Protein Alignment Tep3 and Mug6

DIOPT Version :10

• Sequence 1: NP_523507.2
• Gene: Tep3 / 34045
• FlyBaseID: FBgn0041181
• Length: 1469
• Species: Drosophila melanogaster
• Sequence 2: XP_038963368.1
• Gene: Mug6 / 297572
• RGDID: 1566313
• Length: 1493
• Species: Rattus norvegicus
• Alignment Length: 1558
• Identity: 396/1558 - (25%)
• Similarity: 665/1558 - (42%)
• Gaps: 250/1558 - (16%)

  Fly    14 LILVTACLLCQTSA---QGLYSIIAPNTLRPNSQFHVAVSLHNAPESATFKVGILGSSYT----D 71
            |..|...||...|:   ...|.::.|:.|..::...:.:.|::..|:.|....::....|    |
  Rat    11 LFSVLLALLPSASSFNGNSKYMVLVPSQLYTDTPEKICLHLYHLNETVTVTASLISQRGTRKLFD 75

  Fly    72 FKTVELRPFSTQLLHFEIPAL----RTDRYRLTAEGLGGVQFTNETQLHFESKQHTVLVQTDKSI 132
            ...|:...|  ..|.|.||.|    ..:...:..|| ...:|:....:..::|:..|.|||||.:
  Rat    76 ELVVDKDLF--HCLSFTIPRLPSSEEEESLDINIEG-AKHKFSKRRVVLVKNKESVVFVQTDKPV 137

  Fly   133 YKPGDLVHYRVLILDANLKPAR-----GYGRVHVDIKDSGDNIIRSYKDIRLTNSIYSNELRLSD 192
            ||||..|.:|::.:|.||.|..     .|      |:|...|.|..::||:..|.:......||.
  Rat   138 YKPGQSVKFRIVSMDKNLHPLNELFPLAY------IEDPKINRIMQWQDIKTENGLKQLSFSLSA 196

  Fly   193 SPRFGTWSIVV-DVSDQEHTQTFEILDHILPKFVVDIDTPKHAIYKDGKIAATVRAHYAFGQPIV 256
            .|..|.:.||: ..|..:...:|.:::.:||:|.||:..|......|..|:.|..|.|.:|:|:.
  Rat   197 EPIQGPYKIVILKQSGVKEEHSFTVMEFVLPRFGVDVKVPNAISVYDEIISVTACATYTYGKPVP 261

  Fly   257 GEATLSI---YPTFFGSLQPFVNDLITRKVVPIDGNAYFEFDIE-NELHLKQDY---ERQYLLDA 314
            |...:|:   .|:|....:....:    :...:|.|.....::. .|..||::|   .:.:.::|
  Rat   262 GRVKISLCHGNPSFRSQTKSACKE----EDSELDNNGCSTQEVNITEFRLKENYLKVRQAFHVNA 322

  Fly   315 LVEEKSTGSVQNYSTVLTLHLNHYRVEAVKVPSYYIPGVPFEATARIARNDGGQLRDFNPQI--- 376
            .|.|:.|||..:.|..:.:.....:...:|..|::..|:||....|:....|..:.  |.|:
  Rat   323 TVTEEGTGSEFSGSGRIEVKRTRNKFLFLKADSHFRHGIPFFVKVRLVNIKGDPIP--NQQVFIK 385

  Fly   377 --TAYLTNVYGSSEMYNRTAYSLDASGEIKMKFTVPIGDRDE----------------------F 417
              .|..||. .:::.:....:|:|.||..:....:.:..::|                      .
  Rat   386 AQGAGFTNA-TTTDQHGLAKFSIDTSGISRYILNIKVYHKEENSCIHSSCTAERHAEAHHTAYAV 449

  Fly   418 HSIIVDYQGVISEVGKIPSKHLHSKN---YITAKVLNDRPTVNQEISVVVRSFAPIKYFMYQVVG 479
            :|:...|..:.:|.|.:|....|:..   .:..:||...|.:               .|.|.|:.
  Rat   450 YSLSKSYIYLDTEAGVLPCNQSHTVQAHFILKGQVLGVLPQI---------------VFHYLVMA 499

