Protein Alignment Tep3 and Hc

DIOPT Version :10

• Sequence 1: NP_523507.2
• Gene: Tep3 / 34045
• FlyBaseID: FBgn0041181
• Length: 1469
• Species: Drosophila melanogaster
• Sequence 2: XP_017171158.1
• Gene: Hc / 15139
• MGIID: 96031
• Length: 1684
• Species: Mus musculus
• Alignment Length: 1672
• Identity: 369/1672 - (22%)
• Similarity: 645/1672 - (38%)
• Gaps: 368/1672 - (22%)

  Fly    16 LVTACLLCQTSAQGLYSIIAPNTLRPNSQFHVAVSLHNAPESATFKVGILGSSYTDFKT------ 74
            ||.|..|.      :|.|.||..||..|..:|.:.:|...|:  |...:...||.|.|.
Mouse    18 LVEAATLL------IYVISAPKILRVGSSENVVIQVHGYTEA--FDATLSLKSYPDKKVTFSSGY 74

  Fly    75 VELRPFSTQLLHFEIPALRTDRYRLTAEGLGGVQ--FTNETQLHF-ESKQHTV-------LVQTD 129
            |.|.|.:    .|:..||.|.:..........|.  :......|| :||:..:       .:.||
Mouse    75 VNLSPEN----KFQNAALLTLQPNQVPREESPVSHVYLEVVSKHFSKSKKIPITYNNGILFIHTD 135

  Fly   130 KSIYKPGDLVHYRVLILDANLKPARGYGRV--------HVDIKDSGDNIIRSYKDIRLTNSIYSN 186
            |.:|.|...|..||..|..:||||:....:        .|||.:..|          .|..|...
Mouse   136 KPVYTPDQSVKIRVYSLGDDLKPAKRETVLTFIDPEGSEVDIVEEND----------YTGIISFP 190

  Fly   187 ELRLSDSPRFGTWSIVVDVSDQEHTQT----FEILDHILPKFVVDIDTPKHAI-YKDGK-IAATV 245
            :.::..:|::|.|:|..:.. ::.|.|    |||.:::||:|.|.|:..:..| ||:.| ...||
Mouse   191 DFKIPSNPKYGVWTIKANYK-KDFTTTGTAYFEIKEYVLPRFSVSIELERTFIGYKNFKNFEITV 254

  Fly   246 RAHYAFGQPIVGEATLSIYPTFFGSLQPFVND-------LITRKVVPIDGNAYFEFDIE------ 297
            :|.| |...:|.:|  .:| .||| |:..:.|       ..|:....:||.|...||.|
Mouse   255 KARY-FYNKVVPDA--EVY-AFFG-LREDIKDEEKQMMHKATQAAKLVDGVAQISFDSETAVKEL 314

  Fly   298 --NELHLKQDYERQYLLDALVEEKSTGSVQNYSTV--LTLHLNHYRVEAVKVPSYYIPGVPFEAT 358
              |.|   :|...:||..|:...:|:|.....:.:  :...|:.|.:..|..|.:..||:||...
Mouse   315 SYNSL---EDLNNKYLYIAVTVTESSGGFSEEAEIPGVKYVLSPYTLNLVATPLFVKPGIPFSIK 376

  Fly   359 ARI----ARNDGG-------QLRDFNPQITAYLTNVYGSSEMYNRTAYSLDASGEIKMKFTVPIG 412
            |::    .:..||       |..|.|.:          :|::..:.:.:.|..|.......:|
Mouse   377 AQVKDSLEQAVGGVPVTLMAQTVDVNQE----------TSDLETKRSITHDTDGVAVFVLNLP-- 429

  Fly   413 DRDEFHSIIVDYQGVISEVGKIPSKHLHSKNY-------------ITAKVLNDRP-TVNQEISVV 463
                 .::.|....:.::..::|.::..||.|             ..|...|.:| .|.:.::::
Mouse   430 -----SNVTVLKFEIRTDDPELPEENQASKEYEAVAYSSLSQSYIYIAWTENYKPMLVGEYLNIM 489

