Protein Alignment Tep3 and C4a

DIOPT Version :10

• Sequence 1: NP_523507.2
• Gene: Tep3 / 34045
• FlyBaseID: FBgn0041181
• Length: 1469
• Species: Drosophila melanogaster
• Sequence 2: NP_113692.2
• Gene: C4a / 24233
• RGDID: 620005
• Length: 1737
• Species: Rattus norvegicus
• Alignment Length: 1678
• Identity: 400/1678 - (23%)
• Similarity: 643/1678 - (38%)
• Gaps: 401/1678 - (23%)

  Fly    33 IIAPNTLRPNSQFHVAVSLHNAPESATFKVGILGSSY------------TDFKTVELRPFSTQLL 85
            :.:|:.:...:...|.|.|.:||.....|    ||.|            .|||......|  .||
  Rat    25 LFSPSVVNLGTPLSVGVQLLDAPAGQEVK----GSVYLRNPTSGPCSPKKDFKLSSGNDF--VLL 83

  Fly    86 HFEIP-----------ALRTDRYRLTAEG---LGGVQFTNETQ---LHFESKQHTVLVQTDKSIY 133
            ..|:|           ..|....:|.|..   ........|||   |.|.|::..:.||||:.||
  Rat    84 RLEVPLKDVRSCGLFGLRRAPHIQLVAHSPWLKNTASKATETQGVNLLFSSRRGHIFVQTDQPIY 148

  Fly   134 KPGDLVHYRVLILDANLKPARGYGRVHVDIKDSGDNIIRSYKDIRLTNSIYSNELRLSDSPRFGT 198
            .||..|.|||..||..::|:.  ..:.|.:::|....:|. |::....||:.::..:.|....||
  Rat   149 NPGQRVRYRVFALDQKMRPST--DTLTVTVENSHGLRVRK-KEVFAPTSIFQDDFIIPDISEPGT 210

  Fly   199 WSIVVDVSD---QEHTQTFEILDHILPKFVVDIDTPKHAI-----YKDGKIAATVRAHYAFGQPI 255
            |.|....||   ...:..||:..::||.|.|.:...|..|     |:: :|...|:|.|.:|:|:
  Rat   211 WKISARFSDGLESNRSTHFEVKKYVLPNFEVKLTPWKPYILTVPSYRE-EIQLDVQARYVYGKPV 274

  Fly   256 VGEATLSIYPTFF----GSLQPFVNDLITRKVVPIDGNAYFEFD----------IENELHLKQDY 306
            .|.|    |..|.    ...:.|:..|.|:..: ::|..:....          :..|:   .|.
  Rat   275 QGVA----YTRFALMDEQGKKSFLRGLETQTKL-VEGQTHISISRDQFQAALGKVNTEI---GDL 331

  Fly   307 E--RQYLLDALV-------EEKSTGSVQNYSTVLTLHLNHYRVEAVKVPSYYIPGVPFEATARIA 362
            |  |.|...|::       ||....|....|:..:|.|:|.:       .:.:||.||...|.:.
  Rat   332 EGLRLYAAVAVIESPGGEMEEAELTSWPFVSSAFSLDLSHTK-------QHLVPGAPFLLQALVR 389

  Fly   363 RNDGGQLRDFNPQITAYLTNVYGSSEMYNRTAYSLDASGEIKMKFTVP--IGDRDEFHSIIVDYQ 425
            ...|.:..|...:::|.|.:  ||.........:.:..|::.....||  |.:.    .::|...
  Rat   390 EMSGSEASDVPVKVSATLLS--GSDSKVLDFQQNTNGIGQVSFSIHVPPTITEL----RLLVSAG 448

  Fly   426 GVISEVGKI-----PSKHLHSKNYITAKVLNDR-PTVNQEISVVVRS----FAPIKYFMYQVVGR 480
            .:...|.|:     ||:   ...:::.:.|:.| |.|.....:.:|:    .....::.|.::.|
  Rat   449 SLYPAVAKLTVQAPPSR---GPGFLSIEPLDLRSPRVGDTFVLSLRTVGIPMPTFSHYYYMIISR 510

