DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tep3 and c3a.1

DIOPT Version :9

Sequence 1:	NP_523507.2	Gene:	Tep3 / 34045	FlyBaseID:	FBgn0041181	Length:	1469	Species:	Drosophila melanogaster
Sequence 2:	NP_571317.1	Gene:	c3a.1 / 321046	ZFINID:	ZDB-GENE-990415-35	Length:	1643	Species:	Danio rerio

Alignment Length:	1611	Identity:	375/1611 - (23%)
Similarity:	652/1611 - (40%)	Gaps:	321/1611 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 ILVTACLLCQTSAQGLYSIIAPNTLRPNSQ--------------FHVAVSLHNAPES----ATFK 61
            :|:::.||  |....||.:.|||.||..|.              |.|.:::.|.|:.    .|..
Zfish    10 VLLSSALL--TLCDPLYVLSAPNLLRVGSSENVFVEAQDYSKNAFEVKITVKNHPKKDKQILTKS 72

  Fly    62 VGILGSS----YTDFKTVELR------PFSTQLLHFEIPALRTDRYRLTAEGLGGVQFTNETQLH 116
            |.:...:    .||.|..:.:      |...|.::.:  |:..|.   |.|.:        ..|.
Zfish    73 VNLNAQNNFQILTDIKIPDDQNLFSDDPLEKQYVYLQ--AIFPDH---TLEKV--------VLLS 124

  Fly   117 FESKQHTVLVQTDKSIYKPGDLVHYRVLILDANLKPARGYGRVHVDIKDSGDNIIRSYKDIRLTN 181
            |:|..  :.|||||.||.|...|.||.|.|..||||....| :.|:|.:. .||..|...:....
Zfish   125 FQSGY--IFVQTDKPIYTPSSTVQYRTLSLTPNLKPLSQTG-ITVEIMNP-QNITVSSDKVYPVK 185

  Fly   182 SIYSNELRLSDSPRFGTWSIV---VDVSDQEHTQTFEILDHILPKFVVDIDTPKHAIY-KDGKIA 242
            .:.|.:..:.:....|.|.:|   .:...:..|..||:.:::||.|.|.:...|...| .|..:.
Zfish   186 GMKSGKYAIPEVASLGIWKVVTRFANTPQKTFTAEFEVKEYVLPTFEVKLQPSKLFYYVGDESLT 250

  Fly   243 ATVRAHYAFGQPIVGEATLSIYPTFFGSLQPFVNDLIT---RKVVPIDGNAYFEFDIENELHLKQ 304
            ..:.|.|.||:.:.|.|.:     .||.:.......||   :|:..:.|....|.       .||
Zfish   251 VDIEAKYLFGKQVEGNAFV-----MFGVMDGETKTGITGSLQKIQILKGVGTAEL-------TKQ 303

  Fly   305 DYERQYLLDALV-----------EEKSTGSVQNYSTVLTLHLNHYRVEAVKVPSYYIPGVPFEAT 358
            ..|....:|.||           .|..:..|:.....:.:..:.|.:...|...::.||:||:.:
Zfish   304 MIETYKSIDKLVGQSIYVSVSLLTESGSEMVEAERRGIRIVTSPYTINFKKTAQFFKPGMPFDVS 368

  Fly   359 ARIARND----GGQLRDFNPQITAYLTNVYGSSEMYNRTAYSLDASGEI-KMKFTVPIGDRDEFH 418
            ..:...|    ...:.:.||      ..|.|.::.......:::..|.: ..:.|....|.|
Zfish   369 IYVTNPDETPAQNVIVEVNP------GGVRGQTKANGIAKVTVNTQGNVLTQEITAQTKDPD--- 424

  Fly   419 SIIVDYQGVISEVGKIPSKHLH-----SKNYITAKV------LNDRPTVN-----------QEIS 461
              |.|.:..:.::    :.|.:     ||||:...:      :.|:..||           |:.:
Zfish   425 --ITDEEQAVKKM----TAHAYVPKGGSKNYLHIGIDAAELEIGDQMKVNLNTGQSPGVKDQDYT 483