  Fly   464 VRSFAP----IKYFMYQVVGRGDII-LSRNVDVAPGTFHTIKFLASFAMMPRANLLVYTVIDG-- 521
            |...:|    |.::.|.::.:|.|: ......:...|:..|....:..|:|.|.||||.::.|
Mouse   490 VTPKSPYIDKITHYNYLILSKGKIVQYGTREKLFSSTYQNINIPVTQNMVPSARLLVYYIVTGEQ 554

  Fly   522 --EFVYDEQVIQLEENLLNAVQV----DAPIRAPPGQDIDIGISTKPYSYVGLMLVDQNANDLRS 580
              |.|.|...|.:||...|.:||    |..:.: |||.:.:.:.|:..|:|.|..||:....::.
Mouse   555 TAELVADAVWINIEEKCGNQLQVHLSPDEYVYS-PGQTVSLDMVTEADSWVALSAVDRAVYKVQG 618

  Fly   581 GHDLTHKRLMDALRSYELSDVNTPMGSPGKESGVITMSNTDYFIEKEAESNPALD---REVSTGP 642
            ......:|:..||.  |.||:....|.....:.|..::...:.....|:.:...|   :|:....
Mouse   619 NAKRAMQRVFQALD--EKSDLGCGAGGGHDNADVFHLAGLTFLTNANADDSHYRDDSCKEILRSK 681

  Fly   643 EEDKL----------------------------------TTVRKTDIGP---------------- 657
            ....|                                  ..|.:..|||
Mouse   682 RNLHLLRQKIEEQAAKYKHSVPKKCCYDGARVNFYETCEERVARVTIGPLCIRAFNECCTIANKI 746

  Fly   658 ----AHK------IEVNTLPPGKGRYAFSYTPKPFWHNPRVHVMRDPADTWLFLNISASSDGRNS 712
                .||      |.:.||.|.......||.|                ::||:           .
Mouse   747 RKESPHKPVQLGRIHIKTLLPVMKADIRSYFP----------------ESWLW-----------E 784

  Fly   713 IHR---------RIPSEMTSWVVSAFALDPVNGLGLSPPNG-------KLEAYKEFYISTELPYS 761
            |||         .:|..:|:|        .:.|:|:| .||       |.:.:||.::...:|||
Mouse   785 IHRVPKRKQLQVTLPDSLTTW--------EIQGIGIS-DNGICVADTLKAKVFKEVFLEMNIPYS 840

  Fly   762 IKRDELIAIPFVVHNNRDSDLNVEV---------TFYNSALDFDFPQLDPKATNQPKVELYRRRS 817
            :.|.|.|.:...|:|...|.....|         |..:||....        |::|...:::|
Mouse   841 VVRGEQIQLKGTVYNYMTSGTKFCVKMSAVEGICTSGSSAASLH--------TSRPSRCVFQR-- 895

  Fly   818 LQVPGRSARSVSFIVTPKRVGPLLVKAMAASSQAGDTVEQNLLVEHPGAMERINRGFLFE---LN 879
              :.|.|:..|:|.:.|..:|...:.....:|...|.:.:.|.|...|.......|.:.:   :.
Mouse   896 --IEGSSSHLVTFTLLPLEIGLHSINFSLETSFGKDILVKTLRVVPEGVKRESYAGVILDPKGIR 958

  Fly   880 SNAQNRRNVTIAVPRNAIPESTRIE--VSAVGDLIGSLVG------NLDSLILLPTGCGEQTMVN 936
            .....|:.....:|.:.:|: |::|  :|..|.|:|..:.      .::.|..||.|..|..:::
Mouse   959 GIVNRRKEFPYRIPLDLVPK-TKVERILSVKGLLVGEFLSTVLSKEGINILTHLPKGSAEAELMS 1022

  Fly   937 FVPNLIVLRY--------------LGRLRQLTPEVELRATNNLAIGYQRILYYRHENGAFSAF-G 986
            ..|...|..|              |.:.:.|..:::.        |...::.||:.:.::|.: |
Mouse  1023 IAPVFYVFHYLEAGNHWNIFYPDTLSKRQSLEKKIKQ--------GVVSVMSYRNADYSYSMWKG 1079