  Fly   481 GDII-LSRN-----------VD--VAPGTFHTIKFLASF--AMMPRANLLVYTVIDGEFVYDEQV 529
            |.|: :||.           ||  :||..:    |:|.|  ..:|.||.|:..|..|:.   |..
  Rat   511 GQIMAMSREPRRALTSISVLVDHHLAPSFY----FVAYFYHQGLPVANSLLINVQPGDC---EGK 568

  Fly   530 IQLEENLLNAVQVDAPIRAPPGQDIDIGISTKPYSYVGLMLVDQ--NANDLRSGHDLTHKRLMDA 592
            ::|        :||.......|..:.:.:.|...:.|.|..||.  .|...||...|...::.:.
  Rat   569 LEL--------KVDGAKEYRNGDSMKLQLQTDSEALVALGAVDTALYAVGGRSHKPLDMSKVFEV 625

  Fly   593 LRSYELS----------DVNTPMGSPGKESGVITMSNTDYFIEKEAES----NPALDREVSTGPE 643
            :.||.|.          .|....|....:...:|.:..:....||.:|    |....:.:|
  Rat   626 MNSYNLGCGPGGGDDALQVFQTAGLAFSDGDRLTQTKENLSCPKEKKSRQKRNVNFQKAIS---- 686

  Fly   644 EDKLTTVRKTDIGPAHKIEVNTLPPGKG-RYAFSYTPKPFWHNP-----------RVHVMRDPA- 695
             :||......|.....:..:..||..:. ....:..|:|....|           |.:..|..|
  Rat   687 -EKLGQYSSPDTKRCCQDGMTKLPMARTCEQRAARVPQPACREPFLSCCKFAEDLRRNQTRSQAG 750

  Fly   696 --------------------------DTWLFLNISASSDGRNSIHRRIPSEMTSWVVSAFALDPV 734
                                      :.||:.  ....|....:...:|..:|:|.:...:|...
  Rat   751 LARAQDMLQEEDLIDEDDILVRSFFPENWLWR--VEPVDRSKLLTVWLPDSLTTWEIHGVSLSKS 813

  Fly   735 NGLGLSPPNGKLEAYKEFYISTELPYSIKRDELIAIPFVVHNNRDSDLNVEVTFYNSALDFDFPQ 799
            .||.::.|. ::..::||::...||.|::|.|.:.:..|::|....|:.|.|            .
  Rat   814 KGLCVAKPT-RVRVFREFHLHLRLPISVRRFEQLELRPVLYNYLSEDVTVSV------------H 865

  Fly   800 LDPKATNQPKVE--------LYRRRSLQVPGRSARSVSFIVTPKRVGPLLVKAMAASS-QAGDTV 855
            :.|       ||        |..:: :.||..|||.|:|.|.|.....:.:|.:|..| ..||.|
  Rat   866 VSP-------VEGLCLAGGGLLAQQ-VSVPAGSARPVAFSVVPTAAASIPLKVVARGSFTIGDAV 922

  Fly   856 EQNLLVEHPGAMERINRGFLFELNSNAQNRRNVTIAVP----RNAIPES-----TRIEVSAVGDL 911
            .:.|.:|..||:.|..    ...|.:..|....::.:|    .|.||:.     .|:..|...:.
  Rat   923 SKILQIEKEGAIHREE----IVYNLDPLNNLGRSLEIPGSSDPNVIPDGDFSSFVRVTASEPLET 983

  Fly   912 IGS----LVGNLDSLILLPTGCGEQTMVNFVPNLIVLRYLGRLRQ---LTPEVELRATNNLAIGY 969
            :||    ..|.:.||:.||.||.||||:...|.|....||.|..|   |.||.:..|.:.:..|:
  Rat   984 LGSEGALSPGGVASLLRLPRGCAEQTMIYLAPTLTASHYLDRTEQWSKLPPETKDHAVDLIQKGH 1048

  Fly   970 QRILYYRHENGAFSAFGLDIKR-SSTWLTAYVARSLRQAAPFTQVDSNVLQKALTYLGSVQSANG 1033
            .||..:|.::|:|.|:   :.| |||||||:|.:.|..|..........||:...:|...|..:|
  Rat  1049 MRIQQFRKKDGSFGAW---LHRDSSTWLTAFVLKILSLAQEQIGDSPEKLQETAGWLLGQQLDDG 1110

