Protein Alignment Tep3 and A2M

DIOPT Version :10

• Sequence 1: NP_523507.2
• Gene: Tep3 / 34045
• FlyBaseID: FBgn0041181
• Length: 1469
• Species: Drosophila melanogaster
• Sequence 2: XP_006719119.1
• Gene: A2M / 2
• HGNCID: 7
• Length: 1512
• Species: Homo sapiens
• Alignment Length: 1556
• Identity: 398/1556 - (25%)
• Similarity: 666/1556 - (42%)
• Gaps: 211/1556 - (13%)

  Fly    12 PVLILVTACLL---CQTSAQGLYSIIAPNTLRPNSQFHVAVSLHNAPESATFKVGILG-----SS 68
            |.|:|:...||   ...|.:..|.::.|:.|...:.....|.|....|:.|....:..     |.
Human     9 PSLVLLLLVLLPTDASVSGKPQYMVLVPSLLHTETTEKGCVLLSYLNETVTVSASLESVRGNRSL 73

  Fly    69 YTDFKTVELRPFSTQLLH---FEIPALRTDR--YRLTAEGLGGVQ-FTNETQLHFESKQHTVLVQ 127
            :||.:.      ...:||   |.:|...::.  ..||.:..|..| |...|.:..:::...|.||
Human    74 FTDLEA------ENDVLHCVAFAVPKSSSNEEVMFLTVQVKGPTQEFKKRTTVMVKNEDSLVFVQ 132

  Fly   128 TDKSIYKPGDLVHYRVLILDANLKPARGYGRVHVDIKDSGDNIIRSYKDIRLTNSIYSNELRLSD 192
            |||||||||..|.:||:.:|.|..|......: |.|:|...|.|..::..:|...:......||.
Human   133 TDKSIYKPGQTVKFRVVSMDENFHPLNELIPL-VYIQDPKGNRIAQWQSFQLEGGLKQFSFPLSS 196

  Fly   193 SPRFGTWSIVVDVSDQEHTQ-TFEILDHILPKFVVDIDTPKHAIYKDGKIAATVRAHYAFGQPIV 256
            .|..|::.:||.......|: .|.:.:.:||||.|.:..||.....:.::..:|...|.:|:|:.
Human   197 EPFQGSYKVVVQKKSGGRTEHPFTVEEFVLPKFEVQVTVPKIITILEEEMNVSVCGLYTYGKPVP 261

  Fly   257 GEATLSIYPTFFGS-------LQPFVNDLITRKVVPIDGNAYFEFDIENEL-HLK-QDYERQYLL 312
            |..|:||...:..:       .|.|......:    ::.:..|...::.:: .|| ::||.:...
Human   262 GHVTVSICRKYSDASDCHGEDSQAFCEKFSGQ----LNSHGCFYQQVKTKVFQLKRKEYEMKLHT 322

  Fly   313 DALVEEKST--GSVQNYSTVLTLHLNHYRVEAVKVPSYYIPGVPFEATARIARNDGGQLRDFNPQ 375
            :|.::|:.|  ......|:.:|..:.  ::..|||.|::..|:||....|:....|..:.:....
Human   323 EAQIQEEGTVVELTGRQSSEITRTIT--KLSFVKVDSHFRQGIPFFGQVRLVDGKGVPIPNKVIF 385

  Fly   376 ITAYLTNVY--GSSEMYNRTAYSLDASGEIKMKFTVPIGDRDEFHSIIVDYQGVISEVGKI---- 434
            |.....|.|  .:::.:....:|::.:..:....||.:..:|  .|....||.|..|..:.
Human   386 IRGNEANYYSNATTDEHGLVQFSINTTNVMGTSLTVRVNYKD--RSPCYGYQWVSEEHEEAHHTA 448