  Fly   480 RGDIILSRN--VDVAPGTF-----HTIKFLASFAMMPRANLLVYTVI-DGEFVYDEQVIQLEENL 536
            :|.|:.:.|  ..|.||..     ..::....|:|:|.|.:|:||:: |||.:.|....|:|:.|
  Rat   500 QGSILQTGNHTHQVEPGESPVQGNFALEIPVEFSMVPMAKMLIYTILPDGEVIADSVKFQVEKCL 564

  Fly   537 LNAVQVD-APIRAPPGQDIDIGISTKPYSYVGLMLVDQNANDLRSGHDLTHKRLMDALRSYELSD 600
            .:.|.:. :|.::.|.....:.::..|.|..||..|||:...|:...:|:...:.|.
  Rat   565 RHEVHLSFSPSQSLPASQTHMRVTASPQSLCGLRAVDQSVLLLKPEAELSPSLIYDL-------- 621

  Fly   601 VNTPMGSPG-KESGVITMSNTDYFIEKEAESNPALDR---------EVSTGPEEDKLTTVRKTDI 655
                   || :||..|..|:..:    |.|....:.|         .|..|.|:|....:|.|.:
  Rat   622 -------PGMQESKFIPRSHYPF----EDEDGCVIYRPRVIGKLTYSVPYGREKDVFRYMRDTGL 675

  Fly   656 GPAHKIEVNTLPPGKGRYAFSYTPKPF------------------WHNPRVHVM----------- 691
            .....:::.|       :.|.|...|.                  |.:.||..:
  Rat   676 TALTNLKLRT-------FCFDYDMVPLAVPAARSSDLFNSDGYGSWRSARVKSLPPKKAPHKDPP 733

  Fly   692 -RDPA---------DTWLFLNISASSDGRNSIHRRIPSEMTSWVVSAFALDPVNGLGLSPPNGKL 746
             :||.         :||::..::.:|.|...:...:|..:|.|...|..|....|||||.. ..|
  Rat   734 PKDPVIETIRNYFPETWVWDLVTVNSSGAAELEMTVPDTITEWKAGALCLSNDTGLGLSSV-ATL 797

  Fly   747 EAYKEFYISTELPYSIKRDELIAIPFVVHNNRDSDLNVEVTFYNSALDFDFPQLDPKATNQPKVE 811
            :|::.|::...:|||:.|.|...:...|.|...:.|.:.|....|.   ||..: |...:|...
  Rat   798 QAFQPFFVELTMPYSVIRGEAFTLKATVMNYLPTSLPMAVQLEASP---DFTAV-PVGNDQDSY- 857

  Fly   812 LYRRRSLQVPGRSARSVSFIVTPKRVGPLLVKAMAASSQA----------------GDTVEQNLL 860
                 .|...||  .:.|::||||.:|.:.....|.:.|:                .|||.:.|:
  Rat   858 -----CLGANGR--HTSSWLVTPKSLGNVNFSVSAEAQQSPEPCGSEVATVPETGRKDTVVKVLI 915

  Fly   861 VEHPGAMERINRGFLFE---LNSNAQNRRNVTIAVPRNAIPESTRIEVSAVGDLIGSLVGNLDSL 922
            ||..|    |.|...|.   ..|:|:....:::.:|...:.:|.|...|.:||::.|.:.|..:|
  Rat   916 VEPEG----IKREHTFSSLLCASDAELSETLSLLLPPTVVKDSARAHFSVMGDILSSAIKNTQNL 976

  Fly   923 ILLPTGCGEQTMVNFVPNLIVLRYLGRLRQLTPEVELRATNNLAIGYQRILYYRHENGAFSAFG- 986
            |.:|.|||||.||.|.|::.||:||...:|||.:::.:|...|..||||.|.|:|::|::||||
  Rat   977 IQMPYGCGEQNMVLFAPSIYVLKYLNETQQLTEKIKSKALGYLRAGYQRELNYKHKDGSYSAFGD 1041