  Fly  1034 GFEERGDVFER------FG-DDGISLTAFVTLALMENVDLYPEYRN---------NINKALDFI- 1081
            .|.:...|..|      .| |:.::|||||.:||...:.::.:..:         :|.||..|:
  Rat  1111 SFHDPCPVIHRGMQGGLVGTDETVALTAFVVIALHHGLAVFQDENSQQLKKRVEASITKANSFLG 1175

  Fly  1082 ---TRGLDGSSNLHAMAIGTY--VLSRANHNAKAAFLQRLDSMATNKDGLKWW------------ 1129
               :.||.|:   ||.||..|  .|::|:.:.:......|.:||.......:|
  Rat  1176 QKASAGLLGA---HASAITAYALTLTKASEDLRNVAHNSLMAMAEETGENLYWGSAIGSQDNVVS 1237

  Fly  1130 ------NKTAPAGEQQSPWYNATRSVNIEISAYAALALLENNLVGD-ALPVLNWLMDQRNPKGGF 1187
                  |.:.|..:..:.|        ||.:||..|.||.....|: |..|..||..|.:.:|||
  Rat  1238 STPAPRNPSEPVPQAPALW--------IETTAYGLLHLLLREGKGEMADKVATWLTHQGSFQGGF 1294

  Fly  1188 VASQDTVVGLQALLMF-------AER-----FSSQGNN------LQIGFHYGEGAE--------T 1226
            .::|||||.|.||..:       .|:     .||.|.|      ||:..|..:|.|        :
  Rat  1295 RSTQDTVVTLDALSAYWIASHTTEEKALNVTLSSMGRNGYKSHLLQLNNHQVKGLEEELKFSLGS 1359

  Fly  1227 IINV----NAENSLALQTVELPNNLKN-------LSVSATG--RGMALAQVSYTYNTNVTSAWPR 1278
            .|||    |::.:|.:.......::||       :.|:.||  .....|...|.|:.::.:|
  Rat  1360 TINVKVGGNSKGTLKILRTYNVLDMKNTTCQDLRIEVTVTGYVEYTREANEDYEYDYDMPAA--- 1421

  Fly  1279 FVLDPTVN----------------RNSHADYLHLSACASFVSVVGENEQR--------------- 1312
              .||:|:                |...|.           ....|.|.|
  Rat  1422 --DDPSVHSQPVTPLQLFEGRRSRRRREAP-----------KAADEQESRVQYTVCIWRNGNLGL 1473

  Fly  1313 SNMAVMEVHLPSGFVVDRDTLPTLES-SER-IKKVETQNRNTKVVIYFDYLDRREVCPTLHAYKT 1375
            |.||:.::.|.|||...|..|..|.| |:| :...||...:  |::|||.:.....|....|.:.
  Rat  1474 SGMAIADITLLSGFQALRADLEKLTSLSDRYVSHFETDGPH--VLLYFDSVPTTRECVGFGALQE 1536

  Fly  1376 VKVTKHRPVAVVMYDYYDSARRARQFYRAP-KSNICD-ICEHANCGDLCEKAE 1426
            |.|...:|.:.|:||||....:...||.|| ||.:.. :|.    .|:|:.||
  Rat  1537 VAVGLVQPASAVLYDYYSPDHKCSVFYAAPTKSKLLSTLCS----ADVCQCAE 1585

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tep3	NP_523507.2	YfaS	<128..1399	CDD:441940	360/1523 (24%)
		A2M_2	918..1203	CDD:239227	100/329 (30%)
C4a	NP_113692.2	YfaS	<136..1326	CDD:441940	302/1278 (24%)
		A2M	778..866	CDD:459711	22/102 (22%)
		TED_complement	977..1310	CDD:462227	104/346 (30%)
		A2M_recep	1474..1563	CDD:462226	29/90 (32%)
		NTR_complement_C4	1581..1735	CDD:239639	3/5 (60%)