Protein Alignment Tep3 and A2ml1

DIOPT Version :10

• Sequence 1: NP_523507.2
• Gene: Tep3 / 34045
• FlyBaseID: FBgn0041181
• Length: 1469
• Species: Drosophila melanogaster
• Sequence 2: NP_001001179.2
• Gene: A2ml1 / 232400
• MGIID: 3039594
• Length: 1456
• Species: Mus musculus
• Alignment Length: 1539
• Identity: 360/1539 - (23%)
• Similarity: 620/1539 - (40%)
• Gaps: 256/1539 - (16%)

  Fly    15 ILVTACLLCQT---SAQGLYSIIAPNTLRPNSQFHVAVSLHNAPESATFKVGIL--GSSYT---- 70
            ||::|.||..|   :|:..|.:...:.::..|.....:.|.|..||.:..|.:.  |||.|
Mouse     5 ILLSALLLHFTDVVAAEPRYILWVSSVVQRFSSEKACLHLLNLNESVSLSVTLEYDGSSTTIFDQ 69

  Fly    71 -----------DFKTVELRPFSTQLLHFEIPALRTDRYRLTAEGLGGVQFTNETQLHFESKQHTV 124
                       |||..::   |::.|.|         ..|..:| ..::.:....:...::::..
Mouse    70 PVDEGNFYACADFKVSQM---SSEQLAF---------VALLVQG-NTLKISERRSVAIAAEENAT 121

  Fly   125 LVQTDKSIYKPGDLVHYRVLILDANLKPARGYGRVHVDIKDSGDNIIRSYKDIRLTNSIYSNELR 189
            .||||..::||||.||:||:.|:..|||......: :.::|...|:|..:.::....:|.....:
Mouse   122 FVQTDTPVHKPGDTVHFRVVTLNIWLKPVDDLYPL-ITVQDPQSNVIFQWINVTTFRNITQLSFQ 185

  Fly   190 LSDSPRFGTWSIVVDVSDQEHTQT-FEILDH------ILPKFVVDIDTPKHAIYKDGKIAATVRA 247
            |:..|..|.::||:      .||: ..::||      :||||.|::..|:.....|.:......|
Mouse   186 LTPEPILGDYTIVI------KTQSGTTVMDHFTVNRDVLPKFEVELTAPETITIADSQFQMVTCA 244

  Fly   248 HYAFGQPIVGEATLSIYPTFFGSLQPFVND------------------LITRKVVPIDGNAYFEF 294
            .|.:|||:.|:|.:.:....|.......|:                  :|..||..:|.:..|..
Mouse   245 KYTYGQPVQGKAQIKVCRELFSPAHCESNENEICEQFTVQLKDGCASHIINTKVFQLDRSGLFMT 309

  Fly   295 DIENELHLKQDYERQYLLDALVEEKSTGSVQ---NYSTVLTLHLNHYRVEAVKVPSYYIPGVPFE 356
            ...||               :|.|..|| ||   .:|..:|..|.....|  .:..:|..|:.:.
Mouse   310 LNVNE---------------VVTESGTG-VQMSKTHSVFITSVLGTVSFE--NMDPFYRRGITYF 356

  Fly   357 ATARIARNDGGQLRDFNPQITA-------YLTNVYGSSEMYNRTAYSLDASGEIKMKFTVPIG-- 412
            .|.:.:..:...|.|...|:..       |.|:..|.:.....|:....|...:|..:..|..
Mouse   357 GTLKFSGPNNTPLVDKLLQLELDGKPVGNYTTDENGEARFSINTSEIFGAQISLKAVYVRPRSCH 421

  Fly   413 --------------DRDEFHSIIVDYQGVISEVGKIPSKHLHSKNYITAKVLNDRPTVNQEISVV 463
                          ....|:|....:..:|.|..::|..  ..|.:.....||  |...:|.|.|
Mouse   422 RSSWLSPEYLDAYFSASRFYSQTSSFTKIILEPKQLPCD--QEKMFSVLYSLN--PEAYKEASDV 482

  Fly   464 VRSFAPIKYFMYQVVGRGDIILSRN------VDVAPGTF-HTIKFLASFAMMPRANLLVYTV-ID 520
            .        |.|.|:.||.|  ||:      |....|.| ..|...|..|  |.|:|.|||: ..
Mouse   483 T--------FFYLVMVRGGI--SRSGQKQVRVQAWNGNFSFPISINADLA--PSADLFVYTLHPS 535

  Fly   521 GEFVYDEQVIQLEENLLNAVQVD-APIRAPPGQDIDIGISTKPYSYVGLMLVDQNANDLRSGHDL 584
            ||.|.|...:|:|:...|.|.:: :..:..||.:..:.:...|.|:..|..||::|..|..|.::
Mouse   536 GEIVADNVRLQIEKCFKNKVSINFSRDKDLPGSNTSVHLQAAPDSFCALRAVDKSALLLNHGQEM 600

  Fly   585 THKRLMDAL-----RSYELSDVN----------------------TPMGS--PGKESGVITMSNT 620
            |.:.:...|     ..|..:.:|                      ||.|:  .|..|.:::....
Mouse   601 TPESVYFTLPYIHQYGYFYNGLNLDDQQAEPCIPQKDLFYNGLYYTPTGNIWDGDLSNLLSNMGL 665

  Fly   621 DYFIEKEAESNPALDREVSTGPEEDKLTTVRKTDIGPAHKIEV--NTLPPGKGRY----AFSYTP 679
            ..|.......     .||.:..|...|.   :|...|..:|.:  ...||....:    :.|:..
Mouse   666 KIFTNLHYRK-----PEVCSSQENQPLL---RTFDHPNERIMMYGGGAPPSSAFHDSVDSISHAK 722