  Fly   435 -----PSK---HL----------HSKNYITAKVLNDRPTVN-QEISVVVRSFAPIKYFMYQVVGR 480
                 |||   ||          |::......:||....:. :::|           |.|.::.:
Human   449 YLVFSPSKSFVHLEPMSHELPCGHTQTVQAHYILNGGTLLGLKKLS-----------FYYLIMAK 502

  Fly   481 GDII-------LSRNVDVAPGTFHTIKFLASFAMMPRANLLVYTVI-DGEFVYDEQVIQLEENLL 537
            |.|:       |.:..|: .|.| :|.......:.|.|.||:|.|: .|:.:.|.....:|..|.
Human   503 GGIVRTGTHGLLVKQEDM-KGHF-SISIPVKSDIAPVARLLIYAVLPTGDVIGDSAKYDVENCLA 565

  Fly   538 NAVQVD-APIRAPPGQDIDIGISTKPYSYVGLMLVDQNANDLRSGHDLTHKRLMDALRSYELSDV 601
            |.|.:. :|.::.|.....:.::..|.|...|..|||:...::...:|:...:.:.|...:|:..
Human   566 NKVDLSFSPSQSLPASHAHLRVTAAPQSVCALRAVDQSVLLMKPDAELSASSVYNLLPEKDLTGF 630

  Fly   602 NTPMGSPGKESGV---------IT---MSNTD-----YFIE------------KEAESNPALDRE 637
            ..|:.....|..:         ||   :|:|:     .|:|            ::.:..|.|.:.
Human   631 PGPLNDQDNEDCINRHNVYINGITYTPVSSTNEKDMYSFLEDMGLKAFTNSKIRKPKMCPQLQQY 695

  Fly   638 VSTGPEEDKLTTVRKTDIGPAHKIEVNTLPPGKGRYAFSYTPKPFWHNPRVHVMRDPADTWLFLN 702
            ...|||..:: ...::|:            .|:|.....:..:|.....|.:.    .:||::..
Human   696 EMHGPEGLRV-GFYESDV------------MGRGHARLVHVEEPHTETVRKYF----PETWIWDL 743

  Fly   703 ISASSDGRNSIHRRIPSEMTSWVVSAFALDPVNGLGLSPPNGKLEAYKEFYISTELPYSIKRDEL 767
            :..:|.|...:...:|..:|.|...||.|....|||:| ....|.|::.|::...:|||:.|.|.
Human   744 VVVNSAGVAEVGVTVPDTITEWKAGAFCLSEDAGLGIS-STASLRAFQPFFVELTMPYSVIRGEA 807

  Fly   768 IAIPFVVHNNRDSDLNVEVTFYNSALDFDFPQLDPKATNQPKVELYRRRSLQVPGRSARSVSFIV 832
            ..:...|.|.....:.|.|..          :..|.....|..:......:...||  ::||:.|
Human   808 FTLKATVLNYLPKCIRVSVQL----------EASPAFLAVPVEKEQAPHCICANGR--QTVSWAV 860

  Fly   833 TPKRVGPL--LVKAMAASSQ--------------AGDTVEQNLLVEHPGAMERINRGFLFELNSN 881
            |||.:|.:  .|.|.|..||              ..|||.:.|||| |..:|:..........|.
Human   861 TPKSLGNVNFTVSAEALESQELCGTEVPSVPEHGRKDTVIKPLLVE-PEGLEKETTFNSLLCPSG 924

  Fly   882 AQNRRNVTIAVPRNAIPESTRIEVSAVGDLIGSLVGNLDSLILLPTGCGEQTMVNFVPNLIVLRY 946
            .:....:::.:|.|.:.||.|..||.:||::||.:.|..:|:.:|.|||||.||.|.||:.||.|
Human   925 GEVSEELSLKLPPNVVEESARASVSVLGDILGSAMQNTQNLLQMPYGCGEQNMVLFAPNIYVLDY 989

