DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tep3 and CPAMD8

DIOPT Version :9

Sequence 1:NP_523507.2 Gene:Tep3 / 34045 FlyBaseID:FBgn0041181 Length:1469 Species:Drosophila melanogaster
Sequence 2:XP_011526219.1 Gene:CPAMD8 / 27151 HGNCID:23228 Length:1920 Species:Homo sapiens


Alignment Length:1900 Identity:432/1900 - (22%)
Similarity:681/1900 - (35%) Gaps:620/1900 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    11 IPVLILVTAC----LLCQTSAQGLYSIIAPNTLRPNSQFHVAVSLHNAPESATFKVGILGSSYTD 71
            :|:|:|:.:.    ...|..|.| |.|.||:..|...:..::|::.|:|...|.:..::..   |
Human    57 LPLLLLLLSARDGVRAAQPQAPG-YLIAAPSVFRAGVEEVISVTIFNSPREVTVQAQLVAQ---D 117

  Fly    72 FKTVELRPFSTQLLHFEIPALRTDRYRLTAEGLG-----GVQFTNETQLHFESKQHTVLVQTDKS 131
            ..|::|:          :|.....:..|...|.|     |..|.|:|.:..:.:..:|.:||||.
Human   118 KGTIKLK----------VPTGLRGQALLKVWGRGWQAEEGPLFHNQTSVTVDGRGASVFIQTDKP 172

  Fly   132 IYKPGDLVHYRVLILDANLKPARGYGRVHVDIKDSGDNIIRSYKDIR-----LTNSIYSNELRLS 191
            :|:|...|...:..:..||:|..  .::...|.|...:.:..::.::     :||..:.    ||
Human   173 VYRPQHRVLISIFTVSPNLRPVN--EKLEAYILDPRGSRMIEWRHLKPFCCGITNMSFP----LS 231

  Fly   192 DSPRFGTWSIVVDVSDQEHTQTFEILDHILPKFVVDIDTPKHAIYKDGKIAATVRAHYAFGQPIV 256
            |.|..|.|.|.|::....:.::||:..::||||.:.||.|::....|.....||||.|.||:|:.
Human   232 DQPVLGEWFIFVEMQGHAYNKSFEVQKYVLPKFELLIDPPRYIQDLDACETGTVRARYTFGKPVA 296

  Fly   257 GEATLSIYPTFFGSLQPFVN---------------DLITRKVVP-------------------ID 287
            |...:::.....|.....|.               |:..|.::|                   :|
Human   297 GALMINMTVNGVGYYSHEVGRPVLRTTKILGSRDFDICVRDMIPADVPEHFRGRVSIWAMVTSVD 361

  Fly   288 GNAYFEFDIENELHLKQDYERQYLLDALVEEKSTGSVQNYSTVLTLHLNHYRVEAVKVPSYYIPG 352
            |:....||....:. :|..:.:|..|...:.|                               ||
Human   362 GSQQVAFDDSTPVQ-RQLVDIRYSKDTRKQFK-------------------------------PG 394

  Fly   353 VPFEATARIARNDGGQLRDFNPQITAYLT---NVYGSSEMYNRTAYSLDASGEIKMKFTVPIGDR 414
            :.:.....::..||........||.|.||   |:|.|.                           
Human   395 LAYVGKVELSYPDGSPAEGVTVQIKAELTPKDNIYTSE--------------------------- 432

  Fly   415 DEFHSIIVDYQGVIS-EVGKIPSKHLHSKNYITAKV--LNDRPT--------------------- 455
                  :|..:|::. |:..||:...|.  ::..||  ||.:|.                     
Human   433 ------VVSQRGLVGFEIPSIPTSAQHV--WLETKVMALNGKPVGAQYLPSYLSLGSWYSPSQCY 489

  Fly   456 -----------VNQEISVVVRSFAPIKYFM-YQVVGRGDIILS---------------------- 486
                       |.:|....|:|..|..:.: |:|..||:|:||                      
Human   490 LQLQPPSHPLQVGEEAYFSVKSTCPCNFTLYYEVAARGNIVLSGQQPAHTTQQRSKRAAPALEKP 554

  Fly   487 ----------------RNVDVAPGTFHTIKFLASFAMMPRANLLVYTVID-GEFVYDEQVIQLEE 534
                            ..|||...:.|   ...:.:|:|...|||:.|.: ||.|.|.....:|.
Human   555 IRLTHLSETEPPPAPEAEVDVCVTSLH---LAVTPSMVPLGRLLVFYVRENGEGVADSLQFAVET 616

