DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Tep3 and A2m

DIOPT Version :9

Sequence 1:NP_523507.2 Gene:Tep3 / 34045 FlyBaseID:FBgn0041181 Length:1469 Species:Drosophila melanogaster
Sequence 2:NP_783327.2 Gene:A2m / 232345 MGIID:2449119 Length:1474 Species:Mus musculus


Alignment Length:1535 Identity:393/1535 - (25%)
Similarity:651/1535 - (42%) Gaps:222/1535 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly    12 PVLILVTACLLCQTSA--QGLYSIIAPNTLRPNSQFHVAVSLHNAPESATFKVGILG-----SSY 69
            |:|:|:...|....||  :.:|.::.|:.|...:.....:..::..|:.|.||.:..     |.:
Mouse    17 PLLLLLLLLLPTNASAPQKPIYMVMVPSLLHAGTPEKGCLLFNHLNETVTVKVSMESVRGNQSLF 81

  Fly    70 TDFKTVELRPFSTQLLH---FEIPALRTDRYR-LTAEGLGGV-QFTNETQLHFESKQHTVLVQTD 129
            ||...      ...|.|   |.:|...::... ||.:..|.. :|...:.:..::|:..|..|||
Mouse    82 TDLVV------DKDLFHCASFIVPQSSSNEVMFLTVQVKGPTHEFRRRSTVLIKTKESLVFAQTD 140

  Fly   130 KSIYKPGDLVHYRVLILDANLKPARG-----YGRVHVDIKDSGDNIIRSYKDIRLTNSIYSNELR 189
            |.|||||.:|.:||:.||.|..|...     |      |:||..|.|..:::.||...:......
Mouse   141 KPIYKPGQMVRFRVVSLDENFHPLNELIPLLY------IQDSKKNRIAQWQNFRLEGGLKQLSFP 199

  Fly   190 LSDSPRFGTWSIVVDVSD---QEHTQTFEILDHILPKFVVDIDTPKHAIYKDGKIAATVRAHYAF 251
            ||..|..|::.:|:....   .||  .|.:.:.:||||.|.:..|:.....:.::..:|...|.:
Mouse   200 LSSEPTQGSYKVVIRTESGRTVEH--PFSVKEFVLPKFEVKVAVPETITILEEEMNVSVCGIYTY 262

  Fly   252 GQPIVGEATLSIYPTFFGSLQPFVNDLIT---RKVVPIDGNAYFEFDIENE-LHLK-QDYERQYL 311
            |:|:.|..|::|...:......|..:.:.   :....:||...|...::.: ..|| |:||.|..
Mouse   263 GKPVPGHVTVNICRKYSNPSSCFGEESLAFCEKFSQQLDGRGCFSQLVKTKSFQLKRQEYEMQLD 327

  Fly   312 LDALVEEKSTGSVQNYSTVLTLHLNHYRVEAVKVPSYYIPGVPFEATARIARNDGGQLRDFNPQI 376
            ::|.::|:.||..:....:..:.....::..|.|.:::..|:||.....:....|..:    |..
Mouse   328 VNAKIQEEGTGVEETGKGLTKITRTITKLSFVNVDTHFRQGIPFVGQVLLVDGRGTPI----PYE 388

  Fly   377 TAYL------TNVYGSSEMYNRTAYSLDASGEIKMKFTVPIGDRDEFHSIIVDYQGVISEVGKI- 434
            ..::      .|:..:::......:|::....:....||....:|.  ::...::.:..|..:. 
Mouse   389 MIFIGADEANQNINTTTDKNGLARFSINTDDIMGTSLTVRAKYKDS--NVCYGFRWLTEENVEAW 451

  Fly   435 --------PSK---HLHSKNY---------ITAK-VLNDRPTVNQEISVVVRSFAPIKYFMYQVV 478
                    ||:   ||.|..|         :.|. :|||...:.::..|          |.|.::
Mouse   452 HTANAVFSPSRSFVHLESLPYKLRCEQTLAVQAHYILNDEAVLERKELV----------FYYLMM 506

