DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tep3 and A2ML1

DIOPT Version :9

Sequence 1:	NP_523507.2	Gene:	Tep3 / 34045	FlyBaseID:	FBgn0041181	Length:	1469	Species:	Drosophila melanogaster
Sequence 2:	XP_011518868.1	Gene:	A2ML1 / 144568	HGNCID:	23336	Length:	1467	Species:	Homo sapiens

Alignment Length:	1550	Identity:	362/1550 - (23%)
Similarity:	637/1550 - (41%)	Gaps:	325/1550 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 LGSSYTDFK---TVELRPFSTQLLHFE---------------IPALRTDRY-RLTAEGLG-GVQF 109
            |...|:|.|   |:|.:..:.:||.:.               .||..|:.. .:...|:| .:.|
Human    43 LSPGYSDVKFTVTLETKDKTQKLLEYSGLKKRHLHCISFLVPPPAGGTEEVATIRVSGVGNNISF 107

  Fly   110 TNETQLHFESKQHTVLVQTDKSIYKPGDLVHYRVLILDANLKPARG-YGRVHVDIKDSGDNIIRS 173
            ..:.::..:.:.:...|||||.:|.||..|::|::.:|:|..|... |..  |:::|...|.|..
Human   108 EEKKKVLIQRQGNGTFVQTDKPLYTPGQQVYFRIVTMDSNFVPVNDKYSM--VELQDPNSNRIAQ 170

  Fly   174 YKDIRLTNSIYSNELRLSDSPRFGTWSIVVDVSDQEHTQTFEILDHILPKFVVDIDTPKHAIYKD 238
            :.::.....|.....:|:.....||:::.  |::.:...||.:.:::||||.|::..||......
Human   171 WLEVVPEQGIVDLSFQLAPEAMLGTYTVA--VAEGKTFGTFSVEEYVLPKFKVEVVEPKELSTVQ 233

  Fly   239 GKIAATVRAHYAFGQPIVGEATLSIYPTFFGSLQPFVNDLITRKVVPIDGNAYFEFDIENE---- 299
            ......:...|.:|:|::|...:|:..                     ..|.|:..::|.|
Human   234 ESFLVKICCRYTYGKPMLGAVQVSVCQ---------------------KANTYWYREVEREQLPD 277

  Fly   300 ----LHLKQD--------------------YERQYLLDALVEEKSTGSVQNYSTVLTLHLNHYRV 340
                |..:.|                    |..|..:.|.|.|:.||...|.:..:.:......:
Human   278 KCRNLSGQTDKTGCFSAPVDMATFDLIGYAYSHQINIVATVVEEGTGVEANATQNIYISPQMGSM 342

  Fly   341 EAVKVPSYYIPGVPFEATARIARNDGGQLRDFNPQITAYLTNVYGSSEMYNRT---------AYS 396
            ......::|.|..||....|:..:|...|::.    ..:|. :||::..:|:|         .::
Human   343 TFEDTSNFYHPNFPFSGKIRVRGHDDSFLKNH----LVFLV-IYGTNGTFNQTLVTDNNGLAPFT 402

  Fly   397 LDASG------EIKMKFTVPIGDRDEFHSIIVDYQGVISEVGKIP----SKHLH-------SKNY 444
            |:.||      .::.||.:               :.::....::|    :.:||       ::::
Human   403 LETSGWNGTDVSLEGKFQM---------------EDLVYNPEQVPRYYQNAYLHLRPFYSTTRSF 452

  Fly   445 ITAKVLNDRPTVNQEISVVVRSF------APIK--YFMYQVVGRGDIILSRNVDVAPGTFHT--- 498
            :....||......|...|:|..:      :|.:  .|.|.::|:|.:::.       |..|.
Human   453 LGIHRLNGPLKCGQPQEVLVDYYIDPADASPDQEISFSYYLIGKGSLVME-------GQKHLNSK 510

