Protein Alignment Tep3 and tep-1

DIOPT Version :9

• Sequence 1: NP_523507.2
• Gene: Tep3 / 34045
• FlyBaseID: FBgn0041181
• Length: 1469
• Species: Drosophila melanogaster
• Sequence 2: NP_001367060.1
• Gene: tep-1 / 173367
• WormBaseID: WBGene00013969
• Length: 1516
• Species: Caenorhabditis elegans
• Alignment Length: 1542
• Identity: 416/1542 - (26%)
• Similarity: 726/1542 - (47%)
• Gaps: 181/1542 - (11%)

  Fly    19 ACLLCQTSA---QGLYSIIAPNTLRPNSQFHVAVSLHNAPESATFKVGILGSSYTDFKT------ 74
            |.::..|:|   ...|.::||..:||:..|.|.::|..........|.|      :.:|
 Worm    25 AAVVSTTAAPVKPATYMLVAPAVVRPDQPFSVCMNLLKQATDEDMIVRI------EVRTERNETI 83

  Fly    75 -----VELRPFSTQLLHF-EIPALR-TDR--YRLTAEG---LGGVQFTNETQLHFESKQHTVLVQ 127
                 ..|:|...|.:.. |:||.. |.|  |:|...|   ...:.|.||.:|.::.|..:|.:|
 Worm    84 AARVISNLKPGIAQTVSLSEMPAQSLTPRQSYKLYIRGETLNAELIFENENELKYDQKALSVFIQ 148

  Fly   128 TDKSIYKPGDLVHYRVLILDANLKPARGYGRVHVDIKDSGDNIIRSYKDIRLTNSIYSNELRLSD 192
            ||::||:|..||.||.:::.::|||.  .|...:.|.|...|:|.....:.|...:||.||:|::
 Worm   149 TDRAIYRPASLVRYRAIVVKSDLKPY--VGNATIKIFDPSRNLISQTIGVTLDRGVYSGELQLAE 211

  Fly   193 SPRFGTWSIVVDVSD-QEHTQTFEILDHILPKFVVDIDTPKHAIYKDGKIAATVRAHYAFGQPIV 256
            ....|.|.|.|:.|: .:...:|.:..::||||.|:|.|.......| .::..|.|.|.:|:.:.
 Worm   212 ETLLGDWFIEVETSNGVQDKSSFTVDTYVLPKFEVNIKTSSFITIND-DLSVFVDAKYTYGKGVA 275

  Fly   257 GEATLSIYPTF--FGSLQPFVND---------LITRKVVPID--GNAYFEFDIENELHLKQDYER 308
            |:|.:|:...:  :.::.|.:.|         |:..:.|.::  |.|...|.       ..:.:|
 Worm   276 GKAKVSLELPWHRWHAMVPTIIDENGVKKEEELMVERTVKLNRQGEAAVVFS-------NDELKR 333

  Fly   309 QYLLD----------ALVEEKSTGSVQNYSTVLTLHLNHYRVEAVKVPSYYIPGVPFEATARIAR 363
            ..||.          |.|.|..|...:|.:..::......:::..|....:.||:.:.....:.:
 Worm   334 HKLLHEWGGGSIRIVASVTEDITEIERNATHQISTFREEVKLDVEKQGDTFKPGLTYNVVVALKQ 398

  Fly   364 NDGGQLRDFNP---QITAYLTNVYGS-----SEMYNRTAYSLDASGEIKMKFTVP---------- 410
            .|...::...|   |::.:....|..     .|........:||.|...:....|
 Worm   399 MDDTPVKATLPKRVQVSTFYNYPYNHDTSSLQEEKETKIVEVDAHGTSVLTLQPPINCTSARIEA 463

  Fly   411 ---IGDRDEFHSIIVDYQGVISEVGKIPSKHLHSKNYITAKVLNDRP---TVNQEISVVVRSFAP 469
               ||.:|.|.:..: |..:..|....|:|..       .::|.|..   .|.:.:|..:::..|
 Worm   464 HYDIGGKDNFTATPI-YSSLYVEAAVSPTKSF-------LQLLADNEGAVDVGKSLSFSLKATQP 520