  Fly   535 NLLNAVQVD-APIRAPPGQDIDIGISTKPYSYVGLMLVDQNANDLRSGHDLTHKRLMDALRSYEL 598
            ...|.|.|. :.....||:.:|:.|.....|.|.:..||::...||||..||..::...|..|::
Human   617 FFENQVSVTYSANETQPGEVVDLRIRAARGSCVCVAAVDKSVYLLRSGFRLTPAQVFQELEDYDV 681

  Fly   599 SD--------------------------------VNTPMGSPGKESGVITMSNTDYFIEKEAESN 631
            ||                                :....|....|:|::.|:             
Human   682 SDSFGVSREDGPFWWAGLTAQRRRRSSVFPWPWGITKDSGFAFTETGLVVMT------------- 733

  Fly   632 PALDREVSTGPEEDKLTTVRKTDIGPAHKIEVNTLPPGKGRYAFSYTPKPFWHNPRVHVMRDP-- 694
                         |:::...:.|.|......|....|..|...   ...|..|.||....:..  
Human   734 -------------DRVSLNHRQDGGLYTDEAVPAFQPHTGSLV---AVAPSRHPPRTEKRKRTFF 782

  Fly   695 ADTWLF--LNISASSDGRNSIHRRIPSEMTSWVVSAFALDPVNGLGLSPPNGKLEAYKEFYISTE 757
            .:||::  ||||..| |..::..::|..:||||..|.||....|||::.|: .|:.:|.|::...
Human   783 PETWIWHCLNISDPS-GEGTLSVKVPDSITSWVGEAVALSTSQGLGIAEPS-LLKTFKPFFVDFM 845

  Fly   758 LPYSIKRDELIAIPFVVHNNRDSDLNVEVTFYNSALDFDFPQLDPKATNQPKVELYRRRSLQV-- 820
            ||..|.|.|.:.||..|:|            |....                .|:|.:.|:..  
Human   846 LPALIIRGEQVKIPLSVYN------------YMGTC----------------AEVYMKLSVPKGI 882

  Fly   821 -----PGRSARSVSFIVTPKRVGPLLV--------------KAMAASSQAGDT------------ 854
                 ||:...:....|.|....|:.|              ||:|    .|||            
Human   883 QFVGHPGKRHVTKKMCVAPGEAEPIWVVLSFSDLGLNNITAKALA----YGDTNCCRDGRSSKHP 943

  Fly   855 ---------------VEQNLLVEHPGA------------MERIN----------------RGFLF 876
                           |.::::||..|.            .||::                |...|
Human   944 EENHADRRVPIGVDHVRRSVMVEAEGVPRAYTYSAFFCPSERVHISTPNKYEFQYVQRPLRLTRF 1008

  Fly   877 ELNSNAQNRRNV----------------------------------------------------- 888
            ::...|.|...|                                                     
Human  1009 DVAVRAHNDARVALSSGPQDTAGMIEIVLGGHQNTRSWISTSKMGEPVASAHTAKILSWDEFRTF 1073

  Fly   889 ----------------------------------------------------------------- 888
                                                                             
Human  1074 WISWRGGLIQVGHGPEPSNESVIVAWTLPRPPEVQFIGFSTGWGSMGEFRIWRKMEVDESYSEAF 1138

  Fly   889 TIAVPRNAIPESTRIEVSAVGDLIGSLVGNLDSLILLPTGCGEQTMVNFVPNLIVLRYLGRLRQL 953
            |:.||..|||.|.|...|.:||::|..:.:|::|:.||.|||||.|::|.||:.||:||.:.:||
Human  1139 TLGVPHGAIPGSERATASIIGDVMGPTLNHLNNLLRLPFGCGEQNMIHFAPNVFVLKYLQKTQQL 1203

  Fly   954 TPEVELRATNNLAIGYQRILYYRHENGAFSAFGLDIKRSSTWLTAYVARSLRQAAPFTQVDSNVL 1018
            :||||...|:.|..||||.|.|:.::|::||||......|.||||:|.:|..||..|..||...|
Human  1204 SPEVERETTDYLVQGYQRQLTYKRQDGSYSAFGERDASGSMWLTAFVLKSFAQARSFIFVDPREL 1268

  Fly  1019 QKALTYLGSVQSANGGFEERGDVFERFGDDGI----SLTAFVTLALMENVDLYPEYRNNINKALD 1079
            ..|.:::...|.|:|.|...|.|..:....||    .|||:|.:||:|......|.|.:.:||..
Human  1269 AAAKSWIIQQQQADGSFLAVGRVLNKDIQGGIHGTVPLTAYVVVALLETGTASEEERGSTDKARH 1333