  Fly   499 ---IKFLASFA--------MMPRANLLVYTVIDG------------EFVYDEQVIQLEENLLNAV 540
               :|  |||:        :.|..:|::|.:...            |..:|.|...:.:..|:..
Human   511 KKGLK--ASFSLSLTFTSRLAPDPSLVIYAIFPSGGVVADKIQFSVEMCFDNQADLIPKLYLSLP 573

  Fly   541 QVD---APIRAPPGQDIDIGISTKPYSYVGLMLVDQNANDLRSGHDLTHKRLMD----------- 591
            ||.   :|.:..||.::::.:...|.|...|..||::...||...:|:::.:..
Human   574 QVSLGFSPSQQLPGAEVELQLQAAPGSLCALRAVDESVLLLRPDRELSNRSVYGMFPFWYGHYPY 638

  Fly   592 ALRSYELSDVNTPMGSP-----------GKESGVI----TMSNTDYF-----IEKEAESNPALDR 636
            .:..|:...|:.|...|           ..:..:|    ....||.|     :..:..||..:.:
Human   639 QVAEYDQCPVSGPWDFPQPLIDPMPQGHSSQRSIIWRPSFSEGTDLFSFFRDVGLKILSNAKIKK 703

  Fly   637 EVSTGPEEDKLTTVRKTDIGPAHKIEVNTLPPGKGRYAFSYTPKPFWHNPRVHVMRDP------A 695
            .|.......:.:|               .:..|.|.      |:.|..:..:|...|.      .
Human   704 PVDCSHRSPEYST---------------AMGAGGGH------PEAFESSTPLHQAEDSQVRQYFP 747

  Fly   696 DTWLFLNISASSDGRNSIHRRIPSEMTSWVVSAFALDPVNGLGLSPPNGKLEAYKEFYISTELPY 760
            :|||:......:.|:.::|..:|..:|.|...:|......|.||||..| |.|:|.|::...|||
Human   748 ETWLWDLFPIGNSGKEAVHVTVPDAITEWKAMSFCTSQSRGFGLSPTVG-LTAFKPFFVDLTLPY 811

  Fly   761 SIKRDELIAIPFVVHNNRDSDLNVEVTFYNSALDFDFPQLDPKATNQPKVELY--RRRSLQVPGR 823
            |:.|.|              ...:..|.:|...|....|.|...:::.::|.:  .:.|..:...
Human   812 SVVRGE--------------SFRLTATIFNYLKDCIRVQTDLAKSHEYQLESWADSQTSSCLCAD 862

  Fly   824 SARSVSFIVTPKRVG----PLLVKAMAASSQAG------------DTVEQNLLVEHPGAM-ERIN 871
            .|::..:.:|..::|    .:..|.:.::...|            ||:.:.:||:..|.: |:.:
Human   863 DAKTHHWNITAVKLGHINFTISTKILDSNEPCGGQKGFVPQKGRSDTLIKPVLVKPEGVLVEKTH 927

  Fly   872 RGFLFELNSNAQNRRNVTIAVPRNAIPESTRIEVSAVGDLIGSLVGNLDSLILLPTGCGEQTMVN 936
            ...|......|.  .:|::.:|.:.:|:||:..|:.:||::|:.:.|||.|:.:|:|||||.||.
Human   928 SSLLCPKGKVAS--ESVSLELPVDIVPDSTKAYVTVLGDIMGTALQNLDGLVQMPSGCGEQNMVL 990

  Fly   937 FVPNLIVLRYLGRLRQLTPEVELRATNNLAIGYQRILYYRHENGAFSAFGLDIKRSSTWLTAYVA 1001
            |.|.:.||:||.:...||.|:..||...|.||||:.|.|:|.||::||||......:|||||:|.
Human   991 FAPIIYVLQYLEKAGLLTEEIRSRAVGFLEIGYQKELMYKHSNGSYSAFGERDGNGNTWLTAFVT 1055

