Protein Alignment Tep3 and CPAMD8

DIOPT Version :10

• Sequence 1: NP_523507.2
• Gene: Tep3 / 34045
• FlyBaseID: FBgn0041181
• Length: 1469
• Species: Drosophila melanogaster
• Sequence 2: XP_011526219.1
• Gene: CPAMD8 / 27151
• HGNCID: 23228
• Length: 1920
• Species: Homo sapiens
• Alignment Length: 1900
• Identity: 432/1900 - (22%)
• Similarity: 681/1900 - (35%)
• Gaps: 620/1900 - (32%)

  Fly    11 IPVLILVTAC----LLCQTSAQGLYSIIAPNTLRPNSQFHVAVSLHNAPESATFKVGILGSSYTD 71
            :|:|:|:.:.    ...|..|.| |.|.||:..|...:..::|::.|:|...|.:..::..   |
Human    57 LPLLLLLLSARDGVRAAQPQAPG-YLIAAPSVFRAGVEEVISVTIFNSPREVTVQAQLVAQ---D 117

  Fly    72 FKTVELRPFSTQLLHFEIPALRTDRYRLTAEGLG-----GVQFTNETQLHFESKQHTVLVQTDKS 131
            ..|::|:          :|.....:..|...|.|     |..|.|:|.:..:.:..:|.:||||.
Human   118 KGTIKLK----------VPTGLRGQALLKVWGRGWQAEEGPLFHNQTSVTVDGRGASVFIQTDKP 172

  Fly   132 IYKPGDLVHYRVLILDANLKPARGYGRVHVDIKDSGDNIIRSYKDIR-----LTNSIYSNELRLS 191
            :|:|...|...:..:..||:|..  .::...|.|...:.:..::.::     :||..:.    ||
Human   173 VYRPQHRVLISIFTVSPNLRPVN--EKLEAYILDPRGSRMIEWRHLKPFCCGITNMSFP----LS 231

  Fly   192 DSPRFGTWSIVVDVSDQEHTQTFEILDHILPKFVVDIDTPKHAIYKDGKIAATVRAHYAFGQPIV 256
            |.|..|.|.|.|::....:.::||:..::||||.:.||.|::....|.....||||.|.||:|:.
Human   232 DQPVLGEWFIFVEMQGHAYNKSFEVQKYVLPKFELLIDPPRYIQDLDACETGTVRARYTFGKPVA 296

  Fly   257 GEATLSIYPTFFGSLQPFVN---------------DLITRKVVP-------------------ID 287
            |...:::.....|.....|.               |:..|.::|                   :|
Human   297 GALMINMTVNGVGYYSHEVGRPVLRTTKILGSRDFDICVRDMIPADVPEHFRGRVSIWAMVTSVD 361

  Fly   288 GNAYFEFDIENELHLKQDYERQYLLDALVEEKSTGSVQNYSTVLTLHLNHYRVEAVKVPSYYIPG 352
            |:....||....:. :|..:.:|..|...:.|                               ||
Human   362 GSQQVAFDDSTPVQ-RQLVDIRYSKDTRKQFK-------------------------------PG 394

  Fly   353 VPFEATARIARNDGGQLRDFNPQITAYLT---NVYGSSEMYNRTAYSLDASGEIKMKFTVPIGDR 414
            :.:.....::..||........||.|.||   |:|.|.
Human   395 LAYVGKVELSYPDGSPAEGVTVQIKAELTPKDNIYTSE--------------------------- 432

  Fly   415 DEFHSIIVDYQGVIS-EVGKIPSKHLHSKNYITAKV--LNDRPT--------------------- 455
                  :|..:|::. |:..||:...|.  ::..||  ||.:|.
Human   433 ------VVSQRGLVGFEIPSIPTSAQHV--WLETKVMALNGKPVGAQYLPSYLSLGSWYSPSQCY 489

  Fly   456 -----------VNQEISVVVRSFAPIKYFM-YQVVGRGDIILS---------------------- 486
                       |.:|....|:|..|..:.: |:|..||:|:||
Human   490 LQLQPPSHPLQVGEEAYFSVKSTCPCNFTLYYEVAARGNIVLSGQQPAHTTQQRSKRAAPALEKP 554

  Fly   487 ----------------RNVDVAPGTFHTIKFLASFAMMPRANLLVYTVID-GEFVYDEQVIQLEE 534
                            ..|||...:.|   ...:.:|:|...|||:.|.: ||.|.|.....:|.
Human   555 IRLTHLSETEPPPAPEAEVDVCVTSLH---LAVTPSMVPLGRLLVFYVRENGEGVADSLQFAVET 616

