DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tep3 and Mug2

DIOPT Version :9

Sequence 1:	NP_523507.2	Gene:	Tep3 / 34045	FlyBaseID:	FBgn0041181	Length:	1469	Species:	Drosophila melanogaster
Sequence 2:	XP_006505762.1	Gene:	Mug2 / 17837	MGIID:	99836	Length:	1490	Species:	Mus musculus

Alignment Length:	1578	Identity:	407/1578 - (25%)
Similarity:	671/1578 - (42%)	Gaps:	282/1578 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 LILVTACLLCQTSAQGL-----YSIIAPNTLRPNSQFHVAVSLHNAPESATFKVGILGS----SY 69
            |.|.:..|....||..|     |.::.|:.|...:...:.:.|::..|:.|....::..    :.
Mouse     9 LCLFSVLLAFLPSASSLNGDSKYMVLVPSQLYTETPEKICLHLYHLNETVTVTASLVSQTGRRNL 73

  Fly    70 TDFKTVELRPFSTQLLHFEIPALRT-DRYRLTAEGLGGV--QFTNETQLHFESKQHTVLVQTDKS 131
            .|...|:...|  |.:.|.||.|.: |........:.|.  :|:....:..::|:..|.|||||.
Mouse    74 FDELVVDKDLF--QCVSFIIPTLNSPDEEEFLYVDIKGPTHEFSKRNAVLVKNKESVVFVQTDKP 136

  Fly   132 IYKPGDLVHYRVLILDANLKPAR-----GYGRVHVDIKDSGDNIIRSYKDIRLTNSIYSNELRLS 191
            :||||..|.:||:.:|..|:|..     .|      |:|...|.|..::||:..|.:......|:
Mouse   137 VYKPGQSVKFRVVSMDKTLRPLNELLPLAY------IEDPKKNRIMQWRDIKTENGLKQMSFSLA 195

  Fly   192 DSPRFGTWSIVVDVSD---QEHTQTFEILDHILPKFVVDIDTPKHAIYKDGKIAATVRAHYAFGQ 253
            ..|..|.:.|||....   :||  :|.:::.:||:|.||:..|......|..:..||...|.:|:
Mouse   196 AEPIQGPYKIVVHKQSGVKEEH--SFTVMEFVLPRFNVDLKVPNAISVNDEVLQVTVCGKYTYGK 258

  Fly   254 PIVGEATLSI-YPTFFGSLQPFVNDLITRKVVPIDGNAYFEFDIENELHLKQDYERQ-YLLDALV 316
            |:.|:..:|| :.|..|..:  ||..:..     :|.:..|.:|......|::||.| :.::|.|
Mouse   259 PVPGQVKISICHETEAGCKE--VNSKLDN-----NGCSTQEVNITELQSKKRNYEVQLFHVNATV 316

  Fly   317 EEKSTGSVQNYSTVLTLHLNHY---RVEAV-------KVPSYYIPGVPFEATARIARNDGGQLRD 371
            .|:.||          |..|.|   ::|.:       |..|::..|:||....|:....|..:.:
Mouse   317 TEEGTG----------LEFNGYGTTKIERITNKLIFLKADSHFRHGIPFFVKVRLVDIKGDPIPN 371

  Fly   372 ----FNPQITAYLTNVYGSSEMYNRTAYSLDASGEIKMKFTVPIGDRDEFHSIIVDYQGVIS--- 429
                ...|:..|.:..  :::.:....:|:|.:|     |:     ....| |.|:::|..|
Mouse   372 ERVFIKAQVLGYTSAT--TTDQHGLAKFSIDTAG-----FS-----GSSLH-IKVNHKGKDSCYF 423

  Fly   430 ----EVGKIPSKHLH------SKNYI-----TAKVL--NDRPTVNQEISVVVRSFAPIK--YFMY 475
                |.....::|:.      ||:||     |:.:|  |...|| |...::......:|  .|.|
Mouse   424 FYCMEERYASAEHVAYAVYSLSKSYIYLVKETSSILPCNQIHTV-QAHFILKGDLGVLKELVFYY 487