  Fly   470 IKYFMYQVVGRGDIILSRNVDVAPGTFH-TIKFLASFAMMPRANLLVYTVIDG--EFVYDEQVIQ 531
            :....|||:.|.:|::|:.:.|  .:.| ||.|.|:..|.|::.|:||.:|:.  |.:.|....:
 Worm   521 LSTITYQVMSRSNIVVSQQMTV--NSEHATISFPATANMAPKSRLIVYAIIESSQEVLVDALDFK 583

  Fly   532 LEENLLNAVQVDAPIRA-PPGQDIDIGISTKPYSYVGLMLVDQNANDLRSGHDLTHKRLMDALRS 595
            :|....|.|.:....:| .|||::...:::...|:|||::|||:...|::|:|:|.:::...|.:
 Worm   584 VEGIFQNQVALSIDKQAVEPGQNVKFKVTSDKNSFVGLLVVDQSVLLLKTGNDITREKVEQDLEN 648

  Fly   596 YELSDVNTPMGSP---------------------GKE-------SGVITMSNTDYFIEKEAESNP 632
            |:.::|....|.|                     |.:       :|::.:  ||..:.:|.:
 Worm   649 YDSNNVGGGFGGPRPWEAIDRKKRSIWRPWWGIGGSDAQSIFSNAGLVVL--TDALLYREPQ--- 708

  Fly   633 ALDREVSTGPEEDKLTTVRKTDIGPAHKIEVNTLPPGKGRYAFSYTPKPFWHNPRVHVMRDPADT 697
               ||..:|      |.:|:      :|:.:....||....||:..|......|...|.:....|
 Worm   709 ---REFMSG------TFMRR------NKVMMMDGAPGMAEAAFAAPPMGGSSPPPPTVRKFFPHT 758

  Fly   698 WLFLNISASSDGRNSIHRRIPSEMTSWVVSAFALDPVNGLGLSPPNGKLEAYKEFYISTELPYSI 762
            |::.:::::| |...:....|..:||||.|.||::..||||::|...||..::.|:|...|||::
 Worm   759 WIWSDLNSTS-GEVEMEIEAPDTITSWVASTFAINEENGLGVAPTTSKLRVFRPFFIQLNLPYAV 822

  Fly   763 KRDELIAIPFVVHNNRDSDLNVEVTF-YNSALDFDFPQLDPKATNQPKVELYRRRSLQVP-GRSA 825
            :|.|..|:..:|.|..:.:.:|.||. |:....:|..:.|.....:.:|.....|.:.|. |.::
 Worm   823 RRGEKFALLVLVFNYMEKEQDVTVTLKYDKDSGYDLLKKDGTVVRRDEVGQQNVRIVSVAGGGTS 887

  Fly   826 RSVSFIVTPKRVGPLLVKAMAASSQAGDTVEQNLLVEHPGAMERINRGFLFELNSNAQN-RRNVT 889
            ::|.|.:.|..:|.:.|...|.:||.||.||.||.|:..|.....|..|:.:||:|:.: .:|:.
 Worm   888 KAVYFPIVPSSIGEIPVHISAIASQGGDAVEMNLRVDPQGYKVDRNIPFVIDLNNNSSDFSKNLE 952

  Fly   890 IAVPRNAIPESTRIEVSAVGDLIGSLVGNLDSLILLPTGCGEQTMVNFVPNLIVLRYLGRLRQLT 954
            :..|.:.:..|.:..:..:||::|.::.|...|:.:|.|||||.|:|.|||::|::||....:..
 Worm   953 LIWPNDVVDGSQKARLDVIGDMMGPVLNNAHKLVQMPYGCGEQNMLNLVPNILVVKYLRATNRNE 1017

  Fly   955 PEVELRATNNLAIGYQRILYYRHENGAFSAFGLDIKRSSTWLTAYVARSLRQAAPFTQVDSNVLQ 1019
            .::|.:|...:..|.||.|.|:..:.:|||||...|..||||||:|.||...|..:..||.||:.
 Worm  1018 SQLETKAIKFIEQGIQRELTYKRADNSFSAFGDSDKAGSTWLTAFVVRSFHHAKQYAFVDPNVIS 1082

  Fly  1020 KALTYLGSVQSANGGFEERGDVFER-----FGDDGISLTAFVTLALMENVDLYPEYRNNINKALD 1079
            :|:.:|.|.|..:|.|.|||:|..:     ..|.|::|||||.::::||     ...|  .||:.
 Worm  1083 RAVAFLNSQQMESGAFAERGEVHHKDMQGGAQDGGVALTAFVLISILEN-----GMEN--GKAVT 1140