  Fly   462 VVVRSFAPI-KYFMYQVVGRGDIILSRNV--DVAPGTFHTIKFLASFAMMPRANLLVYTVIDGEF 523
            .::.|...| |...::..|:..|.||:.|  ::.|    :.:|:|           .|.|...|.
Zfish   484 FMILSKGQIVKIDRFKRQGQALITLSQPVTKEMVP----SFRFVA-----------YYHVGANEV 533

  Fly   524 VYDEQVIQLEENLLNAVQVDAPIRA---PPGQDIDIGISTKPYSYVGLMLVDQNANDLRSGHDLT 585
            |.|...:.:::..:..:::....:.   ..|:::.:.||..|.:.|||::||:..:.|.... ||
Zfish   534 VSDSVWVDVKDTCMGKLKLQVKNKQNNYNTGEEVKLQISGDPGARVGLVVVDKAVHVLNKNR-LT 597

  Fly   586 HKRLMDALRSYELSDVNTPMGSPGKESGVI----------TMSNTDYFIEKEAESNPALDREVST 640
            ..::.|.:   |..|.....|......||.          |...||..:..|....|...|..:
Zfish   598 QTKIWDVI---EKHDTGCTAGGGRDVMGVFSDAGLMFESNTAGGTDTRLNPECPDPPKRRRRRT- 658

  Fly   641 GPEEDKLTTVRKTDIGPAHKIEVNTLPPGKGRYAFSYT--------------PKPFWH-----NP 686
              |.:.|.|:..|..|.....:......|.......||              .|.|.|     ..
Zfish   659 --ESENLRTITATLAGQYADGQRQCCIDGMKDNKLGYTCERRATYIGDGPECVKAFLHCCDEMKK 721

  Fly   687 RVHVMRDP---------------------------ADTWLFLNISASSDGRNSIHRR---IPSEM 721
            |.::..:.                           .::||:..|....:...|...:   :...:
Zfish   722 RKNIKTEEEEMILARSDDDDDYYTDSEEIVSRTQFPESWLWEEIDLCDNCPASAMEKAMYLKDSI 786

  Fly   722 TSWVVSAFALDPVNGLGLSPPNGKLEAYKEFYISTELPYSIKRDELIAIPFVVHNNRDSDLNVEV 786
            |:|.|.|.::.|..|:.::.|. ::..:|..:|..::|||..|.|.:.|..::||.......|.|
Zfish   787 TTWQVLAVSMSPTLGICVAEPE-EIVVFKSLFIDLKMPYSAVRGEQLEIKAIIHNYTPDKRKVRV 850

  Fly   787 TFYNSALDFDFPQLDPKATNQPKVELYRRRSLQVPGRSARSVSFIVTPKRVGPLLVKAMAASSQA 851
            .|..||   |...|   |:.:.|.    |.::.:|..|:.||.:::.|..:|..:::..||:..|
Zfish   851 EFMESA---DVCSL---ASKKGKY----RTTVTIPKESSLSVPYVIIPMTLGNHMIEVKAAAYDA 905

  Fly   852 --GDTVEQNLLVEHPGAMERINRGFLF-------ELN--SNAQNRRNVTIAVPRNAIPES-TRIE 904
              .|.|.:.|.|        ::.|.||       |||  .|..:...|...:|.:.:|.: ....
Zfish   906 VYTDGVRKGLKV--------VSEGVLFPLQRPNVELNPVKNGDSPIIVRADIPADRVPGTPAHTH 962

  Fly   905 VSAVGDLI---------GSLVGNLDSLILLPTGCGEQTMVNFVPNLIVLRYLGRLRQ---LTPEV 957
            :|..|:.|         ||.:|   .||:.|.|||||.|:.....:|...||....|   :..:.
Zfish   963 ISITGEEISQTVEQAISGSFMG---QLIVQPHGCGEQNMIFMTLPVIATHYLDSTNQWEAIGMKR 1024

  Fly   958 ELRATNNLAIGYQRILYYRHENGAFSAFGLDIKRSSTWLTAYVARSLRQAAPFTQVDSNVLQKAL 1022
            ...|..::..||.|...||..:|:::|: :| :.||||||||||:....|.....::..||..||
Zfish  1025 RDEAIGHIKTGYNRQQAYRKPDGSYAAW-ID-RPSSTWLTAYVAKIFAMANDLITIEEQVLCSAL 1087

