DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tep3 and Cd109

DIOPT Version :9

Sequence 1:	NP_523507.2	Gene:	Tep3 / 34045	FlyBaseID:	FBgn0041181	Length:	1469	Species:	Drosophila melanogaster
Sequence 2:	NP_694738.1	Gene:	Cd109 / 235505	MGIID:	2445221	Length:	1442	Species:	Mus musculus

Alignment Length:	1570	Identity:	441/1570 - (28%)
Similarity:	733/1570 - (46%)	Gaps:	258/1570 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 ILVTACLLC----QTSAQG-LYSIIAPNTLRPNSQFHVAVS-LHNAPESATFKVGILGSSYTDFK 73
            :|..|.|||    ..:|.| .:.:.||..:||.:...:.|. |.|:|.....|..:       ||
Mouse     6 LLSAAHLLCLCAVALAAPGSRFLVTAPGIIRPGANVTIGVDLLENSPPQVLVKAQV-------FK 63

  Fly    74 TVELRPFSTQLL---------HFE---IPAL---RTDR-YRLTAEGL--GGVQFTNETQLHFESK 120
            ....:  |..:|         ||:   :|||   ..|: |.|...|.  ..:.|:|.|:|.||||
Mouse    64 IASNK--SRSILEAEGVFHRGHFKTLVLPALPLSSADKIYELHINGQSENEIVFSNRTRLTFESK 126

  Fly   121 QHTVLVQTDKSIYKPGDLVHYRVLILDANLKPARGYGRVHVDIKDSGDNIIRSYKDIRLTNSIYS 185
            ..:||:||||:.|||...|.:|||.|.::|||.|  ..|.:.|||...|:|:.:...:....:.|
Mouse   127 SISVLIQTDKAFYKPKQEVKFRVLTLCSDLKPYR--TSVDIFIKDPKSNVIQQWFSQKGDLGVVS 189

  Fly   186 NELRLSDSPRFGTWSIVVDVSDQEHTQTFEILDHILPKFVVDIDTPKHAIYKDGKIAATVRAHYA 250
            ...:||.:|.||.|||.|.|:||::.|:|::|:::||||.|.:.||.:...|..::..:|.|.|.
Mouse   190 KTFQLSSNPIFGDWSIQVQVNDQQYYQSFQVLEYVLPKFEVTVQTPLYCSLKSKQLNGSVIAKYT 254

  Fly   251 FGQPIVGEATLSIYP-TFFGSLQPFVNDLITRKVVPIDGNAYFEFD---IENELHLKQ------- 304
            :|:|:.|..:|:..| :|:|..:...      |...|:|.|.|.||   ::..::||.
Mouse   255 YGKPVKGSLSLTFLPLSFWGKKKNIT------KSFEINGFANFSFDNYEMKKVMNLKPLTDVSEG 313

  Fly   305 DYERQYLLD----------ALVEEKSTGSVQNYSTVLTLHLNHYRVEAVKVPSYYIPGVPFEATA 359
            .||.   :|          |.|.|..||..:..||.:....:.|.:|.....:...|.:.|.||.
Mouse   314 SYEN---VDPSFPGPAEIIATVTESLTGISRMASTNVFFKQHDYIIEIFDYTTVLKPSLNFTATV 375

  Fly   360 RIARNDGGQL------RDFNPQITAYLTNVYGS---SEM-YNRTA-YSLDASGEIKMKFTV-PIG 412
            :::|:||.||      .|....:|....|...|   .|| |.:|. |::..:|.||::|.| .|.
Mouse   376 KVSRSDGNQLTPEEIENDLVTVVTQRKNNHPESQRDQEMDYIQTVNYTIPQNGIIKIEFPVMSIS 440

  Fly   413 DRDEFHSIIVDYQGVISEVGKIPSKHLHSKNYITAKVLNDRPTVNQEISVVVRSFAPIKYFMYQV 477
            ...:..:..:|....::......|.   ||.||..|..::...|.....::|......|...|.|
Mouse   441 GELQLKAYFLDGTSSVTVHSMFTSP---SKTYIQLKTRDEYIKVGSPFDLMVSGNRQFKDLSYMV 502

  Fly   478 VGRGDIIL-----SRNVDVAPGTFHTIKFLASFAMMPRANLLVYTVI-DGEFVYDEQVIQLEENL 536
            :.:|.::.     ||...:.|.        ||:|  |:|.::.|.:. |||.:.|...|.::...
Mouse   503 ISKGQLVAAGKQSSRTFSLTPE--------ASWA--PKACIIAYYIAEDGEIINDILKIPVQLVF 557

