Protein Alignment Tep3 and c3a.2

DIOPT Version :9

• Sequence 1: NP_523507.2
• Gene: Tep3 / 34045
• FlyBaseID: FBgn0041181
• Length: 1469
• Species: Drosophila melanogaster
• Sequence 2: NP_571318.1
• Gene: c3a.2 / 30491
• ZFINID: ZDB-GENE-990415-36
• Length: 1651
• Species: Danio rerio
• Alignment Length: 1628
• Identity: 381/1628 - (23%)
• Similarity: 664/1628 - (40%)
• Gaps: 328/1628 - (20%)

  Fly    15 ILVTACLLCQTSAQGLYSIIAPNTLRPNSQFHVAVSLHN-APESATFKVGILGSSYTDF----KT 74
            :|:::.||  |....||.::|||.||..|..:|.|...: :.|....|:.:......:.    ||
Zfish    11 VLLSSALL--TLCDPLYVLMAPNLLRVGSSENVFVEAQDYSGEPLRVKISVKNFPAKNVEMMQKT 73

  Fly    75 VELRPFSTQLL-HFEIPALRT-------DRYRLTAEGLGGVQFTNETQLHFESKQHTVLVQTDKS 131
            |.|.....|:| ..|||..:.       .:|.........|.......:.|:|..  :.|||||.
Zfish    74 VTLTGEKYQILTDIEIPDDKNFFSDDEKKQYVYLQAHFPSVTLEKVVMVSFQSGY--LFVQTDKP 136

  Fly   132 IYKPGDLVHYRVLILDANLKPARGYGRVHVDIKDS-----GDNIIRSYKDIRLTNSIYSNELRLS 191
            ||.||..|.||:..:..||||....| :.|||.:.     ..:.|::.|.::  :|||:    :.
Zfish   137 IYTPGSNVQYRIFSMTPNLKPLSQPG-ITVDIMNPQGITVASDAIKAEKGVK--SSIYN----IP 194

  Fly   192 DSPRFGTWSIVVDVSD---QEHTQTFEILDHILPKFVVDIDTPKHAIY----------KDGKIAA 243
            |....|.|.:|...::   :..|..||:.:::||.|.|.: ||....|          ::..:..
Zfish   195 DVTSLGMWKVVTRYTNTPLKTFTAEFEVKEYVLPTFEVKL-TPSSFFYYVGDNKQENDEEDSLTV 258

  Fly   244 TVRAHYAFGQPIVGEATLSIYPTFFGSLQ-PFVNDLITRKVVPIDGNAYFEFDIE---------N 298
            .:.|.|.||:.:.|.|.: ::....|:.: ..||.|  :||..::|....|...|         .
Zfish   259 DIEAKYLFGKKMDGNAFV-VFGVMDGAAKTSIVNSL--QKVPVVNGVGTAELTREMITKTFKNIK 320

  Fly   299 ELHLKQDYERQYLL----DALVEEKSTGSVQNYSTVLTLHLNHYRVEAVKVPSYYIPGVPFEATA 359
            :|..|..|....||    ..:||.:..| :|..::..|:   ||:    :...::.||:|...:.
Zfish   321 DLVGKSIYVSVNLLTESGSEMVEAEKRG-IQIVTSPYTI---HYK----RTSQFFKPGMPLGVSV 377

  Fly   360 RIARNDGGQLRDFNPQITAYLTNVYGSSEMYNRTAYSLDASGEIKMKFTVPIG----------DR 414
            .:...|....:|...::.     |.|...:..:|.    .:|..|:|...|.|          ..
Zfish   378 YVTNPDETPAKDVEVEVL-----VDGKGGVSGKTR----DNGIAKVKVNTPGGASTLKITAKTKN 433

  Fly   415 DEFHSIIVDYQGVISEVGK-IPSKHLHSKNYITAKV------LNDRPTVN-----------QEIS 461
            .|:.|   :.|.|.:...: ..:|| .||||:...:      :.|:.|||           |:
Zfish   434 TEYTS---EQQAVKTMTAQAYKTKH-DSKNYLHINIESAEFEIGDQMTVNLITGQSSGDRDQD-- 492

  Fly   462 VVVRSFAPIKYFMYQVVGRGDIILSRNVDVAPGTFHTIKFLASFAMMPRANLLV-YTVIDGEFVY 525
                       :.|.::.:|.|:|:........|..|:....:..|:|....:. |.|...|.|.
Zfish   493 -----------YTYMILSKGQIVLAERFKRQGQTLVTLSLTITKEMVPSFRFVAYYHVGKDEVVS 546

