DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tep3 and Mug1

DIOPT Version :9

Sequence 1:	NP_523507.2	Gene:	Tep3 / 34045	FlyBaseID:	FBgn0041181	Length:	1469	Species:	Drosophila melanogaster
Sequence 2:	XP_006505761.1	Gene:	Mug1 / 17836	MGIID:	99837	Length:	1483	Species:	Mus musculus

Alignment Length:	1532	Identity:	385/1532 - (25%)
Similarity:	660/1532 - (43%)	Gaps:	208/1532 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 AIPVLILVTACLLCQTSAQGLYSIIAPNTLRPNSQFHVAVSLHNAPESATFKVGILGSSYTD--F 72
            ::.:..|.:|.||   :....|.::.|:.|...:...:.:.|:...|:.|....::..|...  |
Mouse    13 SVLLAFLHSASLL---NGDSKYMVLVPSQLYTETPEKICLHLYQLNETVTVTASLVSQSGRKNLF 74

  Fly    73 KTVELRPFSTQLLHFEIPAL-RTDRYRLTAEGLGGV--QFTNETQLHFESKQHTVLVQTDKSIYK 134
            ..:.|.....|.:.|.||.| .:|........:.|.  :|:....:..::|:..|.|||||.:||
Mouse    75 DELVLDKDLFQCVSFIIPRLSSSDEEDFLYVDIKGPTHEFSKRKAVLVKNKESVVFVQTDKPVYK 139

  Fly   135 PGDLVHYRVLILDANLKPAR-----GYGRVHVDIKDSGDNIIRSYKDIRLTNSIYSNELRLSDSP 194
            ||..|.:||:.:|..|:|..     .|      |:|...|.|..::||:..|.:......|:..|
Mouse   140 PGQSVKFRVVSMDKMLRPLNELLPLAY------IEDPKKNRIMQWRDIKTENGLKQMSFSLAAEP 198

  Fly   195 RFGTWSIVV-DVSDQEHTQTFEILDHILPKFVVDIDTPKHAIYKDGKIAATVRAHYAFGQPIVGE 258
            ..|.:.||| ..|.::...:|.:::.:||:|.||:..|......|..::.|....|.:|:|:.|.
Mouse   199 IQGPYKIVVHKESGEKEEHSFTVMEFVLPRFNVDLKVPNAMSVNDEVLSVTACGKYTYGKPVPGH 263

  Fly   259 ATLSI-YPTFFGSLQPFVNDLITRKVVPIDGNAYFEFDIENELHLKQDYERQ-YLLDALVEEKST 321
            ..::: ..|..|..:  ||..:..     :|.:..|.:|......|::||.| :.::|.|.|:.|
Mouse   264 VKINVCRETETGCRE--VNSQLDN-----NGCSTQEVNITELQSKKRNYEVQLFHVNATVTEEGT 321

  Fly   322 GSVQNYSTVLTLHLNHYRVEAVKVPSYYIPGVPFEATARIARNDGGQLRDFNPQI---------- 376
            |...:.|....:.....::..:|..|::..|:||....|:....|..:.  |.::
Mouse   322 GLEFSRSGTTKIERITNKLIFLKADSHFRHGIPFFVKVRLVDIKGDPIP--NEKVFIKAQELSYT 384

  Fly   377 TAYLTNVYGSSEMYNRTAYSLDASGEIKMKFTVPIGDRDE-----FHSIIVDYQGVISEVGKIPS 436
            :|..|:.:|.:|      :|:|.:........:.:..::|     |:.:         |.....:
Mouse   385 SATTTDQHGLAE------FSIDTTCISGSSLHIKVNHKEEDSCSYFYCM---------EERHASA 434

  Fly   437 KHLH------SKNYI-----TAKVL--NDRPTVNQEISVVVRSFAPIK--YFMYQVVGRGDIILS 486
            ||:.      ||:||     |:.:|  |...|| |...::......:|  .|.|.|:.:|.||.:
Mouse   435 KHVAYAVYSLSKSYIYLDTETSSILPCNQIHTV-QAHFILKGDLGVLKELIFYYLVMAQGSIIQT 498