  Fly  1080 FITRGLDG-SSNLHAMAIGTYVLSRA-NHNAKAAFLQRLDSMATNKDG-LKW---WNKTAPAGEQ 1138
            ::.:.||. |.|.:.||:..|.|..| :..|..||..........|.| :|:   ..|.....|.
 Worm  1141 YLEKHLDEVSGNAYTMAVVAYALQLAKSKQAGKAFENLKKHKIVEKSGDVKFASAQKKVEKLKES 1205

  Fly  1139 QSPWYNATRSVNIEISAYAALALLENNLVGDALPVLNWLMDQRNPKGGFVASQDTVVGLQALLMF 1203
            ::..:.| |.|:||.::||.|:.|..|...::|.::.||:.|||..|||.::||||:.||||..:
 Worm  1206 RAYMFQA-RPVDIETTSYAVLSYLAQNQTSESLSIIRWLVSQRNELGGFTSTQDTVMALQALSSY 1269

  Fly  1204 AERFSSQGNNLQIGFHYGEGAETIINVNAENSLALQTVELPNNLKNLSVSATGRGMALAQVSYTY 1268
            |....|..:..|:....|:...: .::|..|::.||:.:|.:....:|::|.|.|:..||:||:|
 Worm  1270 AAVTYSDKHTSQVTILNGKHTHS-FDINIRNAIVLQSYQLSSLNDAVSINANGTGVVFAQLSYSY 1333

  Fly  1269 NTNVTSAWPRFVLDPTVNRNSHADYLHLSACASFVSVVGENEQRSNMAVMEVHLPSGFVVDRDTL 1333
            ..:..:....|.....:......:.|.|..|.::.     ...:||||:.|:...||:..|.:.:
 Worm  1334 YRDSLNDDAPFFCSQEIKEIRAGNRLQLDLCCNYT-----RPGKSNMALAEIDALSGYRFDAEQV 1393

  Fly  1334 PTLESSERIKKVETQNRNTKVVIYFDYLDRREVCPTLHAYKTVKVTKHRPVAVVMYDYYDSARRA 1398
            .||.|.|.:::||.:..:||:.:||:.|..|.||.:|::..|.:|...:|....:.||||...:.
 Worm  1394 HTLTSIEDLQRVEMEKDDTKMNVYFNPLGGRPVCLSLYSDVTYQVADQKPANFRLVDYYDPEEQL 1458

  Fly  1399 RQFYRAPKSNICDICEHANCGDLCEKAEKRESKRPDDYTAIAGHSSG 1445
            :..|.|.::...    ...||:.|..... .|..|.|.:.:.|.|||
 Worm  1459 KMTYAAKQTRSL----QEKCGEDCWPPIS-PSLPPFDESTVTGTSSG 1500

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tep3	NP_523507.2	A2M_N	124..215	CDD:280081	30/91 (33%)
		A2M_N_2	448..573	CDD:285005	37/131 (28%)
		A2M	697..787	CDD:278630	30/89 (34%)
		A2M_2	918..1203	CDD:239227	109/295 (37%)
		A2M_comp	967..1200	CDD:284982	89/243 (37%)
		A2M_recep	1313..1402	CDD:284981	30/88 (34%)
tep-1	NP_001367060.1	YfaS	<100..1316	CDD:225248	344/1265 (27%)
		A2M_N_2	495..631	CDD:400170	39/137 (28%)
		A2M	758..848	CDD:395153	31/90 (34%)
		A2M_2	978..1269	CDD:239227	109/298 (37%)
		A2M_recep	1373..1462	CDD:400149	30/88 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160166531
Domainoid	1	1.000	76	1.000	Domainoid score	I5811
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H25183
Inparanoid	1	1.050	674	1.000	Inparanoid score	I374
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45959
OrthoDB	1	1.010	-	-		D177369at33208
OrthoFinder	1	1.000	-	-		FOG0002157
OrthoInspector	1	1.000	-	-		otm14511
orthoMCL	1	0.900	-	-		OOG6_100452
Panther	1	1.100	-	-	O	PTHR11412
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2582
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	13	12.910