  Fly   526 DEQVIQLEENLLNAVQVDAPIRA---PPGQDIDIGISTKPYSYVGLMLVDQNANDLRSGHDLTHK 587
            |...:.:::..:..:.|:...:.   ..|.|:::.|:..|.:.|||::||:....|.... ||..
Zfish   547 DSVWVDVKDTCMGKLNVEVKEKKNTYETGNDVNLHITGDPGARVGLVVVDKAVQVLNKNR-LTQS 610

  Fly   588 RLMDALRSYELSDVNTPMGSPGKES-GVITMSNTDYFIEKEAESNPALDREVSTGPE-------- 643
            ::.|.:..::....    |..||:| ||.:.:...:      |||.|...:..|.||
Zfish   611 KVWDVIEKHDTGCT----GGGGKDSMGVFSDAGLIF------ESNTAGGTDTRTVPECPAPLKRK 665

  Fly   644 --EDKLTTVRKTDIGP-AHKIEVNTLP---PGKGRYAFSYT--------------PKPFWH---- 684
              .:.|.|:..|..|. ..||.    |   .|.......||              .|.|.|
Zfish   666 RRSESLQTITTTLAGQYTEKIR----PCCYDGMRNNRIGYTCERRASYVIDGEECVKAFLHCCKE 726

  Fly   685 ----------NPRVHVMRDPAD-------------------TWLF----LNISASSDGRNSIHRR 716
                      ...:.:.|...|                   :||:    |....|...::.: ..
Zfish   727 VKNHKEKETEEEELILARSDEDEEGDYKDYDDITSRTQFPESWLWEEFDLCDKCSKPSKDKV-IY 790

  Fly   717 IPSEMTSWVVSAFALDPVNGLGLSPPNGKLEAYKEFYISTELPYSIKRDELIAIPFVVHNNRDSD 781
            :...:|:|.:.|.:|.|.:|:.::.|. ::..:|.|:|..::|||..|.|.:.|..::||.....
Zfish   791 LKDSITTWQILAISLSPTHGICVAEPE-EIVVFKSFFIDLKVPYSAVRGEQVEIKAIIHNYTPKH 854

  Fly   782 L-NVEVTFYNSALDFDFPQLDPKATNQPKVELYRRRSLQVPGRSARSVSFIVTPKRVGPLLVKAM 845
            | .|.|.|..:|      .:...|:.:.|.    |.::.|...|:.:|||::.|..:....::..
Zfish   855 LKKVRVEFLETA------GVCSAASKKGKY----RTTVNVDKDSSVAVSFVIVPMTLESQHIEVK 909

  Fly   846 AASSQAGDTVEQNLLVEHPGAMERINRGFLFELNSNAQNRRNVTI--AVPRNAIPESTRIE--VS 906
            |:.|...|.|.:.|.|...|.:.:. |....|||...:..:.:.:  .:|.:.:| .|.:.  ::
Zfish   910 ASISDYEDGVRKTLKVVSEGVLTKF-RTEKLELNPGKKGEKPLVLRSGIPADQVP-GTPVNSYIT 972

  Fly   907 AVGDLI---------GSLVGNLDSLILLPTGCGEQTMVNFVPNLIVLRYLGRLRQLT-PEVELR- 960
            ..|:.|         ||.:|   .||:.|.|||||.||......|...||....|.. ..::.|
Zfish   973 VTGEEISQSIEQAINGSFMG---ELIIQPHGCGEQNMVTMTLPFIATHYLDNTNQWEYVGIDRRK 1034

  Fly   961 -ATNNLAIGYQRILYYRHENGAFSAFGLDIKR-SSTWLTAYVARSLRQAAPFTQVDSNVLQKALT 1023
             |.|::..||:..|.:|.::|:::   |.|:. ||||||||||:....|:....::.||:..||.
Zfish  1035 VAINHIKTGYEGQLKFRKQDGSYA---LWIETDSSTWLTAYVAKVFAMASKLIAIEENVICSALK 1096