  Fly   479 GRGDIILSRNVDVAPGT------FHTIKFLASFAMMPRANLLVYTVI-DGEFVYDEQVIQLEENL 536
            .:|.|:.: ...|.|.|      ..:|.......:.|.|.|::||:: :||.|.|....::|:.|
Mouse   507 AKGGIVRA-GTHVLPVTQGHKKGHFSILISMETDLAPVARLVLYTILPNGEVVGDTVKYEIEKCL 570

  Fly   537 LNAVQ-VDAPIRAPPGQDIDIGISTKPYSYVGLMLVDQNANDLRSGHDLTHKRLMDALRSYELSD 600
            .|.|. |..|....|.....:.:...|.|..||..|||:....:...:|:...:.|.|...:|:.
Mouse   571 ANKVDLVFHPNIGLPATRAFLSVMASPQSLCGLRAVDQSVLLTKPEAELSASLVYDLLPVKDLTG 635

  Fly   601 VNTPMGSPGKESGVITMSNTDYFIEKEAESNPALDREVSTGPEED----------KLTT---VRK 652
            ....:....:::......|..|.       |..|...|....|||          |:.|   :||
Mouse   636 FPKGVNQQEEDTNGCLKQNDTYI-------NGILYSPVQNTNEEDMYGFLKDMGLKVFTNLNIRK 693

  Fly   653 TDIGPAHKIEVNTLPP-----GKGRY-AF------------SYTPKPFWHNPRVHVMRDPADTWL 699
            ..:  ..::.||.:|.     .:|.. ||            ||.|                :||:
Mouse   694 PKV--CERLGVNKIPAAYHLVSQGHMDAFLESSESPTETTRSYFP----------------ETWI 740

  Fly   700 FLNISASSDGRNSIHRRIPSEMTSWVVSAFALDPVNGLGLSPPNGKLEAYKEFYISTELPYSIKR 764
            :..:...|.|...:...:|..:|.|...||.|....||||||.. ..:|::.|::...:|||:.|
Mouse   741 WDLVIVDSTGVAEMEVTVPDTITEWKAGAFCLSNDTGLGLSPVI-DFQAFQPFFVDLTMPYSVIR 804

  Fly   765 DELIAIPFVVHNNRDSDLNVEVTFYNSALDFDFPQLDPKATNQPKVELYRRRSLQVPGRSARSVS 829
            .|...:...|.|...:.:.|.|....|.   ||     .||.:.|    .::|..:......::|
Mouse   805 GEAFTLKATVLNYLQTCIRVGVQLEASP---DF-----LATPEEK----EQKSHCICMNERHTMS 857

  Fly   830 FIVTPKRVGPL--LVKAMAASSQ--------------AGDTVEQNLLVEHPGAMERINRGFLFEL 878
            :.|.||.:|.:  .|.|.|..|:              ..||:.::||||..|....:....|. .
Mouse   858 WAVIPKSLGNVNFTVSAEALDSKELCRNEVPVVPERGKKDTIIKSLLVEPEGLENEVTFNSLL-C 921

  Fly   879 NSNAQNRRNVTIAVPRNAIPESTRIEVSAVGDLIGSLVGNLDSLILLPTGCGEQTMVNFVPNLIV 943
            .:.|:....:::.:|.:.:.||.|..|:.:||::||.:.|...|:.:|.|||||.||.|.||:.|
Mouse   922 PTGAEVSEQISLKLPSDVVEESARASVTVLGDILGSAMQNTQDLLKMPYGCGEQNMVLFAPNIYV 986

  Fly   944 LRYLGRLRQLTPEVELRATNNLAIGYQRILYYRHENGAFSAFGLDIKRS--STWLTAYVARSLRQ 1006
            |.||....|||.|::.:|...|..||||.|.|:|.:|::|.||....||  :|||||:|.:|..|
Mouse   987 LDYLNETEQLTQEIKTKAITYLNTGYQRQLNYKHRDGSYSTFGDKPGRSHANTWLTAFVLKSFAQ 1051

