Protein Alignment Tep3 and Pzp

DIOPT Version :10

• Sequence 1: NP_523507.2
• Gene: Tep3 / 34045
• FlyBaseID: FBgn0041181
• Length: 1469
• Species: Drosophila melanogaster
• Sequence 2: NP_665722.2
• Gene: Pzp / 252922
• RGDID: 628643
• Length: 1500
• Species: Rattus norvegicus
• Alignment Length: 1566
• Identity: 384/1566 - (24%)
• Similarity: 653/1566 - (41%)
• Gaps: 248/1566 - (15%)

  Fly    11 IPVLILVTACL-LCQTSAQG--LYSIIAPNTLRPNSQFHVAVSLHNAPESATFKVGI-------- 64
            |||.:|:...| ...|:|.|  .|.::.|:.|.......|.|.|::..|:.|..|.:
  Rat     8 IPVFLLLLLLLPRDATAATGKPRYVVLVPSELYAGVPEKVCVHLNHLNETVTLNVTLEYGVQYSN 72

  Fly    65 --------LGSSYTDFKTVELRPFSTQLLHFEIPALRTDRYRLTAEGLGGV-QFTNETQLHFESK 120
                    ..|||....|:. ||.|...|             :..|..|.. .|..:..:.....
  Rat    73 LLIDQAVDKDSSYCSSFTIS-RPLSPSAL-------------IAVEIKGPTHHFIKKKSMWITKA 123

  Fly   121 QHTVLVQTDKSIYKPGDLVHYRVLILDANLKPARGYGRVHVDIKDSGDNIIRSYKDIRLTNSIYS 185
            :..|.|||||.|||||..|.:||:.:|.:.:|......| |.|::...|.|..::::.|...::.
  Rat   124 ESPVFVQTDKPIYKPGQTVKFRVVSVDISFRPVNETFPV-VYIENPKRNRIFQWQNVDLPGGLHQ 187

  Fly   186 NELRLSDSPRFGTWSIVVDV-SDQEHTQTFEILDHILPKFVVDIDTPKHAIYKDGKIAATVRAHY 249
            ....||..|..|.:.:||.. |.::...:||:.:::||||.|.:..||...:.:.::..|....|
  Rat   188 LSFPLSVEPALGIYKVVVQKDSGKKIEHSFEVKEYVLPKFEVQVKMPKTMAFLEEELVVTACGLY 252

  Fly   250 AFGQPIVGEATLSI-------YPTFFGSLQPFV--------------NDLITRKVVPIDGNAYFE 293
            .:|:|:.|..|:.:       |....|.....:              ..::..||.......| :
  Rat   253 TYGKPVPGLVTMKVCRKYTQSYSNCHGQHSKSICEEFSKQADEKGCFRQVVKTKVFQPRQKGY-D 316

  Fly   294 FDIENELHLKQDYERQYLLDALVEEKSTGSVQNYSTVLTLHLNHYRVEAVKVPSYYIPGVPFEAT 358
            ..||.|..:|:|       ...:|...|||.:..:|:       .:::..|..::|.||:||...
  Rat   317 MKIEVEAKIKED-------GTGIELTGTGSCEIANTL-------SKLKFTKANTFYRPGLPFFGQ 367

  Fly   359 ARIARNDGG---------QLRDFNPQITAYLTNVYG-SSEMYNRTAYSLDASG-EIKMKFTVPIG 412
            ..:....|.         |:.....|.| :.|:.:| ::.:.:.|.::....| .:..|......
  Rat   368 VLLVDEKGQPIPNKNLTVQVNSVRSQFT-FTTDEHGLANILIDTTNFTFSFMGIRVIYKQNNICF 431

  Fly   413 DR---DEFHSIIVDYQGVISEVGKIPSKHLHSKNYITAKVLNDRPTVNQEISVVVRSF------- 467
            |.   ||:|: ..|:     ...:|.|.   |::||..:::.......|...:.:...
  Rat   432 DNWWVDEYHT-QADH-----SAARIFSP---SRSYIQLELVLGTLACGQTQEIRIHFLLNEDALK 487