  Fly   680 KPFWHNPRVHVMRDPADTWLFLNISASSDGRNSIHRRIPSEMTSWVVSAFALDPVNGLGLSPPNG 744
            .......|.:..|    ||::..:|..|.|..::...:|..:|.|..|||.::...|.|:| |..
Mouse   723 VAIKETVRTNFPR----TWIWNLVSVDSSGTANVSFLVPDTITQWEASAFCVNGNAGFGIS-PKV 782

  Fly   745 KLEAYKEFYISTELPYSIKRDELIAIPFVVHNNRDSDLNVEVTFYNSALDFDFPQLDPKATNQPK 809
            .|:..:.|::....|:|:.|.|            .||:.|.|..|.:.......||:.....:..
Mouse   783 SLQISQPFFVEVTSPFSVVRSE------------QSDMVVTVFNYLTTCVEISVQLEASENYEAS 835

  Fly   810 VELYRRRSLQV-PGRSARSVSFIVTPKRVGPLLVKAMAASSQA---------------GDTVEQN 858
            :...|....:| .....::..:.:.||.:|.:.|..:|.|.|:               .|||.:.
Mouse   836 INTQRNTDSEVLQAGEQKTYVWTIIPKTLGKVNVTVVATSKQSRACPNDASKEQDVHWKDTVVKT 900

  Fly   859 LLVEHPGAMERINRGFLFELNSNAQNRRNVTIAVPRNAIPESTRIEVSAVGDLIGSLVGNLDSLI 923
            :|||..|..:...:.||. .....:..:...:.:|.|.:..|.|..|:.|||::|..:.||:||:
Mouse   901 MLVEAEGIEKEATQSFLI-CPKGTKASKQTLLELPSNVVEGSVRSFVTIVGDILGVAMQNLESLL 964

  Fly   924 LLPTGCGEQTMVNFVPNLIVLRYLGRLRQLTPEVELRATNNLAIGYQRILYYRHENGAFSAFGLD 988
            .:|.|||||.:.....::.:|.||....|||.|::.:|...|:.|||..|.:::.:|::..|...
Mouse   965 QMPYGCGEQNIAQLASDVYILDYLKATDQLTEELKSKAQRLLSNGYQNHLSFKNYDGSYDVFCQS 1029

  Fly   989 IKRSSTWLTAYVARSLRQAAPFTQVDSNVLQKALTYLGSVQSANGGF---EERGDVFE--RFGD- 1047
            .:..||||:|...:::.:...:..::..|.::.|.:|...|.:||.|   |:..|..:  |.||
Mouse  1030 NQEGSTWLSALSFKTVEKMKEYIFIEETVPKQTLIWLVKKQKSNGCFRRDEKHVDTAQEGREGDQ 1094

  Fly  1048 DGISLTAFVTLALMENVDL---YPEYRNNINKALDFITRGLDGSSNLHAMAIGTYVLSRANHNAK 1109
            :.|:|||:|....:| |.|   :|..||.:....:..:.|:   :|.:..||..||.:.|....:
Mouse  1095 EDIALTAYVVGVFLE-VGLNASFPALRNGLYCLEEAFSNGV---TNGYTQAILAYVFALAGKEQQ 1155

  Fly  1110 A-AFLQRLDSMATNKDGLKWWNKTAPAGEQQSP-WYNATRSVNIEISAYAALALLENNL--VGDA 1170
            | :.|..||..||..:.:.:|.:........|| :..:..|...|.:.|..||:|..:.  :..|
Mouse  1156 AKSLLSILDKSATKTNNMIYWERDEKPETDNSPSFIPSALSGETEKTCYVLLAVLSQDTQDLDYA 1220

  Fly  1171 LPVLNWLMDQRNPKGGFVASQDTVVGLQALLMFAE-RFSSQGNNLQIGFHYGEGAETIINVNAEN 1234
            ..::.||..:.|..|||.|.|||.|.|.||..:.: ..|:..|.:.:.   .|.:|.:..||...
Mouse  1221 SKIVQWLAQRMNSHGGFSAMQDTTVCLLALTQYMKLTGSNPQNTITLS---SEESEEVFYVNRNK 1282

  Fly  1235 SLALQTVELPNNLKNLSVSATGRGMALAQVSYTYNTNVTSAWPRFVLDPTVNRNSHADYLHLSAC 1299
            .|.:|..::....:..:|...|.|.:..|.:..||..:......|.|.....:::.:|...
Mouse  1283 RLLVQHSKVSKGHQQYTVDVEGDGCSFIQATLRYNVPLPKEASGFSLSVKTGKSNSSDEFQ---- 1343

  Fly  1300 ASF---VSVVGENEQRSNMAVM-EVHLPSGFVVDRDTLPTLESSERIK----KVETQNRNTKVVI 1356
            ..|   |::.....:.|::.|: :|.:.|||.      |.:.|:|.:|    ..:|..:|..|:.
Mouse  1344 TKFELTVTLTYTGARESSVTVLVDVKMLSGFT------PVVSSTEELKFNSQVTKTDIKNGHVLF 1402

  Fly  1357 YFDYLDRREVCPTLHAYKTVKVTKHRPVAVVMYDY------YDS 1394
            |.:.:.:.....|....:|..|...:|..|.:|.|      :||
Mouse  1403 YLENVPKEATSLTFSIEQTNHVANIQPAPVTVYSYEKGEYAFDS 1446

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tep3	NP_523507.2	YfaS	<128..1399	CDD:441940	332/1406 (24%)
		A2M_2	918..1203	CDD:239227	90/297 (30%)
A2ml1	NP_001001179.2	YfaS	<122..1416	CDD:441940	325/1377 (24%)
		A2M_2	956..1253	CDD:239227	90/300 (30%)