  Fly  1007 AAPFTQVDSNVLQKALTYLGSVQSANGGFEERGDVFE---RFG-DDGISLTAFVTLALMENVDL- 1066
            |..:..:|.:.:.:|||:|...|..||.|...|.:..   :.| :|.::|:|::|:||:| :.| 
Mouse  1052 ARRYIFIDESHITQALTWLSQQQKDNGCFRSSGSLLNNAMKGGVEDEVTLSAYITIALLE-MSLP 1115

  Fly  1067 --YPEYRNN---INKALDFITRGLDGSSNLHAMAIGTYVLSRA-NHNAKAAFLQRLDSMATNKDG 1125
              :|..||.   ::.|.....||..| ::::..|:..|..:.| |.:.|...|:.||..|..:|.
Mouse  1116 VTHPVVRNALFCLDTAWKSARRGASG-NHVYTKALLAYAFALAGNQDTKKEILKSLDEEAVKEDN 1179

  Fly  1126 LKWWNKTAPAGEQQSPWYN-ATRSVNIEISAYAALALLENNLVGD------ALPVLNWLMDQRNP 1183
            ...|.:..........||. ...|..:|::||..||.|...||..      |:.::.||..|:|.
Mouse  1180 SVHWTRAQKPRVPADLWYQPQAPSAEVEMTAYVLLAYLTTELVPTREDLTAAMLIVKWLTKQQNS 1244

  Fly  1184 KGGFVASQDTVVGLQALLMF-AERFSSQGNNLQIGFHYGEGAETIINVNAENSLALQTVELPNNL 1247
            .|||.::|||||.|.||..: |..|:.......:.........|...||.:|.|.||.|.||...
Mouse  1245 HGGFSSTQDTVVALHALSKYGAATFTRAKKAAHVTIQSSGAFYTKFQVNNDNQLLLQRVTLPTVP 1309

  Fly  1248 KNLSVSATGRGMALAQVSYTYNTNVTSAWPR-----FVLDPTVNRNSHADYLHLSACASF----- 1302
            .:.:....|.|....|.|..|     |..||     |.|.......:..|   |.|..:|     
Mouse  1310 GDYTAKVAGEGCVYLQTSLKY-----SVLPREKEFPFALVVQTLPGTCED---LKAHTTFQISLN 1366

  Fly  1303 VSVVGENEQRSNMAVMEVHLPSGFVVDRDTLPTLESSERIKKVETQNRNTKVVIYFDYLDRREVC 1367
            :|.:|.... ||||:.:|.:.|||:..:.|:..||.|..:.:.|..|.:  |:||.|.:..:.:.
Mouse  1367 ISYIGSRSD-SNMAIADVKMVSGFIPLKPTVKMLERSVHVSRTEVSNNH--VLIYLDKVSNQMLT 1428

  Fly  1368 PTLHAYKTVKVTKHRPVAVVMYDYYDSARRARQFYRAPKS 1407
            ......:.:.|...:|..|.:||||:....|...|.||.|
Mouse  1429 LFFMVQQDIPVRDLKPAIVKVYDYYEKDEFAVAKYSAPCS 1468

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Tep3NP_523507.2 A2M_N 124..215 CDD:280081 32/98 (33%)
A2M_N_2 448..573 CDD:285005 33/133 (25%)
A2M 697..787 CDD:278630 26/89 (29%)
A2M_2 918..1203 CDD:239227 109/304 (36%)
A2M_comp 967..1200 CDD:284982 84/252 (33%)
A2M_recep 1313..1402 CDD:284981 26/88 (30%)
A2mNP_783327.2 A2M_N 135..227 CDD:280081 33/99 (33%)
A2M_N_2 473..612 CDD:285005 36/149 (24%)
Bait region. /evidence=ECO:0000250|UniProtKB:P01023 623..752 28/153 (18%)
A2M 738..828 CDD:278630 27/90 (30%)
A2M_2 958..1264 CDD:239227 109/307 (36%)
A2M_comp 1010..1266 CDD:284982 86/257 (33%)
A2M_recep 1376..1463 CDD:284981 26/88 (30%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167840020
Domainoid 1 1.000 227 1.000 Domainoid score I2492
eggNOG 1 0.900 - - E1_COG2373
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 1 0.950 - 0 Normalized mean entropy S7033
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D177369at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100452
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
76.600

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