  Fly   987 LDIK-RSSTWLTAYVARSLRQAAPFTQVDSNVLQKALTYLGSVQSANGGFEERGDVFE---RFG- 1046
            .|.| :.:|||||:|.:|..||..|..:|.:.:..|.|:|...|..:|.|...|.:|.   :.|
  Rat  1042 HDGKGQGNTWLTAFVLKSFSQAQAFIFIDESHITDAFTWLSHQQKDSGCFRSSGSLFNNAMKGGV 1106

  Fly  1047 DDGISLTAFVTLALMENVDLYPEYRNN-INKAL-------DFITRGLDGSSNLHAMAIGTYVLSR 1103
            ||.|:|:|::|:||:|:  |.|:..:. ::|||       :.|.:|.:||. ::..|:..|..:.
  Rat  1107 DDEITLSAYITVALLES--LPPDTEHPVVSKALSCLESSWENIEQGGNGSF-VYTKALMAYAFAL 1168

  Fly  1104 A-NHNAKAAFLQRLDSMATNKD-GLKWWNKTAPAGEQQSPWYNATRSVNIEISAYAALALLENNL 1166
            | |...:...|:.||..|..:| .:.|.....|....:|.:.....|..:|::||..||    .|
  Rat  1169 AGNQEKRNEILKSLDKEAIKEDNSIHWERPQKPMKSARSLYKPQASSAEVEMNAYVILA----RL 1229

  Fly  1167 VGDALP----------VLNWLMDQRNPKGGFVASQDTVVGLQALLMF-AERFSSQGNNLQIGFHY 1220
            ...:.|          .:.||..|:|.:|||.::|||||.|.||..: |..||.......:....
  Rat  1230 TAQSAPSPKDLALSMGTIKWLTKQQNSRGGFSSTQDTVVALDALSKYGAATFSKSQKTPSVTVQS 1294

  Fly  1221 GEGAETIINVNAENSLALQTVELPNNLKNLSVSATGRGMALAQVSYTYNTNVTSAWPRFVLDP-- 1283
            .........|:..|.|.||.|.||:...|.:||.:|.|...||....||..:....|.|.|..
  Rat  1295 SGSFFQKFQVDNSNRLLLQQVSLPDIPGNYTVSVSGEGCVYAQTMLRYNLPLEKQQPAFALKVQT 1359

  Fly  1284 ---TVNRNSHADYLHLSACASFVSVVGENEQRSNMAVMEVHLPSGFVVDRDTLPTLESSERIKKV 1345
               |.|.....:...:|...|:..    :...|||.:.:|.:.|||:..:.|:..||..|.:.:.
  Rat  1360 VPLTCNNPKGQNSFQISLEISYTG----SRPASNMVIADVKMLSGFIPLKPTVKKLERLEHVSRT 1420

  Fly  1346 ETQNRNTKVVIYFDYLDRREVCPTLHAYKTVKVTKHRPVAVVMYDYYDSARRARQFYRAPKSN 1408
            |....|  |::|.|.:..:.:..:....:.:.|...:|..|.:||||::...|...|.:|.|:
  Rat  1421 EVTTNN--VLLYLDQVTNQTLSFSFIIQQDIPVKNLQPAIVKVYDYYETDEVAFAEYSSPCSS 1481

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tep3	NP_523507.2	YfaS	<128..1399	CDD:441940	365/1422 (26%)
		A2M_2	918..1203	CDD:239227	109/310 (35%)
Mug6	XP_038963368.1	YfaS	<129..1352	CDD:441940	338/1300 (26%)
		A2M	749..839	CDD:459711	26/90 (29%)
		A2M_2	969..1276	CDD:239227	109/313 (35%)
		A2M_recep	1386..1476	CDD:462226	24/91 (26%)