  Fly  1023 TYLG-SVQSANGGFEER---------GDVFERFGDDGISLTAFVTLALMENVDL-------YPEY 1070
            .:|. :.|..:|.|||:         |||..|  |...|||||||:|:.|..:|       .||
Zfish  1088 KWLVLNRQLPDGSFEEKAAVVHGEMVGDVQGR--DAEASLTAFVTIAMQEGRELCGAIVGSLPE- 1149

  Fly  1071 RNNINKALDFITRGLDGSSNLHAMAIGTYVLSRANHNAKAAFLQRLDSMATNKDGLKWWNKTAPA 1135
              :|.||:.|:...|:..:|.:|:|:.:|.::.|:...||..::    .:|..:...:||  .|
Zfish  1150 --SIRKAVSFLEGKLNKLTNPYAVALTSYAMAGADKLNKAVLMK----FSTKGEAGTYWN--VP- 1205

  Fly  1136 GEQQSPWYNATRSVNIEISAYAALALL---ENNLVGDALPVLNWLMDQRNPKGGFVASQDTVVGL 1197
            |:|    |: ||    |.::||.|||:   :.|..|:|   ::||..|....||...:|.|::..
Zfish  1206 GQQ----YH-TR----EATSYAVLALVKARDFNAAGEA---VHWLGSQHYSYGGSGTTQATIMVF 1258

  Fly  1198 QALLMFAERF-SSQGNNLQIGFHY-GEGAETIINVNAENSLALQTVELPNNLKNLSVSATGRGMA 1260
            ||:..:..:. .||..||::.... |....:...:..:|....::.::..| |:.:|:|.|.|.|
Zfish  1259 QAVAEYRTQVKDSQNFNLEVELAVEGRSKPSRYTIKRDNRHVSRSDKVDIN-KDFNVTAKGTGKA 1322

  Fly  1261 -LAQVSYTYNTNVTSAWPRFVLDPTVNRNSHADYLHLSACASFVSVVG----ENEQRSNMAVMEV 1320
             |:.::..|...|.......:.|.:|..:...:..|..|..:|...:.    ..:..:.|.::::
Zfish  1323 TLSVLTLYYARPVEKKSDCTLFDLSVKIDKDPETKHADAIETFKLTMDFFYKNPKSPATMTILDI 1387

  Fly  1321 HLPSGFVVDRDTLPTLESS-----ERIKKVETQNRNTKVVIYFDYLDRRE---VCPTLHAYKTVK 1377
            .:|:||.|:.:.|..|...     |:.:..:..:....:::|...:..:|   :...:|  |.:.
Zfish  1388 GIPTGFTVEYNDLEELTRGKEKYLEKFEMDKALSDRGSLILYLKMVSNKESERIAFRMH--KMLN 1450

  Fly  1378 VTKHRPVAVVMYDYYD-SARRARQFYRAPKSNICDICEHANCGDLCEKAEK 1427
            |...:|.||.:|:||. :||..:.|:...:..|..:|:    ||:|:.||:
Zfish  1451 VGLLQPAAVTIYEYYSPNARCTKYFHPEREGVIYRLCK----GDMCQCAEE 1497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tep3	NP_523507.2	A2M_N	124..215	CDD:280081	28/93 (30%)
		A2M_N_2	448..573	CDD:285005	28/147 (19%)
		A2M	697..787	CDD:278630	22/92 (24%)
		A2M_2	918..1203	CDD:239227	99/307 (32%)
		A2M_comp	967..1200	CDD:284982	84/252 (33%)
		A2M_recep	1313..1402	CDD:284981	21/97 (22%)
c3a.1	NP_571317.1	A2M_N	129..223	CDD:280081	29/97 (30%)
		A2M_N_2	452..588	CDD:285005	29/150 (19%)
		ANATO	666..735	CDD:237984	9/68 (13%)
		A2M	759..851	CDD:278630	22/92 (24%)
		complement_C3_C4_C5	979..1264	CDD:239226	102/313 (33%)
		A2M_comp	1034..1264	CDD:284982	85/255 (33%)
		A2M_recep	1380..1475	CDD:284981	21/96 (22%)
		NTR_complement_C3	1494..1641	CDD:239638	2/4 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170584205
Domainoid	1	1.000	56	1.000	Domainoid score	I10957
eggNOG	1	0.900	-	-		E1_COG2373
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11412
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	6	5.800