DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tep3 and C3

DIOPT Version :9

Sequence 1:	NP_523507.2	Gene:	Tep3 / 34045	FlyBaseID:	FBgn0041181	Length:	1469	Species:	Drosophila melanogaster
Sequence 2:	NP_058690.2	Gene:	C3 / 24232	RGDID:	2232	Length:	1663	Species:	Rattus norvegicus

Alignment Length:	1618	Identity:	370/1618 - (22%)
Similarity:	645/1618 - (39%)	Gaps:	316/1618 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 VLILVTACLLCQTSAQGLYSIIAPNTLRPNSQFHVAVSLHNA----PESATFKVGILGSSYTDFK 73
            :|:|:.:.||...|.  :||||.||.||..|:....:..|:|    |.:.|.:..:.....|..|
  Rat    12 LLLLLASSLLALGSP--MYSIITPNVLRLESEETFILEAHDAQGDVPVTVTVQDFLKKQVLTSEK 74

  Fly    74 TVELRPFSTQL--LHFEIPALRT------DRYRLTAEGLGGVQFTNETQLHFESKQHTVLVQTDK 130
            || |...:..|  :..:|||.:.      .:|.......|.........:.|:|..  :.:||||
  Rat    75 TV-LTGATGHLNRVSIKIPASKEFNADKGHKYVTVVANFGATVVEKAVLVSFQSGY--LFIQTDK 136

  Fly   131 SIYKPGDLVHYRVLILDANLKPARGYGRVHVDIKDSGDNI-IRSYKDIRLTNSIYSNELRLS--- 191
            :||.||..|.||:..:|.||.|.   |:..|.:.::.|.: |:  :||..:::.| ..|.||
  Rat   137 TIYTPGSTVFYRIFTVDNNLLPV---GKTVVIVIETPDGVPIK--RDILSSHNQY-GILPLSWNI 195

  Fly   192 -DSPRFGTWSI---VVDVSDQEHTQTFEILDHILPKFVVDIDTPKHAIYKDGK--IAATVRAHYA 250
             :....|.|.|   ......|..:..||:.:::||.|.|.::..:...|.|..  :..::.|.:.
  Rat   196 PELVNMGQWKIRAFYEHAPKQTFSAEFEVKEYVLPSFEVLVEPTEKFYYIDDPKGLEVSITARFL 260

  Fly   251 FGQPIVGEATLSIYPTFFGSLQPFVNDLITRKVVPIDGNAYFEFDIENE---LHLKQDYERQYLL 312
            :|:                               .:||.|:..|.:::|   :.|.|...|..:.
  Rat   261 YGK-------------------------------NVDGTAFVIFGVQDEDKKISLAQSLTRVLIE 294

  Fly   313 DALVE-----------------EKSTGSVQNYSTVLTLH----------------LNHYRVEAVK 344
            |...|                 |...|.....|..:.||                .:.|::...|
  Rat   295 DGSGEAVLSRKVLMDGVRPSSPEALVGKSLYVSVTVILHSGSDMVEAERSGIPIVTSPYQIHFTK 359

  Fly   345 VPSYYIPGVPFEATARIARNDGGQLRDFNPQIT-----AYLTNVYGSSEMYNRTAYSLDASGEIK 404
            .|.::.|.:||:....:...||...|.. |.:|     ..||...|.:::...|..:       :
  Rat   360 TPKFFKPAMPFDLMVFVTNPDGSPARRV-PVVTQGSDAQALTQDDGVAKLSVNTPNN-------R 416

  Fly   405 MKFTVPIGDRDEFHSIIVDYQGVISEVGKIPSKHLH-SKNYITAKVL------NDRPTVNQEISV 462
            ...|:.:..:.|.   |.|.:.....:...|...:| |.||:...|.      .|...||..:..
  Rat   417 QPLTITVRTKKEG---IPDARQATRTMQAQPYSTMHNSNNYLHLSVSRVELKPGDNLNVNFHLRT 478

  Fly   463 VVRSFAPIKYFMYQVVGRGDIILSRNVDVAPGTFHTI-------KFLASFAMMPRANLLVYTVID 520
            .....|.|:|:.|.|:.:|.::.:......||....:       :|:.||.:     :..||:|.
  Rat   479 DAGQEAKIRYYTYLVMNKGKLLKAGRQVREPGQDLVVLSLPITPEFIPSFRL-----VAYYTLIG 538