  Fly   476 QVVGRGDIILSRN--VDVAPGTF-----HTIKFLASFAMMPRANLLVYTVI-DGEFVYDEQVIQL 532
            .|:.:|.||.:.|  ..|.||..     ..::....|:|.|.|.:|:||:: |||.:.|....::
Mouse   488 LVMAQGSIIQTGNHTHQVEPGEAPVKGNFDLEIPVEFSMAPMAKMLIYTILPDGEVIADSVNFEI 552

  Fly   533 EENLLNAVQVD-APIRAPPGQDIDIGISTKPYSYVGLMLVDQNANDLRSGHDLTHKRLMDALRSY 596
            |:.|.|.|.:. :..::.|.....:.::..|.|..||..|||:...|:...:|:...:      |
Mouse   553 EKCLRNKVDLSFSSSQSLPASQTRLQVTASPQSLCGLRAVDQSVLLLKPEDELSPSWI------Y 611

  Fly   597 ELSDVNTPMGSPGKESGVITMSNTDYFIEKEAESNPALDRE----------------VSTGPEED 645
            .|         ||.:.        :.||...:.|.   |||                |..|.|:|
Mouse   612 NL---------PGMQH--------NKFIPSSSLSE---DREDCILYSSWVAEKHTDWVPHGREKD 656

  Fly   646 KLTTVRKTDI---------------------GPAHKIEV-------NTLPPGKGRYAFSYTPKPF 682
            ....|...|:                     ||..|.::       .||..|.     |..|:|
Mouse   657 VYRYVEDMDLKAFTNLKIKLPKICFDSAPMSGPRGKFDLAFSSEVSGTLQKGS-----SKRPQP- 715

  Fly   683 WHNPRVHVMRDP--------------ADTWLFLNISASSDGRNSIHRRIPSEMTSWVVSAFALDP 733
            ...||    .||              .:||::..::.:|.|...:...:|..:|.|...|..|..
Mouse   716 EEPPR----EDPPPKDPLAETIRKYFPETWVWDIVTVNSTGVAEVEMTVPDTITEWKAGALCLSN 776

  Fly   734 VNGLGLSP--PNGKLEAYKEFYISTELPYSIKRDELIAIPFVVHNNRDSDLNVEVTFYNSALDFD 796
            ..|||||.  |   |:|::.|::...||||:.|.|...:...|.|...:.:.:.|..
Mouse   777 DTGLGLSSVVP---LQAFQPFFVEVSLPYSVVRGEAFMLKATVMNYLPTSMRMSVQL-------- 830

  Fly   797 FPQLDPKATNQPKVELYRRRSLQVPGRSARSVSFIVTPKRVG----PLLVKAMAASSQAG----- 852
              :..|..|..|..:.:....|...||  .:.|::||||.:|    .:.|:|..:|...|
Mouse   831 --EASPDFTAVPVGDDHDSYCLSANGR--HTSSWLVTPKSLGNVNFSVSVEAQQSSEPCGSEVAT 891

  Fly   853 -------DTVEQNLLVEHPGAMERINRGFLFELNSNAQNRRNVTIAVPRNAIPESTRIEVSAVGD 910
                   |||.:.|:||..|..:......|| ..|:|:....:::.:|...:.:|.|...|.:||
Mouse   892 VPETGRKDTVVKVLIVEPEGIKQEHTFNSLF-CASDAEISEKMSLVLPPTVVKDSARAHFSVMGD 955

  Fly   911 LIGSLVGNLDSLILLPTGCGEQTMVNFVPNLIVLRYLGRLRQLTPEVELRATNNLAIGYQRILYY 975
            ::.|.:.|..:|:.:|.|||||.||.|.||:.||:||.:.:|||.:::.:|...|..||||.|.|
Mouse   956 ILSSAIKNTQNLLHMPYGCGEQNMVLFAPNIYVLKYLDKTQQLTQKIKTKALGFLRAGYQRELNY 1020

  Fly   976 RHENGAFSAFG--LDIKRSSTWLTAYVARSLRQAAPFTQVDSNVLQKALTYLGSVQSANGGFEER 1038
            :|::|::||||  ...:..:|||||:|.:|..||..|..:|.:.:..|.|:|...|..||.|...
Mouse  1021 KHKDGSYSAFGDQNGEREGNTWLTAFVLKSFAQARAFIFIDESHITHAFTWLSQQQKDNGCFRSS 1085