  Fly   987 LDIKRSSTWLTAYVARSLRQAAPFTQVDSNVLQKALTYL-GSVQSANGGFEE---------RGDV 1041
            ..   :||||||:..|.|.|.|.:.:.|.|.:..:|.:| ...|..||.|:|         :|.:
Mouse  1080 AS---ASTWLTAFALRVLGQVAKYVKQDENSICNSLLWLVEKCQLENGSFKENSQYLPIKLQGTL 1141

  Fly  1042 FERFGDDGISLTAFVTLALMENVDLYPEYRNNINKALD----FITRGLDGSSNLHAMAIGTYVLS 1102
            .....:..:.||||..:.:.:.||:.|..:  |:.|||    |:......|.:...:||..|.||
Mouse  1142 PAEAQEKTLYLTAFSVIGIRKAVDICPTMK--IHTALDKADSFLLENTLPSKSTFTLAIVAYALS 1204

  Fly  1103 RANHNAKAAFLQRLDSMATNKDGL--------KWWNKTAPAGEQQSPWYNATRSVNIEISAYAAL 1159
            ..:......   ||...|..|:..        ::|..|....:...|  ::..:..:|.:|||.|
Mouse  1205 LGDRTHPRF---RLIVSALRKEAFVKGDPPIYRYWRDTLKRPDSSVP--SSGTAGMVETTAYALL 1264

  Fly  1160 ALLENNLVGDALPVLNWLMDQRNPKGGFVASQDTVVGLQALLMFAERFSSQGNNLQIGFHY-GEG 1223
            |.|:...:..|.|::.||.:::...|||.::|||:..::.|..::........::.|...| .||
Mouse  1265 ASLKLKDMNYANPIIKWLSEEQRYGGGFYSTQDTINAIEGLTEYSLLLKQIHLDMDINVAYKHEG 1329

  Fly  1224 AETIINVNAENSLALQTVELPNNLKNLSVSATGRGMALAQV---SYTYNTNVTSAWPRFVL---D 1282
            ......|..::.|. :.||:  :|.:..|.:||....||.|   :..:..:|:..:..|.|   .
Mouse  1330 DFHKYKVTEKHFLG-RPVEV--SLNDDLVVSTGYSSGLATVYVKTVVHKISVSEEFCSFYLKIDT 1391

  Fly  1283 PTVNRNSH-----ADYLHLSACASFVSVVGENEQRSNMAVMEVHLPSGFVVDRDTLPTLESSERI 1342
            ..:..:||     :.:..:.||||:.....|:...|:.|||::.||:|...:.:.|..|......
Mouse  1392 QDIEASSHFRLSDSGFKRIIACASYKPSKEESTSGSSHAVMDISLPTGIGANEEDLRALVEGVDQ 1456

  Fly  1343 KKVETQNRNTKVVIYFDYLDRRE-VCPTLHAYKTVKVTKHRPVAVVMYDYYDSARRARQFYRAPK 1406
            ...:.|.::..|::..:.:..|: :|.....::..:|....|....:|:|:...::....|....
Mouse  1457 LLTDYQIKDGHVILQLNSIPSRDFLCVRFRIFELFQVGFLNPATFTVYEYHRPDKQCTMIYSISD 1521

  Fly  1407 SNICDICEHANCG-------------DLCEKAEKRESKRPDDYTAIA 1440
            :.:..:||.|.|.             ||...|:.|:.|.....||.|
Mouse  1522 TRLQKVCEGAACTCVEADCAQLQAEVDLAISADSRKEKACKPETAYA 1568

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tep3	NP_523507.2	YfaS	<128..1399	CDD:441940	325/1488 (22%)
		A2M_2	918..1203	CDD:239227	78/321 (24%)
Hc	XP_017171158.1	MG1	25..124	CDD:465508	27/110 (25%)
		YfaS	<131..1308	CDD:441940	283/1282 (22%)
		A2M_BRD	474..614	CDD:462235	38/140 (27%)
		ANATO	690..758	CDD:237984	6/67 (9%)
		complement_C3_C4_C5	1003..1308	CDD:239226	78/322 (24%)
		A2M_recep	1427..1518	CDD:462226	17/90 (19%)
		NTR_like	1535..1683	CDD:470599	8/34 (24%)