  Fly   487 RN--VDVAPGTF-----HTIKFLASFAMMPRANLLVYTVI-DGEFVYDEQVIQLEENLLNAVQVD 543
            .|  ..|.||..     ..::....|:|:|.|.:|:||:: |||.:.|....::|:.|.|.|.:.
Mouse   499 GNHTHQVEPGEAPVKGKFALEIPVEFSMVPMAKMLIYTILPDGEVIADSVNFEIEKCLRNKVDLR 563

  Fly   544 -APIRAPPGQDIDIGISTKPYSYVGLMLVDQNANDLRSGHDLTHKRLMDALRSYELSDVNTPMGS 607
             :..::.|.....:.::..|.|..||..|||:...|:...:|:...:      |.|
Mouse   564 FSTSQSLPASQTRLQVTASPQSLCGLRAVDQSVLLLKPESELSPSWI------YNL--------- 613

  Fly   608 PGKESGVITMSN------------TDYFIEKEAESNP-ALDREVSTGPEEDKLTTVRKTDIG-PA 658
            ||.:......|:            :.:..||.....| ..:::|....|:..||......|. |.
Mouse   614 PGMQQNKFVPSSRLSEDQEDCILYSSWLAEKHTNLVPHGTEKDVYRYVEDMGLTAFTNLMIKLPI 678

  Fly   659 HKIEVNTLPPGKGRYAF--SYTPKPFW-------HNPRVHVMRDPA--------------DTWLF 700
            ...:...:|....|..|  ::||:..|       ..|.....:||:              :||::
Mouse   679 ICFDYGMVPISAPRVEFDLAFTPEISWSLRTTLSKRPEEPPRKDPSSNDPLTETIRKYFPETWVW 743

  Fly   701 LNISASSDGRNSIHRRIPSEMTSWVVSAFALDPVNGLGLSP--PNGKLEAYKEFYISTELPYSIK 763
            ..::.:|.|...:...:|..:|.|...|..|....|||||.  |   |:|:|.|::...||||:.
Mouse   744 DIVTVNSTGLAEVEMTVPDTITEWKAGALCLSNDTGLGLSSVVP---LQAFKPFFVEVSLPYSVV 805

  Fly   764 RDELIAIPFVVHNNRDSDLNVEVTFYNSALDFDFPQLDPKATNQPKVELYRRRSLQVPGRSARSV 828
            |.|...:...|.|...:.:.:.|..          :..|..|..|..:......|...||  .:.
Mouse   806 RGEAFMLKATVMNYLPTSMQMSVQL----------EASPDFTAVPVGDDQDSYCLSANGR--HTS 858

  Fly   829 SFIVTPKRVGPLLVKAMAASSQAG----------------DTVEQNLLVEHPGAMERINRGFLFE 877
            |::||||.:|.:.....|.:.|:.                |||.:.|:||..|..:......||
Mouse   859 SWLVTPKSLGNVNFSVSAEAQQSSEPCGSEVATVPETGRKDTVVKVLIVEPEGIKQEHTFSSLF- 922

  Fly   878 LNSNAQNRRNVTIAVPRNAIPESTRIEVSAVGDLIGSLVGNLDSLILLPTGCGEQTMVNFVPNLI 942
            ..|:|:....:::.:|...:.:|.|...|.:||::.|.:.|..:|:.:|.|||||.||.|.||:.
Mouse   923 CASDAEISEKMSLVLPPTVVKDSARAHFSVMGDILSSAIRNTQNLLHMPYGCGEQNMVLFAPNIY 987

  Fly   943 VLRYLGRLRQLTPEVELRATNNLAIGYQRILYYRHENGAFSAFG--LDIKRSSTWLTAYVARSLR 1005
            ||:||...:|||.:::.:|...|..||||.|.|:|::|::||||  ...:..:|||||:|.:|..
Mouse   988 VLKYLNETQQLTQKIKTKALGFLRAGYQRELNYKHKDGSYSAFGDQNGEREGNTWLTAFVLKSFA 1052