  Fly   521 G----EFVYDEQVIQLEENLLNAVQVDAPIR----APPGQDIDIGISTKPYSYVGLMLVDQNAND 577
            .    |.|.|...:.::::.:..:.|....|    ..||....:.|.....:.|||:.||:....
  Rat   539 ANGQREVVADSVWVDVKDSCVGTLVVKGDPRDNRQPAPGHQTTLRIEGNQGARVGLVAVDKGVFV 603

  Fly   578 LRSGHDLTHKRLMDALRSYELSDVNTPMGSPGKESGVITMSNTDYFIEKEAESNPALDREVSTGP 642
            |...:.||..::.|.:   |.:|:....||....:||...:...:      ::|..|..:....|
  Rat   604 LNKKNKLTQSKIWDVV---EKADIGCTPGSGKNYAGVFMDAGLTF------KTNQGLQTDQREDP 659

  Fly   643 EEDKLTTVRK----------------TDIGPAHKIE--VNTLPPGKGRY---------------- 673
            |..|....|:                ||.|.....|  :..:|.   :|
  Rat   660 ECAKPAARRRRSVQLMERRMDKAGQYTDKGLRKCCEDGMRDIPM---KYSCQRRARLITQGESCL 721

  Fly   674 -AF----SYTPKPFWHNPRVHVM---RDPAD-----------------TWLFLNISASSDGRNSI 713
             ||    :|..|....:.|.||:   |...|                 :||:.........:|.|
  Rat   722 KAFMDCCNYITKLREQHRRDHVLGLARSDVDEDIIPEEDIISRSHFPESWLWTIEELKEPEKNGI 786

  Fly   714 HRRI-----PSEMTSWVVSAFALDPVNGLGLSPPNGKLEAYKEFYISTELPYSIKRDELIAIPFV 773
            ..::     ...:|:|.:.|.:|....|:.::.|. ::...::|:|...||||:.|:|.:.|..|
  Rat   787 STKVMNIFLKDSITTWEILAVSLSDKKGICVADPY-EITVMQDFFIDLRLPYSVVRNEQVEIRAV 850

  Fly   774 VHNNRDSD-LNVEVTFYNSALDFDFPQLDPKATNQPKVELYRRRSLQVPGRSARSVSFIVTPKRV 837
            :.|.|:.: |.|.|...::      |.....||  .|...|  :::::|.:|:.:|.:::.|.::
  Rat   851 LFNYREQEKLKVRVELLHN------PAFCSMAT--AKKRYY--QTIEIPPKSSVAVPYVIVPLKI 905

  Fly   838 G--PLLVKAMAASSQAGDTVEQNLLVEHPGAMERINRGFLF------ELNSNAQNRRNVTIAVPR 894
            |  .:.|||...:....|.|::.|.|...|.  |:|:....      .|......|.:|..|...
  Rat   906 GLQEVEVKAAVFNHFISDGVKKILKVVPEGM--RVNKTVAVRTLDPEHLGQGGVQREDVPAADLS 968

  Fly   895 NAIPES---TRI--EVSAVGDLIGSLVG--NLDSLILLPTGCGEQTMVNFVPNLIVLRYLGRLRQ 952
            :.:|::   |||  :.:.|..:....|.  .|..||:.|:|||||.|:...|.:|.:.||.:..|
  Rat   969 DQVPDTDSETRILLQGTPVAQMAEDAVDGERLKHLIVTPSGCGEQNMIGMTPTVIAVHYLDQTEQ 1033

  Fly   953 LTP---EVELRATNNLAIGYQRILYYRHENGAFSAFGLDIKRSSTWLTAYVARSLRQAAPFTQVD 1014
            ...   |....|...:..||.:.|.::..:.|::||  :.:..||||||||.:....||....:|
  Rat  1034 WEKFGLEKRQEALELIKKGYTQQLAFKQPSSAYAAF--NNRPPSTWLTAYVVKVFSLAANLIAID 1096