  Fly  1024 YL-GSVQSANGGFEERGDVFER---FGDDG----ISLTAFVTLALMENVDL----YPEYRNNINK 1076
            :| ...|..:|.|:|...|:.|   .|.:|    :||||||.:|:.|..::    ......:|.|
Zfish  1097 WLVMHKQLPDGSFKEDKPVYHREIMGGIEGQNTDVSLTAFVLIAMQEGKEICGGAVGSLHESIRK 1161

  Fly  1077 ALDFITRGLDGSSNLHAMAIGTYVLSRANHNAKAAFLQRLDSMATNKDGLKWWNKTAPAGEQQSP 1141
            ::.|:...|...:|.:|.|:.:|.|:.|:...|...::.   .....|| ::||  .|.....|
Zfish  1162 SVAFLKNQLTKLTNPYAAALTSYALANADSLDKEILMKH---STKGNDG-RFWN--VPGWHYHS- 1219

  Fly  1142 WYNATRSVNIEISAYAALALLENNLVGDALPVLNWLMDQRNPKGGFVASQDTVVGLQALLMFAER 1206
                     ||.:|||.|||::......|...::||..|::..||:..:|.|::..||:   ||
Zfish  1220 ---------IEATAYAVLALVKAKDYDTAGEAVHWLAKQKSSHGGYDTTQVTIMVFQAV---AE- 1271

  Fly  1207 FSSQGNNLQIGFHYGEGAETII---------NVNAENSLALQTVELPNNLKNLSVSATGRGMALA 1262
            :.:|..:|:   ::....|.::         .:...|....::..:..| |:.:|.|.|.|.|:.
Zfish  1272 YRAQVQDLK---NFDLNVELVVPGRRKTDRWTIQRSNVHLTRSGSVDMN-KDFTVIAKGTGSAIL 1332

  Fly  1263 QVSYTY-------NTNVTSAWPRFVLD--PTVNRNSHADYLHLSACASFV-SVVGENEQR-SNMA 1316
            .|...|       .|:.|.......||  |.....::..|       :|: ....:|:.. :.|.
Zfish  1333 SVLTLYYARPFEKKTDCTFFDLSVKLDKIPETKPGTNGTY-------NFILDFFYKNKTNDATMT 1390

  Fly  1317 VMEVHLPSGFVVDRDTLPTLESS-----ERIKKVETQNRNTKVVIYFDYLDRREVCPTL--HAYK 1374
            ::::.||:||.:|...|..|.:.     ::.:|.:..:....::||.:.:..:| ..||  ..:|
Zfish  1391 ILDIGLPTGFDIDEADLKQLSTGKERYIQKYEKNKVLSERGSLIIYLNKVSHKE-SETLVFRMHK 1454

  Fly  1375 TVKVTKHRPVAVVMYDYYDSARRARQF----------YRAPKSNICDICEHANCGDLCEKAEKRE 1429
            |..|...:|.:|.:|:||....|.:::          ||..|.::| :|...|| ...:|.:..|
Zfish  1455 TFNVGLLQPASVTIYEYYSPDARCKKYYHPEREDSALYRLCKGDLC-VCAEENC-SYQKKNQVNE 1517

  Fly  1430 SKR 1432
            |.|
Zfish  1518 SDR 1520

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tep3	NP_523507.2	A2M_N	124..215	CDD:280081	30/98 (31%)
		A2M_N_2	448..573	CDD:285005	27/145 (19%)
		A2M	697..787	CDD:278630	24/94 (26%)
		A2M_2	918..1203	CDD:239227	91/300 (30%)
		A2M_comp	967..1200	CDD:284982	73/245 (30%)
		A2M_recep	1313..1402	CDD:284981	23/105 (22%)
c3a.2	NP_571318.1	A2M_N	128..222	CDD:280081	31/102 (30%)
		EMA	388..>469	CDD:280624	19/93 (20%)
		A2M_N_2	463..599	CDD:285005	28/148 (19%)
		ANATO	674..729	CDD:237984	11/58 (19%)
		A2M	768..861	CDD:278630	24/94 (26%)
		complement_C3_C4_C5	987..1272	CDD:239226	96/310 (31%)
		A2M_comp	1042..1272	CDD:284982	76/252 (30%)
		A2M_recep	1387..1482	CDD:284981	23/95 (24%)
		NTR_complement_C3	1502..1649	CDD:239638	7/20 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170584181
Domainoid	1	1.000	56	1.000	Domainoid score	I10957
eggNOG	1	0.900	-	-		E1_COG2373
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11412
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	6	5.800