  Fly   468 -APIKYFMYQVVGRGDIILSRNVDVAPGTFHTIKFLASF------AMMPRANLLVYTVI-DGEFV 524
             |....|.|.:..||.|..|.: .|.|.....:|.:.||      .|.|.|.|:|||:: :.|.:
  Rat   488 DAKDLTFYYLIKARGSIFNSGS-HVLPLEQGKVKGVVSFPIRVEPGMAPVAKLIVYTILPNEELI 551

  Fly   525 YDEQVIQLEENLLNAVQVDAP-IRAPPGQDIDIGISTKPYSYVGLMLVDQNANDLRSGHDLTHKR 588
            .|.|...:|:...|.|.:..| .::.|..|..:.:...|.|...|..|||:...|:....|:.:.
  Rat   552 ADVQKFDIEKCFANTVNLSFPSAQSLPASDTHLTVKATPLSLCALTAVDQSVLLLKPEAKLSPQS 616

  Fly   589 LMDAL-RSYELSDVNTPMGSPGKESGV----ITMSNTDYFIEKEAESNPALDREVSTGPEEDKLT 648
            :.:.| :..|......|:...|.|:.:    ||.:...|..:::...|.|.....|.|.:....|
  Rat   617 IYNLLPQKAEQGAYLGPLPYKGGENCIKAEDITHNGIVYTPKQDLNDNDAYSVFQSIGLKIFTNT 681

  Fly   649 TVRKTDIGPAHKIEVNTLPPGKGRYAFSYTPKPFWHNPRVHVM---------------------- 691
            .|.|....|.::               :|.|.|:...|:...|
  Rat   682 RVHKPRYCPMYQ---------------AYPPLPYVGEPQALAMSAIPGAGYRSSNIRTSSMMMMG 731

  Fly   692 ----------RDPA-----DTWLFLNISASSDGRNSIHRRIPSEMTSWVVSAFALDPVNGLGLSP 741
                      |:..     :||::..:.....|...:..::|..:|.|..|||.|....|||||.
  Rat   732 ASEVAQEVEVRETVRKYFPETWIWDMVPLDLSGDGELPVKVPDTITEWKASAFCLSGTTGLGLSS 796

  Fly   742 PNGKLEAYKEFYISTELPYSIKRDELIAIPFVVHNNRDSDLNVEVTFYNSALDFDFPQLDPKATN 806
            .... :.::.|::...||||:.|.|...:...|.|.....:.:.|:...|.   ||..: |..::
  Rat   797 TISH-KVFQPFFLELTLPYSVVRGEAFILKATVLNYMPHCIRIHVSLEMSP---DFLAV-PVGSH 856

  Fly   807 QPKVELYRRRSLQVPGRSARSVSFIVTPKRVGPLLVKAMAASSQA----------------GDTV 855
            :.        |..:.|...::||:.||||.:|.:...|.|.:.|:                .|||
  Rat   857 ED--------SHCICGNERKTVSWAVTPKSLGEVNFTATAEALQSPELCGNKVAEVPALVQKDTV 913

  Fly   856 EQNLLVEHPGAMERINRGFLFELNSNAQNRRNVTIAVPRNAIPESTRIEVSAVGDLIGSLVGNLD 920
            .:.::|| |..:|:...........:|:.:.|.|:.:|.|.:..|.|...|.:||::||.:.||.
  Rat   914 VKPVIVE-PEGIEKEQTYNTLLCPQDAELQENWTLDLPANVVEGSARATQSVLGDILGSAMQNLQ 977

  Fly   921 SLILLPTGCGEQTMVNFVPNLIVLRYLGRLRQLTPEVELRATNNLAIGYQRILYYRHENGAFSAF 985
            :|:.:|.|||||.||.||||:.||.||...:|||..::.:|.:.|..||||.|.|:|.:|::|.|
  Rat   978 NLLQMPYGCGEQNMVLFVPNIYVLEYLNETQQLTEAIKSKAISYLISGYQRQLNYQHSDGSYSTF 1042