  Fly  1039 GDVFE---RFG-DDGISLTAFVTLALMENVDLYPEYRNNINKALDFIT---RGLDGSSN---LHA 1093
            |.:|.   :.| ||.::|:|::|:||:|:  ..|.....::|||..:.   :.::...|   ::.
Mouse  1086 GSLFHNDIKGGVDDEMTLSAYITMALLES--SLPARHPVVSKALSCLESSWKTIEQGRNANFVYT 1148

  Fly  1094 MAIGTYVLSRA-NHNAKAAFLQRLDSMATNKD-GLKWWNKTAPAGEQQSPWYNATRSVNIEISAY 1156
            .|:..|..:.| |.:.:...|:.||..|..:| .:.|.....|...:.:.:.....||.:|::||
Mouse  1149 KALMAYAFALAGNQDKRNEILKSLDEEAIKEDNSIHWERPQKPRKSEHNLYKPQASSVEVEMNAY 1213

  Fly  1157 AALALLENNLVGDALP----------VLNWLMDQRNPKGGFVASQDTVVGLQALLMF-AERFSSQ 1210
            ..||    .|.....|          .:.||..|:|..|||.::|||||.|.||..: |..||.:
Mouse  1214 VVLA----RLTAQPAPSPEDLTLSRSTIMWLTKQQNSNGGFSSTQDTVVALDALSKYGAVTFSRR 1274

  Fly  1211 GNNLQIGFHYGEGAETIINVNAENSLALQTVELPNNLKNLSVSATGRGMALAQVSYTYNTNVTSA 1275
            .....:.............|...|.|.||.|.||:...:.::|.:|.|...||.:..||.::...
Mouse  1275 QKTSLVTIQSTGSFSQKFQVENSNCLLLQQVPLPDIPGDYTISVSGEGCVYAQTTLRYNMHLEKQ 1339

  Fly  1276 WPRFVL-----DPTVNRNSHADYLHLSACASFVSVVGENEQRSNMAVMEVHLPSGFVVDRDTLPT 1335
            ...|.|     ..|.|.....:...:|...|:..    :...|||.:.:|.:.|||:..:.|:..
Mouse  1340 QSAFALRVQTVPLTCNNPKGHNSFQISLEISYTG----SRPASNMVIADVKMLSGFIPLKPTVKK 1400

  Fly  1336 LESSERIKKVETQNRNTKVVIYFDYLDRREVCPTLHAYKTVKVTKHRPVAVVMYDYYDSARRARQ 1400
            ||..|.|.:.|..|.|  |::|.|.:..:.:..:....:.:.|...:|..|.:||||::...|..
Mouse  1401 LERLEHISRTEVSNNN--VLLYLDQVTNQTLAFSFIIQQDISVRNLQPAIVKVYDYYETDEVAYA 1463

  Fly  1401 FYRAPKSNICDICEHANC 1418
            .|.:|    |...||..|
Mouse  1464 EYSSP----CSSGEHPAC 1477

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tep3	NP_523507.2	A2M_N	124..215	CDD:280081	32/98 (33%)
		A2M_N_2	448..573	CDD:285005	37/137 (27%)
		A2M	697..787	CDD:278630	26/91 (29%)
		A2M_2	918..1203	CDD:239227	103/308 (33%)
		A2M_comp	967..1200	CDD:284982	79/256 (31%)
		A2M_recep	1313..1402	CDD:284981	26/88 (30%)
Mug2	XP_006505762.1	A2M_N	129..221	CDD:376626	33/99 (33%)
		MG3	223..299	CDD:375334	22/82 (27%)
		MG4	340..434	CDD:375332	19/106 (18%)
		A2M_N_2	459..599	CDD:377903	39/140 (28%)
		A2M	740..830	CDD:365945	27/92 (29%)
		A2M_2	960..1266	CDD:239227	103/311 (33%)
		A2M_recep	1378..1465	CDD:369460	26/88 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840032
Domainoid	1	1.000	75	1.000	Domainoid score	I9015
eggNOG	1	0.900	-	-		E1_COG2373
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D177369at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100452
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.650