  Fly   535 NLLNAVQVD-APIRAPPGQDIDIGISTKPYSYVGLMLVDQNANDLRSGHDLTHKRLMDALRSYEL 598
            ...|.|.|. :.....||:.:|:.|.....|.|.:..||::...||||..||..::...|..|::
Human   617 FFENQVSVTYSANETQPGEVVDLRIRAARGSCVCVAAVDKSVYLLRSGFRLTPAQVFQELEDYDV 681

  Fly   599 SD--------------------------------VNTPMGSPGKESGVITMSNTDYFIEKEAESN 631
            ||                                :....|....|:|::.|:
Human   682 SDSFGVSREDGPFWWAGLTAQRRRRSSVFPWPWGITKDSGFAFTETGLVVMT------------- 733

  Fly   632 PALDREVSTGPEEDKLTTVRKTDIGPAHKIEVNTLPPGKGRYAFSYTPKPFWHNPRVHVMRDP-- 694
                         |:::...:.|.|......|....|..|...   ...|..|.||....:..
Human   734 -------------DRVSLNHRQDGGLYTDEAVPAFQPHTGSLV---AVAPSRHPPRTEKRKRTFF 782

  Fly   695 ADTWLF--LNISASSDGRNSIHRRIPSEMTSWVVSAFALDPVNGLGLSPPNGKLEAYKEFYISTE 757
            .:||::  ||||..| |..::..::|..:||||..|.||....|||::.|: .|:.:|.|::...
Human   783 PETWIWHCLNISDPS-GEGTLSVKVPDSITSWVGEAVALSTSQGLGIAEPS-LLKTFKPFFVDFM 845

  Fly   758 LPYSIKRDELIAIPFVVHNNRDSDLNVEVTFYNSALDFDFPQLDPKATNQPKVELYRRRSLQV-- 820
            ||..|.|.|.:.||..|:|            |....                .|:|.:.|:..
Human   846 LPALIIRGEQVKIPLSVYN------------YMGTC----------------AEVYMKLSVPKGI 882

  Fly   821 -----PGRSARSVSFIVTPKRVGPLLV--------------KAMAASSQAGDT------------ 854
                 ||:...:....|.|....|:.|              ||:|    .|||
Human   883 QFVGHPGKRHVTKKMCVAPGEAEPIWVVLSFSDLGLNNITAKALA----YGDTNCCRDGRSSKHP 943

  Fly   855 ---------------VEQNLLVEHPGA------------MERIN----------------RGFLF 876
                           |.::::||..|.            .||::                |...|
Human   944 EENHADRRVPIGVDHVRRSVMVEAEGVPRAYTYSAFFCPSERVHISTPNKYEFQYVQRPLRLTRF 1008

  Fly   877 ELNSNAQNRRNV----------------------------------------------------- 888
            ::...|.|...|
Human  1009 DVAVRAHNDARVALSSGPQDTAGMIEIVLGGHQNTRSWISTSKMGEPVASAHTAKILSWDEFRTF 1073

  Fly   889 ----------------------------------------------------------------- 888
                                                                             
Human  1074 WISWRGGLIQVGHGPEPSNESVIVAWTLPRPPEVQFIGFSTGWGSMGEFRIWRKMEVDESYSEAF 1138

  Fly   889 TIAVPRNAIPESTRIEVSAVGDLIGSLVGNLDSLILLPTGCGEQTMVNFVPNLIVLRYLGRLRQL 953
            |:.||..|||.|.|...|.:||::|..:.:|::|:.||.|||||.|::|.||:.||:||.:.:||
Human  1139 TLGVPHGAIPGSERATASIIGDVMGPTLNHLNNLLRLPFGCGEQNMIHFAPNVFVLKYLQKTQQL 1203

  Fly   954 TPEVELRATNNLAIGYQRILYYRHENGAFSAFGLDIKRSSTWLTAYVARSLRQAAPFTQVDSNVL 1018
            :||||...|:.|..||||.|.|:.::|::||||......|.||||:|.:|..||..|..||...|
Human  1204 SPEVERETTDYLVQGYQRQLTYKRQDGSYSAFGERDASGSMWLTAFVLKSFAQARSFIFVDPREL 1268