  Fly  1080 FITRGLDGSSNLHAMAIGTYVLSRANHNAKAAFLQRLDSMATNKDGLKWWNKTAPAGEQQSPW-- 1142
            |:......:.:.::.|:.||.|:.....|....|::|.|:|..:||:..|:.:       :.|  
Human  1334 FLESAAPLAMDPYSCALTTYALTLLRSPAAPEALRKLRSLAIMRDGVTHWSLS-------NSWDV 1391

  Fly  1143 ------------YNATRSVNIEISAYAALALLENNLVGD---ALPVLNWLMDQRNPKGGFVASQD 1192
                        ..:..|..:|::||   |||...|:||   ||||:.||..|||..|||.::||
Human  1392 DKGTFLSFSDRVSQSVVSAEVEMTAY---ALLTYTLLGDVAAALPVVKWLSQQRNALGGFSSTQD 1453

  Fly  1193 TVVGLQALLMFAERFSSQGNNLQI-----GFHYGEGAETIINVNAENSLALQTVELPNNLKNLSV 1252
            |.|.||||..:|....:.|.||.:     ...|.|..|    ::..|...|||..:|:....|.|
Human  1454 TCVALQALAEYAILSYAGGINLTVSLASTNLDYQETFE----LHRTNQKVLQTAAIPSLPTGLFV 1514

  Fly  1253 SATGRGMALAQVSYTYNTNVTSAWPRFVL----------------------------------DP 1283
            ||.|.|..|.|:..|||.....|.|.|.|                                  ||
Human  1515 SAKGDGCCLMQIDVTYNVPDPVAKPAFQLLVSLQEPEAQGRPPPMPASAAEGSRGDWPPADDDDP 1579

  Fly  1284 TVNRNSHADY-LHLSACASFVSVVGENEQRSNMAVMEVHLPSGFVVDRDTLP--TLESSERIKKV 1345
            ..::: |.:| :.|..|..::     :...|||||:||.|.|||..|.::|.  .|:....:|:.
Human  1580 AADQH-HQEYKVMLEVCTRWL-----HAGSSNMAVLEVPLLSGFRADIESLEQLLLDKHMGMKRY 1638

  Fly  1346 ETQNRNTKVVIYFDYLDRR-EVCPTLHAYKTVKVTKHRPVAVVMYDYYDSARRARQFYRAPKSNI 1409
            |...|  :|:.|||.:..| ..|....|.:...|.:...:.|.:||||:.|..|.:||..  |..
Human  1639 EVAGR--RVLFYFDEIPSRCLTCVRFRALRECVVGRTSALPVSVYDYYEPAFEATRFYNV--STH 1699

  Fly  1410 CDICEHANCGDLCEKAEKRESK-------------RPDDYTAIA----GHSSGSRHTAIPLA--- 1454
            ..:......|..|.:.|:..::             .|::..|||    .|..|::..  |:.   
Human  1700 SPLARELCAGPACNEVERAPARGPGWFPGESGPAVAPEEGAAIARCGCDHDCGAQGN--PVCGSD 1762

  Fly  1455 SVVMVLSMLLKTLSC 1469
            .||...:..|:..:|
Human  1763 GVVYASACRLREAAC 1777

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Tep3NP_523507.2 A2M_N 124..215 CDD:280081 23/95 (24%)
A2M_N_2 448..573 CDD:285005 42/199 (21%)
A2M 697..787 CDD:278630 32/91 (35%)
A2M_2 918..1203 CDD:239227 113/305 (37%)
A2M_comp 967..1200 CDD:284982 86/253 (34%)
A2M_recep 1313..1402 CDD:284981 32/91 (35%)
CPAMD8XP_011526219.1 A2M_N 164..256 CDD:280081 24/97 (25%)
A2M_N_2 492..660 CDD:285005 38/170 (22%)
A2M 785..876 CDD:278630 35/120 (29%)
Methyltransf_FA 1020..1121 CDD:289052 1/100 (1%)
A2M_2 1176..1464 CDD:239227 110/297 (37%)
A2M_comp 1217..1466 CDD:284982 88/258 (34%)
A2M_recep 1604..1694 CDD:284981 32/91 (35%)
KAZAL 1747..>1779 CDD:197624 6/32 (19%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2373
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D177369at33208
OrthoFinder 1 1.000 - - FOG0002157
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.820

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