  Fly  1015 SNVLQKALTYL-GSVQSANGGFEERGDV--------FERFGDDGISLTAFVTLALMENVDLYPEY 1070
            |.||..|:.:| ...|..:|.|:|.|.|        |....:..:||||||.:||.|..|:....
  Rat  1097 SQVLCGAVKWLILEKQKPDGVFQEDGPVIHQEMIGGFRNTKEADVSLTAFVLIALQEARDICEGQ 1161

  Fly  1071 RN----NINKALDFITRGLDGSSNLHAMAIGTYVLSRANHNAKAAFLQRLDSMATNKDGLKWWNK 1131
            .|    :||||.:::..........:.:||..|.|:..| ..:..:|.:.  :.|.||..:|
  Rat  1162 VNSLPGSINKAGEYLEASYLNLQRPYTVAIAGYALALMN-KLEEPYLTKF--LNTAKDRNRW--- 1220

  Fly  1132 TAPAGEQQSPWYNATRSVNIEISAYAALALLENNLVGDALPVLNWLMDQRNPKGGFVASQDTVVG 1196
             ...|:|         ..|:|.::||.||||.........||:.||.:||...||:.::|.|.:.
  Rat  1221 -EEPGQQ---------LYNVEATSYALLALLLLKDFDSVPPVVRWLNEQRYYGGGYGSTQATFMV 1275

  Fly  1197 LQALLMFAERFSSQGN-NLQIGFHY-GEGAETIINVNAENSLALQTVELPNNLKNLSVSATGRGM 1259
            .|||..:........: |:.:..|. ...:.|:..:..|:...|::.|...| :..|::|.|:|.
  Rat  1276 FQALAQYQTDVPDHKDLNMDVSLHLPSRSSPTVFRLLWESGSLLRSEETKQN-EGFSLTAKGKGQ 1339

  Fly  1260 ALAQVSYTYNTNV--TSAWPRFVLDPTVN---------RNSHADYLHLSACASFVSVVGENEQRS 1313
            ....|...|:..|  .:...:|.|..|:.         :::.:..: |..|..::..|.     :
  Rat  1340 GTLSVVTVYHAKVKGKATCKKFDLRVTIKPAPETAKKPQDAKSSMI-LDICTRYLGDVD-----A 1398

  Fly  1314 NMAVMEVHLPSGFVVDRDTLPTLES--SERIKKVET----QNRNTKVVIYFDYLDR-REVCPTLH 1371
            .|:::::.:.:||:.|.:.|..|.|  ...|.|.|.    .|:|| ::||.:.:.. .|.|.:..
  Rat  1399 TMSILDISMMTGFIPDTNDLELLSSGVDRYISKYEMDKAFSNKNT-LIIYLEKISHSEEDCLSFK 1462

  Fly  1372 AYKTVKVTKHRPVAVVMYDYYDSARRARQFYRAPKSN--ICDICEHANCGDLCEKAEK 1427
            .::...|...:|.:|.:|.||:......:||...|.:  :..:|.:    ::|..||:
  Rat  1463 VHQFFNVGLIQPGSVKVYSYYNLEESCTRFYHPEKDDGMLSKLCHN----EMCRCAEE 1516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tep3	NP_523507.2	A2M_N	124..215	CDD:280081	29/98 (30%)
		A2M_N_2	448..573	CDD:285005	30/145 (21%)
		A2M	697..787	CDD:278630	24/95 (25%)
		A2M_2	918..1203	CDD:239227	94/300 (31%)
		A2M_comp	967..1200	CDD:284982	75/245 (31%)
		A2M_recep	1313..1402	CDD:284981	23/95 (24%)
C3	NP_058690.2	A2M_N	129..224	CDD:280081	30/102 (29%)
		A2M_N_2	457..603	CDD:285005	31/150 (21%)
		ANATO	678..747	CDD:237984	13/71 (18%)
		A2M	770..866	CDD:278630	25/96 (26%)
		complement_C3_C4_C5	996..1282	CDD:239226	94/303 (31%)
		A2M_comp	1051..1282	CDD:284982	77/248 (31%)
		A2M_recep	1398..1493	CDD:284981	23/95 (24%)
		NTR_complement_C3	1513..1661	CDD:239638	2/4 (50%)
		Interaction with CFP/properdin. /evidence=ECO:0000250\|UniProtKB:P01024	1634..1659
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166343887
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2373
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11412
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.840