  Fly   986 ---GLDIKRSSTWLTAYVARSLRQAAPFTQVDSNVLQKALTYLGSVQSANGGFEERGDVFE---R 1044
               |:...:.:|||||:|.::..||..:..::...:..|..:|...|..||.|::.|.:..   :
  Rat  1043 GDRGMRHSQGNTWLTAFVLKAFAQAQSYIYIEKTHITNAFNWLSMKQRENGCFQQSGSLLNNAMK 1107

  Fly  1045 FG-DDGISLTAFVTLALMENVDLYPEYRNNINKALDFITRGLDGSSN-----LHAMAIGTYVLSR 1103
            .| ||.::|:|::|:||:|..  .|...:.:..||..:.......||     ::..|:..|..:.
  Rat  1108 GGVDDEVTLSAYITIALLEMP--LPVTHSVVRNALFCLETAWASISNSQESHVYTKALLAYAFAL 1170

  Fly  1104 ANHNAK-AAFLQRLDSMATNKDGLKWW----NKTAPAGEQQSPWYN-ATRSVNIEISAYAALAL- 1161
            |.:.|| :..|:.|:..|.|::....|    |......|.:|..|. ...|..:|::||..||.
  Rat  1171 AGNRAKRSEVLESLNKDAVNEEESVHWQRPKNVEENVREMRSFSYKPRAPSAEVEMTAYVLLAYL 1235

  Fly  1162 ----------LENNLVGDALPVLNWLMDQRNPKGGFVASQDTVVGLQALLMF-AERFSSQGNNLQ 1215
                      |.::.:..|..::.|:..|:|..|||.::|||||.||||..: |..|:.....:.
  Rat  1236 TSASSRPTRDLSSSDLTTASKIVKWISKQQNSHGGFSSTQDTVVALQALSKYGAATFTKSNKEVS 1300

  Fly  1216 IGFHYGEGAETIINVNAENSLALQTVELPNNLKNLSVSATGRGMALAQVSYTYN--TNVTSAWPR 1278
            :...........::||..|.|.||.|.|.:...|.....:|.|....|.|..||  .......|.
  Rat  1301 VTIESSGTVSGTLHVNNGNRLLLQEVRLADLPGNYITKVSGSGCVYLQTSLKYNILPEAEGEAPF 1365

  Fly  1279 FVLDPTVNRN-----SHADY-LHLSACASFVSVVGENEQRSNMAVMEVHLPSGFVVDRDTLPTLE 1337
            .:...|:..|     .|..: :|::     ||.:|| ...|||.:::|.:.|||:..:.::..|:
  Rat  1366 TLKVNTLPLNFDKAEHHRKFQIHIN-----VSYIGE-RPNSNMVIVDVKMVSGFIPVKPSVKKLQ 1424

  Fly  1338 SSERIKKVETQNRNTKVVIYFDYLDRREVCPTLHAYKTVKVTKHRPVAVVMYDYYDSARRARQFY 1402
            ....|::.|....:  |:||.:.|..:.:..:....:.:.|...:|..|.:||||::...|.:.|
  Rat  1425 DQSNIQRTEVNTNH--VLIYIEKLTNQTMGFSFAVEQDIPVKNLKPAPVKVYDYYETDEFAIEEY 1487

  Fly  1403 RAPKSN 1408
            .||.|:
  Rat  1488 SAPFSS 1493

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tep3	NP_523507.2	YfaS	<128..1399	CDD:441940	348/1418 (25%)
		A2M_2	918..1203	CDD:239227	101/313 (32%)
Pzp	NP_665722.2	YfaS	<127..1406	CDD:441940	333/1342 (25%)
		Bait region. /evidence=ECO:0000250|UniProtKB:P01023	686..746		7/74 (9%)
		A2M_2	972..1287	CDD:239227	101/316 (32%)
		Receptor-binding domain. /evidence=ECO:0000269|PubMed:11106161	1360..1500		35/142 (25%)
		A2M_recep	1398..1488	CDD:462226	22/91 (24%)