  Fly  1019 QKALTYLGSVQSANGGFEERGDVFERFGDDGI----SLTAFVTLALMENVDLYPEYRNNINKALD 1079
            ..|.:::...|.|:|.|...|.|..:....||    .|||:|.:||:|......|.|.:.:||..
Human  1269 AAAKSWIIQQQQADGSFLAVGRVLNKDIQGGIHGTVPLTAYVVVALLETGTASEEERGSTDKARH 1333

  Fly  1080 FITRGLDGSSNLHAMAIGTYVLSRANHNAKAAFLQRLDSMATNKDGLKWWNKTAPAGEQQSPW-- 1142
            |:......:.:.::.|:.||.|:.....|....|::|.|:|..:||:..|:.:       :.|
Human  1334 FLESAAPLAMDPYSCALTTYALTLLRSPAAPEALRKLRSLAIMRDGVTHWSLS-------NSWDV 1391

  Fly  1143 ------------YNATRSVNIEISAYAALALLENNLVGD---ALPVLNWLMDQRNPKGGFVASQD 1192
                        ..:..|..:|::||   |||...|:||   ||||:.||..|||..|||.::||
Human  1392 DKGTFLSFSDRVSQSVVSAEVEMTAY---ALLTYTLLGDVAAALPVVKWLSQQRNALGGFSSTQD 1453

  Fly  1193 TVVGLQALLMFAERFSSQGNNLQI-----GFHYGEGAETIINVNAENSLALQTVELPNNLKNLSV 1252
            |.|.||||..:|....:.|.||.:     ...|.|..|    ::..|...|||..:|:....|.|
Human  1454 TCVALQALAEYAILSYAGGINLTVSLASTNLDYQETFE----LHRTNQKVLQTAAIPSLPTGLFV 1514

  Fly  1253 SATGRGMALAQVSYTYNTNVTSAWPRFVL----------------------------------DP 1283
            ||.|.|..|.|:..|||.....|.|.|.|                                  ||
Human  1515 SAKGDGCCLMQIDVTYNVPDPVAKPAFQLLVSLQEPEAQGRPPPMPASAAEGSRGDWPPADDDDP 1579

  Fly  1284 TVNRNSHADY-LHLSACASFVSVVGENEQRSNMAVMEVHLPSGFVVDRDTLP--TLESSERIKKV 1345
            ..::: |.:| :.|..|..::     :...|||||:||.|.|||..|.::|.  .|:....:|:.
Human  1580 AADQH-HQEYKVMLEVCTRWL-----HAGSSNMAVLEVPLLSGFRADIESLEQLLLDKHMGMKRY 1638

  Fly  1346 ETQNRNTKVVIYFDYLDRR-EVCPTLHAYKTVKVTKHRPVAVVMYDYYDSARRARQFYRAPKSNI 1409
            |...|  :|:.|||.:..| ..|....|.:...|.:...:.|.:||||:.|..|.:||..  |..
Human  1639 EVAGR--RVLFYFDEIPSRCLTCVRFRALRECVVGRTSALPVSVYDYYEPAFEATRFYNV--STH 1699

  Fly  1410 CDICEHANCGDLCEKAEKRESK-------------RPDDYTAIA----GHSSGSRHTAIPLA--- 1454
            ..:......|..|.:.|:..::             .|::..|||    .|..|::..  |:.
Human  1700 SPLARELCAGPACNEVERAPARGPGWFPGESGPAVAPEEGAAIARCGCDHDCGAQGN--PVCGSD 1762

  Fly  1455 SVVMVLSMLLKTLSC 1469
            .||...:..|:..:|
Human  1763 GVVYASACRLREAAC 1777

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tep3	NP_523507.2	YfaS	<128..1399	CDD:441940	386/1682 (23%)
		A2M_2	918..1203	CDD:239227	113/305 (37%)
CPAMD8	XP_011526219.1	YfaS	<158..>925	CDD:441940	182/901 (20%)
		MG2	164..256	CDD:426464	24/97 (25%)
		A2M_BRD	490..661	CDD:462235	38/173 (22%)
		A2M	785..876	CDD:459711	35/120 (29%)
		Methyltransf_FA	1020..1121	CDD:463505	1/100 (1%)
		A2M_2	1176..1464	CDD:239227	110/297 (37%)
		A2M_recep	1602..1695	CDD:462226	33/94 (35%)
		PHA03247	<1675..1879	CDD:223021	23/106 (22%)
		KAZAL	1747..>1779	CDD:197624	6/32 (19%)