  Fly  1002 RSLRQAAPFTQVDSNVLQKALTYLGSVQSANGGFEERGDVFE---RFG-DDGISLTAFVTLALME 1062
            :...||..|..:|...:|.||.::...|..:|.:...|::..   :.| ||.:||||:||.||:|
Human  1056 KCFGQAQKFIFIDPKNIQDALKWMAGNQLPSGCYANVGNLLHTAMKGGVDDEVSLTAYVTAALLE 1120

  Fly  1063 NVDLYPEYRNNINKALD--FITRGL-------DGSSNLHAMAIGTYVLSRANH-NAKAAFLQRLD 1117
                       :.|.:|  .:::||       ..::||:..|:..|:.|.|.. :.:...|::||
Human  1121 -----------MGKDVDDPMVSQGLRCLKNSATSTTNLYTQALLAYIFSLAGEMDIRNILLKQLD 1174

  Fly  1118 SMA-TNKDGLKWWNKTAPAGEQQSPWYNATRSVNIEISAYAALA-----LLENNLVGDALPVLNW 1176
            ..| .:.:.:.|..|..|: ...||| :...:|::|::|||.||     .|....:..|..::.|
Human  1175 QQAIISGESIYWSQKPTPS-SNASPW-SEPAAVDVELTAYALLAQLTKPSLTQKEIAKATSIVAW 1237

  Fly  1177 LMDQRNPKGGFVASQDTVVGLQALLMFAERFSSQGNNLQIGFHYGEGAETIINVNAENSLALQTV 1241
            |..|.|..|||.::|||||.||||..:|.........:.:.....|..:...|:.:.|.|..|..
Human  1238 LAKQHNAYGGFSSTQDTVVALQALAKYATTAYMPSEEINLVVKSTENFQRTFNIQSVNRLVFQQD 1302

  Fly  1242 ELPNNLKNLSVSATGRGMALAQVSYTYNTNVTSAWPRFVL----------DPTVNRNSHADYLHL 1296
            .|||.....::.|:|:|....|....||....:....|.|          .||..|:     |.|
Human  1303 TLPNVPGMYTLEASGQGCVYVQTVLRYNILPPTNMKTFSLSVEIGKARCEQPTSPRS-----LTL 1362

  Fly  1297 SACASFVSVVGENEQRSNMAVMEVHLPSGFVVDRDTLPTLESSERIKKVE--TQNRNTKVVIYFD 1359
            :...|:|.    :...||||::||.:.|||.....|...|.....:||||  |...|    ||.|
Human  1363 TIHTSYVG----SRSSSNMAIVEVKMLSGFSPMEGTNQLLLQQPLVKKVEFGTDTLN----IYLD 1419

  Fly  1360 YLDRREVCPTLHAYKTVKVTKHRPVAVVMYDYYDSARRARQFYRAPKSNICDICE 1414
            .|.:.....|....::|.||..:|..:.:||||....:|...|..|       ||
Human  1420 ELIKNTQTYTFTISQSVLVTNLKPATIKVYDYYLPDEQATIQYSDP-------CE 1467

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tep3	NP_523507.2	A2M_N	124..215	CDD:280081	24/91 (26%)
		A2M_N_2	448..573	CDD:285005	32/161 (20%)
		A2M	697..787	CDD:278630	25/89 (28%)
		A2M_2	918..1203	CDD:239227	110/304 (36%)
		A2M_comp	967..1200	CDD:284982	84/252 (33%)
		A2M_recep	1313..1402	CDD:284981	31/90 (34%)
A2ML1	XP_011518868.1	A2M_N	122..211	CDD:280081	25/92 (27%)
		YfaS	<123..>1055	CDD:225248	221/1023 (22%)
		A2M_N_2	455..613	CDD:285005	33/166 (20%)
		A2M	749..839	CDD:278630	29/104 (28%)
		A2M_2	969..1264	CDD:239227	110/307 (36%)
		A2M_comp	1021..1266	CDD:284982	86/257 (33%)
		A2M_recep	1375..1462	CDD:284981	31/90 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149971
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2373
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D177369at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100452
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.650