF 675
            |..:|..:             |.|:.:.||        .:|||.:  ||...|.....|....|.
  Fly   697 NAYFFYNR-------------TAPDYNILTEGFGGSSFAMRKTTV--AHDSHVFHSGAGGPTQAV 746

  Fly   676 SYTPKPFWHNPRVHVMRDPADTWLFLNISASSDGRNSIHRRIPSEMTSWVVSAFALDPVNGLGLS 740
            .::.:....:....|.::.|:||:|.:|.::.:......:.||..:|:|||:.|:|.|..|||::
  Fly   747 GFSAESASASAAPVVRKNFAETWIFADIESTEEEVFKWVKTIPDTITNWVVTGFSLHPQKGLGVT 811

  Fly   741 PPNGKLEAYKEFYISTELPYSIKRDELIAIPFVVHNNRDSDLNVEVTFYNSALDFDFPQLDPKAT 805
            .....::.::.|::|..||||:||.|:|.:|.:|.|.....|:||:|..|...::||..    |:
  Fly   812 NDQTNIKTFQPFFVSVRLPYSVKRGEVINVPALVFNYLPKTLDVELTLDNEDQEYDFVD----AS 872

  Fly   806 NQPKVELYRRRSLQVPGRSARSVSFIVTPKRVGPLLVKAMAASSQAGDTVEQNLLVEHPGAMERI 870
            |:...:..|.::::|....|...||::.||.:|.:|:|..|.|..|||.:.:.|.|...|..:..
  Fly   873 NEVIGDQKRTQNIRVGANEAAGASFLIRPKVIGNILLKFKAISPLAGDAIHKPLKVVPEGITQYQ 937

  Fly   871 NRGFLFELNSNAQNRRNVTIAVPRNAIPESTRIEVSAVGDLIGSLVGNLDSLILLPTGCGEQTMV 935
            ||.|...|....:.:....:.||.:.:|:|.|:|...||||:|.:|.||::|:.||:|||||||.
  Fly   938 NRAFFINLKDTGEFKNTFELEVPEDVVPDSERVEFGLVGDLLGPVVKNLENLLRLPSGCGEQTMS 1002

  Fly   936 NFVPNLIVLRYLGRLRQLTPEVELRATNNLAIGYQRILYYRHENGAFSAFGL-------DIKRSS 993
            ..|||.:|..||..:::|||.::.|...||..|||.:|:|||::|:||:||.       .::..|
  Fly  1003 KLVPNYLVRDYLKSIKKLTPALDTRIKRNLQDGYQHMLHYRHDDGSFSSFGPTKWRQEDPVRNGS 1067

  Fly   994 TWLTAYVARSLRQAAPFTQVDSNVLQKALTYLGSVQSANGGFEERGDVFERFGDDGISLTAFVTL 1058
            |||||||.||..:......:|..:|.|...:|.:.|:.||.|.|.|:.|.......::|||...|
  Fly  1068 TWLTAYVLRSFSKIKDIIDLDEQILAKGYEFLLTRQAENGSFTEHGEYFYSSQRSLLTLTANSLL 1132

  Fly  1059 ALMENVDLYPEYRNN---INKALDFITRGLDGSSNLHAMAIGTYVLSRANHNAKAAFLQRLDSMA 1120
            ||:|      |.:.|   |:||:.:::.....|..|...:|..|.|.:|.....|..:..|.|:|
  Fly  1133 ALLE------EEKPNQAAIDKAVAYLSANTAESIELLPKSIAIYALQKAKAPEAAKQVASLKSLA 1191

  Fly  1121 TNKDGLKWWNKTAP---AGEQQSPWYNATRSVNIEISAYAALALLENN--LVGDALPVLNWLMDQ 1180
            .::|...||.:...   |.:....|:....|.::||::||.|:||:::  .....|..:.||:.|
  Fly  1192 KHEDDRTWWTEDLDKLRASKNCGRWWCWIWSQDVEITSYALLSLLDSDQETADSVLNTVRWLIAQ 1256

  Fly  1181 RNPKGGFVASQDTVVGLQALLMFAERFSSQGNNLQIGF-HYGEGAET-IINVNAENSLALQTVEL 1243
            ||..|||.:||||||||.||:.|||:...:....::.. :.|:..:| .:|.:.||.|.|||||.
  Fly  1257 RNGFGGFASSQDTVVGLTALIKFAEKSGYEAAKWEVTVSNKGKREKTEKLNTSEENDLLLQTVEF 1321

  Fly  1244 PNNLKNLSVSATGRGMALAQVSYTYNTNVTSAWPRFVLDPTVNRNSHADYLHLSACASFVSVVGE 1308
            |...|:|...|.|.|.|:.|:||.||.......|.|.:..||...|....|.||.|..:|. .||
  Fly  1322 PQGTKSLEFEAKGTGAAMVQISYQYNLVEKEPKPSFKIQTTVLPESSPANLELSVCVDYVE-EGE 1385

  Fly  1309 NEQRSNMAVMEVHLPSGFVVDRDTLPTLESSERIKKVETQNRNTKVVIYFDYLDR-REVCPTLHA 1372
            ::: ||||::||.||||:..|.|:...:.:.||::.|||:|.::.|||||:.|.: .|.|..:.|
  Fly  1386 SKE-SNMAILEVSLPSGYTADEDSFADIRNIERVRLVETKNGDSVVVIYFENLAKNEEKCIRIEA 1449

  Fly  1373 YKTVKVTKHRPVAVVMYDYYDSARRARQFYRAPKSNICDICEHANCGDLC 1422
            |:|..|...:|.:||:|||||:.::|.::| :.||.:|||||..:|...|
  Fly  1450 YRTHAVANQKPSSVVLYDYYDTNKKATEYY-SIKSKLCDICEGDDCKSKC 1498

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tep3	NP_523507.2	YfaS	<128..1399	CDD:441940	433/1390 (31%)
		A2M_2	918..1203	CDD:239227	111/299 (37%)
Tep4	NP_001260590.1	YfaS	<76..1411	CDD:441940	424/1377 (31%)
		A2M_2	982..1279	CDD:239227	112/302 (37%)
		A2M_recep	1387..1480	CDD:462226	40/94 (43%)