DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tep3 and LOC297568

DIOPT Version :9

Sequence 1:	NP_523507.2	Gene:	Tep3 / 34045	FlyBaseID:	FBgn0041181	Length:	1469	Species:	Drosophila melanogaster
Sequence 2:	XP_038963365.1	Gene:	LOC297568 / 297568	RGDID:	1584999	Length:	1484	Species:	Rattus norvegicus

Alignment Length:	1533	Identity:	403/1533 - (26%)
Similarity:	660/1533 - (43%)	Gaps:	228/1533 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 YSIIAPNTLRPNSQFHVAVSLHNAPESATFKVGILGSSYTDFKTVELRPFSTQLLH---FEIPAL 92
            |.::.|:.|...:...:.:.|::..|:.|....::....|. |..:.......|.|   |.||.|
  Rat    31 YMVLVPSQLYTETPEKICLHLYHLNETVTVTASLISQRGTR-KLFDELVVDKDLFHCVSFTIPRL 94

  Fly    93 ----RTDRYRLTAEGLGGVQFTNETQLHFESKQHTVLVQTDKSIYKPGDLVHYRVLILDANLKPA 153
                ..:...:..|| ...:|:....:..::|:..|.|||||.:||||..|.:||:.:|.||.|.
  Rat    95 PSSEEEESLDINIEG-AKHKFSERRVVLVKNKESVVFVQTDKPMYKPGQSVKFRVVSMDKNLHPL 158

  Fly   154 R-----GYGRVHVDIKDSGDNIIRSYKDIRLTNSIYSNELRLSDSPRFGTWSIVV-DVSDQEHTQ 212
            .     .|      |:|...|.|..::|::..|.:......||..|..|.:.||: ..|..:...
  Rat   159 NELFPLAY------IEDPKMNRIMQWQDVKTENGLKQLSFSLSAEPIQGPYKIVILKQSGVKEEH 217

  Fly   213 TFEILDHILPKFVVDIDTPKHAIYKDGKIAATVRAHYAFGQPIVGEATLSI---YPTFFGSLQPF 274
            :|.:::.:||:|.||:..|......|..|..|..|.|.:|:|:.|...:|:   .|||....:..
  Rat   218 SFTVMEFVLPRFGVDVKVPNAISVYDEIINVTACATYTYGKPVPGHVKISLCHGNPTFSSETKSA 282

  Fly   275 VNDLITRKVVPIDGNAYFEFDIE-NELHLKQDY---ERQYLLDALVEEKSTGSVQNYSTVLTLHL 335
            ..:..:|    :|.|.....::. .|..||::|   .:.:.::|.|.|:.|||..:.|..:.:..
  Rat   283 CKEEDSR----LDNNGCSTQEVNITEFQLKENYLKMHQAFHVNATVTEEGTGSEFSGSGRIEVER 343

  Fly   336 NHYRVEAVKVPSYYIPGVPFEATARIARNDGGQLRDFNPQI-----TAYLTNVYGSSEMYNRTAY 395
            ...:...:|..|::..|:||....|:....|..:.  |.|:     .|..||. .:::.:....:
  Rat   344 TRNKFLFLKADSHFRHGIPFFVKVRLVDIKGDPIP--NEQVLIKARDAGYTNA-TTTDQHGLAKF 405

  Fly   396 SLDASGEIKMKFTVPIGDRDE----------------------FHSIIVDYQGVISEVGKIPSKH 438
            |:|.||.......:.:..::|                      .:|:...|..:.:|.|.:|...
  Rat   406 SIDTSGISDYSLNIKVYHKEESSCIHSSCTAERHAEAHHTAYAVYSLSKSYIYLDTEAGVLPCNQ 470

  Fly   439 LHSKN---YITAKVLNDRPTVNQEISVVVRSFAPIKYFMYQVVGRGDIILSRN--VDVAPGTFH- 497
            :|:..   .:..:||.    |.|:|           .|.|.|:.:|.|:.:.|  ..|.||...
  Rat   471 IHTVQAHFILKGQVLG----VLQQI-----------VFHYLVMAQGSILQTGNHTHQVEPGESQV 520