  Fly   537 LNAVQV--DAPIRAPPGQDIDIGIS-TKPYSYVGLMLVDQNANDLRSGHDLTHKRLMDALRSYEL 598
            .|.|::  ..| ...|...:.:.|| |:..|.||::.||::...:.:.:.:|.:.::..|..|
Mouse   558 ENKVKLFWSKP-TVKPSDKVSLRISATQSDSLVGIVAVDKSVTLMENSNSITMETMVHELELY-- 619

  Fly   599 SDVNTP------MGSPG--KESGVITMS-------------NTDYFIEKEAESNPALDREVSTGP 642
               ||.      |.|..  :|.|:..::             :|:.:.|:.||.|.|
Mouse   620 ---NTEYYLGMFMNSFAVFQECGLWVLTDATLIRDSIDEVYDTEEYSERFAEENEA--------- 672

  Fly   643 EEDKLTTVRKTDIGPAHKIEVNTLPPGKGRYAFSYTPKPFWHNPRVHVMRDPADTWLFLNISASS 707
                    ...|...|..:.                        .|||.::..:||::|:....|
Mouse   673 --------NLVDFEDASSVN------------------------NVHVRKNFPETWIWLDAYMGS 705

  Fly   708 DGRNSIHRRIPSEMTSWVVSAFALDPVNGLGLSPPNGKLEAYKEFYISTELPYSIKRDELIAIPF 772
            .........:|..:||||.|||.:....|.||:....:|:|::.|::...||||:.|.|..|:..
Mouse   706 KIYEEFEVTVPDSITSWVASAFVISEDLGFGLTTVPAELQAFQPFFLFLNLPYSVIRGEEFALEV 770

  Fly   773 VVHNNRDSDLNVEVTFYNSALDFDFPQLDPKATNQPKVELYRRRSLQVPGRSARSVSFIVTPKRV 837
            .:.|.....:.|.:....|. .||...    .:|.....:| |:::|||..:..::.|.:.|..:
Mouse   771 SIVNYLKDTIKVVILIEESD-SFDILM----TSNDTNGTIY-RKTVQVPRDNGVTLVFPIKPTHL 829

  Fly   838 GPLLVKAMAASSQAGDTVEQNLLVEHPGAMERINRGFLFEL-NSNAQNR-RNVTIAVPRNAIPES 900
            |.:.:...|||..|.|.|.|.::|:..|..:..::..|.:| :||.::: :::..:.|.:.:..|
Mouse   830 GEIPITVTAASPTASDAVTQTIVVKPEGIEKSYSKSVLLDLTDSNVESKQQSMRFSFPPDTVIGS 894

  Fly   901 TRIEVSAVGDLIGSLVGNLDSLILLPTGCGEQTMVNFVPNLIVLRYLGRLRQLTPEVELRATNNL 965
            .|::::|:||::||.:..|.|||.:|.|||||.|:.|.||:.:|.||.:.:|||..::.:|.:.:
Mouse   895 ERVQITAIGDILGSSINGLSSLIRMPYGCGEQNMIYFAPNIYILDYLTKQKQLTVNLKEKALSYM 959

  Fly   966 AIGYQRILYYRHENGAFSAFGLDIKRS-STWLTAYVARSLRQAAPFTQVDSNVLQKALTYLGSVQ 1029
            ..||||.|.|:.|:|:||||| ||..| ||||:|:|.|...:|..:..:|.:||.:..|:|.:.:
Mouse   960 RQGYQRELLYQREDGSFSAFG-DIDSSGSTWLSAFVLRCFLEADYYIDIDQDVLHRTYTWLNAHK 1023

  Fly  1030 SANGGFEERGDVFERFGDDG----ISLTAFVTLALMENVDLYPEYRNNIN-----KALDF-ITRG 1084
            ..||.|.|.|.|.......|    ::|||::..:::.    |.:|:.||:     |.|:| .:||
Mouse  1024 KFNGEFWEPGRVIHSELQGGTKSPVTLTAYIVTSVLG----YKKYQPNIDVQDSIKFLEFEFSRG 1084