  Fly   947 LGRLRQLTPEVELRATNNLAIGYQRILYYRHENGAFSAFGLDIKRS--STWLTAYVARSLRQAAP 1009
            |...:|||||::.:|...|..||||.|.|:|.:|::|.||....|:  :|||||:|.::..||..
Human   990 LNETQQLTPEIKSKAIGYLNTGYQRQLNYKHYDGSYSTFGERYGRNQGNTWLTAFVLKTFAQARA 1054

  Fly  1010 FTQVDSNVLQKALTYLGSVQSANGGFEERGDVFE---RFG-DDGISLTAFVTLALMENVDL---Y 1067
            :..:|...:.:||.:|...|..||.|...|.:..   :.| :|.::|:|::|:||:| :.|   :
Human  1055 YIFIDEAHITQALIWLSQRQKDNGCFRSSGSLLNNAIKGGVEDEVTLSAYITIALLE-IPLTVTH 1118

  Fly  1068 PEYRNN---INKALDFITRGLDGSSNLHAMAIGTYVLSRA-NHNAKAAFLQRLDSMATNKDGLKW 1128
            |..||.   :..|......| |..|:::..|:..|..:.| |.:.:...|:.|:..|..||....
Human  1119 PVVRNALFCLESAWKTAQEG-DHGSHVYTKALLAYAFALAGNQDKRKEVLKSLNEEAVKKDNSVH 1182

  Fly  1129 WNK----TAPAG---EQQSPWYNATRSVNIEISAYAALALL------ENNLVGDALPVLNWLMDQ 1180
            |.:    .||.|   |.|:|      |..:|:::|..||.|      .:..:..|..::.|:..|
Human  1183 WERPQKPKAPVGHFYEPQAP------SAEVEMTSYVLLAYLTAQPAPTSEDLTSATNIVKWITKQ 1241

  Fly  1181 RNPKGGFVASQDTVVGLQALLMF-AERFSSQGNNLQIGFHYGEGAETIINVNAENSLALQTVELP 1244
            :|.:|||.::|||||.|.||..: |..|:..|...|:.........:...|:..|.|.||.|.||
Human  1242 QNAQGGFSSTQDTVVALHALSKYGAATFTRTGKAAQVTIQSSGTFSSKFQVDNNNRLLLQQVSLP 1306

  Fly  1245 NNLKNLSVSATGRGMALAQVSYTYNTNVTSAWPRFVLD-PTVNRNSHADYLHLSACASF-VSVVG 1307
            ......|:..||.|....|.|..||.........|.|. .|:.:.......|.|...|. ||..|
Human  1307 ELPGEYSMKVTGEGCVYLQTSLKYNILPEKEEFPFALGVQTLPQTCDEPKAHTSFQISLSVSYTG 1371

  Fly  1308 ENEQRSNMAVMEVHLPSGFVVDRDTLPTLESSERIKKVETQNRNTKVVIYFDYLDRREVCPTLHA 1372
             :...||||:::|.:.|||:..:.|:..||.|..:.:.|..:.:  |:||.|.:..:.:......
Human  1372 -SRSASNMAIVDVKMVSGFIPLKPTVKMLERSNHVSRTEVSSNH--VLIYLDKVSNQTLSLFFTV 1433

  Fly  1373 YKTVKVTKHRPVAVVMYDYYDSARRARQFYRAPKSNICDICEHANCGDLCEKAEKRESKRP 1433
            .:.|.|...:|..|.:||||::...|...|.||       |.......|.:||.:..|..|
Human  1434 LQDVPVRDLKPAIVKVYDYYETDEFAIAEYNAP-------CSKGKPLTLLQKAVRAPSACP 1487

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tep3	NP_523507.2	YfaS	<128..1399	CDD:441940	359/1390 (26%)
		A2M_2	918..1203	CDD:239227	106/310 (34%)
A2M	XP_006719119.1	YfaS	<129..1338	CDD:441940	328/1269 (26%)
		A2M	738..828	CDD:459711	26/90 (29%)
		A2M_2	958..1264	CDD:239227	106/313 (34%)
		A2M_recep	1374..1464	CDD:462226	26/91 (29%)