  Fly   498 ----TIKFLASFAMMPRANLLVYTVI-DGEFVYDEQVIQLEENLLNAVQVD-APIRAPPGQDIDI 556
                .::....|:|:|.|.:|:||:: |||.:.|....|:|:.|.|.||:. :|.::.|.....:
  Rat   521 QGNFALEIPVEFSMVPVAKMLIYTILPDGEVIADSVKFQVEKCLRNKVQLSFSPSQSLPASQTHM 585

  Fly   557 GISTKPYSYVGLMLVDQNANDLRSGHDLTHKRLMD---ALRSYELSDVNTP--------MGSP-- 608
            .::..|.|..||..|||:....:...:|:...:.|   ...|..::..|.|        |..|
  Rat   586 RVTASPQSLCGLRAVDQSVLLQKPEAELSPSLIYDLPGMQDSNFIASSNDPFEDEDYCLMYQPIA 650

  Fly   609 --------GKESGVI----------TMSNTDYFIEKEAESNPALDREVSTGPEEDKLTTVRKTDI 655
                    .:|:|::          |..||||.:...|....|||.....|..| .|..|
  Rat   651 REKDVYRYVRETGLMAFTNLKIKLPTYCNTDYDMVPLAVPAVALDSSTDRGMYE-SLPVV----- 709

  Fly   656 GPAHKIEVNTLPPGKGRYAFSYTPKPFWHNPRVHVMRD--PADTWLFLNISASSDGRNSIHRRIP 718
              |.|..:...||.|       .|.|  .:|.:..:|:  | :||::..::.:|.|...:...:|
  Rat   710 --AVKSPLPQEPPRK-------DPPP--KDPVIETIRNYFP-ETWIWDLVTVNSSGVTELEMTVP 762

  Fly   719 SEMTSWVVSAFALDPVNGLGLSPPNGKLEAYKEFYISTELPYSIKRDELIAIPFVVHNNRDSDLN 783
            ..:|.|...|..|....|||||.. ...:|::.|::...:|||:.|.|...:...|.|...:.|.
  Rat   763 DTITEWKAGALCLSNDTGLGLSSV-ASFQAFQPFFVELTMPYSVIRGEAFTLKATVLNYLPTSLP 826

  Fly   784 VEVTFYNSALDFDFPQLDPKATNQPKVELYRRRSLQVPGRSARSVSFIVTPKRVGPLLVKAMAAS 848
            :.|....|.   ||..: |...||...      .|...||  .:.|::||||.:|.:.....|.:
  Rat   827 MAVLLEASP---DFTAV-PVENNQDSY------CLGANGR--HTSSWLVTPKSLGNVNFSVSAEA 879

  Fly   849 SQA----------------GDTVEQNLLVEHPGAMERINRGFLFE---LNSNAQNRRNVTIAVPR 894
            .|:                .|||.:.|:||..|    |.:...|.   ..|:|:....:::.:|.
  Rat   880 RQSPGPCGSEVATVPETGRKDTVVKVLIVEPEG----IKKEHTFSSLLCASDAELSETLSLLLPP 940

  Fly   895 NAIPESTRIEVSAVGDLIGSLVGNLDSLILLPTGCGEQTMVNFVPNLIVLRYLGRLRQLTPEVEL 959
            ..:.:|.|...|.:||::.|.:.|..:||.:|.|||||.||.|.||:.||:||...:|||.:::.
  Rat   941 TVVKDSARAHFSVMGDILSSAIKNTQNLIQMPYGCGEQNMVLFAPNIYVLKYLNETQQLTEKIKS 1005

  Fly   960 RATNNLAIGYQRILYYRHENGAFSAFGLDIK---RSSTWLTAYVARSLRQAAPFTQVDSNVLQKA 1021
            :|...|..||||.|.|:|::|::|||| |..   :.:|||||:|.:|..||..|..:|.:.:..|
  Rat  1006 KALGYLRAGYQRELNYKHKDGSYSAFG-DHNGQGQGNTWLTAFVLKSFAQARAFIFIDESHITDA 1069