  Fly  1085 LDGSSNLHAMAIGTYVLSRANHNAKAAFLQRLDSMATNKDG-LKWWNKTAPAGEQQSPWYNATRS 1148
            :   |:.:.:||.:|.||... :.||.....|....:.|:| .::|..:.||  ....|  ..||
Mouse  1085 I---SDNYTLAIISYALSTVG-SPKAEEALNLLMQRSEKEGDTQFWLSSGPA--LSGSW--QPRS 1141

  Fly  1149 VNIEISAYAALALLENNLVGDALPVLNWLMDQRNPKGGFVASQDTVVGLQALLMFAERFSSQGNN 1213
            |:|||:|||.||...:: |.:.:||:.||:.|||..||||::|||||.|:||..|:.....:..:
Mouse  1142 VDIEIAAYALLAHTLHH-VSEGIPVMRWLIQQRNSLGGFVSTQDTVVALKALSEFSALVHKENTD 1205

  Fly  1214 LQI---------GFHYGEGAETIINVNAENSLALQTVELPNNLKNLSVSATGRGMALAQVSYTYN 1269
            :|:         ..|:...::.:..::.|...||..:       .::|||.|.|.|:.|::..||
Mouse  1206 IQLTVTGPGIPRSIHFRIDSQNLFLLHQEELHALDPI-------TVNVSAHGSGFAICQLNVDYN 1263

  Fly  1270 TNVTSAWPR---------FVLDPTVNRNSHADYLHLSACASFVSVVGENEQRSNMAVMEVHLPSG 1325
            ...:.:..|         |.||..||......:|:|:.|.|.:     ..:|:.|.:|||:|.||
Mouse  1264 VKGSGSSKRRRSTENQEVFDLDVIVNNEDDISHLNLNVCTSHL-----GSERTGMVLMEVNLLSG 1323

  Fly  1326 FVVDRDTLPTLESSERIKKVETQNRNTKVVIYFDYLDRREVCPTLHAYKTVKVTKHRPVAVVMYD 1390
            |....|::|.   ||.:||||..  |.|:.:|.|.::..:.|..:...:..||:..|..:|.:.|
Mouse  1324 FSASSDSIPL---SETLKKVEYD--NGKLNLYLDSVNESQFCVNIPTVRDYKVSNIRDGSVSVMD 1383

  Fly  1391 YYDSARRA-RQFYRAPKSNICDICEHANCGDLCEKAEKRESKRPDDYTAIAGHSSGSRHTAIPLA 1454
            ||:..|:| |.:....|.:.|.:....||                     ..|:.|:..:....:
Mouse  1384 YYEPRRQAVRSYNTQVKLSSCYLSPDTNC---------------------KSHTDGATDSLRRSS 1427

  Fly  1455 SVVMVLSMLL 1464
            |:::..|:||
Mouse  1428 SLLVFCSVLL 1437

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tep3	NP_523507.2	A2M_N	124..215	CDD:280081	38/90 (42%)
		A2M_N_2	448..573	CDD:285005	32/133 (24%)
		A2M	697..787	CDD:278630	27/89 (30%)
		A2M_2	918..1203	CDD:239227	115/296 (39%)
		A2M_comp	967..1200	CDD:284982	92/244 (38%)
		A2M_recep	1313..1402	CDD:284981	31/89 (35%)
Cd109	NP_694738.1	YfaS	<122..>1002	CDD:225248	270/957 (28%)
		A2M_N	129..220	CDD:280081	39/92 (42%)
		A2M_N_2	475..598	CDD:285005	32/133 (24%)
		Bait region (approximate). /evidence=ECO:0000250	595..704		24/154 (16%)
		A2M	695..782	CDD:278630	26/86 (30%)
		A2M_2	909..1195	CDD:239227	115/299 (38%)
		A2M_comp	961..1197	CDD:284982	95/249 (38%)
		A2M_recep	1311..1395	CDD:284981	31/88 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840008
Domainoid	1	1.000	75	1.000	Domainoid score	I9015
eggNOG	1	0.900	-	-		E1_COG2373
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H25183
Inparanoid	1	1.050	558	1.000	Inparanoid score	I1099
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45959
OrthoDB	1	1.010	-	-		D177369at33208
OrthoFinder	1	1.000	-	-		FOG0002157
OrthoInspector	1	1.000	-	-		otm42370
orthoMCL	1	0.900	-	-		OOG6_100452
Panther	1	1.100	-	-	O	PTHR11412
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2582
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	14	13.810