  Fly  1006 QAAPFTQVDSNVLQKALTYLGSVQSANGGFEERGDVFE---RFG-DDGISLTAFVTLALMENVDL 1066
            ||..|..:|.:.:..|.|:|...|..||.|...|.:|.   :.| ||.::|:|::|:||:|:  .
Mouse  1053 QARAFIFIDESHITHAFTWLSQKQKDNGCFRSSGSLFNNAMKGGVDDEMTLSAYITMALLES--S 1115

  Fly  1067 YPEYRNNINKALDFITRGLD------GSSNLHAMAIGTYVLSRA-NHNAKAAFLQRLDSMATNKD 1124
            .|.....::|||..:.....      .:|.::..|:..|..:.| |.|.:...|:.||..|..::
Mouse  1116 LPATHPVVSKALSCLESSWKTIEQERNASFVYTKALMAYAFALAGNQNKRDEILKSLDEEAIKEN 1180

  Fly  1125 GLKWWNKTAPAGEQQSPWYN-ATRSVNIEISAYAALALLENNLVGD------ALPVLNWLMDQRN 1182
            ....|.:...:.:.:...|. ...|..:|::||..||.|.......      ::..:.||..|:|
Mouse  1181 NSIHWKRPQKSRKSEHHLYKPQASSAEVEMNAYVVLARLTAQPAPSPEDLTLSMSTIMWLTKQQN 1245

  Fly  1183 PKGGFVASQDTVVGLQALLMF-AERFSSQGNNLQIGFHYGEGAETIINVNAENSLALQTVELPNN 1246
            ..|||.::|||||.|.||..: |..||.......:.............|...|.|.||.|.||:.
Mouse  1246 SNGGFSSTQDTVVALDALSKYGAVTFSRSQKTTLVTIQSTGSFSQKFQVENSNRLLLQQVALPDI 1310

  Fly  1247 LKNLSVSATGRGMALAQVSYTYNTNVT------SAWPRFVLDPTVNRNSHADYLHLSACASFVSV 1305
            ..:.::|.:|.|...||....||.::.      :.|.:.|.....|...|..: .:|...|:..
Mouse  1311 PGDYTISVSGEGCVYAQTMLRYNMHLEKQLSAFAIWVQTVPLTCNNPKGHNSF-QISLEISYTG- 1373

  Fly  1306 VGENEQRSNMAVMEVHLPSGFVVDRDTLPTLESSERIKKVETQNRNTKVVIYFDYLDRREVCPTL 1370
               :...|||.:.:|.:.|||:..:.|:..||..|.:.:.|..|.|  |:||.|.:..:.:..:.
Mouse  1374 ---SRPASNMVIADVKMLSGFIPLKPTVKKLERLEHVSRTEVSNNN--VLIYLDQVTNQTLAFSF 1433

  Fly  1371 HAYKTVKVTKHRPVAVVMYDYYDSARRARQFYRAPKS 1407
            ...:.:.|...:|..|.:||||::...|...|.:|.|
Mouse  1434 IIQQDIPVRNLQPAIVKVYDYYETDEMAFAEYSSPCS 1470

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tep3	NP_523507.2	A2M_N	124..215	CDD:280081	31/96 (32%)
		A2M_N_2	448..573	CDD:285005	37/137 (27%)
		A2M	697..787	CDD:278630	27/91 (30%)
		A2M_2	918..1203	CDD:239227	101/304 (33%)
		A2M_comp	967..1200	CDD:284982	77/252 (31%)
		A2M_recep	1313..1402	CDD:284981	26/88 (30%)
Mug1	XP_006505761.1	A2M_N	129..221	CDD:376626	32/97 (33%)
		MG3	223..299	CDD:375334	19/82 (23%)
		MG4	340..439	CDD:375332	19/115 (17%)
		A2M_N_2	449..599	CDD:377903	41/150 (27%)
		A2M	740..830	CDD:365945	28/92 (30%)
		A2M_2	960..1266	CDD:239227	101/307 (33%)
		A2M_recep	1378..1465	CDD:369460	26/88 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840036
Domainoid	1	1.000	227	1.000	Domainoid score	I2492
eggNOG	1	0.900	-	-		E1_COG2373
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D177369at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100452
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.650