  Fly  1022 LTYLGSVQSANGGFEERGDVFE---RFG-DDGISLTAFVTLALMENVDLYPEYRNNINKAL---- 1078
            .|:|...|..:|.|...|.:..   :.| ||.|:|:|::|:||:|:  ..|:....::|||
  Rat  1070 FTWLSKQQKDSGCFRSSGSLLNNAMKGGVDDEITLSAYITMALLES--SLPDTDPVVSKALSCLE 1132

  Fly  1079 ---DFITRGLDGSSNLHAMAIGTYVLSRA-NHNAKAAFLQRLDSMATNKDGLKWWNKTAPAGEQQ 1139
               :.|.:|.:||. ::..|:..|..:.| |...:...|:.||..|..:|....|.:  |....:
  Rat  1133 SSWENIEQGGNGSF-VYTKALMAYAFALAGNQEKRNEILKSLDKEAIKEDNSIHWER--PQKPTK 1194

  Fly  1140 SPWYNAT---RSVNIEISAYAALALLENNLVGDALP----------VLNWLMDQRNPKGGFVASQ 1191
            |..|..|   .|..:|:|||..||    .|.....|          .:.||..|:|..|||.::|
  Rat  1195 SEGYLYTPQASSAEVEMSAYVVLA----RLTAQPAPSPEDLALSMGTIKWLTKQQNSYGGFSSTQ 1255

  Fly  1192 DTVVGLQALLMF-AERFSSQGNNLQIGFHYGEGAETIINVNAENSLALQTVELPNNLKNLSVSAT 1255
            ||||.|.||..: |..||.......:.............|:..|.|.||.|.||....|.:||.:
  Rat  1256 DTVVALDALSKYGAATFSKSQKTPSVTVQSSGSFSQKFQVDKSNRLLLQQVSLPYIPGNYTVSVS 1320

  Fly  1256 GRGMALAQVSYTYNTNVTSAWPRFVLDP-----TVNRNSHADYLHLSACASFVSVVGENEQRSNM 1315
            |.|...||.:..||..:....|.|.|..     |.|.....:...:|...|:..    :...|||
  Rat  1321 GEGCVYAQTTLRYNVPLEKQQPAFALKVQTVPLTCNNPKGQNSFQISLEISYTG----SRPASNM 1381

  Fly  1316 AVMEVHLPSGFVVDRDTLPTLESSERIKKVETQNRNTKVVIYFDYLDRREVCPTLHAYKTVKVTK 1380
            .:.:|.:.|||:..:.|:..||....:.:.|....|  |::|.|.:..:.:..:....:.:.|..
  Rat  1382 VIADVKMLSGFIPLKPTVKKLERLGHVSRTEVTTNN--VLLYLDQVTNQTLSFSFIIQQDIPVKN 1444

  Fly  1381 HRPVAVVMYDYYDSARRARQFYRAPKSN--ICDICEHA 1416
            .:|..|.:||||::...|...|.:|.|:  ...:.|||
  Rat  1445 LQPAIVKVYDYYETDEVAFAEYSSPCSSGKHLALLEHA 1482

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tep3	NP_523507.2	A2M_N	124..215	CDD:280081	31/96 (32%)
		A2M_N_2	448..573	CDD:285005	38/133 (29%)
		A2M	697..787	CDD:278630	24/89 (27%)
		A2M_2	918..1203	CDD:239227	110/312 (35%)
		A2M_comp	967..1200	CDD:284982	85/260 (33%)
		A2M_recep	1313..1402	CDD:284981	23/88 (26%)
LOC297568	XP_038963365.1	A2M_N	129..221	CDD:396416	32/97 (33%)
		MG3	223..309	CDD:407663	23/89 (26%)
		MG4	348..443	CDD:407661	17/97 (18%)
		A2M_N_2	457..606	CDD:400170	44/163 (27%)
		A2M	741..831	CDD:395153	25/90 (28%)
		A2M_2	961..1267	CDD:239227	110/315 (35%)
		A2M_recep	1379..1466	CDD:400149	23/88 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	64	1.000	Domainoid score	I9862
eggNOG	1	0.900	-	-		E1_COG2373
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D177369at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100452
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.720